熔点	173-177 ºC

危险品标志	Xi
危险类别码	R36/37/38
安全说明书	S24/25

来源	SDS样本
没有数据	没有数据

产品合成路线

更多

名称	CAS号

更多

文章

同行评议文献

Lifespan Extending and Stress Resistant Properties of Vitexin from Vigna angularis in Caenorhabditis elegans.Eun Byeol Lee et al.Biomolecules & therapeutics, 23(6), 582-589 (2015-11-05) Extracts from hardwood trees used in commercial paper mills contain biologically active neurochemical disruptors.Niladri Basu et al.The Science of the total environment, 414, 205-209 (2011-12-06) The battle against biofilm infections: juglone loaded nanoparticles as an anticandidal agent.Busra Gumus et al.Journal of biotechnology, 316, 17-26 (2020-04-22) Juglone potentiates TRAIL‑induced apoptosis in human melanoma cells via activating the ROS‑p38‑p53 pathway.Xiao Liu et al.Molecular medicine reports, 16(6), 9645-9651 (2017-10-19) Formal Radical Cyclization onto Benzene Rings: A General Method and Its Use in the Synthesis of ent-Nocardione A.Clive DLJ, et al. The Journal of Organic Chemistry, 69(10), 3282-3293 (2004) How the oligophage codling moth Cydia pomonella survives on walnut despite its secondary metabolite juglone.Rafal Piskorski et al.Journal of insect physiology, 57(6), 744-750 (2011-03-02) Pin1 Inhibitor Juglone Exerts Anti-Oncogenic Effects on LNCaP and DU145 Cells despite the Patterns of Gene Regulation by Pin1 Differing between These Cell Lines.Ryuhei Kanaoka et al.PloS one, 10(6), e0127467-e0127467 (2015-06-04) TGF-β1-PML SUMOylation-peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) form a positive feedback loop to regulate cardiac fibrosis.Di Wu et al.Journal of cellular physiology, 234(5), 6263-6273 (2018-09-25) Molecular evolution of the bacterial pseudouridine-5'-phosphate glycosidase protein family.Keshav Thapa et al.The FEBS journal, 281(19), 4439-4449 (2014-08-02) A screening platform to monitor RNA processing and protein-RNA interactions in ribonuclease P uncovers a small molecule inhibitor.Ezequiel-Alejandro Madrigal-Carrillo et al.Nucleic acids research, 47(12), 6425-6438 (2019-04-19) Biofilm Inhibition by Novel Natural Product- and Biocide-Containing Coatings Using High-Throughput Screening.Maria Salta et al.International journal of molecular sciences, 19(5) (2018-05-12) Determination of the Juglone Content of Juglans regia Leaves by GC/MS.Irena Matławska et al.Natural product communications, 10(7), 1239-1242 (2015-09-29) Study of the DNA hybridization transduction behavior of a quinone-containing electroactive polymer by cyclic voltammetry and electrochemical impedance spectroscopy.Piro B, et al. Journal of Electroanalytical Chemistry, 577(1), 155-165 (2005) Evaluation of 5-hydroxy-1,4-naphthoquinone-cobalt(III) complexes for hypoxia-activated drug delivery.Marcos Vinícius Palmeira de Mello et al.Journal of inorganic biochemistry, 199, 110756-110756 (2019-07-13) Juglone Suppresses LPS-induced Inflammatory Responses and NLRP3 Activation in Macrophages.Nam-Hun Kim et al.Molecules (Basel, Switzerland), 25(13) (2020-07-11) Prolyl isomerase Pin1 regulates the osteogenic activity of Osterix.Sung Ho Lee et al.Molecular and cellular endocrinology, 400, 32-40 (2014-12-03) Actions of juglone on energy metabolism in the rat liver.Simoni Cristina Saling et al.Toxicology and applied pharmacology, 257(3), 319-327 (2011-09-29) Structure activity relationship of plumbagin in BRCA1 related cancer cells.Thasni K A et al.Molecular