熔点	-48 ºC
水溶性	15.9 g/L (20 ºC)
沸点	100 ºC
闪点	8 ºC
密度	0.943
折射率	1.413-1.415

危险品标志	F;Xi
危险类别码	R11;R37/38;R43
安全说明书	S24;S37;S46

来源	SDS样本
没有数据	没有数据

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MiR-181a contributes to bufalin-induced apoptosis in PC-3 prostate cancer cells.Xiao-feng Zhai et al.BMC complementary and alternative medicine, 13, 325-325 (2013-11-26) Effects of bufalin on the mTOR/p70S6K pathway and apoptosis in esophageal squamous cell carcinoma in nude mice.Yao Liu et al.International journal of molecular medicine, 40(2), 357-366 (2017-06-29) Steroid-like compounds in Chinese medicines promote blood circulation via inhibition of Na+/K+ -ATPase.Ronald J Y Chen et al.Acta pharmacologica Sinica, 31(6), 696-702 (2010-06-05) Bufalin induced apoptosis in SCC‑4 human tongue cancer cells by decreasing Bcl‑2 and increasing Bax expression via the mitochondria‑dependent pathway.Han-Yu Chou et al.Molecular medicine reports, 16(6), 7959-7966 (2017-10-07) Redox-responsive PEGylated self-assembled prodrug-nanoparticles formed by single disulfide bond bridge periplocymarin-vitamin E conjugate for liver cancer chemotherapy.Huiyun Zhang et al.Drug delivery, 24(1), 1170-1178 (2017-08-25) The biological role of autophagy in regulating and controlling the proliferation of liver cancer cells induced by bufalin.Xia Sheng et al.Oncology reports, 39(6), 2931-2941 (2018-04-17) Blocking autophagy enhances the pro-apoptotic effect of bufalin on human gastric cancer cells through endoplasmic reticulum stress.Hongyan Zhao et al.Biology open, 6(10), 1416-1422 (2017-08-26) Pluronic F127-based micelles for tumor-targeted bufalin delivery.Haijun Wang et al.International journal of pharmaceutics, 559, 289-298 (2019-02-02) Preparation of bufalin-loaded pluronic polyetherimide nanoparticles, cellular uptake, distribution, and effect on colorectal cancer.Qiang Hu et al.International journal of nanomedicine, 9, 4035-4041 (2014-09-05) Hepatitis B virus efficiently infects non-adherent hepatoma cells via human sodium taurocholate cotransporting polypeptide.Kaori Okuyama-Dobashi et al.Scientific reports, 5, 17047-17047 (2015-11-26) Bufalin enhances radiosensitivity of glioblastoma by suppressing mitochondrial function and DNA damage repair.Xin Zhang et al.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 94, 627-635 (2017-08-09) miR-155-5p antagonizes the apoptotic effect of bufalin in triple-negative breast cancer cells.Qian Wang et al.Anti-cancer drugs, 27(1), 9-16 (2015-09-24) Synergistic anticancer effects of bufalin and sorafenib by regulating apoptosis associated proteins.Haiyong Wang et al.Molecular medicine reports, 17(6), 8101-8110 (2018-04-26) Bufalin Inhibits Cellular Proliferation and Cancer Stem Cell-Like Phenotypes via Upregulation of MiR-203 in Glioma.Tao Liu et al.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 44(2), 671-681 (2017-11-24) Bufalin induces protective autophagy by Cbl-b regulating mTOR and ERK signaling pathways in gastric cancer cells.Hai-Yan Qi et al.Cell biology international, 43(1), 33-43 (2018-11-24) Bufalin induces cell death in human lung cancer cells through disruption of DNA damage response pathways.Shin-Hwar Wu et al.The American journal of Chinese medicine, 42(3), 729-742 (2014-05-30) ATP1A1-mediated Src signaling inhibits coronavirus entry into host cells.Christine Burkard et al.Journal of virology, 89(8), 4434-4448 (2015-02-06) Toll-like receptor 3 activation selectively reverses HIV latency in microglial cells.David Alvarez-Carbonell et al.Retrovirology, 14(1), 9-9 (2017-02-09) Bufalin sensitizes human bladder carcinoma cells to TRAIL-mediated apoptosis.Kyung-Hwa Kang et al.Oncology letters, 14(1), 853-859 (2017-07-12) MK2206 enhances the cytocidal effects of bufalin in multiple myeloma by inhibiting the AKT/mTOR pathway.Ru-Fang Xiang et al.Cell death & disease, 8(5), e2776-e2776 (2017-05-12) New therapeutic aspects of steroidal cardiac glycosides: the anticancer properties of Huachansu and its main active constituent Bufalin.Chien-Shan Cheng et al.Cancer cell international, 19, 92-92 (2019-04-24) Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects.Yannan Li et al.Toxicology letters, 294, 27-36 (2018-05-13) Bufalin Enhances Immune Responses in Leukemic Mice Through Enhancing Phagocytosis of Macrophage In Vivo.Yung-Luen Shih et al.In vivo (Athens, Greece), 32(5), 1129-1136 (2018-08-29) Bufalin inhibited the growth of human osteosarcoma MG-63 cells via down-regulation of Bcl-2/Bax and triggering of the mitochondrial pathway.Dewei Wang et al.