熔点	-3 ºC
水溶性	5.13 g/L (20 ºC)
沸点	209 ºC
闪点	98 ºC
密度	1.213
折射率	1.587-1.589

危险品标志	T;N
危险类别码	R23/24/25;R33;R50/53
安全说明书	S28A;S36/37;S45;S60;S61

来源	SDS样本
没有数据	没有数据

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The new buzz: Investigating the antimicrobial interactions between bioactive compounds found in South African propolis.K Kharsany et al.Journal of ethnopharmacology, 238, 111867-111867 (2019-04-13) Improved quantitative structure-activity relationship models to predict antioxidant activity of flavonoids in chemical, enzymatic, and cellular systems.Andrei I Khlebnikov et al.Bioorganic & medicinal chemistry, 15(4), 1749-1770 (2006-12-15) Naringenin degradation by the endophytic diazotroph Herbaspirillum seropedicae SmR1.A M Marin et al.Microbiology (Reading, England), 159(Pt 1), 167-175 (2012-11-06) Chrysin enhances sensitivity of BEL-7402/ADM cells to doxorubicin by suppressing PI3K/Akt/Nrf2 and ERK/Nrf2 pathway.Ai-Mei Gao et al.Chemico-biological interactions, 206(1), 100-108 (2013-09-03) Inhibitors of alphavirus entry and replication identified with a stable Chikungunya replicon cell line and virus-based assays.Leena Pohjala et al.PloS one, 6(12), e28923-e28923 (2011-12-30) Effects of Various 5,7-Dihydroxyflavone Analogs on Adipogenesis in 3T3-L1 Cells.Atsuyoshi Nishina et al.Biological & pharmaceutical bulletin, 38(11), 1794-1800 (2015-11-03) Effect of flavonoids on androgen and glucocorticoid receptors based on in vitro reporter gene assay.Yosuke Nishizaki et al.Bioorganic & medicinal chemistry letters, 19(16), 4706-4710 (2009-07-14) Ultra high performance liquid chromatography with mass spectrometry method for the simultaneous determination of phenolic constituents in honey from various floral sources using multiwalled carbon nanotubes as extraction sorbents.Saikh Mohammad Wabaidur et al.Journal of separation science, 38(15), 2597-2606 (2015-05-20) Combined experimental and in silico approaches for exploring antiperoxidative potential of structurally diverse classes of antioxidants on docetaxel-induced lipid peroxidation using 4-HNE as the model marker.Partha Pratim Roy et al.Bioorganic chemistry, 56, 1-7 (2014-06-03) Systemic exposure to and disposition of catechols derived from Salvia miltiorrhiza roots (Danshen) after intravenous dosing DanHong injection in human subjects, rats, and dogs.Meijuan Li et al.Drug metabolism and disposition: the biological fate of chemicals, 43(5), 679-690 (2015-02-12) Alleviation of hepatic injury by chrysin in cisplatin administered rats: probable role of oxidative and inflammatory markers.Muneeb U Rehman et al.Pharmacological reports : PR, 66(6), 1050-1059 (2014-12-03) Rational design of novel, potent small molecule pan-selectin antagonists.Remo Kranich et al.Journal of medicinal chemistry, 50(6), 1101-1115 (2007-02-17) Chrysin, a natural and biologically active flavonoid, influences a murine leukemia model in vivo through enhancing populations of T-and B-cells, and promoting macrophage phagocytosis and NK cell cytotoxicity.Chin-Chung Lin et al.In vivo (Athens, Greece), 26(4), 665-670 (2012-07-10) Use of ethyl lactate to extract bioactive compounds from Cytisus scoparius: Comparison of pressurized liquid extraction and medium scale ambient temperature systems.Marta Lores et al.Talanta, 140, 134-142 (2015-06-07) Evaluation of the in vitro/in vivo drug interaction potential of BST204, a purified dry extract of ginseng, and its four bioactive ginsenosides through cytochrome P450 inhibition/induction and UDP-glucuronosyltransferase inhibition.Yu Fen Zheng et al.