
Pentetrazol | CAS:54-95-5
Pentetrazol
- 名称:戊四唑; 1,5-五亚甲基-1H-四唑; 6,7,8,9-四氢-5H-四唑并氮杂卓; 戊撑四唑; 戊四氮; 五甲烯四氮唑 | Pentetrazol
- CAS号:54-95-5
- 别名:1,5-Pentamethylene-1H-tetrazole; 6,7,8,9-Tetrahydro-5H-tetrazolo[1,5-a]azepine
- 分子式:C6H10N4
- 分子量:138.17
- EINESC号:200-219-3
产品描述
物理化学性质
熔点 | 59-61 ºC |
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沸点 | 194 ºC (12 mmHg) |
安全数据
危险品标志 | T |
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危险类别码 | R25;R36/37/38 |
安全说明书 | S26;S36/37/39;S45 |
SDS
来源 | SDS样本 |
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没有数据 | 没有数据 |
产品合成路线
名称 | CAS号 |
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Effective anodic oxidation of naproxen by platinum nanoparticles coated FTO glass.Ching-Ju Monica Chin et al.Journal of hazardous materials, 277, 110-119 (2014-03-25)
Tunable thermo-responsive hydrogels: synthesis, structural analysis and drug release studies.Giuseppe Cirillo et al.Materials science & engineering. C, Materials for biological applications, 48, 499-510 (2015-01-13)
Simultaneous determination of naproxen, ketoprofen and phenol red in samples from rat intestinal permeability studies: HPLC method development and validationZakeri-Milani P, et al. Journal of Pharmaceutical and Biomedical Analysis, 39(3-4), 624-630 (2005)
The adsorption of naproxen enantiomers on the chiral stationary phase (R,R)-whelk-O1 under supercritical fluid conditions.Fahimeh Kamarei et al.Journal of chromatography. A, 1345, 200-206 (2014-05-06)
Sumatriptan/naproxen sodium combination for the treatment of migraine.Catalina Cleves et al.Expert review of neurotherapeutics, 8(9), 1289-1297 (2008-09-02)
Naproxcinod: AZD 3582, HCT 3012, naproxen nitroxybutylester, nitronaproxen, NO-naproxen. Drugs in R&D, 8(4), 255-258 (2007-06-29)
A sulfated-polysaccharide fraction from seaweed Gracilaria birdiae prevents naproxen-induced gastrointestinal damage in rats.Renan O Silva et al.Marine drugs, 10(12), 2618-2633 (2013-01-25)
Recurrent angioedema after naproxen use in a patient stabilized with losartan.Jineane V Venci et al.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 113(6), 666-667 (2014-10-06)
Structural attributes of model protein formulations prepared by rapid freeze-drying cycles in a microscale heating stage.Björn-Hendrik Peters et al.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 87(2), 347-356 (2014-03-13)
Photo-controllable molecular hydrogels for drug delivery.Hanxia Liu et al.Journal of nanoscience and nanotechnology, 14(7), 4837-4842 (2014-04-25)
Monitoring and removal of residual phthalate esters and pharmaceuticals in the drinking water of Kaohsiung City, Taiwan.Gordon C C Yang et al.Journal of hazardous materials, 277, 53-61 (2014-04-08)
Delayed-release lansoprazole plus naproxen.Monique P Curran et al.Drugs, 64(17), 1915-1919 (2004-08-27)
Simultaneous analysis of naproxen, nabumetone and its major metabolite 6-methoxy-2-naphthylacetic acid in pharmaceuticals and human urine by high-performance liquid chromatography.E Mikami et al.Journal of pharmaceutical and biomedical analysis, 23(5), 917-925 (2000-10-07)
The anti-inflammatory drugs diclofenac, naproxen and ibuprofen are found in the bile of wild fish caught downstream of a wastewater treatment plant.Jenny-Maria Brozinski et al.Environmental science & technology, 47(1), 342-348 (2012-11-29)
Multiresidue method for the determination of pharmacologically active substances in egg and honey using a continuous solid-phase extraction system and gas chromatography-mass spectrometry.Abdelmonaim Azzouz et al.Food chemistry, 178, 63-69 (2015-02-24)
Naproxen with or without an antiemetic for acute migraine headaches in adults.Simon Law et al.The Cochrane database of systematic reviews, 10(10), CD009455-CD009455 (2013-10-22)
The concept of axial spondyloarthritis. Lessons from the INFAST study.Henning Zeidler Annals of the rheumatic diseases, 73(4), e18-e18 (2013-12-10)
Evaluation of detection sensitivity in comprehensive two-dimensional liquid chromatography separations of an active pharmaceutical ingredient and its degradants.Dwight R Stoll et al.Analytical and bioanalytical chemistry, 407(1), 265-277 (2014-07-30)
