
4-Chloro-7-fluoro-2-methylquinazoline | CAS:1206694-32-7
4-Chloro-7-fluoro-2-methylquinazoline
- 名称:4-氯-7-氟-2-甲基喹唑啉 | 4-Chloro-7-fluoro-2-methylquinazoline
- CAS号:1206694-32-7
- 别名:
- 分子式:C9H6ClFN2
- 分子量:196.61
- EINESC号:
产品描述
物理化学性质
沸点 | 216 ºC |
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闪点 | 84 ºC |
密度 | 1.380 |
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Sorption comparison between phenanthrene and its degradation intermediates, 9,10-phenanthrenequinone and 9-phenanthrol in soils/sediments.Di Xiao et al.Chemosphere, 86(2), 183-189 (2011-11-08)
One-pot formation of 1,3,4-oxadiazol-2(3H)-ones and dibenzo[c,e]azepines by concomitant cathodic reduction of diazonium salts and phenanthrenequinones.Belen Batanero et al.The Journal of organic chemistry, 78(18), 9477-9481 (2013-08-21)
9,10-phenanthrenequinone induces monocytic differentiation of U937 cells through regulating expression of aldo-keto reductase 1C3.Toshiyuki Matsunaga et al.Biological & pharmaceutical bulletin, 35(9), 1598-1602 (2012-09-15)
Targeting triple negative breast cancer cells by N3-substituted 9,10-phenanthrenequinone thiosemicarbazones and their metal complexes.Zahra Afrasiabi et al.Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 114, 114-119 (2013-06-19)
Acetylation Regulates Thioredoxin Reductase Oligomerization and Activity.David E Wright et al.Antioxidants & redox signaling, 29(4), 377-388 (2017-11-10)
Involvement of an aldo-keto reductase (AKR1C3) in redox cycling of 9,10-phenanthrenequinone leading to apoptosis in human endothelial cells.Toshiyuki Matsunaga et al.Chemico-biological interactions, 181(1), 52-60 (2009-05-16)
Quinone-enhanced reduction of nitric oxide by xanthine/xanthine oxidase.Pedro Sanchez-Cruz et al.Chemical research in toxicology, 22(5), 818-823 (2009-03-24)
Fluorescence Titrations of Bio-relevant Complexes with DNA: Synthesis, Structural Investigation, DNA Binding/Cleavage, Antimicrobial and Molecular Docking Studies.Thesingu Rajan Arun et al.Journal of fluorescence, 25(4), 1127-1140 (2015-07-08)
The role of Ala231 and Trp227 in the substrate specificities of fungal 17β-hydroxysteroid dehydrogenase and trihydroxynaphthalene reductase: Steroids versus smaller substrates.Mojca Brunskole Svegelj et al.The Journal of steroid biochemistry and molecular biology, 129(1-2), 92-98 (2011-03-29)
The catalytic mechanism of NADH-dependent reduction of 9,10-phenanthrenequinone by Candida tenuis xylose reductase reveals plasticity in an aldo-keto reductase active site.Simone L Pival et al.The Biochemical journal, 421(1), 43-49 (2009-04-17)
Dual effects of N-acetyl-L-cysteine dependent on NQO1 activity: suppressive or promotive of 9,10-phenanthrenequinone-induced toxicity.Tatsushi Toyooka et al.Toxicology and applied pharmacology, 264(3), 404-412 (2012-08-29)
Naturally occurring variants of human aldo-keto reductases with reduced in vitro metabolism of daunorubicin and doxorubicin.Onkar S Bains et al.The Journal of pharmacology and experimental therapeutics, 335(3), 533-545 (2010-09-15)
Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1.Janice L Hyatt et al.Journal of medicinal chemistry, 50(23), 5727-5734 (2007-10-19)
Method development for the measurement of quinone levels in urine.Dianne Lim et al.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879(30), 3592-3598 (2011-10-26)
4-Carbomethoxybenzaldehyde as a highly sensitive pre-column fluorescence derivatization reagent for 9,10-phenanthrenequinone.Naoya Kishikawa et al.Talanta, 85(1), 809-812 (2011-06-08)
Redox processes in the iron(III)/9,10-phenanthraquinone system.Petr Milko et al.Inorganic chemistry, 48(24), 11734-11742 (2009-11-26)
Aldo-keto reductase 1C15 as a quinone reductase in rat endothelial cell: its involvement in redox cycling of 9,10-phenanthrenequinone.Toshiyuki Matsunaga et al.Free radical research, 45(7), 848-857 (2011-06-01)
An indomethacin analogue, N-(4-chlorobenzoyl)-melatonin, is a selective inhibitor of aldo-keto reductase 1C3 (type 2 3alpha-HSD, type 5 17beta-HSD, and prostaglandin F synthase), a potential target for the treatment of hormone dependent and hormone independent malignancies.Michael C Byrns et al.Biochemical pharmacology, 75(2), 484-493 (2007-10-24)
Nucleoid compaction by MrgA(Asp56Ala/Glu60Ala) does not contribute to staphylococcal cell survival against oxidative stress and phagocytic killing by macrophages.Yuri Ushijima et al.FEMS microbiology letters, 360(2), 144-151 (2014-09-18)