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 68, 117-127 (2014-03-19) Scuteflorins A and B, dihydropyranocoumarins from Scutellaria lateriflora.Jing Li et al.Journal of natural products, 72(6), 983-987 (2009-06-27) Interdependence of hypoxia and β-adrenergic receptor signaling in pulmonary arterial hypertension.Olivia R Stephens et al.American journal of physiology. Lung cellular and molecular physiology, 317(3), L369-L380 (2019-06-27) Chrysin, an anti-inflammatory molecule, abrogates renal dysfunction in type 2 diabetic rats.Ahad A, Ganai AA, Mujeeb M, et al. Toxicology and Applied Pharmacology, 279(1), 1-7 (2014) Chrysin: a histone deacetylase 8 inhibitor with anticancer activity and a suitable candidate for the standardization of Chinese propolis.Li-Ping Sun et al.Journal of agricultural and food chemistry, 60(47), 11748-11758 (2012-11-09) Potent inhibitor scaffold against Trypanosoma cruzi trans-sialidase.Shingo Arioka et al.Bioorganic & medicinal chemistry, 18(4), 1633-1640 (2010-01-26) Ethanolic extract of propolis, chrysin, CAPE inhibit human astroglia cells.R Markiewicz-Żukowska et al.Advances in medical sciences, 57(2), 208-216 (2012-11-28) Characterization of chrysin glucuronidation in UGT1A1-overexpressing HeLa cells: elucidating the transporters responsible for efflux of glucuronide.Enxi Quan et al.Drug metabolism and disposition: the biological fate of chemicals, 43(4), 433-443 (2015-01-18) Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoids.Vasilis P Androutsopoulos et al.Bioorganic & medicinal chemistry, 19(9), 2842-2849 (2011-04-13) QSAR modeling of the interaction of flavonoids with GABA(A) receptor.Pablo R Duchowicz et al.European journal of medicinal chemistry, 43(8), 1593-1602 (2007-12-26) Luteolin and Apigenin Attenuate 4-Hydroxy-2-Nonenal-Mediated Cell Death through Modulation of UPR, Nrf2-ARE and MAPK Pathways in PC12 Cells.Pei-Shan Wu et al.PloS one, 10(6), e0130599-e0130599 (2015-06-19) Chrysin inhibits human airway smooth muscle cells proliferation through the extracellular signal-regulated kinase 1/2 signaling pathway.Jing Yao et al.Molecular medicine reports, 12(5), 7693-7698 (2015-10-28) UHPLC-UV method for the determination of flavonoids in dietary supplements and for evaluation of their antioxidant activities.Sylwia Magiera et al.Journal of pharmaceutical and biomedical analysis, 102, 468-475 (2014-12-03) Isoform-selective inhibition of chrysin towards human cytochrome P450 1A2. Kinetics analysis, molecular docking, and molecular dynamics simulations.Lin He et al.Bioorganic & medicinal chemistry letters, 20(20), 6008-6012 (2010-09-14) Chrysin alleviates testicular dysfunction in adjuvant arthritic rats via suppression of inflammation and apoptosis: comparison with celecoxib.Hebatallah A Darwish et al.Toxicology and applied pharmacology, 279(2), 129-140 (2014-06-17) Antitumor properties of a vanadyl(IV) complex with the flavonoid chrysin [VO(chrysin)2EtOH]2 in a human osteosarcoma model: the role of oxidative stress and apoptosis.I E Leon et al.Dalton transactions (Cambridge, England : 2003), 42(33), 11868-11880 (2013-06-14) Analysis of the erythroid differentiation effect of flavonoid apigenin on K562 human chronic leukemia cells.Hiroko Isoda et al.Chemico-biological interactions, 220, 269-277 (2014-07-25) Simultaneous determination of eight flavonoids in propolis using chemometrics-assisted high performance liquid chromatography-diode array detection.Yan-Mei Sun et al.