询 单
请 填 写 相 关 信 息
产品信息
产品名称
别名
CAS号
结构式 上传
联系方式
公司
联系人
电话
邮箱
内容
提交
中文版 English
请输入产品名称、CAS式、分子式
alpha-Toxicarol | CAS:82-09-7
alpha-Toxicarol
  • 名称:alpha-灰叶酚 | alpha-Toxicarol
  • CAS号:82-09-7
  • 别名:(7aS,13aS)-13,13a-Dihydro-6-hydroxy-9,10-dimethoxy-3,3-dimethyl-3H-bis[1]benzopyrano[3,4-b:6',5'-e]pyran-7(7aH)-one
  • 分子式:C23H22O7
  • 分子量:410.42
  • EINESC号:

产品描述

物理化学性质

熔点 222 ºC**
密度 1.312±0.06 g/cm3 (20 º
折射率 >1.768***

安全数据

没有数据没有数据

SDS

来源 SDS样本
没有数据没有数据
产品合成路线
更多

名称 CAS号
更多
文章
同行评议文献
Effects of cigarette smoking on quinine pharmacokinetics in malaria.S Pukrittayakamee et al.European journal of clinical pharmacology, 58(5), 315-319 (2002-08-20) Subcellular Characterization of Nicotinamide Adenine Dinucleotide Biosynthesis in Metastatic Melanoma by Using Organelle-Specific Biosensors.Federica Gaudino et al.Antioxidants & redox signaling, 31(15), 1150-1165 (2019-08-29) Organic anion transporting polypeptides 1B1 and 1B3 play an important role in uremic toxin handling and drug-uremic toxin interactions in the liver.Toshihiro Sato et al.Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 17(4), 475-484 (2015-01-13) 2-Aminonicotinic acid 1-oxides are chemically stable inhibitors of quinolinic acid synthesis in the mammalian brain: a step toward new antiexcitotoxic agents.Gian Paolo Vallerini et al.Journal of medicinal chemistry, 56(23), 9482-9495 (2013-11-28) Plasma cysteine deficiency and decreased reduction of nitrososulfamethoxazole with HIV infection.D J Naisbitt et al.AIDS research and human retroviruses, 16(18), 1929-1938 (2001-01-12) Effects of translocator protein (18 kDa) ligands on microglial activation and neuronal death in the quinolinic-acid-injected rat striatum.Katherine R Leaver et al.ACS chemical neuroscience, 3(2), 114-119 (2012-08-04) Connecting inflammation with glutamate agonism in suicidality.Sophie Erhardt et al.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 38(5), 743-752 (2013-01-10) The clinical significance of cerebrospinal fluid levels of kynurenine pathway metabolites and lactate in severe malaria.Isabelle M Medana et al.The Journal of infectious diseases, 185(5), 650-656 (2002-02-28) Therapeutic criteria in hydrocephalic children.M Castro-Gago et al.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 5(6), 361-363 (1989-12-01) Assessment of antioxidant reserves and oxidative stress in cerebrospinal fluid after severe traumatic brain injury in infants and children.Hulya Bayir et al.Pediatric research, 51(5), 571-578 (2002-04-30) Manipulation with kynurenines: a possible tool for treating neurodegenerative diseases?Laszlo Vecsei et al.Expert review of clinical pharmacology, 5(4), 351-353 (2012-09-05) Quinolinic acid and other kynurenines in the central nervous system.T W Stone et al.Neuroscience, 15(3), 597-617 (1985-07-01) Increase in the content of quinolinic acid in cerebrospinal fluid and frontal cortex of patients with hepatic failure.F Moroni et al.Journal of neurochemistry, 47(6), 1667-1671 (1986-12-01) Determination of tryptophan derivatives in kynurenine pathway in fermented foods using liquid chromatography tandem mass spectrometry.Cemile Yılmaz et al.Food chemistry, 243, 420-427 (2017-11-18) Increased serum levels of quinolinic acid indicate enhanced severity of hepatic dysfunction in patients with liver cirrhosis.Imad Lahdou et al.Human immunology, 74(1), 60-66 (2012-10-11) JAK2 inhibition is neuroprotective and reduces astrogliosis after quinolinic acid striatal lesion in adult mice.Raffaela Silvestre Ignarro et al.Journal of chemical neuroanatomy, 48-49, 14-22 (2013-02-14) Effects of hypoxia-inducible factor 1α on bone conduction impairment in otitis media with effusion.Han Zhou et