carcinogenesis, 52(5), 392-403 (2012-02-01) The oxidative stress in allelopathy: Participation of prenyllipid antioxidants in the response to juglone in Chlamydomonas reinhardtii.Beatrycze Nowicka et al.Phytochemistry, 144, 171-179 (2017-09-25) Loss of Pin1 Suppresses Hedgehog-Driven Medulloblastoma Tumorigenesis.Tao Xu et al.Neoplasia (New York, N.Y.), 19(3), 216-225 (2017-02-09) Potential immunomodulatory effect of allelochemical juglone in mice vaccinated with BCG.Sujay Gaikwad et al.Toxicon : official journal of the International Society on Toxinology, 157, 43-52 (2018-11-13) Lifespan-extending and stress resistance properties of brazilin from Caesalpinia sappan in Caenorhabditis elegans.Eun Byeol Lee et al.Archives of pharmacal research, 40(7), 825-835 (2017-07-02) Juglone reduces growth and migration of U251 glioblastoma cells and disrupts angiogenesis.Jian Wang et al.Oncology reports, 38(4), 1959-1966 (2017-08-10) 5-Hydroxy-1,4-naphthalenedione exerts anticancer effects on glioma cells through interaction with the mitochondrial electron transport chain.Kastytis Sidlauskas et al.Neuroscience letters, 639, 207-214 (2017-01-11) A chemical screening approach reveals that indole fluorescence is quenched by pre-fibrillar but not fibrillar amyloid-beta.Ashley A Reinke et al.Bioorganic & medicinal chemistry letters, 19(17), 4952-4957 (2009-07-31) Anti-ageing and anti-Parkinsonian effects of natural flavonol, tambulin from Zanthoxyllum aramatum promotes longevity in Caenorhabditis elegans.Taruna Pandey et al.Experimental gerontology, 120, 50-61 (2019-03-03) In vivo antioxidant activities of essential oils and their constituents from leaves of the Taiwanese Cinnamomum osmophloeum.Fu-Lan Hsu et al.Journal of agricultural and food chemistry, 60(12), 3092-3097 (2012-03-03) Organoruthenium(II) Complexes Ameliorates Oxidative Stress and Impedes the Age Associated Deterioration in Caenorhabditis elegans through JNK-1/DAF-16 Signalling.G Devagi et al.Scientific reports, 8(1), 7688-7688 (2018-05-18) Diosgenin a phytosterol substitute for cholesterol, prolongs the lifespan and mitigates glucose toxicity via DAF-16/FOXO and GST-4 in Caenorhabditis elegans.Govindan Shanmugam et al.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 95, 1693-1703 (2017-09-29) Ability of the oriental fruit moth Grapholita molesta (Lepidoptera: Tortricidae) to detoxify juglone, the main secondary metabolite of the non-host plant walnut.Rafal Piskorski et al.Journal of chemical ecology, 37(10), 1110-1116 (2011-09-09) Mitochondrial and cytoplasmic ROS have opposing effects on lifespan.Claire E Schaar et al.PLoS genetics, 11(2), e1004972-e1004972 (2015-02-12) Pin1 is required for ultraviolet A-stimulated cyclooxygenase-2 induction in mouse epidermal cells.Bui Thu Quyen et al.Cancer letters, 335(1), 31-40 (2013-02-06) Evaluation of pharmacokinetic, biodistribution, pharmacodynamic, and toxicity profile of free juglone and its sterically stabilized liposomes.B Kiran Aithal et al.Journal of pharmaceutical sciences, 100(8), 3517-3528 (2011-04-28) Regulation of synaptic nlg-1/neuroligin abundance by the skn-1/Nrf stress response pathway protects against oxidative stress.Trisha A Staab et al.PLoS genetics, 10(1), e1004100-e1004100 (2014-01-24) Peptidyl-prolyl isomerase 1 (Pin1) preserves the phosphorylation state of tissue factor and prolongs its release within microvesicles.Camille