2,2'-[(4-Methylphenyl)imino]bisethanol | CAS:3077-12-1
2,2'-[(4-Methylphenyl)imino]bisethanol
- 名称:N,N-二羟乙基对甲苯胺 | 2,2'-[(4-Methylphenyl)imino]bisethanol
- CAS号:3077-12-1
- 别名:N,N-Dihydroxyethyl-p-toluidine
- 分子式:C11H17NO2
- 分子量:195.26
- EINESC号:221-359-1
产品描述
物理化学性质
熔点 | 49-53 ºC |
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沸点 | 338-340 ºC |
闪点 | 113 ºC |
安全数据
危险品标志 | Xn |
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危险类别码 | R22;R37/38;R41;R52/53 |
安全说明书 | S26;S39;S61 |
产品合成路线
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Mechanisms of antihyperglycaemic action of efaroxan in mice: time for reappraisal of α2A-adrenergic antagonism in the treatment of type 2 diabetes?Z Lehner et al.Diabetologia, 55(11), 3071-3082 (2012-08-18)
Adenosine Triphosphate-Sensitive Potassium Channel Kir Subunits Implicated in Cardioprotection by Diazoxide.Matthew C Henn et al.Journal of the American Heart Association, 4(8), e002016-e002016 (2015-08-26)
Glucose-dependent granule docking limits insulin secretion and Is decreased in human type 2 diabetesGandasi NR, et al. Cell Metabolism, 27(2), 470-478 (2018)
Skeletal muscle post-conditioning by diazoxide, anti-oxidative and anti-apoptotic mechanisms.Mehdi Moghtadaei et al.Molecular biology reports, 39(12), 11093-11103 (2012-10-12)
Co-inheritance of two ABCC8 mutations causing an unresponsive congenital hyperinsulinism: clinical and functional characterization of two novel ABCC8 mutations.Flavio Faletra et al.Gene, 516(1), 122-125 (2012-12-26)
Inhibition of Succinate Dehydrogenase by Diazoxide Is Independent of the ATP-Sensitive Potassium Channel Subunit Sulfonylurea Type 1 Receptor.Melissa M Anastacio et al.Journal of the American College of Surgeons, 216(6), 1144-1149 (2013-03-29)
Opening of astrocytic mitochondrial ATP-sensitive potassium channels upregulates electrical coupling between hippocampal astrocytes in rat brain slices.Jiangping Wang et al.PloS one, 8(2), e56605-e56605 (2013-02-19)
Structural and Dynamic Changes in Mitochondria of Rat Myocardium under Acute Hypoxic Hypoxia: Role of Mitochondrial ATP-Dependent Potassium Channel.E V Rozova et al.Biochemistry. Biokhimiia, 80(8), 994-1000 (2015-11-08)
Pharmacological Preconditioning with Diazoxide in the Experimental Hypothermic Circulatory Arrest ModelHaapanen H, et al. The Heart Surgery Forum (2017)
Glucagon regulates orexin A secretion in humans and rodents.Ayman M Arafat et al.Diabetologia, 57(10), 2108-2116 (2014-07-27)
Late anti-apoptotic effect of K(ATP) channel opening in skeletal muscle.Hossein Farahini et al.Clinical and experimental pharmacology & physiology, 39(11), 909-916 (2012-10-11)
Diazoxide for Lowering Insulin Levels in Breast Cancer Patients.Fink MK and Klement RJ Oncologist, 22(4), 491-491 (2017)
Beneficial effects of adenosine triphosphate-sensitive K+ channel opener on liver ischemia/reperfusion injury.Mateus Antunes Nogueira et al.World journal of gastroenterology, 20(41), 15319-15326 (2014-11-12)
Diazoxide.R Paulissian International anesthesiology clinics, 16(2), 201-237 (1978-01-01)
Diagnosis and treatment of an insulinoma in a guinea pig (Cavia porcellus).Laurie R Hess et al.Journal of the American Veterinary Medical Association, 242(4), 522-526 (2013-02-01)
Po2 cycling protects diaphragm function during reoxygenation via ROS, Akt, ERK, and mitochondrial channels.Li Zuo et al.American journal of physiology. Cell physiology, 309(11), C759-C766 (2015-10-02)
Pharmacokinetics and response to diazoxide in renal failure.R M Pearson Clinical pharmacokinetics, 2(3), 198-204 (1977-05-01)
