沸点	177 ºC
闪点	82 ºC
密度	0.927

危险品标志	C
危险类别码	R34
安全说明书	S26;S36/37/39;S45

来源	SDS样本
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Silibinin synergizes with histone deacetylase and DNA methyltransferase inhibitors in upregulating E-cadherin expression together with inhibition of migration and invasion of human non-small cell lung cancer cells.Samiha Mateen et al.The Journal of pharmacology and experimental therapeutics, 345(2), 206-214 (2013-03-07) Silibinin protects murine fibroblast L929 cells from UVB-induced apoptosis through the simultaneous inhibition of ATM-p53 pathway and autophagy.Weiwei Liu et al.The FEBS journal, 280(18), 4572-4584 (2013-07-09) Silibinin in vitro protects A549 cells from Staphylococcus aureus-mediated injury and in vivo alleviates the lung injury of staphylococcal pneumonia.Xin Wang et al.Planta medica, 79(2), 110-115 (2013-01-10) Silibinin for cyclopeptide mushroom poisonings.Daniel R Limoges et al.American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 69(21), 1856-1856 (2012-11-01) A novel role of silibinin as a putative epigenetic modulator in human prostate carcinomaAnestopoulos L, et al. Molecules (Basel), 22(1), 62-62 (2017) Safety and anti-HCV effect of prolonged intravenous silibinin in HCV genotype 1 subjects in the immediate liver transplant period.Rafael Bárcena et al.Journal of hepatology, 58(3), 421-426 (2012-10-18) The multidrug resistance pumps are inhibited by silibinin and apoptosis induced in K562 and KCL22 leukemia cell lines.Mohammad Reza Noori-Daloii et al.Leukemia research, 38(5), 575-580 (2014-02-14) Silibinin inhibits the invasion of IL-6-stimulated colon cancer cells via selective JNK/AP-1/MMP-2 modulation in vitro.Chiu-Mei Lin et al.Journal of agricultural and food chemistry, 60(51), 12451-12457 (2012-12-06) Targeting silibinin in the antiproliferative pathway.Lei Li et al.Expert opinion on investigational drugs, 19(2), 243-255 (2010-01-06) Chemopreventive and anti-cancer efficacy of silibinin against growth and progression of lung cancer.Samiha Mateen et al.Nutrition and cancer, 65 Suppl 1, 3-11 (2013-05-25) [An updated review at molecular pharmacological level for the mechanism of anti-tumor, antioxidant and immunoregulatory action of silibinin].Hong-jun Wang et al.Yao xue xue bao = Acta pharmaceutica Sinica, 45(4), 413-421 (2011-03-02) Silibinin as a potential therapeutic for sulfur mustard injuries.Frank Balszuweit et al.Chemico-biological interactions, 206(3), 496-504 (2013-07-03) In vivo absorption comparison of nanotechnology-based silybin tablets with its water-soluble derivative.Di Xu et al.Drug development and industrial pharmacy, 41(4), 552-559 (2014-02-06) Thorium decorporation efficacy of rationally-selected biocompatible compounds with relevance to human application.Manjoor Ali et al.Journal of hazardous materials, 365, 952-961 (2019-01-09) [Clinical toxicology of mushroom poisoning. Amanita virosa].Makoto Onodera Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology, 26(3), 210-214 (2013-11-15) Silibinin upregulates the expression of cyclin-dependent kinase inhibitors and causes cell cycle arrest and apoptosis in human colon carcinoma HT-29 cells.Chapla Agarwal et al.Oncogene, 22(51), 8271-8282 (2003-11-14) Silibinin efficacy against human hepatocellular carcinomaVarghese L, et al. Clinical Cancer Research, 11(23), 8441-8448 (2005) Silibinin inhibits proliferation, induces apoptosis and causes cell cycle arrest in human gastric cancer MGC803 cells via STAT3 pathway inhibition.Yi-Xin Wang et al.Asian Pacific journal of cancer prevention : APJCP, 15(16), 6791-6798 (2014-08-30) p53-mediated autophagy adjustment is involved in the protection of silibinin against murine dermal inflammation and epidermal apoptosis induced by UVB irradiation.Qiong Wang et al.Journal of Asian natural products research, 15(2), 117-129 (2013-02-21) Targeting tumor microenvironment with silibinin: promise and potential for a translational cancer chemopreventive strategy.Gagan Deep et al.Current cancer drug targets, 13(5), 486-499 (2013-04-27) Icaritin ameliorates carbon tetrachloride-induced acute