熔点	89-92 ºC

危险品标志	Xi
危险类别码	R36/37/38
安全说明书	S26;S37/39

来源	SDS样本
没有数据	没有数据

产品合成路线

更多

名称	CAS号

更多

文章

同行评议文献

Fabrication of plumbagin on silver nanoframework for tunable redox modulation: Implications for therapeutic angiogenesis.Natarajan Duraipandy et al.Journal of cellular physiology, 234(8), 13110-13127 (2018-12-18) Plumbagin treatment leads to apoptosis in human K562 leukemia cells through increased ROS and elevated TRAIL receptor expression.Jingping Sun et al.Leukemia research, 35(10), 1402-1408 (2011-07-12) Plumbagin reverses proliferation and resistance to apoptosis in experimental PAH.Audrey Courboulin et al.The European respiratory journal, 40(3), 618-629 (2012-04-13) Oxidative stress via inhibition of the mitochondrial electron transport and Nrf-2-mediated anti-oxidative response regulate the cytotoxic activity of plumbagin.Arvinder Kapur et al.Scientific reports, 8(1), 1073-1073 (2018-01-20) NADPH oxidase 4 is involved in the triethylene glycol dimethacrylate-induced reactive oxygen species and apoptosis in human embryonic palatal mesenchymal and dental pulp cells.Cheng-Chang Yeh et al.Clinical oral investigations, 19(6), 1463-1471 (2014-12-04) Increased production of plumbagin in Plumbago indica root cultures by gamma ray irradiationJaisi A, et al. Pharmaceutical biology, 51(8), 1047-1051 (2013) Plumbagin inhibits invasion and migration of breast and gastric cancer cells by downregulating the expression of chemokine receptor CXCR4.Kanjoormana Aryan Manu et al.Molecular cancer, 10, 107-107 (2011-09-02) Coproduction and ecological significance of naphthoquinones in carnivorous sundews (Drosera).Paul A Egan et al.Chemistry & biodiversity, 9(6), 1033-1044 (2012-06-16) In vivo micronucleus assay and GST activity in assessing genotoxicity of plumbagin in Swiss albino mice.V SivaKumar et al.Drug and chemical toxicology, 28(4), 499-507 (2005-11-22) Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) induces apoptosis and cell cycle arrest in A549 cells through p53 accumulation via c-Jun NH2-terminal kinase-mediated phosphorylation at serine 15 in vitro and in vivo.Ya-Ling Hsu et al.The Journal of pharmacology and experimental therapeutics, 318(2), 484-494 (2006-04-25) Comparison of the Effect of Native 1,4-Naphthoquinones Plumbagin, Menadione, and Lawsone on Viability, Redox Status, and Mitochondrial Functions of C6 Glioblastoma Cells.Daiva Majiene et al.Nutrients, 11(6) (2019-06-12) Plumbagin-induced oxidative stress leads to inhibition of Na+/K+-ATPase (NKA) in canine cancer cells.Yousef Alharbi et al.Scientific reports, 9(1), 11471-11471 (2019-08-09) Plumbagin inhibits amyloid-β-induced neurotoxicity: regulation of oxidative stress and nuclear factor erythroid 2-related factor 2 activation.Suhong Wang et al.Neuroreport, 29(15), 1269-1274 (2018-08-11) Application of SPECT/CT imaging system and radiochemical analysis for investigation of blood kinetics and tissue distribution of radiolabeled plumbagin in healthy and Plasmodium berghei-infected mice.W Sumsakul et al.Experimental parasitology, 161, 54-61 (2015-12-30) Plumbagin improves the efficacy of androgen deprivation therapy in prostate cancer: A pre-clinical study.Parisa Abedinpour et al.The Prostate, 77(16), 1550-1562 (2017-10-04) Secreted pitfall-trap fluid of carnivorous Nepenthes plants is unsuitable for microbial growth.Franziska Buch et al.Annals of botany, 111(3), 375-383 (2012-12-25) Plumbagin suppresses chronic periodontitis in rats via down-regulation of TNF-α, IL-1β and IL-6 expression.Xin-Yi Zheng et al.Acta pharmacologica Sinica, 38(8), 1150-1160 (2017-05-30) Tanshinone