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4-Methyl-2-nitroaniline | CAS:89-62-3
4-Methyl-2-nitroaniline
  • 名称:4-甲基-2-硝基苯胺; 2-硝基-4-甲苯胺 | 4-Methyl-2-nitroaniline
  • CAS号:89-62-3
  • 别名:2-Nitro-p-toluidine; 4-Amino-3-nitrotoluene
  • 分子式:C7H8N2O2
  • 分子量:152.15
  • EINESC号:201-924-9

产品描述

物理化学性质

熔点 112-115 ºC
沸点 169 ºC (21 mmHg)
闪点 157 ºC

安全数据

危险品标志 T;N
危险类别码 R23/24/25;R33;R51/53
安全说明书 S28;S36/37;S45;S61

SDS

来源 SDS样本
没有数据没有数据
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Influence of the extra ring of the bridging ligand on the DNA interaction and cytotoxic activity.Héctor J Lozano et al.Dalton transactions (Cambridge, England : 2003), 46(11), 3611-3622 (2017-03-01) Synthesis and cytotoxicity study of alkannin derivatives.Zhi-Shu Huang et al.European journal of medicinal chemistry, 39(9), 755-764 (2004-09-01) Alkaline-earth cations enhance ortho-quinone-catalyzed ascorbate oxidation.Antonio E Alegría et al.Free radical biology & medicine, 37(10), 1631-1639 (2004-10-13) Cytotoxicity in vitro of naphthazarin derivatives from Onosma arenaria.Tatjana Kundaković et al.Phytotherapy research : PTR, 20(7), 602-604 (2006-05-24) Novel anti-cancer role of naphthazarin in human gastric cancer cells.Jin-Ah Kim et al.International journal of oncology, 40(1), 157-162 (2011-09-10) Sirtuin 3 rescues neurons through the stabilisation of mitochondrial biogenetics in the virally-expressing mutant α-synuclein rat model of parkinsonism.Jacqueline A Gleave et al.Neurobiology of disease, 106, 133-146 (2017-07-05) United States Department of Agriculture-Agricultural Research Service studies on polyketide toxins of Fusarium oxysporum f sp vasinfectum: potential targets for disease control.Alois A Bell et al.Pest management science, 59(6-7), 736-747 (2003-07-09) Naphthazarin and methylnaphthazarin cause vascular dysfunction by impairment of endothelium-derived nitric oxide and increased superoxide anion generation.Jaw-Jou Kang et al.Toxicology in vitro : an international journal published in association with BIBRA, 20(1), 43-51 (2005-07-16) Naphthazarin protects against glutamate-induced neuronal death via activation of the Nrf2/ARE pathway.Tae Gen Son et al.Biochemical and biophysical research communications, 433(4), 602-606 (2013-03-30) Role of lysosomal cathepsins in naphthazarin- and Fas-induced apoptosis in oral squamous cell carcinoma cells.Ann-Charlotte Johansson et al.Acta oto-laryngologica, 126(1), 70-81 (2005-11-26) Biological activity of some naturally occurring resins, gums and pigments against in vitro LDL oxidation.Nikolaos K Andrikopoulos et al.Phytotherapy research : PTR, 17(5), 501-507 (2003-05-16) Mitochondrial dysfunction precedes other sub-cellular abnormalities in an in vitro model linked with cell death in Parkinson's disease.C J Yong-Kee et al.Neurotoxicity research, 21(2), 185-194 (2011-07-21) Inhibitory effect of a naphthazarin derivative, S64, on heat shock factor (Hsf) activation and glutathione status following hypoxia.E M Park et al.Cell biology and toxicology, 19(5), 273-284 (2004-01-02) Synthesis and evaluation of antitumor activity of novel 1,4-naphthoquinone derivatives (IV).Bok Hee Kim et al.Archives of pharmacal research, 29(2), 123-130 (2006-03-11) Extension of lifespan in C. elegans by naphthoquinones that act through stress hormesis mechanisms.Piper R Hunt et al.PloS one, 6(7), e21922-e21922 (2011-07-19) Maintenance and pharmacologic targeting of ROR1 protein levels via UHRF1 in t(1;19) pre-B-ALL.Marilynn Chow et al.Oncogene, 37(38), 5221-5232 (2018-06-01) Is nitric oxide decrease observed with naphthoquinones in LPS stimulated RAW 264.7 macrophages a beneficial property?Brígida R Pinho et al.PloS one, 6(8), e24098-e24098 (2011-09-03) Fourier transform infrared and Raman spectra, vibrational assignment and density functional theory calculations of naphthazarin.Mansoureh Zahedi Tabrizi et al.Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 60(1-2), 111-120 (2003-12-13) Synthesis of (1,4)-naphthoquinono-[3,2-c]-1H-pyrazoles and their (1,4)-naphthohydroquinone derivatives as antifungal, antibacterial, and anticancer agents.Vishnu K Tandon et al.Bioorganic & medicinal chemistry letters, 15(13), 3288-3291 (2005-05-26) Use of 1,4-naphthoquinones for control of Erwinia carotovora.Luis F C Medina et al.Canadian journal of microbiology, 50(11), 951-956 (2005-01-13) Stimulation of Suicidal Erythrocyte Death by Naphthazarin.Omar Aljanadi et al.Basic & clinical pharmacology & toxicology, 117(6), 369-374 (2015-05-28) Evidence for synergism between cell death mechanisms in a cellular model of neurodegeneration in Parkinson's disease.C J Yong-Kee et al.Neurotoxicity research, 22(4), 355-364 (2012-04-25) Effects of redox cycling compounds on DT diaphorase activity in the liver of rainbow trout (Oncorhynchus mykiss).Joachim Sturve et al.Comparative hepatology, 4(1), 4-4 (2005-05-06) Naphthazarin enhances ionizing radiation-induced cell cycle arrest and apoptosis in human breast cancer cells.Min Young Kim et al.International journal of oncology, 46(4), 1659-1666 (2015-01-31) An efficient formal synthesis of the human telomerase inhibitor (+/-)-gamma-rubromycin.Dominea C K Rathwell et al.Angewandte Chemie (International ed. in English), 48(43), 7996-8000 (2009-08-01) Concise formal total synthesis of hybocarpone and related naturally occurring naphthazarins.Christina L L Chai et al.The Journal of organic chemistry, 71(3), 992-1001 (2006-01-28) Naphthazarin has a protective effect on the 1-methyl-4-phenyl-1,2,3,4-tetrahydropyridine-induced Parkinson's disease model.Seon Young Choi et al.Journal of neuroscience research, 90(9), 1842-1849 (2012-04-20) Application of Sustainable Natural Resources in Agriculture: Acaricidal and Enzyme Inhibitory Activities of Naphthoquinones and Their Analogs against Psoroptes cuniculi.Xiao-Fei Shang et al.Scientific reports, 8(1), 1609-1609 (2018-01-27) Total synthesis of hybocarpone, a cytotoxic naphthazarin derivative from the lichen Lecanora hybocarpa, and related compounds.Sergey V Dragana et al.Natural product communications, 9(12), 1765-1768 (2015-01-30) Determination of naphthazarin derivatives in endemic Turkish Alkanna species by reversed phase high performance liquid chromatography.Gulseren Pekin et al.Planta medica, 73(3), 267-272 (2007-02-24) Synthesis of 5-nitro-2-furancarbohydrazides and their cis-diamminedichloroplatinum complexes as bitopic and irreversible human thioredoxin reductase inhibitors.Régis Millet et al.Journal of medicinal chemistry, 48(22), 7024-7039 (2005-10-28) The microtubule depolymerizing agent naphthazarin induces both apoptosis and autophagy in A549 lung cancer cells.Bipul R Acharya et al.Apoptosis : an international journal on programmed cell death, 16(9), 924-939 (2011-06-15) Effect of colloidal silver against the cytotoxicity of hydrogen peroxide and naphthazarin on primary cultured cortical astrocytes.Dong-Woo Kim et al.The International journal of neuroscience, 117(3), 387-400 (2007-03-17) Thioredoxin glutathione reductase from Schistosoma mansoni: an essential parasite enzyme and a key drug target.Angela N Kuntz et al.PLoS medicine, 4(6), e206-e206 (2007-06-21)
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