liver injury mainly because of the antioxidative function through estrogen-like effects.Peng Liu et al.In vitro cellular & developmental biology. Animal, 50(10), 899-908 (2014-08-26) Intravenous silibinin monotherapy shows significant antiviral activity in HCV-infected patients in the peri-transplantation period.Zoe Mariño et al.Journal of hepatology, 58(3), 415-420 (2012-10-16) The antioxidant silybin prevents high glucose-induced oxidative stress and podocyte injury in vitro and in vivo.Khaled Khazim et al.American journal of physiology. Renal physiology, 305(5), F691-F700 (2013-06-28) Silibinin ameliorates arsenic induced nephrotoxicity by abrogation of oxidative stress, inflammation and apoptosis in rats.S Milton Prabu et al.Molecular biology reports, 39(12), 11201-11216 (2012-10-17) Antimetastatic efficacy of silibinin: molecular mechanisms and therapeutic potential against cancer.Gagan Deep et al.Cancer metastasis reviews, 29(3), 447-463 (2010-08-18) Down-regulation of LPCAT expression increases platelet-activating factor level in cirrhotic rat liver: potential antiinflammatory effect of silybin.Eleonora Stanca et al.Biochimica et biophysica acta, 1832(12), 2019-2026 (2013-07-16) Silybin-Phosphatidylcholine Complex Protects Human Gastric and Liver Cells from Oxidative Stress.Alessandro Federico et al.In vivo (Athens, Greece), 29(5), 569-575 (2015-09-12) Prostate cancer chemoprevention by silibinin: bench to bedside.Rana P Singh et al.Molecular carcinogenesis, 45(6), 436-442 (2006-04-26) Mechanisms and preclinical efficacy of silibinin in preventing skin cancer.Rana P Singh et al.European journal of cancer (Oxford, England : 1990), 41(13), 1969-1979 (2005-08-09) Molecular mechanisms of silibinin-mediated cancer chemoprevention with major emphasis on prostate cancer.Harold Ting et al.The AAPS journal, 15(3), 707-716 (2013-04-17) Food Byproducts as a New and Cheap Source of Bioactive Compounds: Lignans with Antioxidant and Anti-inflammatory Properties from Crataegus pinnatifida Seeds.Xiao-Xiao Huang et al.Journal of agricultural and food chemistry, 63(32), 7252-7260 (2015-08-04) Silibinin attenuates sulfur mustard analog-induced skin injury by targeting multiple pathways connecting oxidative stress and inflammation.Neera Tewari-Singh et al.PloS one, 7(9), e46149-e46149 (2012-10-03) Cytoprotective effect of silybin against lasalocid-induced toxicity in HepG2 cells.L Radko et al.Polish journal of veterinary sciences, 16(2), 275-282 (2013-08-27) Cosmeceuticals and silibinin.Rana P Singh et al.Clinics in dermatology, 27(5), 479-484 (2009-08-22) Silibinin attenuates oxidative metabolism and cytokine production by monocytes from preeclamptic women.R Cristofalo et al.Free radical research, 47(4), 268-275 (2013-01-16) Engineered silybin nanoparticles educe efficient control in experimental diabetes.Suvadra Das et al.PloS one, 9(7), e101818-e101818 (2014-07-06) Interference of silibinin with IGF-1R signalling pathways protects human epidermoid carcinoma A431 cells from UVB-induced apoptosis.Weiwei Liu et al.Biochemical and biophysical research communications, 432(2), 314-319 (2013-02-12) Epidermal growth factor receptor mediates silibinin-induced cytotoxicity in a rat glioma cell line.Lin Qi et al.Cancer biology & therapy, 2(5), 526-531 (2003-11-14) Effect of silibinin on the pharmacokinetics of nitrendipine in rabbits.Swathi Voruganti et al.European journal of drug metabolism and pharmacokinetics, 39(4), 277-281 (2013-10-05) Successful outcome of severe Amanita phalloides poisoning in children.Enke Grabhorn et al.Pediatric transplantation, 17(6), 550-555 (2013-06-01) Complementary and alternative medicine (CAM) in prostate and bladder cancer.Yiannis Philippou et al.BJU international, 112(8), 1073-1079 (2013-08-16) A cancer chemopreventive agent silibinin, targets mitogenic and survival signaling in prostate cancer.Rana P Singh et al.Mutation research, 555(1-2), 21-32 (2004-10-13) The binding of silibinin to ERp57.Caterina Grillo et al.Chemico-biological interactions, 213, 37-43 (2014-02-18) Analysis of hepatitis C virus resistance to silibinin in vitro