
(S)-5-Benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-4H-1,2,4-triazole-3-carboxamide | CAS:1622848-92-3
(S)-5-Benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-4H-1,2,4-triazole-3-carboxamide
- 名称:(S)-5-苄基-N-(5-甲基-4-氧代-2,3,4,5-四氢苯并[b][1,4]氧氮杂卓-3-基)-4H-1,2,4-三唑-3-甲酰胺 | (S)-5-Benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-4H-1,2,4-triazole-3-carboxamide
- CAS号:1622848-92-3
- 别名:3-(Phenylmethyl)-N-[(3S)-2,3,4,5-tetrahydro-5-methyl-4-oxo-1,5-benzoxazepin-3-yl]-1H-1,2,4-triazole-5-carboxamide
- 分子式:C20H19N5O3
- 分子量:377.40
- EINESC号:
产品描述
物理化学性质
密度 | 1.40±0.1 g/cm3 (20 ºC |
---|
安全数据
没有数据 | 没有数据 |
---|
SDS
来源 | SDS样本 |
---|---|
没有数据 | 没有数据 |
产品合成路线
名称 | CAS号 |
---|
更多
文章
同行评议文献
Repositioning of the antipsychotic trifluoperazine: Synthesis, biological evaluation and in silico study of trifluoperazine analogs as anti-glioblastoma agents.Seokmin Kang et al.European journal of medicinal chemistry, 151, 186-198 (2018-04-04)
Snake Deltavirus Utilizes Envelope Proteins of Different Viruses To Generate Infectious Particles.Leonora Szirovicza et al.mBio, 11(2) (2020-03-19)
Calcium and Calmodulin Are Involved in Nitric Oxide-Induced Adventitious Rooting of Cucumber under Simulated Osmotic Stress.Lijuan Niu et al.Frontiers in plant science, 8, 1684-1684 (2017-10-13)
Bacteriophage trigger antiviral immunity and prevent clearance of bacterial infection.Johanna M Sweere et al.Science (New York, N.Y.), 363(6434) (2019-03-30)
A Flow Cytometric Method to Quantify the Endosomal Escape of a Protein Toxin to the Cytosol of Target Cells.Harrison J Wensley et al.Pharmaceutical research, 37(1), 16-16 (2019-12-25)
Trifluoperazine Activates FOXO1-Related Signals to Inhibit Tumor Growth in Hepatocellular Carcinoma.Jingwen Jiang et al.DNA and cell biology, 36(10), 813-821 (2017-09-07)
Pentabromophenol suppresses TGF-β signaling by accelerating degradation of type II TGF-β receptors via caveolae-mediated endocytosis.Chun-Lin Chen et al.Scientific reports, 7, 43206-43206 (2017-02-24)
Dissecting the Anticancer Mechanism of Trifluoperazine on Pancreatic Ductal Adenocarcinoma.Can Huang et al.Cancers, 11(12) (2019-11-27)
Immunomodulatory properties of titanium dioxide nanostructural materials.T Sree Latha et al.Indian journal of pharmacology, 49(6), 458-464 (2018-04-21)
Calmodulin of the tropical sea cucumber: Gene structure, inducible expression and contribution to nitric oxide production and pathogen clearance during immune response.Ting Chen et al.Fish & shellfish immunology, 45(2), 231-238 (2015-04-29)
The determination of Plutella xylostella (L.) GSTs (PxGSTs) involved in the detoxification metabolism of Tolfenpyrad.Yifan Li et al.Pest management science, 76(12), 4036-4045 (2020-06-10)
Leukemia-Associated Mutations in Nucleophosmin Alter Recognition by CRM1: Molecular Basis of Aberrant Transport.Igor Arregi et al.PloS one, 10(6), e0130610-e0130610 (2015-06-20)
Action of anti-M₃muscarinic acetylcholine receptor IgG of primary Sjögren's syndrome on the enzymatic antioxidant system in rat submandibular gland.Silvia Reina et al.Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 44(10), 876-883 (2015-03-03)
NaNarattaphol Charoenphandhu et al.Molecular and cellular biochemistry, 427(1-2), 201-208 (2016-12-21)
3-Chlorodiphenylamine activates cardiac troponin by a mechanism distinct from bepridil or TFP.Svetlana B Tikunova et al.The Journal of general physiology, 151(1), 9-17 (2018-11-18)
