2-Methyl-1-propanol | CAS:78-83-1
2-Methyl-1-propanol
- 名称:异丁醇; 2-甲基丙醇 | 2-Methyl-1-propanol
- CAS号:78-83-1
- 别名:Isobutyl alcohol; Isobutanol
- 分子式:C4H10O
- 分子量:74.12
- EINESC号:201-148-0
产品描述
物理化学性质
熔点 | -108 ºC |
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水溶性 | 95 g/L (20 ºC) |
沸点 | 108 ºC |
闪点 | 28 ºC |
密度 | 0.802 |
折射率 | 1.3945-1.3765 |
安全数据
危险品标志 | Xi |
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危险类别码 | R10;R37/38;R41;R67 |
安全说明书 | S13;S26;S37/39;S46;S7/9 |
SDS
来源 | SDS样本 |
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没有数据 | 没有数据 |
产品合成路线
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Thermodynamic studies of Fenbufen, Diflunisal, and Flurbiprofen: sublimation, solution and solvation of biphenyl substituted drugs.Sergey V Kurkov et al.International journal of pharmaceutics, 357(1-2), 100-107 (2008-03-18)
Evaluation of the drug-polymer interaction in calcium alginate beads containing diflunisal.B Mandal et al.Die Pharmazie, 65(2), 106-109 (2010-03-17)
Modulation of the fibrillogenesis inhibition properties of two transthyretin ligands by halogenation.Ellen Y Cotrina et al.Journal of medicinal chemistry, 56(22), 9110-9121 (2013-10-24)
A modern approach for controlled transdermal delivery of diflunisal: optimization and in vivo evaluation.Marwa Ahmed Sallam et al.Drug development and industrial pharmacy, 39(4), 600-610 (2012-06-16)
Single dose oral diflunisal for acute postoperative pain in adults.Jack O Wasey et al.The Cochrane database of systematic reviews, (4)(4), CD007440-CD007440 (2010-04-16)
Cyclodextrin-crosslinked poly(acrylic acid): Synthesis, physicochemical characterization and controlled release of diflunisal and fluconazole from hydrogels.Marguerite J Kutyła et al.International journal of pharmaceutics, 444(1-2), 175-184 (2013-01-19)
Simultaneous determination of two anti-inflammatory drugs in serum using isopotential fluorimetry.J A Murillo Pulgarín et al.Analytica chimica acta, 625(1), 47-54 (2008-08-30)
The Diflunisal Trial: study accrual and drug tolerance.John L Berk et al.Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, 19 Suppl 1, 37-38 (2012-05-04)
[Familial amyloid polyneuropathies: therapeutic issues].David Adams et al.Bulletin de l'Academie nationale de medecine, 196(7), 1333-1345 (2013-07-03)
The advantages and limitations of the analgesics available for control of postoperative pain after a dental procedure.Jasmin Davey SAAD digest, 29, 70-81 (2013-04-02)
Stability of the transthyretin molecule as a key factor in the interaction with a-beta peptide--relevance in Alzheimer's disease.Carlos A Ribeiro et al.PloS one, 7(9), e45368-e45368 (2012-10-03)
Rapid simultaneous determination of four non-steroidal anti-inflammatory drugs by means of derivative nonlinear variable-angle synchronous fluorescence spectrometry.José A Murillo Pulgarín et al.Applied spectroscopy, 64(8), 949-955 (2010-08-20)
Influence of soluble and insoluble cyclodextrin polymers on drug release from hydroxypropyl methylcellulose tablets.Maria Esther Zugasti et al.Drug development and industrial pharmacy, 35(10), 1264-1270 (2009-06-27)
Iodine atoms: a new molecular feature for the design of potent transthyretin fibrillogenesis inhibitors.Teresa Mairal et al.PloS one, 4(1), e4124-e4124 (2009-01-07)
Diflunisal--a long-acting non-steroidal anti-inflammatory drug. A review of its pharmacology and effectiveness in management of postoperative dental pain.G M Lawton et al.Australian dental journal, 38(4), 265-271 (1993-08-01)
[Therapeutic strategy for familial amyloid polyneuropathy (FAP)].Shu-ichi Ikeda Rinsho shinkeigaku = Clinical neurology, 49(11), 953-955 (2009-12-25)