IIA blocks dexamethasone-induced apoptosis in osteoblasts through inhibiting Nox4-derived ROS production.Jia Li et al.International journal of clinical and experimental pathology, 8(10), 13695-13706 (2016-01-02) NADPH oxidase 4 regulates anoikis resistance of gastric cancer cells through the generation of reactive oxygen species and the induction of EGFR.Shangce Du et al.Cell death & disease, 9(10), 948-948 (2018-09-22) Plumbagin shows anticancer activity in human osteosarcoma (MG-63) cells via the inhibition of S-Phase checkpoints and down-regulation of c-myc.Chao-Hua Yan et al.International journal of clinical and experimental medicine, 8(8), 14432-14439 (2015-11-10) Nrf2 and NF-κB modulation by Plumbagin attenuates functional, behavioural and biochemical deficits in rat model of neuropathic pain.Vijay Arruri et al.Pharmacological reports : PR, 69(4), 625-632 (2017-05-16) Development and validation of a luminescence-based, medium-throughput assay for drug screening in Schistosoma mansoni.Cristiana Lalli et al.PLoS neglected tropical diseases, 9(1), e0003484-e0003484 (2015-01-31) Synthesis and Biological Evaluation of Lipophilic 1,4-Naphthoquinone Derivatives against Human Cancer Cell Lines.Shao-Hung Wang et al.Molecules (Basel, Switzerland), 20(7), 11994-12015 (2015-07-03) The relationship and mechanism between education and functional health status transition among older persons in China.He Chen et al.BMC geriatrics, 18(1), 89-89 (2018-04-13) Plumbagin suppresses dendritic cell functions and alleviates experimental autoimmune encephalomyelitis.Zhang K, Ge Z, Da Y, et al. Journal of Neuroimmunology, 273(1-2), 42-52 (2014) Potential of the genetically transformed root cultures of Plumbago europaea for biomass and plumbagin production.Mina Beigmohamadi et al.Biotechnology progress, 36(2), e2905-e2905 (2019-09-13) Mycobacterium tuberculosis thymidylate synthase (ThyX) is a target for plumbagin, a natural product with antimycobacterial activity.Apurba Sarkar et al.PloS one, 15(2), e0228657-e0228657 (2020-02-06) Evaluation of plumbagin and its derivative as potential modulators of redox thiol metabolism of Leishmania parasite.Neha Sharma et al.Parasitology research, 110(1), 341-348 (2011-07-01) Plumbagin ameliorates liver fibrosis via a ROS-mediated NF-кB signaling pathway in vitro and in vivo.Yongxin Chen et al.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 116, 108923-108923 (2019-06-04) Plumbagin Enhances the Anticancer Efficacy of Cisplatin by Increasing Intracellular ROS in Human Tongue Squamous Cell Carcinoma.Danfeng Xue et al.Oxidative medicine and cellular longevity, 2020, 5649174-5649174 (2020-04-21) Plumbagin inhibits tumour angiogenesis and tumour growth through the Ras signalling pathway following activation of the VEGF receptor-2.Li Lai et al.British journal of pharmacology, 165(4b), 1084-1096 (2011-06-11) In vitro antibacterial activity of plumbagin isolated from Plumbago zeylanica L. against methicillin-resistant Staphylococcus aureus.H Periasamy et al.Letters in applied microbiology, 69(1), 41-49 (2019-05-03) Plumbagin inhibits breast tumor bone metastasis and osteolysis by modulating the tumor-bone microenvironment.Z Li et al.Current molecular medicine, 12(8), 967-981 (2012-05-12) Betulinic acid is a PPARγ antagonist that improves glucose uptake, promotes osteogenesis and inhibits adipogenesis.Gloria Brusotti et al.Scientific reports, 7(1), 5777-5777 (2017-07-20) Permeability of plumbagin across human intestinal cell in vitro.Wiriyaporn Sumsakul et al.Archives of pharmacal research, 39(3), 380-389 (2015-12-02) Activation