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 962, 59-67 (2014-06-08) Phytochemical investigation of labdane diterpenes from the rhizomes of Hedychium spicatum and their cytotoxic activity.P Prabhakar Reddy et al.Bioorganic & medicinal chemistry letters, 19(21), 6078-6081 (2009-09-29) Chrysin attenuates allergic airway inflammation by modulating the transcription factors T-bet and GATA-3 in mice.Qiang Du et al.Molecular medicine reports, 6(1), 100-104 (2012-05-04) Vasorelaxant effect of flavonoids through calmodulin inhibition: Ex vivo, in vitro, and in silico approaches.Mariana Torres-Piedra et al.Bioorganic & medicinal chemistry, 19(1), 542-546 (2010-12-07) Structure-activity relationship of flavonoids as influenza virus neuraminidase inhibitors and their in vitro anti-viral activities.Ai-Lin Liu et al.Bioorganic & medicinal chemistry, 16(15), 7141-7147 (2008-07-22) Chrysin activates Notch1 signaling and suppresses tumor growth of anaplastic thyroid carcinoma in vitro and in vivo.Xiao-Min Yu et al.Cancer, 119(4), 774-781 (2012-09-20) Chrysin protects human osteoarthritis chondrocytes by inhibiting inflammatory mediator expression via HMGB1 suppression.Chi Zhang et al.Molecular medicine reports, 19(2), 1222-1229 (2018-12-12) Nanoparticles Containing Curcumin Useful for Suppressing Macrophages In Vivo in Mice.Chie Amano et al.PloS one, 10(9), e0137207-e0137207 (2015-09-12) Combination of chrysin and cisplatin promotes the apoptosis of Hep G2 cells by up-regulating p53.Xin Li et al.Chemico-biological interactions, 232, 12-20 (2015-03-17) Flavonoids are inhibitors of human organic anion transporter 1 (OAT1)-mediated transport.Guohua An et al.Drug metabolism and disposition: the biological fate of chemicals, 42(9), 1357-1366 (2014-07-09) Quality assessment and antiplasmodial activity of West African Cochlospermum species.Aline Lamien-Meda et al.Phytochemistry, 119, 51-61 (2015-10-03) 5-allyl-7-gen-difluoromethoxychrysin enhances TRAIL-induced apoptosis in human lung carcinoma A549 cells.Zhao-Hui Xie et al.BMC cancer, 11, 322-322 (2011-08-02) Synthesis, biological evaluation of chrysin derivatives as potential immunosuppressive agents.Peng-Cheng Lv et al.European journal of medicinal chemistry, 46(1), 393-398 (2010-12-07) Chrysin inhibits diabetic renal tubulointerstitial fibrosis through blocking epithelial to mesenchymal transition.Min-Kyung Kang et al.Journal of molecular medicine (Berlin, Germany), 93(7), 759-772 (2015-06-13) 8-bromo-7-methoxychrysin suppress stemness of SMMC-7721 cells induced by co-culture of liver cancer stem-like cells with hepatic stellate cells.Qi Wen et al.BMC cancer, 19(1), 224-224 (2019-03-15) Phytochemical fingerprints of lime honey collected in serbia.Uroš Gašić et al.Journal of AOAC International, 97(5), 1259-1267 (2015-04-24) Enzymatic modification of chitosan with quercetin and its application as antioxidant edible films.E Torres et al.Prikladnaia biokhimiia i mikrobiologiia, 48(2), 175-182 (2012-05-17) Simultaneous determination of baicalin, wogonoside, baicalein, wogonin, oroxylin A and chrysin of Radix scutellariae extract in rat plasma by liquid chromatography tandem mass spectrometry.Ling Tong et al.Journal of pharmaceutical and biomedical analysis, 70, 6-12 (2012-06-19) An efficient and economical MTT assay for determining the antioxidant activity of plant natural product extracts and pure compounds.Yunbao Liu et al.Journal of natural products, 73(7), 1193-1195 (2010-06-23) Cytotoxic constituents of chinese propolis.Na Sha et al.Journal of natural products, 72(4), 799-801 (2009-03-13) Induction of apoptosis by 7-piperazinethylchrysin in HCT-116 human colon cancer cells.Jie Ren et al.Oncology reports, 28(5), 1719-1726 (2012-09-06) Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH): identification of phenmedipham and amperozide as FAAH inhibitors.Fabien Vincent et al.Bioorganic & medicinal chemistry letters, 19(23), 6793-6796 (2009-10-24) Luteolin suppresses TCDD-induced wasting syndrome in a cultured adipocyte model.Hitoshi Ashida et al.Pesticide biochemistry and physiology, 120, 14-20 (2015-05-20) A comparative study of flavonoid analogues on streptozotocin-nicotinamide induced diabetic rats: quercetin as a potential antidiabetic agent acting via 11beta-hydroxysteroid dehydrogenase type 1 inhibition.Mariana Torres-Piedra et al.European