Advanced Glycation-Modified Human Serum Albumin Evokes Alterations in Membrane and Eryptosis in Erythrocytes.Saurabh Awasthi et al.Applied biochemistry and biotechnology, 177(5), 1013-1024 (2015-08-16)
[Development of selective determination methods for quinones with fluorescence and chemiluminescence detection and their application to environmental and biological samples].Naoya Kishikawa Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 130(10), 1319-1324 (2010-10-12)
Redox cycling of 9,10-phenanthraquinone to cause oxidative stress is terminated through its monoglucuronide conjugation in human pulmonary epithelial A549 cells.Keiko Taguchi et al.Free radical biology & medicine, 44(8), 1645-1655 (2008-02-26)
Salt stress induces production of melanin related metabolites in the phytopathogenic fungus Leptosphaeria maculans.M Soledade C Pedras et al.Natural product communications, 4(1), 53-58 (2009-04-18)
Electronic structures of ruthenium and osmium complexes of 9,10-phenanthrenequinone.Manas Kumar Biswas et al.Inorganic chemistry, 51(12), 6687-6699 (2012-06-06)
NADP(+)-dependent dehydrogenase activity of carbonyl reductase on glutathionylhydroxynonanal as a new pathway for hydroxynonenal detoxification.Roberta Moschini et al.Free radical biology & medicine, 83, 66-76 (2015-02-15)
Determination of 9, 10-phenanthrenequinone in airborne particulates by High-Performance Liquid Chromatography with post-column fluorescence derivatization using 2-aminothiophenol.Naoya Kishikawa et al.Talanta, 81(4-5), 1852-1855 (2010-05-06)
Electronic structure and band alignment of 9, 10-phenanthrenequinone passivated silicon surfacesAvasthi, Sushobhan, et al. Surface Science, 605(13), 1308-1312 (2011)
Mutagenicity of quinones: pathways of metabolic activation and detoxification.P L Chesis et al.Proceedings of the National Academy of Sciences of the United States of America, 81(6), 1696-1700 (1984-03-01)
Exposure to 9,10-phenanthrenequinone accelerates malignant progression of lung cancer cells through up-regulation of aldo-keto reductase 1B10.Matsunaga T, Morikawa Y, Haga M, et al. Toxicology and Applied Pharmacology, 278(2), 180-189 (2014)
3-Deoxyglucosone: a potential glycating agent accountable for structural alteration in H3 histone protein through generation of different AGEs.Jalaluddin M Ashraf et al.PloS one, 10(2), e0116804-e0116804 (2015-02-18)
Interaction of 9,10-phenanthraquinone with dithiol causes oxidative modification of Cu,Zn-superoxide dismutase (SOD) through redox cycling.Rie Koizumi et al.The Journal of toxicological sciences, 38(3), 317-324 (2013-05-15)
Identification of metabolites from phenanthrene oxidation by phenoloxidases and dioxygenases of Polyporus sp. S133.Tony Hadibarata et al.Journal of microbiology and biotechnology, 21(3), 299-304 (2011-04-06)
9,10-Phenanthrenequinone induces DNA deletions and forward mutations via oxidative mechanisms in the yeast Saccharomyces cerevisiae.Chester E Rodriguez et al.Toxicology in vitro : an international journal published in association with BIBRA, 22(2), 296-300 (2007-10-26)
9,10-Phenanthrenedione biodegradation by a soil bacterium and identification of transformation products by LC/ESI-MS/MS.Robert A Kanaly et al.Chemosphere, 92(11), 1442-1449 (2013-04-25)
Synthesis of highly functionalized 9,10-phenanthrenequinones by oxidative coupling using MoCl5.Simon Trosien et al.Organic letters, 14(12), 2976-2979 (2012-06-05)
Temperature dependence properties of holographic gratings in phenanthrenquinone doped poly(methyl methacrylate) photopolymers.Juan Manuel Russo et al.Applied optics, 46(30), 7494-7499 (2007-10-24)
Human carbonyl reductase 4 is a mitochondrial NADPH-dependent quinone reductase.Satoshi Endo et al.Biochemical and biophysical research communications, 377(4), 1326-1330 (2008-11-13)
Nitric oxide mitigates apoptosis in human endothelial cells induced by 9,10-phenanthrenequinone: role of proteasomal function.Toshiyuki Matsunaga et al.Toxicology, 268(3), 191-197 (2009-12-23)
Sulfa drugs inhibit sepiapterin reduction and chemical redox cycling by sepiapterin reductase.Shaojun Yang et al.The Journal of pharmacology and experimental therapeutics, 352(3), 529-540 (2015-01-01)
9,10-Phenanthrenequinone promotes secretion of pulmonary aldo-keto reductases with surfactant.Toshiyuki Matsunaga et al.Cell and tissue research, 347(2), 407-417 (2012-01-28)
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