al.Acta oto-laryngologica, 132(9), 938-943 (2012-05-10) Controllable supramolecular structures and luminescent properties of unique trimeric Zn(II) 8-hydroxyquinolinates tuned by functional substituents.Guozan Yuan et al.Dalton transactions (Cambridge, England : 2003), 42(8), 2921-2929 (2012-12-18) Impact of minocycline on cerebrospinal fluid markers of oxidative stress, neuronal injury, and inflammation in HIV-seropositive individuals with cognitive impairment.Ned Sacktor et al.Journal of neurovirology, 20(6), 620-626 (2014-11-08) Behavioral Deficits Are Accompanied by Immunological and Neurochemical Changes in a Mouse Model for Neuropsychiatric Lupus (NP-SLE).Yan Li et al.International journal of molecular sciences, 16(7), 15150-15171 (2015-07-08) Establishment of true niacin deficiency in quinolinic acid phosphoribosyltransferase knockout mice.Miki Terakata et al.The Journal of nutrition, 142(12), 2148-2153 (2012-10-26) The kynurenine pathway and inflammation in amyotrophic lateral sclerosis.Yiquan Chen et al.Neurotoxicity research, 18(2), 132-142 (2009-11-19) Neuron-specific enolase, nucleotides, nucleosides, purine bases, oxypurines and uric acid concentrations in cerebrospinal fluid of children with meningitis.Antonio Rodríguez-Núñez et al.Brain & development, 25(2), 102-106 (2003-02-13) Cooperation of non-effective concentration of glutamatergic system modulators and antioxidant against oxidative stress induced by quinolinic acid.Fernando Dobrachinski et al.Neurochemical research, 37(9), 1993-2003 (2012-06-08) The CB₁ cannabinoid receptor signals striatal neuroprotection via a PI3K/Akt/mTORC1/BDNF pathway.C Blázquez et al.Cell death and differentiation, 22(10), 1618-1629 (2015-02-24) Successive ion layer adsorption and reaction (SILAR) technique synthesis of Al(III)-8-hydroxy-5-nitrosoquinolate nano-sized thin films: characterization and factors optimization.Sawsan M S Haggag et al.Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 102, 150-158 (2012-12-12) Human microglia convert l-tryptophan into the neurotoxin quinolinic acid.M P Heyes et al.The Biochemical journal, 320 ( Pt 2), 595-597 (1996-12-01) ECNI GC-MS analysis of picolinic and quinolinic acids and their amides in human plasma, CSF, and brain tissue.George A Smythe et al.Advances in experimental medicine and biology, 527, 705-712 (2004-06-23) Developmentally coordinated extrinsic signals drive human pluripotent stem cell differentiation toward authentic DARPP-32+ medium-sized spiny neurons.Alessia Delli Carri et al.Development (Cambridge, England), 140(2), 301-312 (2012-12-20) Systemic tryptophan and kynurenine catabolite levels relate to severity of rhinovirus-induced asthma exacerbation: a prospective study with a parallel-group design.Koenraad F van der Sluijs et al.Thorax, 68(12), 1122-1130 (2013-07-25) Correlations between behavioural and oxidative parameters in a rat quinolinic acid model of Huntington's disease: protective effect of melatonin.Ethel Antunes Wilhelm et al.European journal of pharmacology, 701(1-3), 65-72 (2013-01-24) Amino acid neurotransmitter abnormalities in Huntington's disease and the quinolinic acid animal model of Huntington's disease.D W Ellison et al.Brain : a journal of neurology, 110 ( Pt 6), 1657-1673 (1987-12-01) Therapeutic criteria in hydrocephalic children.M Castro-Gago et al.