journal of medicinal chemistry, 45(6), 2606-2612 (2010-03-30) Reliability of bond dissociation enthalpy calculated by the PM6 method and experimental TEAC values in antiradical QSAR of flavonoids.Dragan Amić et al.Bioorganic & medicinal chemistry, 18(1), 28-35 (2009-12-01) QSAR study of flavonoids and biflavonoids as influenza H1N1 virus neuraminidase inhibitors.Andrew G Mercader et al.European journal of medicinal chemistry, 45(5), 1724-1730 (2010-02-02) Discovery of nonsteroidal 17beta-hydroxysteroid dehydrogenase 1 inhibitors by pharmacophore-based screening of virtual compound libraries.Daniela Schuster et al.Journal of medicinal chemistry, 51(14), 4188-4199 (2008-06-07) Docking and 3D-QSAR (quantitative structure activity relationship) studies of flavones, the potent inhibitors of p-glycoprotein targeting the nucleotide binding domain.Gugan Kothandan et al.European journal of medicinal chemistry, 46(9), 4078-4088 (2011-07-05) Hepatoprotective activity of chrysin is mediated through TNF-α in chemically-induced acute liver damage: AnAnca Hermenean et al.Experimental and therapeutic medicine, 13(5), 1671-1680 (2017-06-02) Zinc-binding sites on selected flavonoids.Yibin Wei et al.Biological trace element research, 161(2), 223-230 (2014-08-16) Synthesis and promotion angiogenesis effect of chrysin derivatives coupled to NO donors.Sheng-Ming Peng et al.Bioorganic & medicinal chemistry letters, 19(4), 1264-1266 (2009-01-27) Comparative molecular field analysis of flavonoid inhibitors of the PIM-1 kinase.Sheldon Holder et al.Bioorganic & medicinal chemistry, 15(19), 6463-6473 (2007-07-20) Prenylflavonoids and prenyl/alkyl-phloroacetophenones: synthesis and antitumour biological evaluation.P Basabe et al.European journal of medicinal chemistry, 45(9), 4258-4269 (2010-07-14) Cytotoxic and Pro-Apoptotic Effects of Honey Bee Venom and Chrysin on Human Ovarian Cancer Cells.Amini E, et al. Asia Pacific Journal of Medical Toxicology, 4 (2015) Heme binding site in apomyoglobin may be effectively targeted with small molecules to control aggregation.Mehrnaz Azami-Movahed et al.The international journal of biochemistry & cell biology, 45(2), 299-307 (2012-10-24) AMP-activated protein kinase (AMPK) activation is involved in chrysin-induced growth inhibition and apoptosis in cultured A549 lung cancer cells.Jun-jie Shao et al.Biochemical and biophysical research communications, 423(3), 448-453 (2012-06-05) Protection by chrysin, apigenin, and luteolin against oxidative stress is mediated by the Nrf2-dependent up-regulation of heme oxygenase 1 and glutamate cysteine ligase in rat primary hepatocytes.Chin-Shiu Huang et al.Archives of toxicology, 87(1), 167-178 (2012-08-07) A chrysin derivative suppresses skin cancer growth by inhibiting cyclin-dependent kinases.Haidan Liu et al.The Journal of biological chemistry, 288(36), 25924-25937 (2013-07-28) Chrysin improves cognitive deficits and brain damage induced by chronic cerebral hypoperfusion in rats.Xiao-Li He et al.European journal of pharmacology, 680(1-3), 41-48 (2012-02-09) Chrysin, apigenin and acacetin inhibit tumor necrosis factor-related apoptosis-inducing ligand receptor-1 (TRAIL-R1) on activated RAW264.7 macrophages.Monika Warat et al.International journal of molecular sciences, 15(7), 11510-11522 (2014-07-01) Synthesis of C(7) modified chrysin derivatives designing to inhibit beta-ketoacyl-acyl carrier protein synthase III (FabH) as antibiotics.Huan-Qiu Li et al.Bioorganic & medicinal chemistry, 17(17), 6264-6269 (2009-08-12) Analysis of Phenolic Compounds in Some Medicinal Herbs by LC-MS.Alina O Matei et al.Journal of chromatographic science, 53(7), 1147-1154 (2015-01-15) Inhibitory effects of acetylmelodorinol, chrysin and polycarpol from Mitrella kentii on prostaglandin E₂ and Thromboxane B₂ production and platelet activating factor receptor binding.Sakina Saadawi et al.Molecules (Basel, Switzerland), 17(5), 4824-4835 (2012-04-28) Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19).Yagmur Muftuoglu et al.Bioorganic & medicinal chemistry letters, 20(10), 3050-3064 (2010-04-24) Effect of kumquat (Fortunella crassifolia) pericarp on natural killer cell activity in vitro and in vivo.Kiyoko Nagahama et al.Bioscience, biotechnology, and biochemistry, 79(8), 1327-1336 (2015-04-08) Nanostructured lipid systems modified with waste material of propolis for wound healing: Design, in vitro and in vivo evaluation.Hélen Cássia Rosseto et al.Colloids and surfaces. B, Biointerfaces, 158, 441-452 (2017-07-21) Natural inhibitors of indoleamine 3,5-dioxygenase induced by interferon-gamma in human neural stem cells.S Chen et al.Biochemical and biophysical research communications, 429(1-2), 117-123 (2012-10-16) Chrysin abrogates cisplatin-induced oxidative stress, p53 expression, goblet cell disintegration and apoptotic responses in the jejunum of Wistar rats.Rehan Khan et al.The British journal of nutrition, 108(9), 1574-1585 (2012-02-09) Chrysin, baicalein and galangin are indirect activators of the human constitutive androstane receptor (CAR).Alejandro Carazo Fernández et al.Toxicology letters, 233(2), 68-77 (2015-01-28) Plant HDAC inhibitor chrysin arrest cell growth and induce p21WAF1 by altering chromatin of STAT response element in A375 cells.Manika Pal-Bhadra et al.BMC cancer, 12, 180-180 (2012-05-18) Inhibitory effects of dietary flavonoids on purified hepatic NADH-cytochrome b5 reductase: structure-activity relationships.Haydar Çelik et al.Chemico-biological interactions, 197(2-3), 103-109 (2012-05-01) Chrysin suppresses human CD14(+) monocyte-derived dendritic cells and ameliorates experimental autoimmune encephalomyelitis.Kai Zhang et al.Journal of neuroimmunology, 288, 13-20 (2015-11-05) Potent and selective steroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 7, an enzyme that catalyzes the reduction of the key hormones estrone and dihydrotestosterone.Edith Bellavance et al.Journal of medicinal chemistry, 52(23), 7488-7502 (2009-09-24) Flavonoid Chrysin prevents age-related cognitive decline via attenuation of oxidative stress and modulation of BDNF levels in aged mouse brain.Leandro Cattelan Souza et al.Pharmacology, biochemistry, and behavior, 134, 22-30 (2015-05-02) Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids.Deniz Tasdemir et al.Journal of medicinal chemistry, 49(11), 3345-3353 (2006-05-26) Chrysin alleviates allergic inflammation and airway remodeling in a murine model of chronic asthma.Jing Yao et al.International immunopharmacology, 32, 24-31 (2016-01-19) Inhibition of aromatase activity by flavonoids.H J Jeong et al.Archives of pharmacal research, 22(3), 309-312 (1999-07-14) Synthesis and biological evaluation of novel 8-aminomethylated oroxylin A analogues as alpha-glucosidase inhibitors.T Hari Babu et al.Bioorganic & medicinal chemistry letters, 18(5), 1659-1662 (2008-02-08) Simple criterion for selection of flavonoid compounds with anti-HIV activity.Veljko Veljkovic et al.Bioorganic & medicinal chemistry letters, 17(5), 1226-1232 (2006-12-27) Discovery of a potent and selective inhibitor for human carbonyl reductase 1 from propionate scanning applied to the macrolide zearalenone.Tobias J Zimmermann et al.Bioorganic & medicinal chemistry, 17(2), 530-536 (2008-12-23) Chrysin abrogates early hepatocarcinogenesis and induces apoptosis in N-nitrosodiethylamine-induced preneoplastic nodules in rats.Mahaboob S Khan et al.Toxicology and applied pharmacology, 251(1), 85-94 (2010-12-21) Nephroprotective efficacy of chrysin against cisplatin-induced toxicity via attenuation of oxidative stress.Sarwat Sultana