gamma-Butyrolactone | CAS:96-48-0
gamma-Butyrolactone
- 名称:gamma-丁内酯; 4-羟基丁酸内酯 | gamma-Butyrolactone
- CAS号:96-48-0
- 别名:4-Hydroxybutyric acid gamma-lactone; BLO; endo-cis-5-Norbornene-endo-2,3-dicarboxylic anhydride
- 分子式:C4H6O2
- 分子量:86.09
- EINESC号:202-509-5
产品描述
物理化学性质
熔点 | -45 ºC |
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水溶性 | MISCIBLE |
沸点 | 204-205 ºC |
闪点 | 98 ºC |
密度 | 1.12 |
折射率 | 1.4355-1.4375 |
安全数据
危险品标志 | Xn |
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危险类别码 | R22;R36 |
安全说明书 | S26;S39 |
SDS
来源 | SDS样本 |
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没有数据 | 没有数据 |
产品合成路线
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4-Aminobiphenyl and DNA reactivity: case study within the context of the 2006 IPCS Human Relevance Framework for Analysis of a cancer mode of action for humans.Samuel M Cohen et al.Critical reviews in toxicology, 36(10), 803-819 (2006-11-23)
Comparison of exposure to selected cigarette smoke constituents in adult smokers and nonsmokers in a European, multicenter, observational study.Dirk Lindner et al.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 20(7), 1524-1536 (2011-05-27)
Analysis of 4-aminobiphenyl hemoglobin adducts in smokers and nonsmokers by pseudo capillary on-column gas chromatography- tandem mass spectrometry.Tiffany H Seyler et al.Journal of analytical toxicology, 34(6), 304-311 (2010-07-29)
Human DNA damage by the synergistic action of 4-aminobiphenyl and nitric oxide: an immunochemical study.Moinuddin et al.Environmental toxicology, 29(5), 568-576 (2012-05-23)
DNA adducts of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 4-aminobiphenyl are infrequently detected in human mammary tissue by liquid chromatography/tandem mass spectrometry.Dan Gu et al.Carcinogenesis, 33(1), 124-130 (2011-11-11)
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LogP determination for highly lipophilic hydrogen-bonding anion receptor molecules.Sofja Tshepelevitsh et al.Analytica chimica acta, 1132, 123-133 (2020-09-28)
Comparative carcinogenicity of 4-aminobiphenyl and the food pyrolysates, Glu-P-1, IQ, PhIP, and MeIQx in the neonatal B6C3F1 male mouse.K L Dooley et al.Cancer letters, 62(3), 205-209 (1992-03-15)
Codominant expression of N-acetylation and O-acetylation activities catalyzed by N-acetyltransferase 2 in human hepatocytes.Mark A Doll et al.The Journal of pharmacology and experimental therapeutics, 334(2), 540-544 (2010-05-01)
Influence of arylamine N-acetyltransferase, sex, and age on 4-aminobiphenyl-induced in vivo mutant frequencies and spectra in mouse liver.Shuang Wang et al.Environmental and molecular mutagenesis, 53(5), 350-357 (2012-04-18)
Toxicological assessment of kretek cigarettes: Part 1: background, assessment approach, and summary of findings.E Roemer et al.Regulatory toxicology and pharmacology : RTP, 70 Suppl 1, S2-14 (2014-12-17)
Differences between human slow N-acetyltransferase 2 alleles in levels of 4-aminobiphenyl-induced DNA adducts and mutations.Jean Bendaly et al.Mutation research, 671(1-2), 13-19 (2009-08-18)
Scientific assessment of the use of sugars as cigarette tobacco ingredients: a review of published and other publicly available studies.Ewald Roemer et al.Critical reviews in toxicology, 42(3), 244-278 (2012-01-24)
Analysis of 4-aminobiphenyl in smoker's and nonsmoker's urine by tandem mass spectrometry.Tiffany H Seyler et al.Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 16(3), 212-221 (2011-03-29)
Unusual sequence effects on nucleotide excision repair of arylamine lesions: DNA bending/distortion as a primary recognition factor.Vipin Jain et al.Nucleic acids research, 41(2), 869-880 (2012-11-28)
Rationally designing safer anilines: the challenging case of 4-aminobiphenyls.Alan M Birch et al.Journal of medicinal chemistry, 55(8), 3923-3933 (2012-04-06)
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Organ specificity of the bladder carcinogen 4-aminobiphenyl in inducing DNA damage and mutation in mice.Jae-In Yoon et al.Cancer prevention research (Philadelphia, Pa.), 5(2), 299-308 (2011-11-17)
An improved liquid chromatography-tandem mass spectrometry method for the quantification of 4-aminobiphenyl DNA adducts in urinary bladder cells and tissues.Kristen L Randall et al.Journal of chromatography. A, 1217(25), 4135-4143 (2009-11-26)
Acquired immunogenicity of human DNA damaged by N-hydroxy-N-acetyl-4-aminobiphenyl.Uzma Shahab et al.IUBMB life, 64(4), 340-345 (2012-03-02)
DNA adduct formation of 4-aminobiphenyl and heterocyclic aromatic amines in human hepatocytes.Gwendoline Nauwelaers et al.Chemical research in toxicology, 24(6), 913-925 (2011-04-05)
Reduced 4-aminobiphenyl-induced liver tumorigenicity but not DNA damage in arylamine N-acetyltransferase null mice.Kim S Sugamori et al.Cancer letters, 318(2), 206-213 (2011-12-24)
MicroRNA regulation of DNA repair gene expression in 4-aminobiphenyl-treated HepG2 cells.Lin Chen Huan et al.Toxicology, 322, 69-77 (2014-05-27)
Biomonitoring of smoke constituents: exposure to 4-aminobiphenyl and 4-aminobiphenyl hemoglobin adduct levels in nonsmokers and smokers.Matthias K Schorp et al.Inhalation toxicology, 22(9), 725-737 (2010-05-04)
Mechanisms of oxidative DNA damage induced by carcinogenic arylamines.Mariko Murata et al.Frontiers in bioscience (Landmark edition), 16, 1132-1143 (2011-01-05)
NATb/NAT1*4 promotes greater arylamine N-acetyltransferase 1 mediated DNA adducts and mutations than NATa/NAT1*4 following exposure to 4-aminobiphenyl.Lori M Millner et al.Molecular carcinogenesis, 51(8), 636-646 (2011-08-13)
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DNA adducts of ortho-toluidine in human bladder.Francine Böhm et al.Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 16(2), 120-128 (2010-12-02)
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Functional analysis of arylamine N-acetyltransferase 1 (NAT1) NAT1*10 haplotypes in a complete NATb mRNA construct.Lori M Millner et al.Carcinogenesis, 33(2), 348-355 (2011-11-25)
备注
Products protected by valid patents are not offered for sale in countries where the sale of such products constitutes a patent infringement and its liability is at buyer's risk.
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271 +A13(1).
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