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 5(6), 361-363 (1989-12-01) Kynurenine pathway enzymes in brain. Properties of enzymes and regulation of quinolinic acid synthesis.K Saito et al.Advances in experimental medicine and biology, 398, 485-492 (1996-01-01) The relationship between plasma and brain quinolinic acid levels and the severity of hepatic encephalopathy.A S Basile et al.Gastroenterology, 108(3), 818-823 (1995-03-01) Age-related reference values for urinary organic acids in a healthy Turkish pediatric population.F Guneral et al.Clinical chemistry, 40(6), 862-866 (1994-06-01) Neopterin concentrations in pediatric human immunodeficiency virus infection as predictor of disease activity.M Ellaurie et al.The Pediatric infectious disease journal, 11(4), 286-289 (1992-04-01) D-mannitol in cerebrospinal fluid of patients with AIDS and cryptococcal meningitis.G M Megson et al.Journal of clinical microbiology, 34(1), 218-221 (1996-01-01) The niacin required for optimum growth can be synthesized from L-tryptophan in growing mice lacking tryptophan-2,3-dioxygenase.Miki Terakata et al.The Journal of nutrition, 143(7), 1046-1051 (2013-05-24) Heme oxygenase-1 (HO-1) upregulation delays morphological and oxidative damage induced in an excitotoxic/pro-oxidant model in the rat striatum.A L Colín-González et al.Neuroscience, 231, 91-101 (2012-12-04) Human microglia convert l-tryptophan into the neurotoxin quinolinic acid.M P Heyes et al.The Biochemical journal, 320 ( Pt 2), 595-597 (1996-12-01) The kynurenine pathway and quinolinic acid: pivotal roles in HIV associated neurocognitive disorders.Apsara Kandanearatchi et al.The FEBS journal, 279(8), 1366-1374 (2012-01-21) Quinolinic acid: an endogenous neurotoxin with multiple targets.Rafael Lugo-Huitrón et al.Oxidative medicine and cellular longevity, 2013, 104024-104024 (2013-10-04) Effects of immune activation on quinolinic acid and neuroactive kynurenines in the mouse.K Saito et al.Neuroscience, 51(1), 25-39 (1992-11-01) HIV-1 associated dementia: clinical features and pathogenesis.C Power et al.The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 22(2), 92-100 (1995-05-01) Automated screening of urine samples for carbohydrates, organic and amino acids after treatment with urease.J D Shoemaker et al.Journal of chromatography, 562(1-2), 125-138 (1991-01-02) Increased conversion of tryptophan to nicotinamide in rats by dietary valproate.Katsumi Shibata et al.Bioscience, biotechnology, and biochemistry, 77(2), 295-300 (2013-02-09) Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases.Nathan R Rose et al.Journal of medicinal chemistry, 51(22), 7053-7056 (2008-10-24) Quinolinic acid/tryptophan ratios predict neurological disease in SIV-infected macaques and remain elevated in the brain under cART.Julia L Drewes et al.Journal of neurovirology, 21(4), 449-463 (2015-03-18) The absence of indoleamine 2,3-dioxygenase expression protects against NMDA receptor-mediated excitotoxicity in mouse brain.G Mazarei et al.Experimental neurology, 249, 144-148 (2013-09-03) Competitive inhibitors of the CphA metallo-beta-lactamase from Aeromonas hydrophila.L E Horsfall et al.Antimicrobial agents and chemotherapy, 51(6), 2136-2142 (2007-02-20) Oxidative stress is related to the deleterious effects of heme oxygenase-1 in an in vivo neuroinflammatory rat model.Claire Tronel et al.Oxidative medicine and cellular longevity, 2013, 264935-264935 (2013-03-28) Age-dependent alterations of the kynurenine pathway in the YAC128 mouse model of Huntington disease.Gelareh Mazarei et al.Journal of neurochemistry, 127(6), 852-867 (2013-06-22) Involvement of quinolinic acid in AIDS dementia complex.Gilles J Guillemin et al.Neurotoxicity research, 7(1-2), 103-123 (2005-01-11) Chemical genetics reveals a complex functional ground state of neural stem cells.Phedias Diamandis et al.Nature chemical biology, 3(5), 268-273 (2007-04-10) Central role of hypothalamic digoxin in conscious perception, neuroimmunoendocrine integration, and coordination of cellular function: relation to hemispheric