Ettelaie et al.Biochimica et biophysica acta, 1865(1), 12-24 (2017-10-01) Overexpression of Hes1 is involved in sensitization of K562 cells to Imatinib.Sedigheh Eskandari et al.Journal of cellular biochemistry, 120(6), 10128-10136 (2018-12-15) Carotid body type I cells engage flavoprotein and Pin1 for oxygen sensing.André Bernardini et al.American journal of physiology. Cell physiology, 318(4), C719-C731 (2020-01-23) Tumor growth inhibitory effect of juglone and its radiation sensitizing potential: in vivo and in vitro studies.Kiran B Aithal et al.Integrative cancer therapies, 11(1), 68-80 (2011-04-19) Application of Sustainable Natural Resources in Agriculture: Acaricidal and Enzyme Inhibitory Activities of Naphthoquinones and Their Analogs against Psoroptes cuniculi.Xiao-Fei Shang et al.Scientific reports, 8(1), 1609-1609 (2018-01-27) Room-temperature B(OAc)3-promoted Diels-Alder reaction of juglone with styrenes: total syntheses of tetrangulol and anhydrolandomycinone.Day-Shin Hsu et al.The Journal of organic chemistry, 77(6), 2659-2666 (2012-02-24) Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression.Nicolas J Lehrbach et al.Cell, 177(3), 737-750 (2019-04-20) Antimutagenic and antioxidant properties of plumbagin and other naphthoquinones.Sanjeev Kumar et al.Mutation research, 755(1), 30-41 (2013-05-22) Pyrroloquinoline quinone modulates the kinetic parameters of the mammalian selenoprotein thioredoxin reductase 1 and is an inhibitor of glutathione reductase.Jianqiang Xu et al.Biochemical pharmacology, 83(6), 815-820 (2012-01-10) Pin1 deficiency causes endothelial dysfunction and hypertension.Valorie L Chiasson et al.Hypertension (Dallas, Tex. : 1979), 58(3), 431-438 (2011-08-04) Identification of transcriptome profiles and signaling pathways for the allelochemical juglone in rice roots.Wen-Chang Chi et al.Plant molecular biology, 77(6), 591-607 (2011-11-09) Juglone as antihypertensive agent acts through multiple vascular mechanisms.Taseer Ahmad et al.Clinical and experimental hypertension (New York, N.Y. : 1993), 42(4), 335-344 (2019-09-17) Binding Interaction of Juglone with Lysozyme: Spectroscopic Studies Aided by In Silico Calculations.Saumen Saha et al.Journal of photochemistry and photobiology. B, Biology, 193, 89-99 (2019-03-03) Plumbagin and juglone induce caspase-3-dependent apoptosis involving the mitochondria through ROS generation in human peripheral blood lymphocytes.Priya Seshadri et al.Free radical biology & medicine, 51(11), 2090-2107 (2011-10-11) PIN1 is a new therapeutic target of craniosynostosis.H R Shin et al.Human molecular genetics, 27(22), 3827-3839 (2018-07-15) Further characterization of Bacillus subtilis antibiotic biosensors and their use for antibacterial mode-of-action studies.Katherine R Mariner et al.Antimicrobial agents and chemotherapy, 55(4), 1784-1786 (2011-02-02) Accelerated removal of Sudan dye by Shewanella oneidensis MR-1 in the presence of quinones and humic acids.Guangfei Liu et al.World journal of microbiology & biotechnology, 29(9), 1723-1730 (2013-03-30) Inhibitory effect of novel 5-O-acyl juglones on mammalian DNA polymerase activity, cancer cell growth and inflammatory response.Sayako Maruo et al.Bioorganic & medicinal chemistry, 19(19), 5803-5812 (2011-09-10) Interleukin-22 promotes epithelial cell transformation and breast tumorigenesis via MAP3K8 activation.Karam Kim et