沸点	101 ºC
闪点	44 ºF
密度	0.873
折射率	1.389-1.391

危险品标志	F
危险类别码	R11
安全说明书	S16;S33;S9

来源	SDS样本
Alfa-Aesar	浏览或下载
Sigma-Aldrich	浏览或下载
TCI	浏览或下载

产品合成路线

更多

名称	CAS号

更多

文章

同行评议文献

Stable carbon isotope discrimination by human 3-hydroxy-3-methylglutaryl-coenzyme A reductase.Svena M Lüdke et al.Journal of lipid research, 49(12), 2620-2626 (2008-08-02) Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia.Geneviève Dubuc et al.Arteriosclerosis, thrombosis, and vascular biology, 24(8), 1454-1459 (2004-06-05) 4,8-Dimethyldecanal, the aggregation pheromone of Tribolium castaneum, is biosynthesized through the fatty acid pathway.Junheon Kim et al.Journal of chemical ecology, 31(6), 1381-1400 (2005-10-14) Biosynthesis of sesqui- and diterpenes by the gibberellin producer Fusarium fujikuroi.Nelson L Brock et al.Chembiochem : a European journal of chemical biology, 12(17), 2667-2676 (2011-10-13) Increased Cholesterol Biosynthesis Is a Key Characteristic of Breast Cancer Stem Cells Influencing Patient Outcome.Sidse Ehmsen et al.Cell reports, 27(13), 3927-3938 (2019-06-27) Effects of cholesterol and nuclear hormone receptor agonists on the production of transforming growth factor-beta in macrophages.Ya Sh Schwartz et al.Bulletin of experimental biology and medicine, 148(3), 406-409 (2010-04-17) [Mevalonolactone: a volatile compound produced by Psammotettix alienus (Dhb)].Salah Alla et al.Comptes rendus biologies, 325(9), 941-946 (2002-12-17) Statins stimulate in vitro membrane FasL expression and lymphocyte apoptosis through RhoA/ROCK pathway in murine melanoma cells.Guillaume Sarrabayrouse et al.Neoplasia (New York, N.Y.), 9(12), 1078-1090 (2007-12-18) Adaptation of hydroxymethylbutenyl diphosphate reductase enables volatile isoprenoid production.Mareike Bongers et al.eLife, 9 (2020-03-13) Analysis of the isoprenoid biosynthesis pathways in Listeria monocytogenes reveals a role for the alternative 2-C-methyl-D-erythritol 4-phosphate pathway in murine infection.Begley M Infection and Immunity, 76, 5392-5401 (2008) Transcriptome-based identification of lovastatin as a breast cancer stem cell-targeting drug.Luz X Vásquez-Bochm et al.Pharmacological reports : PR, 71(3), 535-544 (2019-04-27) Mevalonate depletion mediates the suppressive impact of geranylgeraniol on murine B16 melanoma cells.Rajasekhar Katuru et al.Experimental biology and medicine (Maywood, N.J.), 236(5), 604-613 (2011-05-05) Deamidation Shunts RelA from Mediating Inflammation to Aerobic Glycolysis.Jun Zhao et al.Cell metabolism, 31(5), 937-955 (2020-04-24) Protective effects of a squalene synthase inhibitor, lapaquistat acetate (TAK-475), on statin-induced myotoxicity in guinea pigs.Tomoyuki Nishimoto et al.Toxicology and applied pharmacology, 223(1), 39-45 (2007-06-30) Methodology for synthesis and isolation of 5-phosphomevalonic acid.Chang-Zeng Wang et al.Analytical biochemistry, 321(2), 272-275 (2003-09-27) Biogenetic studies in Syringa vulgaris L.: synthesis and bioconversion of deuterium-labeled precursors into lilac aldehydes and lilac alcohols.Mirjam Kreck et al.Journal of agricultural and food chemistry, 51(2), 463-469 (2003-01-09) Genetic evidence for the role of isopentenyl diphosphate isomerases in the mevalonate pathway and plant development in Arabidopsis.Kazunori Okada et al.Plant & cell physiology, 49(4), 604-616 (2008-02-28) Therapeutic levels of the hydroxmethylglutaryl-coenzyme A reductase inhibitor lovastatin activate ras signaling via phospholipase D2.Kwang-Jin Cho et al.Molecular and cellular biology, 31(6), 1110-1120 (2011-01-20) Calmodulin antagonist W-7 inhibits de novo synthesis of cholesterol and suppresses secretion of de novo synthesized and preformed lipids from cultured hepatocytes.Mehdi Rasouli et al.Biochimica et biophysica acta, 1682(1-3), 92-101 (2004-05-26) In vitro and in vivo anticancer effects of mevalonate pathway modulation on human cancer cells.P Jiang et al.British journal of cancer, 111(8), 1562-1571 (2014-08-06) Cell-based screen of HMG-CoA reductase inhibitors and expression regulators using LC-MS.Raphaele Gerber et al.Analytical biochemistry, 329(1), 28-34 (2004-05-12) Biosynthesis of mono- and sesquiterpenes in strawberry fruits and foliage: 2H labeling studies.Daniela Hampel et al.Journal of agricultural and food chemistry, 54(4), 1473-1478 (2006-02-16) Effect of phytosterols on cholesterol metabolism and MAP kinase in MDA-MB-231 human breast cancer cells.Atif B Awad et al.The Journal of nutritional biochemistry, 14(2), 111-119 (2003-04-02) Effect of geraniol on fatty-acid and mevalonate metabolism in the human hepatoma cell line Hep G2.Monica P Polo et al.Biochemistry and cell biology = Biochimie et biologie cellulaire, 84(1), 102-111 (2006-02-08) Liquid chromatography-tandem mass spectrometry method for the measurement of serum mevalonic acid: a novel marker of hydroxymethylglutaryl coenzyme A reductase inhibition by statins.Jenna Waldron et al.Annals of clinical biochemistry, 48(Pt 3), 223-232 (2011-03-01) The effects of different types of statins on proliferation and migration of HGF-induced Human Umbilical Vein Endothelial Cells (HUVECs).Burgazli KM European Review for Medical and Pharmacological Sciences, 17, 2874-2883 (2013) A mevalonate bypass system facilitates elucidation of plastid biology in malaria parasites.Russell P Swift et al.PLoS pathogens, 16(2), e1008316-e1008316 (2020-02-15) Inhibiting Airway Smooth Muscle Contraction Using Pitavastatin: A Role for the Mevalonate Pathway in Regulating Cytoskeletal Proteins.Robin A Lu et al.Frontiers in pharmacology, 11, 469-469 (2020-05-22) Rab11b-mediated integrin recycling promotes brain metastatic adaptation and outgrowth.Erin N Howe et al.Nature communications, 11(1), 3017-3017 (2020-06-17) Synthesis and HMG-CoA reductase inhibition of 2-cyclopropyl-4-thiophenyl-quinoline mevalonolactones.Shikui Zhao et al.Bioorganic & medicinal chemistry, 17(23), 7915-7923 (2009-11-03) Ciliopathy proteins regulate paracrine signaling by modulating proteasomal degradation of mediators.Yangfan P Liu et al.The Journal of clinical investigation, 124(5), 2059-2070 (2014-04-03) Leukaemia inhibitory factor or oncostatin M induction of Swiss 3T3 cells does not require mevalonic acid synthesis nor protein isoprenylation to initiate DNA replication.Moira Sauane et al.Biochemical and biophysical research communications, 313(4), 926-930 (2004-01-07) Highly sensitive assay of HMG-CoA reductase activity by LC-ESI-MS/MS.Akira Honda et al.Journal of lipid research, 48(5), 1212-1220 (2007-02-03) Statins inhibit protein lipidation and induce the unfolded protein response in the non-sterol producing nematode Caenorhabditis elegans.Catarina Mörck et al.Proceedings of the National Academy of Sciences of the United States of America, 106(43), 18285-18290 (2009-10-15) Involvement of the phospholipid sterol acyltransferase1 in plant sterol homeostasis and leaf senescence.Pierrette Bouvier-Navé et al.Plant physiology, 152(1), 107-119 (2009-11-20) Activators of the energy sensing kinase AMPK inhibit random cell movement and chemotaxis in U937 cells.John Kanellis et al.Immunology and cell biology, 84(1), 6-12 (2006-01-13) Conserved statin-mediated activation of the p38-MAPK pathway protects Caenorhabditis elegans from the cholesterol-independent effects of statins.Irina Langier Goncalves et al.Molecular metabolism, 39, 101003-101003 (2020-04-28) Coenzyme Q 10 production in recombinant Escherichia coli strains engineered with a heterologous decaprenyl diphosphate synthase gene and foreign mevalonate pathway.Zahiri HS Metabolic engineering, 8, 406-416 (2006) Isoprenoids are essential for fruiting body formation in Myxococcus xanthus.Wolfram Lorenzen et al.Journal of bacteriology, 191(18), 5849-5853 (2009-07-21) Prooxidative toxicity and selenoprotein suppression by cerivastatin in muscle cells.Jessica Fuhrmeister et al.Toxicology letters, 215(3), 219-227 (2012-10-25)

备注