Inhibitory effects of imperatorin on voltage-gated K(+) channels and ATP-sensitive K(+) channels.Yu-Wen Wang et al.Pharmacological reports : PR, 67(1), 134-139 (2015-01-07)
Multiplicity of effectors of the cardioprotective agent, diazoxide.William A Coetzee Pharmacology & therapeutics, 140(2), 167-175 (2013-06-25)
Congenital hyperinsulinism caused by hexokinase I expression or glucokinase-activating mutation in a subset of β-cells.Jean-Claude Henquin et al.Diabetes, 62(5), 1689-1696 (2013-01-01)
Analysis of mitochondrial 3D-deformation in cardiomyocytes during active contraction reveals passive structural anisotropy of orthogonal short axes.Yael Yaniv et al.PloS one, 6(7), e21985-e21985 (2011-07-23)
Diazoxide: a review of its pharmacological properties and therapeutic use in hypertensive crises. Drugs, 2(2), 78-137 (1971-01-01)
Clinical and molecular characterisation of 300 patients with congenital hyperinsulinism.Ritika R Kapoor et al.European journal of endocrinology, 168(4), 557-564 (2013-01-25)
Cardioprotective mechanism of diazoxide involves the inhibition of succinate dehydrogenase.Melissa M Anastacio et al.The Annals of thoracic surgery, 95(6), 2042-2050 (2013-05-07)
1,4,2-Benzo/pyridodithiazine 1,1-dioxides structurally related to the ATP-sensitive potassium channel openers 1,2,4-Benzo/pyridothiadiazine 1,1-dioxides exert a myorelaxant activity linked to a distinct mechanism of action.Bernard Pirotte et al.Journal of medicinal chemistry, 56(8), 3247-3256 (2013-03-23)
Tolbutamide controls glucagon release from mouse islets differently than glucose: involvement of K(ATP) channels from both α-cells and δ-cells.Rui Cheng-Xue et al.Diabetes, 62(5), 1612-1622 (2013-02-06)
Protective effect of cromakalim and diazoxide, and proulcerogenic effect of glibenclamide on indomethacin-induced gastric injury.F Akar et al.European journal of pharmacology, 374(3), 461-470 (1999-07-28)
Na(+)-H+ exchange inhibition attenuates ischemic injury in rat random pattern skin flap: the role of mitochondrial ATP-sensitive potassium channels.Hamed Emami et al.European journal of pharmacology, 698(1-3), 330-334 (2012-11-06)
The treatment effect of diazoxide on 44 patients with congenital hyperinsulinism.Shuwen Hu et al.Journal of pediatric endocrinology & metabolism : JPEM, 25(11-12), 1119-1122 (2013-01-19)
Diazoxide and the secretion of insulin. Nutrition reviews, 30(8), 194-198 (1972-08-01)
Direct effects of diazoxide on mitochondria in pancreatic B-cells and on isolated liver mitochondria.T Grimmsmann et al.British journal of pharmacology, 123(5), 781-788 (1998-04-16)
[Pharmacodynamical and clinical experimental studies of the treatment of hypoglycemia by diazoxide].A Loubatières et al.La Presse medicale, 75(15), 725-729 (1967-03-25)
The neuroprotective effect of diazoxide is mediated by mitochondrial ATP-dependent potassium channels in a rat model of acute subdural hematoma.Ichiro Nakagawa et al.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 20(1), 144-147 (2012-10-06)
Topology-dependent, bifurcated mitochondrial quality control under starvation.Yanshuang Zhou et al.Autophagy, 16(3), 562-574 (2019-06-27)
KATP channel as well as SGLT1 participates in GIP secretion in the diabetic state.Hidetada Ogata et al.The Journal of endocrinology, 222(2), 191-200 (2014-06-04)
Islet O-GlcNAcylation Is Required for Lipid Potentiation of Insulin Secretion through SERCA2.Amber Lockridge et al.Cell reports, 31(5), 107609-107609 (2020-05-07)
CDK8 Regulates Insulin Secretion and Mediates Postnatal and Stress-Induced Expression of Neuropeptides in Pancreatic β Cells.Jing Xue et al.Cell reports, 28(11), 2892-2904 (2019-09-12)