of AMP-activated protein kinase (AMPK) mediates plumbagin-induced apoptosis and growth inhibition in cultured human colon cancer cells.Min-Bin Chen et al.Cellular signalling, 25(10), 1993-2002 (2013-05-29) Copper (II) complexes of bidentate ligands exhibit potent anti-cancer activity regardless of platinum sensitivity status.Mohamed Wehbe et al.Investigational new drugs, 35(6), 682-690 (2017-07-25) Plumbagin-mediating GLUT1 suppresses the growth of human tongue squamous cell carcinoma.S Na et al.Oral diseases, 24(6), 920-929 (2017-10-29) [Study on chemical constituents of Drosera peltata var. multisepala].Lin Li et al.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 37(2), 222-225 (2012-06-29) Anti-inflammatory, antimicrobial and antioxidant activities of Diospyros bipindensis (Gürke) extracts and its main constituents.I Cesari et al.Journal of ethnopharmacology, 146(1), 264-270 (2013-01-22) Plumbagin induces apoptosis in human osteosarcoma through ROS generation, endoplasmic reticulum stress and mitochondrial apoptosis pathway.Chia-Chia Chao et al.Molecular medicine reports, 16(4), 5480-5488 (2017-08-30) Nepenthes insignis uses a C2-portion of the carbon skeleton of L-alanine acquired via its carnivorous organs, to build up the allelochemical plumbagin.Heiko Rischer et al.Phytochemistry, 59(6), 603-609 (2002-02-28) Nanoparticle-Based Celecoxib and Plumbagin for the Synergistic Treatment of Melanoma.Raghavendra Gowda et al.Molecular cancer therapeutics, 16(3), 440-452 (2016-12-23) Plumbagin inhibits cancer stem-like cells, angiogenesis and suppresses cell proliferation and invasion by targeting Wnt/β-catenin pathway in endocrine resistant breast cancer.Nithidol Sakunrangsit et al.Pharmacological research, 150, 104517-104517 (2019-11-07) Genotoxicity of plumbagin and its effects on catechol and NQNO-induced DNA damage in mouse lymphoma cellsDing Y, et al. The Journal of Pharmacy and Pharmacology, 57(1), 111-116 (2005) Plumbagin inhibits prostate cancer development in TRAMP mice via targeting PKCε, Stat3 and neuroendocrine markers.Bilal Bin Hafeez et al.Carcinogenesis, 33(12), 2586-2592 (2012-09-15) Plumbagin protects against glucocorticoid-induced osteoporosis through Nrf-2 pathway.Shuai Zhang et al.Cell stress & chaperones, 20(4), 621-629 (2015-05-06) Plumbagin Ameliorates Collagen-Induced Arthritis by Regulating Treg/Th17 Cell Imbalances and Suppressing Osteoclastogenesis.Tingyu Wang et al.Frontiers in immunology, 9, 3102-3102 (2019-01-24) Plumbagin enhances TRAIL-induced apoptosis of human leukemic Kasumi‑1 cells through upregulation of TRAIL death receptor expression, activation of caspase-8 and inhibition of cFLIP.Xiaoyang Kong et al.Oncology reports, 37(6), 3423-3432 (2017-05-13) Peptidyl-prolyl isomerase 1 (Pin1) preserves the phosphorylation state of tissue factor and prolongs its release within microvesicles.Camille Ettelaie et al.Biochimica et biophysica acta, 1865(1), 12-24 (2017-10-01) Plumbagin suppresses the migration and invasion of glioma cells via downregulation of MMP-2/9 expression and inaction of PI3K/Akt signaling pathway in vitro.Guanghui Chen et al.Journal of pharmacological sciences, 134(1), 59-67 (2017-05-17) The anti-allergic and anti-inflammatory effects of Benjakul extract (a Thai traditional medicine), its constituent plants and its some pure constituents using in vitro experiments.Sunita Makchuchit et al.