Renal effects of selective cyclooxygenase-2 inhibition in normotensive salt-depleted subjects.J Rossat et al.Clinical pharmacology and therapeutics, 66(1), 76-84 (1999-08-03)
Genotoxic response and oxidative stress induced by diclofenac, ibuprofen and naproxen in Daphnia magna.Leobardo Manuel Gómez-Oliván et al.Drug and chemical toxicology, 37(4), 391-399 (2014-01-08)
Sumatriptan-naproxen fixed combination for acute treatment of migraine: a critical appraisal.Chaouki K Khoury et al.Drug design, development and therapy, 4, 9-17 (2010-04-07)
[Acute kidney injury following naproxene use in an ultraendurance female athlete].Mathias Poussel et al.Presse medicale (Paris, France : 1983), 42(9 Pt 1), 1274-1276 (2013-03-05)
Efficacy and safety of infliximab plus naproxen versus naproxen alone in patients with early, active axial spondyloarthritis: results from the double-blind, placebo-controlled INFAST study, Part 1.J Sieper et al.Annals of the rheumatic diseases, 73(1), 101-107 (2013-05-23)
Imidazolium-based functional monomers for the imprinting of the anti-inflammatory drug naproxen: comparison of acrylic and sol-gel approaches.Porkodi Kadhirvel et al.Journal of chromatography. A, 1314, 115-123 (2013-09-24)
A simple high-performance liquid chromatography method for simultaneous determination of three triazole antifungals in human plasma.Mei Zhang et al.Antimicrobial agents and chemotherapy, 57(1), 484-489 (2012-11-14)
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A hydrogen sulfide-releasing cyclooxygenase inhibitor markedly accelerates recovery from experimental spinal cord injury.Michela Campolo et al.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 27(11), 4489-4499 (2013-08-01)
Crystallization and dissolution behavior of naproxen/polyethylene glycol solid dispersions.Qing Zhu et al.The journal of physical chemistry. B, 117(5), 1494-1500 (2013-01-17)
Effects of ibuprofen, diclofenac, naproxen, and piroxicam on the course of pregnancy and pregnancy outcome: a prospective cohort study.K Nezvalová-Henriksen et al.BJOG : an international journal of obstetrics and gynaecology, 120(8), 948-959 (2013-03-16)
D-amino acids boost the selectivity and confer supramolecular hydrogels of a nonsteroidal anti-inflammatory drug (NSAID).Jiayang Li et al.Journal of the American Chemical Society, 135(2), 542-545 (2012-11-10)
Molecular interactions of Alzheimer's biomarker FDDNP with Aβ peptide.Christopher Lockhart et al.Biophysical journal, 103(11), 2341-2351 (2013-01-04)
Enhanced catalysis and enantioselective resolution of racemic naproxen methyl ester by lipase encapsulated within iron oxide nanoparticles coated with calix[8]arene valeric acid complexes.Serkan Sayin et al.Organic & biomolecular chemistry, 12(34), 6634-6642 (2014-07-12)
Innovative sampling and extraction methods for the determination of nonsteroidal anti-inflammatory drugs in water.Shivani Tanwar et al.Journal of pharmaceutical and biomedical analysis, 106, 100-106 (2014-12-01)
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Synthesis and pharmacological evaluation of polyfunctional benzimidazole-NSAID chimeric molecules combining anti-inflammatory, immunomodulatory and antioxidant activities.Yogita Bansal et al.Archives of pharmacal research, 37(11), 1426-1436 (2013-11-06)
Single dose oral naproxen and naproxen sodium for acute postoperative pain in adults.Christopher Derry et al.The Cochrane database of systematic reviews, (1)(1), CD004234-CD004234 (2009-01-23)
Effect of chronic bile duct obstruction and LPS upon targeting of naproxen to the liver using naproxen-albumin conjugate.C Albrecht et al.Journal of drug targeting, 6(2), 105-117 (1999-01-14)
A new method for the enhancement of electromembrane extraction efficiency using carbon nanotube reinforced hollow fiber for the determination of acidic drugs in spiked plasma, urine, breast milk and wastewater samples.Kobra Sadat Hasheminasab et al.Journal of chromatography. A, 1285, 1-6 (2013-03-12)
Topical provocation in fixed drug eruption due to metamizol and naproxen.E Ozkaya-Bayazit Clinical and experimental dermatology, 29(4), 419-422 (2004-07-13)