et al.The Journal of pharmacy and pharmacology, 64(6), 872-881 (2012-05-11) Role of flavonoids on oxidative stress and mineral contents in the retinoic acid-induced bone loss model of rat.Nada Oršolić et al.European journal of nutrition, 53(5), 1217-1227 (2013-11-26) A chrysin analog exhibited strong inhibitory activities against both PGE2 and NO production.Haiyan Che et al.European journal of medicinal chemistry, 46(9), 4657-4660 (2011-07-02) Effects of in ovo injection of chrysin, quercetin and ascorbic acid on hatchability, somatic attributes, hepatic oxidative status and early post-hatch performance of broiler chicks.F Khaligh et al.Journal of animal physiology and animal nutrition, 102(1), e413-e420 (2017-06-22) Structural basis of inhibitor specificity of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM-1) kinase.Alex N Bullock et al.Journal of medicinal chemistry, 48(24), 7604-7614 (2005-11-24) Synthesis, characterization and vasculoprotective effects of nitric oxide-donating derivatives of chrysin.Xiao-Qing Zou et al.Bioorganic & medicinal chemistry, 18(9), 3020-3025 (2010-04-17) A novel relationship between the radical-scavenging activity of flavonoids and enthalpy of formation revealed with Hartree-Fock computations and thermochemical deduction.Ameha Seyoum Woldu et al.Redox report : communications in free radical research, 17(3), 115-130 (2012-06-27) Optimization of microwave-assisted extraction of polyphenols from herbal teas and evaluation of their in vitro hypochlorous acid scavenging activity.Burcu Bekdeşer et al.Journal of agricultural and food chemistry, 62(46), 11109-11115 (2014-11-05) LC-MS guided isolation, quantification and antioxidant evaluation of bioactive principles from Epimedium elatum.Syed Naseer et al.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 989, 62-70 (2015-03-26) The Flavone Luteolin Suppresses SREBP-2 Expression and Post-Translational Activation in Hepatic Cells.Tsz Yan Wong et al.PloS one, 10(8), e0135637-e0135637 (2015-08-25) Apoptotic effects of chrysin in human cancer cell lines.Khoo BY, et al. International Journal of Molecular Sciences, 11, 2188-2188 (2010) Structure-activity relationships of flavonoids as inhibitors of breast cancer resistance protein (BCRP).Anne Pick et al.Bioorganic & medicinal chemistry, 19(6), 2090-2102 (2011-03-01) Inhibition of 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) by aldose reductase inhibitors.Urmi Dhagat et al.Bioorganic & medicinal chemistry, 16(6), 3245-3254 (2008-01-01) Effects of flavonoids on cell proliferation and caspase activation in a human colonic cell line HT29: an SAR study.Jean-Baptiste Daskiewicz et al.Journal of medicinal chemistry, 48(8), 2790-2804 (2005-04-15) Study on the constituents of Mexican propolis and their cytotoxic activity against PANC-1 human pancreatic cancer cells.Feng Li et al.Journal of natural products, 73(4), 623-627 (2010-03-24) Chrysin induces G1 phase cell cycle arrest in C6 glioma cells through inducing p21Waf1/Cip1 expression: involvement of p38 mitogen-activated protein kinase.Weng MS, et al. Biochemical Pharmacology, 69, 1815-1815 (2005) Dietary bioflavonoids inhibit Escherichia coli ATP synthase in a differential manner.Chinnam N, et al. International Journal of Biological Macromolecules, 46, 478-478 (2010) 7-Hydroxy-benzopyran-4-one derivatives: a novel pharmacophore of peroxisome proliferator-activated receptor alpha and -gamma (PPARalpha and gamma) dual agonists.Azadeh Matin et al.Journal of medicinal chemistry, 52(21), 6835-6850 (2009-10-08) Evaluation of the mutagenic activity of chrysin, a flavonoid inhibitor of the aromatization process.G A R Oliveira et al.Journal of toxicology and environmental health. Part A, 75(16-17), 1000-1011 (2012-08-03) Selective inhibition of methoxyflavonoids