al.Carcinogenesis, 35(6), 1352-1361 (2014-02-13) The 1,4-naphthoquinone scaffold in the design of cysteine protease inhibitors.Cláudia Valente et al.Bioorganic & medicinal chemistry, 15(15), 5340-5350 (2007-05-29) Inhibition of cell proliferation and migration by oxidative stress from ascorbate-driven juglone redox cycling in human bladder-derived T24 cells.M R Kviecinski et al.Biochemical and biophysical research communications, 421(2), 268-273 (2012-04-18) Isoliquiritigenin exerts antioxidant activity in Caenorhabditis elegans via insulin-like signaling pathway and SKN-1.Pille Link et al.Phytomedicine : international journal of phytotherapy and phytopharmacology, 55, 119-124 (2019-01-23) Antiproliferative activity of synthetic naphthoquinones related to lapachol. First synthesis of 5-hydroxylapachol.Evelyn L Bonifazi et al.Bioorganic & medicinal chemistry, 18(7), 2621-2630 (2010-03-23) Longevity and Stress Resistant Property of 6-Gingerol from Zingiber officinale Roscoe in Caenorhabditis elegans.Eun Byeol Lee et al.Biomolecules & therapeutics, 26(6), 568-575 (2018-03-15) Rethinking Dithiothreitol-Based Particulate Matter Oxidative Potential: Measuring Dithiothreitol Consumption versus Reactive Oxygen Species Generation.Qianshan Xiong et al.Environmental science & technology, 51(11), 6507-6514 (2017-05-11) Preliminary studies of 3,4-dichloroaniline amides as antiparasitic agents: structure-activity analysis of a compound library in vitro against Trichomonas vaginalis.Padraick J Dornbush et al.Bioorganic & medicinal chemistry letters, 20(17), 5299-5301 (2010-07-30) Phosphosite Analysis of the Cytomegaloviral mRNA Export Factor pUL69 Reveals Serines with Critical Importance for Recruitment of Cellular Proteins Pin1 and UAP56/URH49.Marco Thomas et al.Journal of virology, 94(8) (2020-01-24) Multiconstituent identification in root, branch, and leaf extracts of Juglans mandshurica using ultra high performance liquid chromatography with quadrupole time-of-flight mass spectrometry.Tian-Min Wang et al.Journal of separation science, 40(17), 3440-3452 (2017-07-07) Juglone eliminates MDSCs accumulation and enhances antitumor immunity.Hefei Wang et al.International immunopharmacology, 73, 118-127 (2019-05-16) Mechanism of Juglone-Induced Cell Cycle Arrest and Apoptosis in Ishikawa Human Endometrial Cancer Cells.Yuan-Yuan Zhang et al.Journal of agricultural and food chemistry, 67(26), 7378-7389 (2019-06-12) Parvulin 14 and Parvulin 17 Bind to HBx and cccDNA and Upregulate Hepatitis B Virus Replication from cccDNA to Virion in an HBx-Dependent Manner.Umar Saeed et al.Journal of virology, 93(6) (2018-12-21) PIN1 Attenuation Improves Midface Hypoplasia in a Mouse Model of Apert Syndrome.B Kim et al.Journal of dental research, 99(2), 223-232 (2019-12-24) Activity-dependent isomerization of Kv4.2 by Pin1 regulates cognitive flexibility.Jia-Hua Hu et al.Nature communications, 11(1), 1567-1567 (2020-03-29) Phosphoinositol 3-kinase, a novel target molecule for the inhibitory effects of juglone on TPA-induced cell transformation.Jung-Il Chae et al.International journal of molecular medicine, 30(1), 8-14 (2012-04-17) Enhanced ROS production leads to excessive fat accumulation through DAF-16 in Caenorhabditis elegans.Kejie Wang et al.Experimental gerontology, 112, 20-29 (2018-08-19) Pin1 inhibition activates cyclin D and produces neurodegenerative pathology.Kutay Deniz