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Agar films containing silver nanoparticles as new supports for electromembrane extraction.Cristina Román Hidalgo et al.Analytical and bioanalytical chemistry, 407(5), 1519-1525 (2014-12-19)
[O-methyl 14C]naproxen O-demethylase activity in human liver microsomes: evidence for the involvement of cytochrome P4501A2 and P4502C9/10.A D Rodrigues et al.Drug metabolism and disposition: the biological fate of chemicals, 24(1), 126-136 (1996-01-01)
Role of wetland organic matters as photosensitizer for degradation of micropollutants and metabolites.Eunkyung Lee et al.Journal of hazardous materials, 276, 1-9 (2014-05-28)
Evaluation of stationary phases packed with superficially porous particles for the analysis of pharmaceutical compounds using supercritical fluid chromatography.Alexandre Grand-Guillaume Perrenoud et al.Journal of chromatography. A, 1360, 275-287 (2014-08-19)
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Model-based analysis of thromboxane B₂ and prostaglandin E₂ as biomarkers in the safety evaluation of naproxen.Tarjinder Sahota et al.Toxicology and applied pharmacology, 278(3), 209-219 (2014-03-29)
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High performance liquid chromatography with photo diode array for separation and analysis of naproxen and esomeprazole in presence of their chiral impurities: enantiomeric purity determination in tabletsRagab MAA and Eman I Journal of Chromatography A, 1497, 110-117 (2017)
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Dual drug release from core-shell nanoparticles with distinct release profiles.Yang Cao et al.Journal of pharmaceutical sciences, 103(10), 3205-3216 (2014-08-15)
Severe reversible renal failure due to naproxen-associated acute interstitial nephritis.R Becker-Cohen et al.European journal of pediatrics, 160(5), 293-295 (2001-06-05)
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Pre-clinical pharmacokinetics of the cyclooxygenase-inhibiting nitric oxide donor (CINOD) AZD3582.U Fagerholm et al.The Journal of pharmacy and pharmacology, 57(5), 587-597 (2005-05-20)
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Enantiomers separation by nano-liquid chromatography: use of a novel sub-2 μm vancomycin silica hydride stationary phase.Silvia Rocchi et al.Journal of chromatography. A, 1381, 149-159 (2015-01-24)
Effect of transpiration on plant accumulation and translocation of PPCP/EDCs.Laurel K Dodgen et al.Environmental pollution (Barking, Essex : 1987), 198, 144-153 (2015-01-17)
NO-naproxen (AstraZeneca).Nat Monck IDrugs : the investigational drugs journal, 6(6), 593-599 (2003-06-18)
Rapid analysis of pharmaceuticals and personal care products in fish plasma micro-aliquots using liquid chromatography tandem mass spectrometry.Fangfang Chen et al.Journal of chromatography. A, 1383, 104-111 (2015-02-03)
Evaluation of the use of sumatriptan-naproxen sodium for menstrual migraine and dysmenorrhea.Gianni Allais et al.Expert review of neurotherapeutics, 11(10), 1383-1387 (2011-10-01)
Stereoselective glucuronidation of (R)- and (S)-naproxen by recombinant rat phenol UDP-glucuronosyltransferase (UGT1A1) and its human orthologue.M el Mouelhi et al.Biochemical pharmacology, 46(7), 1298-1300 (1993-10-05)
Absence of pharmacokinetic interaction between orally co-administered naproxen sodium and diphenhydramine hydrochloride.R D Toothaker et al.Biopharmaceutics & drug disposition, 21(6), 229-233 (2001-04-17)
Single dose oral naproxen and naproxen sodium for acute postoperative pain.L Mason et al.The Cochrane database of systematic reviews, (4)(4), CD004234-CD004234 (2004-10-21)
An in-vivo study on placental transfer of naproxen in early human pregnancy.S S N Siu et al.Human reproduction (Oxford, England), 17(4), 1056-1059 (2002-04-02)
Pharmacodynamic interaction of naproxen with low-dose aspirin in healthy subjects.Marta L Capone et al.Journal of the American College of Cardiology, 45(8), 1295-1301 (2005-04-20)
Hypersensitivity to nabumetone: cross reactivity with naproxen.Patricia Rojas Perez-Ezquerra et al.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 111(1), 74-75 (2013-06-29)