dominance.Ravi Kumar Kurup et al.The International journal of neuroscience, 112(6), 705-739 (2002-09-28) Quinolinic acid concentrations in brain and cerebrospinal fluid of patients with intractable complex partial seizures.M P Heyes et al.Epilepsia, 31(2), 172-177 (1990-03-01) The 1993 Upjohn Award Lecture. Quinolinic acid induced brain neurotransmitter deficits: modulation by endogenous excitotoxin antagonists.K H Jhamandas et al.Canadian journal of physiology and pharmacology, 72(12), 1473-1482 (1994-12-01) The phosphorylation status and cytoskeletal remodeling of striatal astrocytes treated with quinolinic acid.Paula Pierozan et al.Experimental cell research, 322(2), 313-323 (2014-03-04) Implications for the kynurenine pathway and quinolinic acid in amyotrophic lateral sclerosis.Gilles J Guillemin et al.Neuro-degenerative diseases, 2(3-4), 166-176 (2006-08-16) In vivo inhibition of the mitochondrial H+-ATP synthase in neurons promotes metabolic preconditioning.Laura Formentini et al.The EMBO journal, 33(7), 762-778 (2014-02-14) Centella asiatica and Its Fractions Reduces Lipid Peroxidation Induced by Quinolinic Acid and Sodium Nitroprusside in Rat Brain Regions.Naiani Ferreira Marques et al.Neurochemical research, 40(6), 1197-1210 (2015-04-24) Within-event learning in rats with lesions of the basolateral amygdala.Pam Blundell et al.Behavioural brain research, 236(1), 48-55 (2012-09-05) Differential regulation of neurotoxin in HIV clades: role of cocaine and methamphetamine.Madhavan P N Nair et al.Current HIV research, 10(5), 429-434 (2012-05-18) Sensitivity to neurotoxic stress is not increased in progranulin-deficient mice.Terri L Petkau et al.Neurobiology of aging, 34(11), 2548-2550 (2013-05-25) The quinolinic acid hypothesis in Huntington's chorea.R P Bruyn et al.Journal of the neurological sciences, 95(1), 29-38 (1990-01-01) Simultaneous voltammetric analysis of tryptophan and kynurenine in culture medium from human cancer cells.Ilona Sadok et al.Talanta, 209, 120574-120574 (2020-01-02) The crossroads of neuroinflammation in infectious diseases: endothelial cells and astrocytes.Valéry Combes et al.Trends in parasitology, 28(8), 311-319 (2012-06-26) Cerebrospinal fluid quinolinic acid concentrations are increased in acquired immune deficiency syndrome.M P Heyes et al.Annals of neurology, 26(2), 275-277 (1989-08-01) Post-training unilateral amygdala lesions selectively impair contextual fear memories.Charlotte R Flavell et al.Learning & memory (Cold Spring Harbor, N.Y.), 19(6), 256-263 (2012-05-23) Quinolinic acid in neurological disease: opportunities for novel drug discovery.J F Reinhard et al.Advances in pharmacology (San Diego, Calif.), 30, 85-127 (1994-01-01) Progerin-Induced Transcriptional Changes in Huntington's Disease Human Pluripotent Stem Cell-Derived Neurons.Dorit Cohen-Carmon et al.Molecular neurobiology, 57(3), 1768-1777 (2019-12-14) Proton MR CSF analysis and a new software as predictors for the differentiation of meningitis in children.Arunachalam Subramanian et al.NMR in biomedicine, 18(4), 213-225 (2005-01-01) Metabolic adaptation of renal carbohydrate metabolism. IV. The use of site-specific liver gluconeogenesis inhibitors to ascertain the role of renal gluconeogenesis.L Garcia-Salguero et al.Archives internationales de physiologie, de biochimie et de biophysique, 99(3), 237-242 (1991-06-01) Metabolism and neuropathologic significance of quinolinic acid and kynurenic acid.M P Heyes Biochemical Society transactions, 21(1), 83-89 (1993-02-01) Mutant huntingtin affects endocytosis in striatal cells by altering the binding of AP-2 to membranes.Janina E Borgonovo et al.Experimental neurology, 241, 75-83 (2012-12-12) Of