Melatonin and calcium modulate the production of rosmarinic acid, luteolin, and apigenin in Dracocephalum kotschyi under salinity stress.Farinaz Vafadar et al.Phytochemistry, 177, 112422-112422 (2020-07-01)
Immunomodulator mediated changes in plasma membrane calcium ATPase in controlling visceral leishmaniasis.Nivedita Roy et al.Experimental parasitology, 217, 107948-107948 (2020-07-23)
Local Government Competition and Regional Green Development in China: The Mediating Role of Environmental Regulation.Na Zhang et al.International journal of environmental research and public health, 17(10) (2020-05-21)
Bioresponsive interfaces composed of calmodulin and poly(ethylene glycol): Toggling the interfacial film thickness by protein-ligand binding.Süleyman Cinar et al.Colloids and surfaces. B, Biointerfaces, 158, 9-15 (2017-06-29)
Real-time monitoring and regulating auditory cortex alpha activity in patients with chronic tinnitus.Azim Malekshahi et al.Journal of neural engineering, 17(1), 016032-016032 (2019-11-15)
Pseudomonas aeruginosa ExlA and Serratia marcescens ShlA trigger cadherin cleavage by promoting calcium influx and ADAM10 activation.Emeline Reboud et al.PLoS pathogens, 13(8), e1006579-e1006579 (2017-08-24)
A rapid and affordable screening platform for membrane protein trafficking.Joshua C Snyder et al.BMC biology, 13, 107-107 (2015-12-19)
Transcriptome Analyses Shed New Insights into Primary Metabolism and Regulation ofFan-Song Zeng et al.Frontiers in plant science, 8, 1146-1146 (2017-07-18)
Pharmacokinetic Characterization and Tissue Distribution of Fusion Protein Therapeutics by Orthogonal Bioanalytical Assays and Minimal PBPK Modeling.Hiroshi Sugimoto et al.Molecules (Basel, Switzerland), 25(3) (2020-01-30)
The Interplay between Calmodulin and Membrane Interactions with the Pleckstrin Homology Domain of Akt.Constance Agamasu et al.The Journal of biological chemistry, 292(1), 251-263 (2016-11-23)
The histidine-rich calcium binding protein (HRC) promotes tumor metastasis in hepatocellular carcinoma and is upregulated by SATB1.Jingmei Liu et al.Oncotarget, 6(9), 6811-6824 (2015-03-13)
Extracellular Galectin-3 Induces Accelerated Oligodendroglial Differentiation Through Changes in Signaling Pathways and Cytoskeleton Dynamics.Laura Thomas et al.Molecular neurobiology, 56(1), 336-349 (2018-04-29)
Protein expression guided chemical profiling of living cells by the simultaneous observation of Raman scattering and anti-Stokes fluorescence emission.Liang-da Chiu et al.Scientific reports, 7, 43569-43569 (2017-03-09)
Photochemical and Pharmacokinetic Characterization of Orally Administered Chemicals to Evaluate Phototoxic Risk.Yosuke Iyama et al.Journal of pharmaceutical sciences, 108(3), 1303-1308 (2018-10-20)
Drug and Chemical Glucosidation by Control Supersomes and Membranes from Spodoptera frugiperda (Sf) 9 Cells: Implications for the Apparent Glucuronidation of Xenobiotics by UDP-glucuronosyltransferase 1A5.Nuy Chau et al.Drug metabolism and disposition: the biological fate of chemicals, 47(3), 271-278 (2018-12-14)
Tamoxifen Induces Cytotoxic Autophagy in Glioblastoma.Christopher D Graham et al.Journal of neuropathology and experimental neurology, 75(10), 946-954 (2016-08-16)
Simultaneous Monitoring of Multi-Enzyme Activity and Concentration in Tumor Using a Triply Labeled Fluorescent In Vivo Imaging Probe.Jenny Tam et al.International journal of molecular sciences, 21(9) (2020-05-01)
Estimation of the shielding ability of a tungsten functional paper for diagnostic x-rays and gamma rays.Hajime Monzen et al.Journal of applied clinical medical physics, 18(5), 325-329 (2017-06-29)