and in vivo points to a novel mechanism involving nonstructural protein 4B.Katharina Esser-Nobis et al.Hepatology (Baltimore, Md.), 57(3), 953-963 (2013-01-17) Survival following investigational treatment of amanita mushroom poisoning: thistle or shamrock?Kathryn M Gores et al.Chest, 146(4), e126-e129 (2014-10-08) Protective role of silibinin against myocardial ischemia/reperfusion injury-induced cardiac dysfunction.Yi-He Chen et al.International journal of biological sciences, 16(11), 1972-1988 (2020-05-14) Evaluation of hepatocyteprotective and anti-hepatitis B virus properties of Cichoric acid from Cichorium intybus leaves in cell culture.Hong-Li Zhang et al.Biological & pharmaceutical bulletin, 37(7), 1214-1220 (2014-04-25) Epigenetic modifications and p21-cyclin B1 nexus in anticancer effect of histone deacetylase inhibitors in combination with silibinin on non-small cell lung cancer cells.Samiha Mateen et al.Epigenetics, 7(10), 1161-1172 (2012-09-12) Ameliorative effect of silibinin against N-nitrosodimethylamine-induced hepatic fibrosis in rats.Devaraj Ezhilarasan et al.Environmental toxicology and pharmacology, 34(3), 1004-1013 (2012-09-19) Milk thistle and its derivative compounds: a review of opportunities for treatment of liver disease.E S Hackett et al.Journal of veterinary internal medicine, 27(1), 10-16 (2012-11-13) Silibinin: an old drug in the high tech era of liver transplantation.Peter Ferenci et al.Journal of hepatology, 58(3), 409-411 (2012-12-01) Synergistic inhibition of breast cancer metastasis by silibinin-loaded lipid nanoparticles containing TPGS.Pengfei Xu et al.International journal of pharmaceutics, 454(1), 21-30 (2013-07-09) Silibinin inhibits endometrial carcinoma via blocking pathways of STAT3 activation and SREBP1-mediated lipid accumulation.Zhengzheng Shi et al.Life sciences, 217, 70-80 (2018-11-20) Involvement of NF-kappaB and caspases in silibinin-induced apoptosis of endothelial cells.Hyeon G Yoo et al.International journal of molecular medicine, 13(1), 81-86 (2003-12-05) Hepatitis C viral kinetics: the past, present, and future.Anushree Chatterjee et al.Clinics in liver disease, 17(1), 13-26 (2012-11-28) Combinatorial strategies for cancer eradication by silibinin and cytotoxic agents: efficacy and mechanisms.Komal Raina et al.Acta pharmacologica Sinica, 28(9), 1466-1475 (2007-08-29) High-performance thin-layer chromatography linked with (bio)assays and mass spectrometry - a suited method for discovery and quantification of bioactive components? Exemplarily shown for turmeric and milk thistle extracts.Mahmoud N Taha et al.Journal of chromatography. A, 1394, 137-147 (2015-04-08) Silibinin down-regulates expression of secreted phospholipase A2 enzymes in cancer cells.Albert Hagelgans et al.Anticancer research, 34(4), 1723-1729 (2014-04-03) Protection by silibinin against experimental ischemic stroke: up-regulated pAkt, pmTOR, HIF-1α and Bcl-2, down-regulated Bax, NF-κB expression.Chaohui Wang et al.Neuroscience letters, 529(1), 45-50 (2012-09-25) Silibinin inhibits ultraviolet B radiation-induced DNA-damage and apoptosis by enhancing interleukin-12 expression in JB6 cells and SKH-1 hairless mouse skin.Sreekanth Narayanapillai et al.Molecular carcinogenesis, 53(6), 471-479 (2013-01-30) Prostate cancer prevention by silibinin.Rana P Singh et al.Current cancer drug targets, 4(1), 1-11 (2004-02-18) [Poisoning with Amanita mushrooms].Till Hauffe et al.Praxis, 102(25), 1507-1515 (2013-12-12) Inhibition of Kupffer cell functions as an explanation for the hepatoprotective properties of silibininDehmlow C, et al. Hepatology, 23(4), 749-754 (1996) Interaction between oblongifolin C and UDP-glucuronosyltransferase isoforms in human liver and intestine microsomes.Cui Gao et al.Xenobiotica; the fate of foreign compounds in biological systems, 45(7), 578-585 (2015-02-26) Silibinin reverses drug resistance in human small-cell lung carcinoma cells.David Sadava et al.Cancer letters, 339(1), 102-106 (2013-07-25) Hepatoprotective effect of 2,3-dehydrosilybin on carbon tetrachloride-induced liver injury in rats.Byoung-Ok Cho et al.Food