mice, rats and men: Revisiting the quinolinic acid hypothesis of Huntington's disease.Robert Schwarcz et al.Progress in neurobiology, 90(2), 230-245 (2009-04-28) The effects of acute falciparum malaria on the disposition of caffeine and the comparison of saliva and plasma-derived pharmacokinetic parameters in adult Nigerians.O O Akinyinka et al.European journal of clinical pharmacology, 56(2), 159-165 (2000-07-06) Identification of quinolinic acid in rat and human brain tissue.M Wolfensberger et al.Neuroscience letters, 41(3), 247-252 (1983-11-11) Improving the serum D-xylose test for the identification of patients with small intestinal malabsorption.E D Ehrenpreis et al.Journal of clinical gastroenterology, 33(1), 36-40 (2001-06-22) Diagnosis of tuberculous meningitis by detection of tuberculostearic acid in cerebrospinal fluid.G L French et al.Lancet (London, England), 2(8551), 117-119 (1987-07-18) RETRACTED: Curcumin restores Nrf2 levels and prevents quinolinic acid-induced neurotoxicity.Iván Carmona-Ramírez et al.The Journal of nutritional biochemistry, 24(1), 14-24 (2012-06-19) Quinolinic acid, the inescapable neurotoxin.Gilles J Guillemin The FEBS journal, 279(8), 1356-1365 (2012-01-18) Implications of the kynurenine pathway and quinolinic acid in Alzheimer's disease.Gilles J Guillemin et al.Redox report : communications in free radical research, 7(4), 199-206 (2002-10-25) Central-nervous-system methyl-group metabolism in children with neurological complications of HIV infection.R Surtees et al.Lancet (London, England), 335(8690), 619-621 (1990-03-17) Quinolinic acid and kynurenic acid in the mammalian brain.R Schwarcz et al.Advances in experimental medicine and biology, 294, 185-199 (1991-01-01) Quinolinic acid in tumors, hemorrhage and bacterial infections of the central nervous system in children.M P Heyes et al.Journal of the neurological sciences, 133(1-2), 112-118 (1995-11-01) 3-Hydroxyanthranilic acid inhibits PDK1 activation and suppresses experimental asthma by inducing T cell apoptosis.Tomoko Hayashi et al.Proceedings of the National Academy of Sciences of the United States of America, 104(47), 18619-18624 (2007-11-16) Cell signaling in NMDA preconditioning and neuroprotection in convulsions induced by quinolinic acid.Patricia Cardoso Severino et al.Life sciences, 89(15-16), 570-576 (2011-06-21) The urinary ratio of 3-hydroxykynurenine/3-hydroxyanthranilic acid is an index to predicting the adverse effects of D-tryptophan in rats.Katsumi Shibata et al.Journal of nutritional science and vitaminology, 60(4), 261-268 (2014-10-10) Biochemical characterization of quinolinic acid phosphoribosyltransferase from Mycobacterium tuberculosis H37Rv and inhibition of its activity by pyrazinamide.Hyun Kim et al.PloS one, 9(6), e100062-e100062 (2014-06-21) Activation of the kynurenine pathway and increased production of the excitotoxin quinolinic acid following traumatic brain injury in humans.Edwin B Yan et al.Journal of neuroinflammation, 12, 110-110 (2015-05-31) The kynurenine pathway in neurodegenerative diseases: mechanistic and therapeutic considerations.Lin Tan et al.Journal of the neurological sciences, 323(1-2), 1-8 (2012-09-04) Development and validation of a single analytical method for the determination of tryptophan, and its kynurenine metabolites in rat plasma.Marisa Möller et al.