Dendrimer-functionalized mesoporous silica as a reversed-phase/anion-exchange mixed-mode sorbent for solid phase extraction of acid drugs in human urine.Yun Li et al.Journal of chromatography. A, 1392, 28-36 (2015-03-22)
Experimental and computational studies of physicochemical properties influence NSAID-cyclodextrin complexation.Linda A Felton et al.AAPS PharmSciTech, 15(4), 872-881 (2014-04-11)
The peculiar behavior of the glass transition temperature of amorphous drug-polymer films coated on inert sugar spheres.Aswin Dereymaker et al.Journal of pharmaceutical sciences, 104(5), 1759-1766 (2015-02-24)
Pharmacokinetic comparison study of a combination containing 500 mg of Naproxen and 20 mg of Esomeprazole: a randomized, single-dose, 2-way crossover, open-label study in healthy Korean men.Hyun-Gyu Choi et al.Clinical therapeutics, 37(1), 83-93 (2014-12-09)
Development of a SPE-UHPLC-MS/MS methodology for the determination of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawater.Paula Paíga et al.Journal of pharmaceutical and biomedical analysis, 106, 61-70 (2014-07-09)
Pre-existent asymmetry in the human cyclooxygenase-2 sequence homodimer.Liang Dong et al.The Journal of biological chemistry, 288(40), 28641-28655 (2013-08-21)
Membranous nephropathy and nonsteroidal anti-inflammatory agents.Fareha A Nawaz et al.American journal of kidney diseases : the official journal of the National Kidney Foundation, 62(5), 1012-1017 (2013-06-19)
Controlled release of liposome-encapsulated Naproxen from core-sheath electrospun nanofibers.Zhuang Li et al.Carbohydrate polymers, 111, 18-24 (2014-07-20)
Naproxen/esomeprazole fixed-dose combination: for the treatment of arthritic symptoms and to reduce the risk of gastric ulcers.Sohita Dhillon Drugs & aging, 28(3), 237-248 (2011-02-19)
Physicians should be cautious when prescribing diclofenac.Sarah Spitz CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 185(6), 470-470 (2013-03-06)
Comparative in vitro dissolution and in vivo bioavailability of diflunisal/naproxen fixed-dose combination tablets and concomitant administration of diflunisal and naproxen in healthy adult subjects.S A Helmy et al.Drug research, 63(3), 150-158 (2013-02-28)
Determination of some antirheumatics by capillary isotachophoresis.A Hercegová et al.Electrophoresis, 21(14), 2842-2847 (2000-09-23)
Relationship between the solution thermodynamic properties of naproxen in organic solvents and its release profiles from PLGA microspheres.Diana Marcela Aragón et al.Journal of microencapsulation, 30(3), 218-224 (2013-02-02)
Construction and analysis of a human hepatotoxicity database suitable for QSAR modeling using post-market safety data.Xiao Zhu et al.Toxicology, 321, 62-72 (2014-04-12)
Determination of pharmaceuticals in bivalves using QuEChERS extraction and liquid chromatography-tandem mass spectrometry.Mireia Núñez et al.Analytical and bioanalytical chemistry, 407(13), 3841-3849 (2015-03-18)
Influence of copolymer composition on the phase behavior of solid dispersions.Anke Prudic et al.Molecular pharmaceutics, 11(11), 4189-4198 (2014-10-09)
Comparison between NSAID and intra-articular corticosteroid injection in frozen shoulder of diabetic patients; a randomized clinical trial.A Dehghan et al.Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 121(2), 75-79 (2013-02-22)
Maintenance of biologic-free remission with naproxen or no treatment in patients with early, active axial spondyloarthritis: results from a 6-month, randomised, open-label follow-up study, INFAST Part 2.J Sieper et al.Annals of the rheumatic diseases, 73(1), 108-113 (2013-06-07)
Effect of clopidogrel on naproxen-induced gastrointestinal blood loss in healthy volunteers.A van Hecken et al.Drug metabolism and drug interactions, 14(3), 193-205 (1999-06-15)
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A novel murine model for the in vivo study of transdermal drug penetration.Gábor Eros et al.TheScientificWorldJournal, 2012, 543536-543536 (2012-01-25)
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