chemistry, 138(1), 107-115 (2012-12-26) The in-vitro effect of complementary and alternative medicines on cytochrome P450 2C9 activity.Kim D Mooiman et al.The Journal of pharmacy and pharmacology, 66(9), 1339-1346 (2014-04-16) Silibinin inhibits VEGF secretion and age-related macular degeneration in a hypoxia-dependent manner through the PI-3 kinase/Akt/mTOR pathway.C H Lin et al.British journal of pharmacology, 168(4), 920-931 (2012-09-26) Antiviral activity of silymarin against chikungunya virus.Rafidah Lani et al.Scientific reports, 5, 11421-11421 (2015-06-17) Milk thistle: early seeds of potential.Abby B Siegel et al.The Lancet. Oncology, 14(10), 929-930 (2013-09-03) Silibinin suppresses epithelial-mesenchymal transition in human non-small cell lung cancer cells by restraining RHBDD1.Suyan Xu et al.Cellular & molecular biology letters, 25, 36-36 (2020-06-13) Silibinin Inhibits Platelet-Derived Growth Factor-Driven Cell Proliferation via Downregulation of N-Glycosylation in Human Tenon's Fibroblasts in a Proteasome-Dependent MannerChen YH, et al. Testing, 11(12), e0168765-e0168765 (2016) [Silibinin and its hepatoprotective action from the perspective of a toxicologist].Halina Kostek et al.Przeglad lekarski, 69(8), 541-543 (2012-12-19) Seventy-two-hour release formulation of the poorly soluble drug silybin based on porous silica nanoparticles: in vitro release kinetics and in vitro/in vivo correlations in beagle dogs.Xia Cao et al.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 48(1-2), 64-71 (2012-11-06) Silibinin--a promising new treatment for cancer.Catherine Wing Ying Cheung et al.Anti-cancer agents in medicinal chemistry, 10(3), 186-195 (2009-12-18) Dietary bioflavonoids inhibit Escherichia coli ATP synthase in a differential mannerChinnam N, et al. International Journal of Biological Macromolecules, 46(5), 478-486 (2010) Amanita phalloides poisoning and treatment with silibinin in the Australian Capital Territory and New South Wales.Darren M Roberts et al.The Medical journal of Australia, 198(1), 43-47 (2013-01-22) Isolation and purification of diastereoisomeric flavonolignans from silymarin by binary-column recycling preparative high-performance liquid chromatography.Weiquan Zhao et al.Journal of separation science, 37(17), 2300-2306 (2014-06-14) Media effects on the mechanism of antioxidant action of silybin and 2,3-dehydrosilybin: role of the enol group.Ewelina van Wenum et al.The Journal of organic chemistry, 78(18), 9102-9112 (2013-09-07) Silibinin-induced endoplasmic reticulum stress and mitochondrial dysfunction suppress growth of endometriotic lesionsHam J, et al. Journal of Cellular Physiology, 234(4), 4327-4341 (2019) Quality assessment and antiplasmodial activity of West African Cochlospermum species.Aline Lamien-Meda et al.Phytochemistry, 119, 51-61 (2015-10-03) Prediction of Permeation and Cellular Transport of Silybum marianum Extract Formulated in a Nanoemulsion by Using PAMPA and Caco-2 Cell Models.Vieri Piazzini et al.Planta medica, 83(14-15), 1184-1193 (2017-05-05) Recent advances in the nanotechnology-based drug delivery of Silybin.Yancai Wang et al.Journal of biomedical nanotechnology, 10(4), 543-558 (2014-04-17) Quality assessment and antiplasmodial activity of West African Cochlospermum species.Aline Lamien-Meda et al.Phytochemistry, 119, 51-61 (2015-10-03) Apoptosis induction by OTA and TNF-α in cultured primary rat hepatocytes and prevention by silibinin.Ebtisam Essid et al.Toxins, 4(11), 1139-1156 (2012-12-04) Silibinin-induced endoplasmic reticulum stress and mitochondrial dysfunction suppress growth of endometriotic lesionsHam J, et al. Journal of Cellular Physiology, 234(4), 4327-4341 (2019) Silibinin down-regulates survivin protein and mRNA expression and causes caspases activation and apoptosis in human bladder transitional-cell papilloma RT4 cells.Anil K Tyagi et al.Biochemical and biophysical research communications, 312(4), 1178-1184 (2003-12-04) Prostate cancer prevention by silibininSingh RP, et al. Current Cancer Drug Targets, 4(1), 1-11 (2004)

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