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 89, 1018-1026 (2017-03-16) Application of Sustainable Natural Resources in Agriculture: Acaricidal and Enzyme Inhibitory Activities of Naphthoquinones and Their Analogs against Psoroptes cuniculi.Xiao-Fei Shang et al.Scientific reports, 8(1), 1609-1609 (2018-01-27) Identifying crosstalk of mTOR signaling pathway of lobular breast carcinomas.G Sun et al.European review for medical and pharmacological sciences, 16(10), 1355-1361 (2012-10-30) Antidiabetic effect of plumbagin isolated from Plumbago zeylanica L. root and its effect on GLUT4 translocation in streptozotocin-induced diabetic rats.Christudas Sunil et al.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 50(12), 4356-4363 (2012-09-11) The in vitro anthelmintic effects of plumbagin on newly excysted and 4-weeks-old juvenile parasites of Fasciola gigantica.Natcha Lorsuwannarat et al.Experimental parasitology, 136, 5-13 (2013-10-26) Antimutagenic and antioxidant properties of plumbagin and other naphthoquinones.Sanjeev Kumar et al.Mutation research, 755(1), 30-41 (2013-05-22) 5-O-Acyl plumbagins inhibit DNA polymerase activity and suppress the inflammatory response.Takefumi Onodera et al.Archives of biochemistry and biophysics, 573, 100-110 (2015-03-10) Plumbagin Prevents IL-1β-Induced Inflammatory Response in Human Osteoarthritis Chondrocytes and Prevents the Progression of Osteoarthritis in Mice.Wenhao Zheng et al.Inflammation, 40(3), 849-860 (2017-02-09) Plumbagin alters telomere dynamics, induces DNA damage and cell death in human brain tumour cells.Aik Kia Khaw et al.Mutation research. Genetic toxicology and environmental mutagenesis, 793, 86-95 (2015-11-02) Resistance Modulation Action, Time-Kill Kinetics Assay, and Inhibition of Biofilm Formation Effects of Plumbagin from Plumbago zeylanica Linn.Emmanuel B A Adusei et al.Journal of tropical medicine, 2019, 1250645-1250645 (2019-12-31) Heterologous Expression of Chaperones from Hyperthermophilic Archaea Inhibits Aminoglycoside-Induced Protein Misfolding in Escherichia coli.S Peng et al.Biochemistry. Biokhimiia, 82(10), 1169-1175 (2017-10-19) Oleic acid and ergosterol supplementation mitigates oxidative stress in wine strains of Saccharomyces cerevisiaeLandolfo S, et al. International Journal of Food Microbiology, 141(3), 229-235 (2010) Oleic acid and ergosterol supplementation mitigates oxidative stress in wine strains of Saccharomyces cerevisiae.Sara Landolfo et al.International journal of food microbiology, 141(3), 229-235 (2010-07-14) Inhibition of ANO1/TMEM16A Chloride Channel by Idebenone and Its Cytotoxicity to Cancer Cell Lines.Yohan Seo et al.PloS one, 10(7), e0133656-e0133656 (2015-07-22) Pongapin and Karanjin, furanoflavanoids of Pongamia pinnata, induce G2/M arrest and apoptosis in cervical cancer cells by differential reactive oxygen species modulation, DNA damage, and nuclear factor kappa-light-chain-enhancer of activated B cell signaling.Rituparna Roy et al.Phytotherapy research : PTR, 33(4), 1084-1094 (2019-03-06) Evaluation of 5-hydroxy-1,4-naphthoquinone-cobalt(III) complexes for hypoxia-activated drug delivery.Marcos Vinícius Palmeira de Mello et al.Journal of inorganic biochemistry, 199, 110756-110756 (2019-07-13) Plumbagin inhibits the proliferation and survival of esophageal cancer cells by blocking STAT3-PLK1-AKT signalingCao YY, et al. Cell Death & Disease, 9(2), 17-17 (2018) Plumbagin-Loaded Nanoemulsion Drug Delivery Formulation and Evaluation of Antiproliferative Effect on Prostate Cancer CellsChrastina A, et al. BioMed Research International, 2018 (2018) Regulation of anoikis resistance by NADPH oxidase 4 and epidermal growth factor receptor.Hyeryeong Kim et al.British journal of cancer, 116(3), 370-381 (2017-01-13) The Mammalian circadian clock gene