Synthesis and biological evaluation of amide derivatives of diflunisal as potential anti-tumor agents.Guang-Xiang Zhong et al.Bioorganic & medicinal chemistry letters, 19(15), 4399-4402 (2009-06-12)
Differential scanning calorimetry study on drug release from an inulin-based hydrogel and its interaction with a biomembrane model: pH and loading effect.Francesco Castelli et al.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 35(1-2), 76-85 (2008-07-16)
Simultaneous determination of the two non-steroidal anti-inflammatory drugs ; diflunisal and naproxen in their tablets by chemometric spectrophotometry and HPLC.Abdel-Aziz M Wahbi et al.Pakistan journal of pharmaceutical sciences, 22(1), 8-17 (2009-01-27)
Modifications of diflunisal and meclofenamate carboxyl groups affect their allosteric effects on GABAA receptor ligand binding.Mikko Uusi-Oukari et al.Neurochemical research, 39(7), 1183-1191 (2014-06-14)
[Familial amyloid polyneuropathy: diflunisal].Yoshiki Sekijima Rinsho shinkeigaku = Clinical neurology, 50(11), 836-836 (2011-09-17)
Nonsteroidal anti-inflammatory therapy and recurrent acute anterior uveitis.Vanessa M B Fiorelli et al.Ocular immunology and inflammation, 18(2), 116-120 (2010-04-08)
Review of the animal and clinical pharmacology of diflunisal.R O Davies Pharmacotherapy, 3(2 Pt 2), 9S-22S (1983-03-01)
Synthesis and biological evaluation of amide derivatives of diflunisal as potential anti-inflammatory agents.Guang-Xiang Zhong et al.Bioorganic & medicinal chemistry letters, 19(2), 516-519 (2008-11-29)
A new hydrate form of diflunisal precipitated from a microemulsion system.Hsuan-Lei Sung et al.Colloids and surfaces. B, Biointerfaces, 109, 68-73 (2013-04-30)
Cyclodextrin-crosslinked poly(acrylic acid): adhesion and controlled release of diflunisal and fluconazole from solid dosage forms.Marguerite J Kutyła et al.AAPS PharmSciTech, 14(1), 301-311 (2013-01-12)
Simultaneous determination of ezetimibe and simvastatin in pharmaceutical preparations by MEKC.Ceren Yardimci et al.Journal of chromatographic science, 48(2), 95-99 (2010-01-30)
Comparative in vitro dissolution and in vivo bioavailability of diflunisal/naproxen fixed-dose combination tablets and concomitant administration of diflunisal and naproxen in healthy adult subjects.S A Helmy et al.Drug research, 63(3), 150-158 (2013-02-28)
Repurposing diflunisal for familial amyloid polyneuropathy: a randomized clinical trial.John L Berk et al.JAMA, 310(24), 2658-2667 (2013-12-26)
2D solid-state NMR analysis of inclusion in drug-cyclodextrin complexes.Frederick G Vogt et al.Molecular pharmaceutics, 9(11), 3357-3374 (2012-09-27)
Non-steroidal anti-inflammatory drug diflunisal interacting with Cu(II). Structure and biological features.Stella Fountoulaki et al.Journal of inorganic biochemistry, 105(12), 1645-1655 (2011-11-11)
Diflunisal: a review of its pharmacological properties and therapeutic use in pain and musculoskeletal strains and sprains and pain in osteoarthritis.R N Brogden et al.Drugs, 19(2), 84-106 (1980-02-01)
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An insight on human skin penetration of diflunisal: lipogel versus hydrogel microemulsion.Marwa Ahmed Sallam et al.Drug development and industrial pharmacy, 41(1), 141-147 (2013-11-01)
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Products protected by valid patents are not offered for sale in countries where the sale of such products constitutes a patent infringement and its liability is at buyer's risk.
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271 +A13(1).
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