Atabay et al.Journal of neurochemistry, 120(3), 430-439 (2011-03-30) Anticancer activity and mechanism of juglone on human cervical carcinoma HeLa cells.Wei Zhang et al.Canadian journal of physiology and pharmacology, 90(11), 1553-1558 (2012-11-28) Eco-friendly walnut shell powder based facile fabrication of biogenic Ag-nanodisks, and their interaction with bovine serum albumin.Zoya Zaheer Journal of photochemistry and photobiology. B, Biology, 193, 8-17 (2019-02-25) Multitarget drug design strategy: quinone-tacrine hybrids designed to block amyloid-β aggregation and to exert anticholinesterase and antioxidant effects.Nepovimova E, et al. Journal of medicinal chemistry, 57(20), 8576-8589 (2014) Investigation of apoptotic effect of juglone on CCL-228-SW 480 colon cancer cell line.Dilek Bayram et al.Journal of cancer research and therapeutics, 15(1), 68-74 (2019-03-19) 2-and 3-substituted 1, 4-naphthoquinone derivatives as subversive substrates of trypanothione reductase and lipoamide dehydrogenase from trypanosoma c ruzi: synthesis and correlation between redox cycling activities and in vitro cytotoxicity.Salmon-Chemin L, et al. Journal of Medicinal Chemistry, 44(4), 548-565 (2001) Juglone Inhibits Proliferation of HPV-Positive Cervical Cancer Cells Specifically.Xingyu Zhao et al.Biological & pharmaceutical bulletin, 42(3), 475-480 (2019-01-05) Enzyme-less electrochemical displacement heterogeneous immunosensor for diclofenac detection.T T K Nguyen et al.Biosensors & bioelectronics, 97, 246-252 (2017-06-13) Antioxidant Activity of an Aqueous Leaf Extract from Uncaria tomentosa and Its Major Alkaloids Mitraphylline and Isomitraphylline in Caenorhabditis elegans.Bruna C Azevedo et al.Molecules (Basel, Switzerland), 24(18) (2019-09-13) Targeted juglone blocks the invasion and metastasis of HPV-positive cervical cancer cells.Xingyu Zhao et al.Journal of pharmacological sciences, 140(3), 211-217 (2019-08-26) Inhibiting Aβ toxicity in Alzheimer's disease by a pyridine amine derivative.Zhenzhu Zhu et al.European journal of medicinal chemistry, 168, 330-339 (2019-03-04) Juglone-ascorbic acid synergy inhibits metastasis and induces apoptotic cell death in poorly differentiated thyroid carcinoma by perturbing SOD and catalase activities.Sujay Gaikwad et al.Journal of biochemical and molecular toxicology, 32(9), e22176-e22176 (2018-07-12) Yellow Pigment Aurovertins Mediate Interactions between the Pathogenic Fungus Pochonia chlamydosporia and Its Nematode Host.Yan-li Wang et al.Journal of agricultural and food chemistry, 63(29), 6577-6587 (2015-07-08) Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors.Sanjeev Kumar et al.Journal of medicinal chemistry, 51(6), 1706-1718 (2008-03-06) Shatavarin IV elicits lifespan extension and alleviates Parkinsonism in Caenorhabditis elegans.Shachi Shuchi Smita et al.Free radical research, 51(11-12), 954-969 (2017-10-27) A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action.Elena Campaner et al.Nature communications, 8, 15772-15772 (2017-06-10) Structure-activity relationships and mechanism of action of tetragomycin derivatives as inhibitors of Staphylococcus aureus staphyloxanthin biosynthesis.L M B C Ribeiro et al.Microbial pathogenesis, 144, 104127-104127 (2020-03-15) Bioactivities of simplified adociaquinone B and naphthoquinone derivatives against Cdc25B, MKP-1, and MKP-3 phosphatases.Shugeng Cao et