on human CYP1B1 activity.Hitomi Takemura et al.Bioorganic & medicinal chemistry, 18(17), 6310-6315 (2010-08-11) Evaluation of the effect of Chrysin and Caffeic acid phenethyl ester on eIF4E expression in AGS cell line.Abolhasani M, et al. Journal of HerbMed Pharmacology, 3 (2014) Isocratic and gradient elution in micellar liquid chromatography with Brij-35.Ester Peris-García et al.Journal of separation science, 38(12), 2059-2067 (2015-04-14) Chrysin suppresses renal carcinogenesis via amelioration of hyperproliferation, oxidative stress and inflammation: plausible role of NF-κB.Muneeb U Rehman et al.Toxicology letters, 216(2-3), 146-158 (2012-12-01) Protective role of chrysin against oxidative stress in d-galactose-induced aging in an experimental rat model.Kalaiselvi Velayutham Anand et al.Geriatrics & gerontology international, 12(4), 741-750 (2012-04-04) Inhibitory effects of flavonoids isolated from Fragaria ananassa Duch on IgE-mediated degranulation in rat basophilic leukemia RBL-2H3.Tomohiro Itoh et al.Bioorganic & medicinal chemistry, 17(15), 5374-5379 (2009-07-15) Quercitrin and taxifolin stimulate osteoblast differentiation in MC3T3-E1 cells and inhibit osteoclastogenesis in RAW 264.7 cells.María Satué et al.Biochemical pharmacology, 86(10), 1476-1486 (2013-09-26) Effects of Hydroxy Groups in the A-Ring on the Anti-proteasome Activity of Flavone.Kasumi Nakamura et al.Biological & pharmaceutical bulletin, 38(6), 935-940 (2015-03-27) Gastroprotective flavonoid constituents from Oroxylum indicum Vent.T Hari Babu et al.Bioorganic & medicinal chemistry letters, 20(1), 117-120 (2009-12-02) Determination of pharmacokinetics of chrysin and its conjugates in wild-type FVB and Bcrp1 knockout mice using a validated LC-MS/MS method.Shufan Ge et al.Journal of agricultural and food chemistry, 63(11), 2902-2910 (2015-02-27) (-)-Epigallocatechin-3-gallate inhibits entry of hepatitis B virus into hepatocytes.Hsiu-Chen Huang et al.Antiviral research, 111, 100-111 (2014-09-28) Evaluation of the neuroprotective effect of chrysin via modulation of endogenous biomarkers in a rat model of spinal cord injury.Amit D Kandhare et al.Journal of natural medicines, 68(3), 586-603 (2014-05-03) Preparation and evaluation of surface-bonded tricationic ionic liquid silica as stationary phases for high-performance liquid chromatography.Lizhen Qiao et al.Journal of chromatography. A, 1396, 62-71 (2015-04-22) Furoxan nitric oxide donor coupled chrysin derivatives: synthesis and vasculoprotection.Xiao-Qing Zou et al.Bioorganic & medicinal chemistry letters, 21(4), 1222-1226 (2011-01-25) Chrysin ameliorates chemically induced colitis in the mouse through modulation of a PXR/NF-κB signaling pathway.Wei Dou et al.The Journal of pharmacology and experimental therapeutics, 345(3), 473-482 (2013-03-29) Synthesis and biological evaluation of novel C (7) modified chrysin analogues as antibacterial agents.K Suresh Babu et al.Bioorganic & medicinal chemistry letters, 16(1), 221-224 (2005-10-11) The O-methylation of chrysin markedly improves its intestinal anti-inflammatory properties: Structure-activity relationships of flavones.Alexandrine During et al.Biochemical pharmacology, 86(12), 1739-1746 (2013-10-19) Multivariate QSAR study on the antimutagenic activity of flavonoids against 3-NFA on Salmonella typhimurium TA98.Eduardo Borges de Melo et al.European journal of medicinal chemistry, 45(10), 4562-4569 (2010-08-11) 2-Styrylchromones: novel strong scavengers of reactive oxygen and nitrogen species.Ana Gomes et al.Bioorganic & medicinal chemistry, 15(18), 6027-6036 (2007-07-13) Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).Jenny M Pedersen et al.Journal of medicinal chemistry, 51(11), 3275-3287 (2008-05-07)

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