per2 modulates cell death in response to oxidative stress.Maria Chiara Magnone et al.Frontiers in neurology, 5, 289-289 (2015-01-30) Paramphistomum cervi: the in vitro effect of plumbagin on motility, survival and tegument structure.Naruwan Saowakon et al.Experimental parasitology, 133(2), 179-186 (2012-12-05) The role of thioredoxin reductase and glutathione reductase in plumbagin-induced, reactive oxygen species-mediated apoptosis in cancer cell lines.Geun Hye Hwang et al.European journal of pharmacology, 765, 384-393 (2015-09-06) Proapoptotic and Growth-inhibitory Effects of Plumbagin on Human Gastric Cancer Cells Via Suppression of Signal Transducer and Activator of Transcription 3 and Protein Kinase B.Jing Li et al.Alternative therapies in health and medicine, 23(5), 42-48 (2017-02-27) Oxidative stress in E. coli cells upon exposure to heat treatments.María Marcén et al.International journal of food microbiology, 241, 198-205 (2016-10-30) Combination of silver nanoparticles and Drosera binata extract as a possible alternative for antibiotic treatment of burn wound infections caused by resistant Staphylococcus aureus.Marta Krychowiak et al.PloS one, 9(12), e115727-e115727 (2015-01-01) IL-35 prevent bone loss through promotion of bone formation and angiogenesis in rheumatoid arthritis.Siyan Liu et al.Clinical and experimental rheumatology, 37(5), 820-825 (2019-02-16) Posttranslational Regulation of Human DNA Polymerase ι.Justyna McIntyre et al.The Journal of biological chemistry, 290(45), 27332-27344 (2015-09-16) Permeability of plumbagin across human intestinal cell in vitro.Wiriyaporn Sumsakul et al.Archives of pharmacal research, 39(3), 380-389 (2015-12-02) Plumbagin inhibits tumour angiogenesis and tumour growth through the Ras signalling pathway following activation of the VEGF receptor-2.Li Lai et al.British journal of pharmacology, 165(4b), 1084-1096 (2011-06-11) In vitro antibacterial activity of plumbagin isolated from Plumbago zeylanica L. against methicillin-resistant Staphylococcus aureus.H Periasamy et al.Letters in applied microbiology, 69(1), 41-49 (2019-05-03) Plumbagin inhibits breast tumor bone metastasis and osteolysis by modulating the tumor-bone microenvironment.Z Li et al.Current molecular medicine, 12(8), 967-981 (2012-05-12) Nanoparticle-Based Celecoxib and Plumbagin for the Synergistic Treatment of Melanoma.Raghavendra Gowda et al.Molecular cancer therapeutics, 16(3), 440-452 (2016-12-23) Betulinic acid is a PPARγ antagonist that improves glucose uptake, promotes osteogenesis and inhibits adipogenesis.Gloria Brusotti et al.Scientific reports, 7(1), 5777-5777 (2017-07-20) Plumbagin inhibits cancer stem-like cells, angiogenesis and suppresses cell proliferation and invasion by targeting Wnt/β-catenin pathway in endocrine resistant breast cancer.Nithidol Sakunrangsit et al.Pharmacological research, 150, 104517-104517 (2019-11-07) Novel solvent-free gelucire extract of Plumbago zeylanica using non-everted rat intestinal sac method for improved therapeutic efficacy of plumbagin.Chellampillai Bothiraja et al.Journal of pharmacological and toxicological methods, 66(1), 35-42 (2012-06-02) Pharmacological targeting of ROS reaction network in myeloid leukemia cells monitored by ultra-weak photon emission.Rosilene Cristina Rossetto Burgos et al.Oncotarget, 9(2), 2028-2034 (2018-02-09) The Pseudomonas syringae pv. tomato DC3000 PSPTO_0820 multidrug transporter is involved in resistance to plant antimicrobials and bacterial survival during tomato plant infection.Saray Santamaría-Hernando et al.PloS one, 14(6), e0218815-e0218815 (2019-06-27) In vitro callus induction and estimation of plumbagin content from Plumbago auriculata Lam.Deshpande J, et al. Indian Journal of Experimental Biology, 52(11), 122-1127 (2014) Formulation of plumbagin loaded long circulating pegylated liposomes: in vivo evaluation in C57BL/6J mice bearing B16F1 melanoma.M R Sunil Kumar et al.Drug delivery, 18(7), 511-522 (2011-07-29) Plumbagin Enhances the Anticancer Efficacy of Cisplatin by Increasing Intracellular ROS in Human Tongue Squamous Cell Carcinoma.Danfeng Xue et al.Oxidative medicine and cellular longevity, 2020, 5649174-5649174 (2020-04-21) The naphthoquinone plumbagin suppresses ADP-induced rat platelet aggregation through P2Y1-PLC signaling pathway.Qianrui Zhang et al.Pakistan journal of pharmaceutical sciences, 30(2(Suppl.)), 573-578 (2017-06-27) Plumbagin inhibits tumorigenesis and angiogenesis of ovarian cancer cells in vivo.Sutapa Sinha et al.International journal of cancer, 132(5), 1201-1212 (2012-07-19) Plumbagin, a vitamin K3 analogue ameliorate malaria pathogenesis by inhibiting oxidative stress and inflammation.Amit Chand Gupta et al.Inflammopharmacology, 26(4), 983-991 (2018-03-24) Synthesis, characterization, molecular docking and cytotoxic activity of novel plumbagin hydrazones against breast cancer cells.Prasad Dandawate et al.Bioorganic & medicinal chemistry letters, 22(9), 3104-3108 (2012-04-10) A fast and specific fluorescent probe for thioredoxin reductase that works via disulphide bond cleavage.Xinming Li et al.Nature communications, 10(1), 2745-2745 (2019-06-23) Perspectives on medicinal properties of plumbagin and its analogs.Subhash Padhye et al.Medicinal research reviews, 32(6), 1131-1158 (2012-10-13) Quinones derived from plant secondary metabolites as anti-cancer agents.Jin-Jian Lu et al.Anti-cancer agents in medicinal chemistry, 13(3), 456-463 (2012-08-31) Designing new iridium(iii) arene complexes of naphthoquinone derivatives as anticancer agents: a structure-activity relationship study.Leila Tabrizi et al.Dalton transactions (Cambridge, England : 2003), 46(7), 2339-2349 (2017-02-01) The monoheme cytochrome c subunit of Alternative Complex III is a direct electron donor to caa3 oxygen reductase in Rhodothermus marinus.Patrícia N Refojo et al.Biological chemistry, 398(9), 1037-1044 (2017-02-01) Evaluation of wound healing activity of plumbagin in diabetic rats.Yi Shao et al.Life sciences, 231, 116422-116422 (2019-05-07) Small-Molecule Disruption of the Myb/p300 Cooperation Targets Acute Myeloid Leukemia Cells.Sagar Uttarkar et al.Molecular cancer therapeutics, 15(12), 2905-2915 (2016-10-22) The natural anticancer agent plumbagin induces potent cytotoxicity in MCF-7 human breast cancer cells by inhibiting a PI-5 kinase for ROS generation.Ju-Hee Lee et al.PloS one, 7(9), e45023-e45023 (2012-10-03) Plumbagin inhibits cytokinesis in Bacillus subtilis by inhibiting FtsZ assembly--a mechanistic study of its antibacterial activity.Anusri Bhattacharya et al.The FEBS journal, 280(18), 4585-4599 (2013-07-12) Binding and Anticancer Properties of Plumbagin with Human Serum Albumin.Yi Gou et al.Chemical biology & drug design, 86(3), 362-369 (2014-12-24) Plumbagin reduces human colon cancer cell survival by inducing cell cycle arrest and mitochondria-mediated apoptosis.Binil Eldhose et al.International journal of oncology, 45(5), 1913-1920 (2014-08-12) Cell Suspension Culture of Plumbago europaea L. Towards Production of Plumbagin.Mina Beigmohamadi et al.Iranian journal of biotechnology, 17(2), e2169-e2169 (2019-08-29) Benzoquinone, a leukemogenic metabolite of benzene, catalytically