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 35(5), 4885-4890 (2014-02-27) Synergistic anti-hepatoma effect of bufalin combined with sorafenib via mediating the tumor vascular microenvironment by targeting mTOR/VEGF signaling.Haiyong Wang et al.International journal of oncology, 52(6), 2051-2060 (2018-04-06) Cardiac glycoside/aglycones inhibit HIV-1 gene expression by a mechanism requiring MEK1/2-ERK1/2 signaling.Raymond W Wong et al.Scientific reports, 8(1), 850-850 (2018-01-18) Critical role of heat shock protein 27 in bufalin-induced apoptosis in human osteosarcomas: a proteomic-based research.Xian-biao Xie et al.PloS one, 7(10), e47375-e47375 (2012-10-24) Specialized sorting of GLUT4 and its recruitment to the cell surface are independently regulated by distinct Rabs.L Amanda Sadacca et al.Molecular biology of the cell, 24(16), 2544-2557 (2013-06-28) Bufalin enhances anti-angiogenic effect of sorafenib via AKT/VEGF signaling.Haiyong Wang et al.International journal of oncology, 48(3), 1229-1241 (2016-01-20) Bufalin induces apoptosis in the U‑2OS human osteosarcoma cell line via triggering the mitochondrial pathway.Ya Chen et al.Molecular medicine reports, 13(1), 817-822 (2015-12-10) Bufalin enhances TRAIL-induced apoptosis by redistributing death receptors in lipid rafts in breast cancer cells.Shunchao Yan et al.Anti-cancer drugs, 25(6), 683-689 (2014-04-09) Determination of Endogenous Bufalin in Serum of Patients With Hepatocellular Carcinoma Based on HPLC-MS/MS.Mengfei Han et al.Frontiers in oncology, 9, 1572-1572 (2020-02-11) Bufalin, a Traditional Chinese Medicine Compound, Prevents Tumor Formation in Two Murine Models of Colorectal Cancer.Xiao Sun et al.Cancer prevention research (Philadelphia, Pa.), 12(10), 653-666 (2019-08-23) Bufalin-loaded bovine serum albumin nanoparticles demonstrated improved anti-tumor activity against hepatocellular carcinoma: preparation, characterization, pharmacokinetics and tissue distribution.Huiqing Zhang et al.Oncotarget, 8(38), 63311-63323 (2017-10-04) Bufalin attenuates cancer-induced pain and bone destruction in a model of bone cancer.Dongxing Ji et al.Naunyn-Schmiedeberg's archives of pharmacology, 390(12), 1211-1219 (2017-08-26) Tracing MYC Expression for Small Molecule Discovery.Jutta Steinberger et al.Cell chemical biology, 26(5), 699-710 (2019-03-19) Reversal effect of bufalin on multidrug resistance in K562/VCR vincristine-resistant leukemia cell line.Xiaofeng Zhai et al.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 34(6), 678-683 (2015-01-27) Modulatory effects of bufalin, an active ingredient from toad venom on voltage-gated sodium channels.Jie Tao et al.Molecular biology reports (2018-06-23) Degradation of Mcl-1 through GSK-3β Activation Regulates Apoptosis Induced by Bufalin in Non-Small Cell Lung Cancer H1975 Cells.Xiao-Hong Kang et al.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 41(5), 2067-2076 (2017-04-19) Simultaneous Determination of Bufalin and Its Nine Metabolites in Rat Plasma for Characterization of Metabolic Profiles and Pharmacokinetic Study by LC⁻MS/MS.Wenlong Wei et al.Molecules (Basel, Switzerland), 24(9) (2019-05-01) Bufalin and 5-fluorouracil synergistically induce apoptosis in colorectal cancer cells.Xiao-Yu Dai et al.Oncology letters, 15(5), 8019-8026 (2018-06-01) Bufalin, a component in Chansu, inhibits proliferation and invasion of hepatocellular carcinoma cells.Dong-Ze Qiu et al.BMC complementary and alternative medicine, 13, 185-185 (2013-07-23) Anti-tumor Activity of Bufalin by Inhibiting c-MET Mediated MEK/ERK and PI3K/AKT Signaling Pathways in Gallbladder Cancer.Liqiang Qian et al.Journal of Cancer, 11(11), 3114-3123 (2020-04-02) Bufalin-Loaded CaP/DPPE-PEG-EGF Nanospheres: Preparation, Cellular Uptake, Distribution, and Anti-Tumor Effects.Jie Xu et al.Journal of biomedical nanotechnology, 15(2), 329-339 (2019-01-01) Bufalin reverses ABCB1-mediated drug resistance in colorectal cancer.Ze-Ting Yuan et al.Oncotarget, 8(29), 48012-48026 (2017-06-19) Octreotide-periplocymarin conjugate prodrug for improving targetability and anti-tumor efficiency: synthesis, in vitro and in vivo evaluation.Hui-Yun Zhang et al.Oncotarget, 7(52), 86326-86338 (2016-11-20) A research update on the anticancer effects of bufalin and its derivatives.Yu-Long Lan et al.Oncology letters, 17(4), 3635-3640 (2019-03-28) Bufalin Induces Glioma Cell Death by Apoptosis or Necroptosis.Hai Rui LingHu et al.OncoTargets and therapy, 13, 4767-4778 (2020-06-26) Bufalin loaded biotinylated chitosan nanoparticles: an efficient drug delivery system for targeted chemotherapy against breast carcinoma.Xin Tian et al.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 87(3), 445-453 (2014-05-23) Bufalin suppresses the migration and invasion of prostate cancer cells through HOTAIR, the sponge of miR-520b.Jian-Jun Zhang et al.Acta pharmacologica Sinica, 40(9), 1228-1236 (2019-04-28) Bufalin suppresses the proliferation and metastasis of renal cell carcinoma by inhibiting the PI3K/Akt/mTOR signaling pathway.Jinlin Xie et al.Oncology letters, 16(3), 3867-3873 (2018-08-22) Bufalin inhibits glioblastoma growth by promoting proteasomal degradation of the Na+/K+-ATPase α1 subunit.Yu-Long Lan et al.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 103, 204-215 (2018-04-14) Bufalin induces cell cycle arrest and apoptosis in gallbladder carcinoma cells.Lin Jiang et al.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 35(11), 10931-10941 (2014-08-03) Bufalin induces lung cancer cell apoptosis via the inhibition of PI3K/Akt pathway.Zhitu Zhu et al.International journal of molecular sciences, 13(2), 2025-2035 (2012-03-13) Long noncoding RNA NORAD is upregulated in epithelial ovarian cancer and its downregulation suppressed cancer cell functions by competing with miR-155-5p.Lingling Tong et al.Cancer medicine, 8(10), 4782-4791 (2019-06-30) Inhibitory effect of bufalin on retinoblastoma cells (HXO-RB44) via the independent mitochondrial and death receptor pathway.Qingfeng Meng et al.American journal of translational research, 8(11), 4968-4974 (2016-12-03) Bufalin induces apoptosis in vitro and has Antitumor activity against human lung cancer xenografts in vivo.Shin-Hwar Wu et al.Environmental toxicology, 32(4), 1305-1317 (2016-07-23) Secreted protein acidic and rich in cysteine antagonizes bufalin-induced apoptosis in gastric cancer cells.Aodi Li et al.Molecular medicine reports, 12(2), 2926-2932 (2015-05-06) Bufalin engages in RIP1-dependent and ROS-dependent programmed necroptosis in breast cancer cells by targeting the RIP1/RIP3/PGAM5 pathway.Yanlan Li et al.Anti-cancer drugs, 30(7), e0770-e0770 (2019-03-05) NCOA3 Loss Disrupts Molecular Signature of Chondrocytes and Promotes Posttraumatic Osteoarthritis Progression.Bing Zhang et al.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 49(6), 2396-2413 (2018-09-28) Bufalin induces apoptosis in human esophageal carcinoma ECA109 cells by inhibiting the activation of the mTOR/p70S6K pathway.Yan Ding et al.Oncology letters, 15(6), 9339-9346 (2018-05-29) Dual-locus DNA metabarcoding reveals southern hairy-nosed wombats (Lasiorhinus latifrons Owen) have a summer diet dominated by toxic invasive plants.Amanda Camp et al.PloS one, 15(3), e0229390-e0229390 (2020-03-07) Bufalin Reverses HGF-Induced Resistance to EGFR-TKIs in EGFR Mutant Lung Cancer Cells via Blockage of Met/PI3k/Akt Pathway and Induction of Apoptosis.Xiao-Hong Kang et al.Evidence-based complementary and alternative medicine : eCAM, 2013, 243859-243859 (2013-03-28) BF211, a derivative of bufalin, enhances the cytocidal effects in multiple myeloma cells by inhibiting the IL-6/JAK2/STAT3 pathway.Xiao-Yu Wu et al.International immunopharmacology, 64, 24-32 (2018-08-27) Bufalin inhibits human breast cancer