al.Bioorganic & medicinal chemistry, 17(6), 2276-2281 (2008-11-26) COT phosphorylates prolyl-isomerase Pin1 to promote tumorigenesis in breast cancer.Garam Kim et al.Molecular carcinogenesis, 54(6), 440-448 (2013-11-23) Small molecule inhibitors of aggregation indicate that amyloid beta oligomerization and fibrillization pathways are independent and distinct.Mihaela Necula et al.The Journal of biological chemistry, 282(14), 10311-10324 (2007-02-08) Quinones derived from plant secondary metabolites as anti-cancer agents.Jin-Jian Lu et al.Anti-cancer agents in medicinal chemistry, 13(3), 456-463 (2012-08-31) Juglone, from Juglans mandshruica Maxim, inhibits growth and induces apoptosis in human leukemia cell HL-60 through a reactive oxygen species-dependent mechanism.Hua Li Xu et al.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 50(3-4), 590-596 (2012-01-24) Human erythrocytes exposure to juglone leads to an increase of superoxide anion production associated with cytochrome b5 reductase uncoupling.Gabriel N Valério et al.Biochimica et biophysica acta. Bioenergetics, 1861(2), 148134-148134 (2019-12-12) Chromatographic evaluation and QSAR optimization for benzoic acid analogues against carbonic anhydrase III.Muhammed Alzweiri et al.Journal of enzyme inhibition and medicinal chemistry, 30(3), 420-429 (2014-07-30) A new anti-Helicobacter pylori juglone from Reynoutria japonica.Atif Ali Khan Khalil et al.Archives of pharmacal research, 42(6), 505-511 (2019-05-11) Enhanced eryptosis following juglone exposure.Salvatrice Calabrò et al.Basic & clinical pharmacology & toxicology, 116(6), 460-467 (2014-10-29) Ameliorative effect of aspalathin from rooibos (Aspalathus linearis) on acute oxidative stress in Caenorhabditis elegans.Wei Chen et al.Phytomedicine : international journal of phytotherapy and phytopharmacology, 20(3-4), 380-386 (2012-12-12) Vitamin C protects against defects induced by juglone during porcine oocyte maturation.Xue Zhang et al.Journal of cellular physiology, 234(11), 19574-19581 (2019-04-14) Application of an Enyne Metathesis/Diels-Alder Cycloaddition Sequence: A New Versatile Approach to the Syntheses of C-Aryl Glycosides and Spiro-C-Aryl Glycosides.Subrahmanyam AV, et al. Chemistry?A European Journal , 16(28), 8545-8556 (2010) γ-Aminobutyric acid type A (GABAA) receptor activation modulates tau phosphorylation.Niko-Petteri Nykänen et al.The Journal of biological chemistry, 287(9), 6743-6752 (2012-01-12) Transthyretin Amyloid Fibril Disrupting Activities of Extracts and Fractions from Juglans mandshurica Maxim. var. cordiformis (Makino) Kitam.Niraj Chaudhary et al.Molecules (Basel, Switzerland), 24(3) (2019-02-02) Redox effects and cytotoxic profiles of MJ25 and auranofin towards malignant melanoma cells.Marijke C C Sachweh et al.Oncotarget, 6(18), 16488-16506 (2015-06-02) Reduction of bitterness in green walnuts by conventional and ultrasound-assisted maceration.Serdar Uğurlu et al.Ultrasonics sonochemistry, 66, 105094-105094 (2020-04-03) Lifespan-extending property of 6-shogaol from Zingiber officinale Roscoe in Caenorhabditis elegans.Eun Byeol Lee et al.Archives of pharmacal research, 41(7), 743-752 (2018-07-07) Dipeptidyl peptidase 4 promotes epithelial cell transformation and breast tumourigenesis via induction of PIN1 gene expression.H J Choi et al.British journal of pharmacology, 172(21), 5096-5109 (2015-08-13)

备注