Trends in sustainable logistics in major cities in China.Shulin Lan et al.The Science of the total environment, 712, 136381-136381 (2020-01-16)
Drug-Drug Interaction Potentials of Tyrosine Kinase Inhibitors via Inhibition of UDP-Glucuronosyltransferases.Nan Zhang et al.Scientific reports, 5, 17778-17778 (2015-12-09)
Aldrichimica Acta, 27, 27-27 (1994)
In vitro and in vivo evaluation of anti-cancer activity: Shape-dependent properties of TiOT Sree Latha et al.Materials science & engineering. C, Materials for biological applications, 78, 969-977 (2017-06-04)
Trifluoperazine induces apoptosis through the upregulation of Bax/Bcl‑2 and downregulated phosphorylation of AKT in mesangial cells and improves renal function in lupus nephritis mice.Baodong Wang et al.International journal of molecular medicine, 41(6), 3278-3286 (2018-03-24)
Calmodulin antagonist enhances DR5-mediated apoptotic signaling in TRA-8 resistant triple negative breast cancer cells.Romone M Fancy et al.Journal of cellular biochemistry, 119(7), 6216-6230 (2018-04-18)
The association between newborn screening analytes and childhood autism in a Texas Medicaid population, 2010-2012.Mark A Canfield et al.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 180(5), 291-304 (2019-04-25)
Chain conformation and physicochemical properties of polysaccharide (glucuronoxylomannan) from Fruit Bodies of Tremella fuciformis.Xiaoqi Xu et al.Carbohydrate polymers, 245, 116354-116354 (2020-07-29)
The brain acid-soluble protein 1 (BASP1) interferes with the oncogenic capacity of MYC and its binding to calmodulin.Markus Hartl et al.Molecular oncology, 14(3), 625-644 (2020-01-17)
Amphiphilic Residues 29-44 of DREAM N-Termini Mediate Calmodulin:DREAM Complex Formation.Walter G Gonzalez et al.Biochemistry, 54(28), 4391-4403 (2015-06-26)
Inhibition of human UDP-glucuronosyltransferase (UGT) enzymes by kinase inhibitors: Effects of dabrafenib, ibrutinib, nintedanib, trametinib and BIBF 1202.Porntipa Korprasertthaworn et al.Biochemical pharmacology, 169, 113616-113616 (2019-08-25)
Trifluoperazine-Induced Suicidal Erythrocyte Death and S-Nitrosylation Inhibition, Reversed by the Nitric Oxide Donor Sodium Nitroprusside.Mehrdad Ghashghaeinia et al.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 42(5), 1985-1998 (2017-08-10)
Regulation of Type IV Pili Contributes to Surface Behaviors of Historical and Epidemic Strains of Clostridium difficile.Erin B Purcell et al.Journal of bacteriology, 198(3), 565-577 (2015-11-26)
Liraglutide restores angiogenesis in palmitate-impaired human endothelial cells through PI3K/Akt-Foxo1-GTPCH1 pathway.Jing Ke et al.Peptides, 86, 95-101 (2016-10-30)
VAMP8-dependent fusion of recycling endosomes with the plasma membrane facilitates T lymphocyte cytotoxicity.Misty R Marshall et al.The Journal of cell biology, 210(1), 135-151 (2015-07-01)
Estrogen Regulates Duodenal Calcium Absorption Through Differential Role of Estrogen Receptor on Calcium Transport Proteins.Xubiao Nie et al.Digestive diseases and sciences, 65(12), 3502-3513 (2020-01-25)
Mara Roxana Rubinstein et al.EMBO reports, 20(4) (2019-03-06)Fusobacterium nucleatum, a Gram-negative oral anaerobe, is a significant contributor to colorectal cancer. Using an in vitro cancer progression model, we discover that F. nucleatum stimulates the growth of colorectal cancer cells without affecting the pre-cancerous adenoma cells. Annexin A1, a previously...