tumorigenesis by inducing cell death through the ROS-mediated RIP1/RIP3/PARP-1 pathways.Yanlan Li et al.Carcinogenesis, 39(5), 700-707 (2018-03-17) Bufalin, a bufanolide steroid from the parotoid glands of the Chinese toad, suppresses hERG KTao Song et al.Fundamental & clinical pharmacology, 31(6), 695-700 (2017-07-30) Bufalin inhibits glycolysis-induced cell growth and proliferation through the suppression of Integrin β2/FAK signaling pathway in ovarian cancer.Haoran Li et al.American journal of cancer research, 8(7), 1288-1296 (2018-08-11) Cardiac glycosides are potent inhibitors of interferon-β gene expression.Junqiang Ye et al.Nature chemical biology, 7(1), 25-33 (2010-11-16) SRC-3 inhibition blocks tumor growth of pancreatic ductal adenocarcinoma.Xianzhou Song et al.Cancer letters, 442, 310-319 (2018-11-14) Bufalin Induces Apoptosis and Improves the Sensitivity of Human Glioma Stem-Like Cells to Temozolamide.Jia Liu et al.Oncology research, 27(4), 475-486 (2018-05-26) Improved Antitumor Efficacy and Pharmacokinetics of Bufalin via PEGylated Liposomes.Jiani Yuan et al.Nanoscale research letters, 12(1), 585-585 (2017-11-11) Novel augmentation by bufalin of protein kinase C-induced cyclooxygenase-2 and IL-8 production in human breast cancer cells.Hsiao-Ting Chen et al.Innate immunity, 23(1), 54-66 (2016-11-09) Bufalin, a bioactive component of the Chinese medicine chansu, inhibits inflammation and invasion of human rheumatoid arthritis fibroblast-like synoviocytes.Xiaofeng Rong et al.Inflammation, 37(4), 1050-1058 (2014-02-12) Anticancer effects of bufalin on human hepatocellular carcinoma HepG2 cells: roles of apoptosis and autophagy.Qing Miao et al.International journal of molecular sciences, 14(1), 1370-1382 (2013-01-25) Comparative Analysis of the Bufonis Venenum by Using TLC, HPLC, and LC-MS for Different Extraction Methods.Hyo-Jae Lee et al.Journal of pharmacopuncture, 15(4), 52-65 (2012-12-01) Bufalin inhibits pancreatic cancer by inducing cell cycle arrest via the c-Myc/NF-κB pathway.Xia Liu et al.Journal of ethnopharmacology, 193, 538-545 (2016-10-01) Bufalin inhibits gefitinib resistant NCI-H460 human lung cancer cell migration and invasion in vitro.An-Cheng Huang et al.Journal of ethnopharmacology, 194, 1043-1050 (2016-11-12) Bufalin is a potent small-molecule inhibitor of the steroid receptor coactivators SRC-3 and SRC-1.Ying Wang et al.Cancer research, 74(5), 1506-1517 (2014-01-07) Bufalin inhibits cell proliferation and migration of hepatocellular carcinoma cells via APOBEC3F induced intestinal immune network for IgA production signaling pathway.Zongguo Yang et al.Biochemical and biophysical research communications, 503(3), 2124-2131 (2018-08-14) Targeting poly (ADP-ribose) polymerase partially contributes to bufalin-induced cell death in multiple myeloma cells.He Huang et al.PloS one, 8(6), e66130-e66130 (2013-06-14) Age- and environment-dependent changes in chemical defences of larval and post-metamorphic toads.Bálint Üveges et al.BMC evolutionary biology, 17(1), 137-137 (2017-06-15) Triggering apoptotic death of human malignant melanoma a375.s2 cells by bufalin: involvement of caspase cascade-dependent and independent mitochondrial signaling pathways.Yu-Ping Hsiao et al.Evidence-based complementary and alternative medicine : eCAM, 2012, 591241-591241 (2012-06-22) Silencing c-Myc Enhances the Antitumor Activity of Bufalin by Suppressing the HIF-1α/SDF-1/CXCR4 Pathway in Pancreatic Cancer Cells.Xia Liu et al.Frontiers in pharmacology, 11, 495-495 (2020-05-05) Neurofibromin Is an Estrogen Receptor-α Transcriptional Co-repressor in Breast Cancer.Ze-Yi Zheng et al.Cancer cell, 37(3), 387-402 (2020-03-07) Bufalin-loaded mPEG-PLGA-PLL-cRGD nanoparticles: preparation, cellular uptake, tissue distribution, and anticancer activity.Peihao Yin et al.International journal of nanomedicine, 7, 3961-3969 (2012-08-14) Bufalin Suppresses Migration and Invasion of Hepatocellular Carcinoma Cells Elicited by Poly (I:C) Therapy.Yinglu Feng et al.Oncoimmunology, 7(5), e1426434-e1426434 (2018-05-04)

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