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 898, 121-129 (2012-05-23) Peripheral indoleamine 2,3-dioxygenase 1 is required for comorbid depression-like behavior but does not contribute to neuropathic pain in mice.Wenjun Zhou et al.Brain, behavior, and immunity, 46, 147-153 (2015-02-01) Rapid mapping of insertional mutations to probe cell wall regulation in Cryptococcus neoformans.Shannon K Esher et al.Fungal genetics and biology : FG & B, 82, 9-21 (2015-06-27) Vitamin B1 deficiency inhibits the increased conversion of tryptophan to nicotinamide in severe food-restricted rats.Katsumi Shibata et al.Bioscience, biotechnology, and biochemistry, 79(1), 103-108 (2014-09-26) Selenium-induced antioxidant protection recruits modulation of thioredoxin reductase during excitotoxic/pro-oxidant events in the rat striatum.Perla D Maldonado et al.Neurochemistry international, 61(2), 195-206 (2012-05-15) Regulation of quinolinic acid synthesis by mitochondria and o-methoxybenzoylalanine.A Chiarugi et al.Advances in experimental medicine and biology, 467, 233-239 (2000-03-18) Possible mediation of quinolinic acid-induced hippocampal damage by reactive oxygen species.T W Stone et al.Amino acids, 19(1), 275-281 (2000-10-12) Elevated cerebrospinal fluid quinolinic acid levels are associated with region-specific cerebral volume loss in HIV infection.M P Heyes et al.Brain : a journal of neurology, 124(Pt 5), 1033-1042 (2001-05-04) Formation of P-C bond through reductive coupling between bridging phosphido and benzoquinolinate groups. Isolation of complexes of the Pt(II)/Pt(IV)/Pt(II) sequence.Andersson Arias et al.Inorganic chemistry, 51(23), 12682-12696 (2012-11-13) Hypothalamic digoxin, hemispheric chemical dominance, and Alzheimer's disease.Ravi Kumar Kurup et al.The International journal of neuroscience, 113(3), 361-381 (2003-06-14) Baicalin inhibits the fenton reaction by enhancing electron transfer from Fe (2+) to dissolved oxygen.Daisuke Nishizaki et al.The American journal of Chinese medicine, 43(1), 87-101 (2015-02-03) Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression.Arun Sreekumar et al.Nature, 457(7231), 910-914 (2009-02-13) Identifying chelators for metalloprotein inhibitors using a fragment-based approach.Jennifer A Jacobsen et al.Journal of medicinal chemistry, 54(2), 591-602 (2010-12-30) Quinolinic acid and inflammation.M P Heyes Annals of the New York Academy of Sciences, 679, 211-216 (1993-05-28) Biochemical, histopathological and behavioral alterations caused by intrastriatal administration of quinolic acid to young rats.Paula Pierozan et al.The FEBS journal, 281(8), 2061-2073 (2014-03-13) Cerebrospinal fluid taurine after traumatic brain injury.Yukio Seki et al.Neurochemical research, 30(1), 123-128 (2005-03-11) Quinolinate salvage and insights for targeting NAD biosynthesis in group A streptococci.Leonardo Sorci et al.Journal of bacteriology, 195(4), 726-732 (2012-12-04) Metabolites of the kynurenine pathway of tryptophan metabolism in the cerebrospinal fluid of Malawian children with malaria.Isabelle M Medana et al.The Journal of infectious diseases, 188(6), 844-849 (2003-09-10) Acute intrastriatal injection of quinolinic acid provokes long-lasting misregulation of the cytoskeleton in the striatum, cerebral cortex and hippocampus of young rats.Paula Pierozan et al.Brain research, 1577, 1-10 (2014-07-01) Time-dependent effects of L-tryptophan administration on urinary excretion of L-tryptophan metabolites.Chiaki Hiratsuka et al.Journal of nutritional science and vitaminology, 60(4), 255-260 (2014-10-10) Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease.M P Heyes et al.Brain : a journal of neurology, 115 ( Pt 5), 1249-1273 (1992-10-01)
备注

Products protected by valid patents are not offered for sale in countries where the sale of such products constitutes a patent infringement and its liability is at buyer's risk.

Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271 +A13(1).

名称 CAS号

相关产品

相关资讯

热门标签
询 单
请 填 写 相 关 信 息
产品信息
产品名称
别名
CAS号
结构式 上传
联系方式
公司
联系人
电话
邮箱
内容
提交