Orbital Crossings Activated through Electron Injection: Opening Communication between Orthogonal Orbitals in Anionic C1-C5 Cyclizations of Enediynes.Paul W Peterson et al.Journal of the American Chemical Society, 138(48), 15617-15628 (2016-12-10)
Calcium-dependent binding of Myc to calmodulin.Philipp Raffeiner et al.Oncotarget, 8(2), 3327-3343 (2016-12-08)
A distinct role for recombination repair factors in an early cellular response to transcription-replication conflicts.Xin Shao et al.Nucleic acids research, 48(10), 5467-5484 (2020-04-25)
Imaging IGF-I uptake in growth plate cartilage using in vivo multiphoton microscopy.Maria A Serrat et al.Journal of applied physiology (Bethesda, Md. : 1985), 123(5), 1101-1109 (2017-08-12)
Building Polyelectrolyte Multilayers with Calmodulin: A Neutron and X-ray Reflectivity Study.Süleyman Cinar et al.Langmuir : the ACS journal of surfaces and colloids, 33(16), 3982-3990 (2017-04-06)
Ca(2+)-CaM regulating viability of Candida guilliermondii under oxidative stress by acting on detergent resistant membrane proteins.Bang An et al.Journal of proteomics, 109, 38-49 (2014-07-08)
Trifluoperazine, a Well-Known Antipsychotic, Inhibits Glioblastoma Invasion by Binding to Calmodulin and Disinhibiting Calcium Release Channel IP3R.Seokmin Kang et al.Molecular cancer therapeutics, 16(1), 217-227 (2017-01-08)
Transdermal fentanyl patch for postoperative analgesia in total knee arthroplasty: a randomized double-blind controlled trial.Thepakorn Sathitkarnmanee et al.Journal of pain research, 7, 449-454 (2014-08-15)
Low concentration trifluoperazine promotes proliferation and reduces calcium-dependent apoptosis in glioma cells.Yulin Wen et al.Scientific reports, 8(1), 1147-1147 (2018-01-20)
Characterization of the Photophysical, Thermodynamic, and Structural Properties of the Terbium(III)-DREAM Complex.Walter G Gonzalez et al.Biochemistry, 55(12), 1873-1886 (2016-02-24)
Inhibitor and peptide binding to calmodulin characterized by high pressure Fourier transform infrared spectroscopy and Förster resonance energy transfer.Süleyman Cinar et al.Biochimica et biophysica acta, 1866(5-6), 617-623 (2018-03-21)
Kinetic analysis and binding studies of a new recombinant human factor VIIa for treatment of haemophilia.J Grandoni et al.Haemophilia : the official journal of the World Federation of Hemophilia, 23(2), 300-308 (2016-12-21)
Novel porous β-cyclodextrin/pillar[5]arene copolymer for rapid removal of organic pollutants from water.Pengpeng Lu et al.Carbohydrate polymers, 216, 149-156 (2019-05-03)
Transcriptome analysis of Pseudostellaria heterophylla in response to the infection of pathogenic Fusarium oxysporum.Xianjin Qin et al.BMC plant biology, 17(1), 155-155 (2017-09-20)
Noneffervescent Method for Catalysis-Based Palladium Detection with Color or Fluorescence.Matthew Nieberding et al.ACS sensors, 2(11), 1737-1743 (2017-10-24)
Mechanism Underlying the Reversal of Drug Resistance in P-Glycoprotein-Expressing Leukemia Cells by Pinoresinol and the Study of a Derivative.María L González et al.Frontiers in pharmacology, 8, 205-205 (2017-05-11)
Measuring the relative hydrogen-bonding strengths of alcohols in aprotic organic solvents.Malcolm E Tessensohn et al.Chemphyschem : a European journal of chemical physics and physical chemistry, 16(1), 160-168 (2014-11-25)
Cryo-EM structure of human mitochondrial trifunctional protein.Kai Liang et al.Proceedings of the National Academy of Sciences of the United States of America, 115(27), 7039-7044 (2018-06-20)
Social Cooperativity of Bacteria during Reversible Surface Attachment in Young Biofilms: a Quantitative Comparison of Pseudomonas aeruginosa PA14 and PAO1.Calvin K Lee et al.mBio, 11(1) (2020-02-27)
Inhibition of human UDP-glucuronosyltransferase enzymes by midostaurin and ruxolitinib: implications for drug-drug interactions.Zhe Wang et al.Biopharmaceutics & drug disposition, 41(6), 231-238 (2020-05-22)
Trifluoperazine, a novel autophagy inhibitor, increases radiosensitivity in glioblastoma by impairing homologous recombination.Xin Zhang et al.Journal of experimental & clinical cancer research : CR, 36(1), 118-118 (2017-09-06)
Is the transdermal fentanyl patch an efficient way to achieve acute postoperative pain control?: A randomized controlled trial.Ji Su Jang et al.Medicine, 97(51), e13768-e13768 (2018-12-24)
Polyamidoamine (PAMAM) dendrimers modified with short oligopeptides for early endosomal escape and enhanced gene delivery.Le Thi Thuy et al.International journal of pharmaceutics, 492(1-2), 233-243 (2015-07-19)
备注
Products protected by valid patents are not offered for sale in countries where the sale of such products constitutes a patent infringement and its liability is at buyer's risk.
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271 +A13(1).
名称 | CAS号 |
---|

相关产品
相关资讯
问
热门标签
询 单
请 填 写 相 关 信 息
- 请填写产品名称!
- CAS号
- 请正确填写公司名称!
- 请正确填写联系人!
- 请正确填写联系电话!
- 请正确填写联系邮箱!
- 请描述您的问题!