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oxidoreductase-2-mediated prodrug cancer therapy.Mark R Middleton et al.Science translational medicine, 2(40), 40ra50-40ra50 (2010-07-16) Discovery and evaluation of Escherichia coli nitroreductases that activate the anti-cancer prodrug CB1954.G A Prosser et al.Biochemical pharmacology, 79(5), 678-687 (2009-10-27) Creation and screening of a multi-family bacterial oxidoreductase library to discover novel nitroreductases that efficiently activate the bioreductive prodrugs CB1954 and PR-104A.Gareth A Prosser et al.Biochemical pharmacology, 85(8), 1091-1103 (2013-02-13) Antitumor activity of a selectively replication competent herpes simplex virus (HSV) with enzyme prodrug therapy.Lynne Braidwood et al.Anticancer research, 29(6), 2159-2166 (2009-06-17) The synthesis of 2-nitroaryl-1,2,3,4-tetrahydroisoquinolines, nitro-substituted 5,6-dihydrobenzimidazo[2,1-a]isoquinoline N-oxides and related heterocycles as potential bioreducible substrates for the enzymes NAD(P)H: quinone oxidoreductase 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