inhibits the protein tyrosine phosphatase PTPN2 and alters STAT1 signaling.Romain Duval et al.The Journal of biological chemistry, 294(33), 12483-12494 (2019-06-30) Plumbagin induces apoptosis in Her2-overexpressing breast cancer cells through the mitochondrial-mediated pathway.Anna Kawiak et al.Journal of natural products, 75(4), 747-751 (2012-04-20) Neuroprotection by plumbagin involves BDNF-TrkB-PI3K/Akt and ERK1/2/JNK pathways in isoflurane-induced neonatal rats.Jun-Hui Yuan et al.The Journal of pharmacy and pharmacology, 69(7), 896-906 (2017-05-04) Synergistic inhibitory effects of Celecoxib and Plumbagin on melanoma tumor growth.Raghavendra Gowda et al.Cancer letters, 385, 243-250 (2016-10-25) Plumbagin suppresses the human large cell lung cancer cell lines by inhibiting IL-6/STAT3 signaling in vitro.Tao Yu et al.International immunopharmacology, 55, 290-296 (2018-01-03) Development of plumbagin-loaded phospholipid-Tween® 80 mixed micelles: formulation, optimization, effect on breast cancer cells and human blood/serum compatibility testing.Chellampillai Bothiraja et al.Therapeutic delivery, 4(10), 1247-1259 (2013-10-15) Mitochondrial reactive oxygen species regulate the induction of CD8+ T cells by plasmacytoid dendritic cells.Marine Oberkampf et al.Nature communications, 9(1), 2241-2241 (2018-06-10) Plumbagin induces growth inhibition of human glioma cells by downregulating the expression and activity of FOXM1.Xuejiao Liu et al.Journal of neuro-oncology, 121(3), 469-477 (2014-12-22) Plumbagin inhibits neuronal apoptosis, intimal hyperplasia and also suppresses TNF-α/NF-κB pathway induced inflammation and matrix metalloproteinase-2/9 expression in rat cerebral ischemia.Xiao-Juan Chen et al.Saudi journal of biological sciences, 25(6), 1033-1039 (2018-09-04) Antitumorigenic effect of plumbagin by induction of SH2-containing protein tyrosine phosphatase 1 in human gastric cancer cells.Moon Kyung Joo et al.International journal of oncology, 46(6), 2380-2388 (2015-03-31) Naphthazarin protects against glutamate-induced neuronal death via activation of the Nrf2/ARE pathway.Tae Gen Son et al.Biochemical and biophysical research communications, 433(4), 602-606 (2013-03-30) Conformational preferences of plumbagin with phenyl-1-thioglucoside conjugates in solution and bound to MshB determined by aromatic association.Ian L Rogers et al.Carbohydrate research, 371, 52-60 (2013-03-19) PolA1, a putative DNA polymerase I, is coexpressed with PerR and contributes to peroxide stress defenses of group A Streptococcus.Chadia Toukoki et al.Journal of bacteriology, 195(4), 717-725 (2012-12-04) Plumbagin enhances TRAIL-induced apoptosis of human leukemic Kasumi‑1 cells through upregulation of TRAIL death receptor expression, activation of caspase-8 and inhibition of cFLIP.Xiaoyang Kong et al.Oncology reports, 37(6), 3423-3432 (2017-05-13) The anthelmintic effect of plumbagin on Schistosoma mansoni.Natcha Lorsuwannarat et al.Experimental parasitology, 133(1), 18-27 (2012-10-23) Peptidyl-prolyl isomerase 1 (Pin1) preserves the phosphorylation state of tissue factor and prolongs its release within microvesicles.Camille Ettelaie et al.Biochimica et biophysica acta, 1865(1), 12-24 (2017-10-01) Plumbagin alters telomere dynamics, induces DNA damage and cell death in human brain tumour cells.Aik Kia Khaw et al.Mutation research. Genetic toxicology and environmental mutagenesis, 793, 86-95 (2015-11-02) Plumbagin protects against glucocorticoid-induced osteoporosis through Nrf-2 pathway.Shuai Zhang et al.Cell stress & chaperones, 20(4), 621-629 (2015-05-06)

备注