Mechanisms of antihyperglycaemic action of efaroxan in mice: time for reappraisal of α2A-adrenergic antagonism in the treatment of type 2 diabetes?Z Lehner et al.Diabetologia, 55(11), 3071-3082 (2012-08-18)
Glucose-dependent granule docking limits insulin secretion and Is decreased in human type 2 diabetesGandasi NR, et al. Cell Metabolism, 27(2), 470-478 (2018)
Skeletal muscle post-conditioning by diazoxide, anti-oxidative and anti-apoptotic mechanisms.Mehdi Moghtadaei et al.Molecular biology reports, 39(12), 11093-11103 (2012-10-12)
Co-inheritance of two ABCC8 mutations causing an unresponsive congenital hyperinsulinism: clinical and functional characterization of two novel ABCC8 mutations.Flavio Faletra et al.Gene, 516(1), 122-125 (2012-12-26)
Inhibition of Succinate Dehydrogenase by Diazoxide Is Independent of the ATP-Sensitive Potassium Channel Subunit Sulfonylurea Type 1 Receptor.Melissa M Anastacio et al.Journal of the American College of Surgeons, 216(6), 1144-1149 (2013-03-29)
Opening of astrocytic mitochondrial ATP-sensitive potassium channels upregulates electrical coupling between hippocampal astrocytes in rat brain slices.Jiangping Wang et al.PloS one, 8(2), e56605-e56605 (2013-02-19)
Structural and Dynamic Changes in Mitochondria of Rat Myocardium under Acute Hypoxic Hypoxia: Role of Mitochondrial ATP-Dependent Potassium Channel.E V Rozova et al.Biochemistry. Biokhimiia, 80(8), 994-1000 (2015-11-08)
Pharmacological Preconditioning with Diazoxide in the Experimental Hypothermic Circulatory Arrest ModelHaapanen H, et al. The Heart Surgery Forum (2017)
Glucagon regulates orexin A secretion in humans and rodents.Ayman M Arafat et al.Diabetologia, 57(10), 2108-2116 (2014-07-27)
Adenosine Triphosphate-Sensitive Potassium Channel Kir Subunits Implicated in Cardioprotection by Diazoxide.Matthew C Henn et al.Journal of the American Heart Association, 4(8), e002016-e002016 (2015-08-26)
Diazoxide for Lowering Insulin Levels in Breast Cancer Patients.Fink MK and Klement RJ Oncologist, 22(4), 491-491 (2017)
Beneficial effects of adenosine triphosphate-sensitive K+ channel opener on liver ischemia/reperfusion injury.Mateus Antunes Nogueira et al.World journal of gastroenterology, 20(41), 15319-15326 (2014-11-12)
Diazoxide.R Paulissian International anesthesiology clinics, 16(2), 201-237 (1978-01-01)
Diagnosis and treatment of an insulinoma in a guinea pig (Cavia porcellus).Laurie R Hess et al.Journal of the American Veterinary Medical Association, 242(4), 522-526 (2013-02-01)
Po2 cycling protects diaphragm function during reoxygenation via ROS, Akt, ERK, and mitochondrial channels.Li Zuo et al.American journal of physiology. Cell physiology, 309(11), C759-C766 (2015-10-02)
Pharmacokinetics and response to diazoxide in renal failure.R M Pearson Clinical pharmacokinetics, 2(3), 198-204 (1977-05-01)
Inhibitory effects of imperatorin on voltage-gated K(+) channels and ATP-sensitive K(+) channels.Yu-Wen Wang et al.Pharmacological reports : PR, 67(1), 134-139 (2015-01-07)
Multiplicity of effectors of the cardioprotective agent, diazoxide.William A Coetzee Pharmacology & therapeutics, 140(2), 167-175 (2013-06-25)
Diazoxide and the secretion of insulin. Nutrition reviews, 30(8), 194-198 (1972-08-01)
Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK.Mengqi Li et al.Cell metabolism, 30(3), 508-524 (2019-06-18)
The sulfonylurea receptor 1 (Sur1)-transient receptor potential melastatin 4 (Trpm4) channel.Seung Kyoon Woo et al.The Journal of biological chemistry, 288(5), 3655-3667 (2012-12-21)
GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation.Makoto Shigeto et al.The Journal of clinical investigation, 125(12), 4714-4728 (2015-11-17)
Stability of diazoxide in extemporaneously compounded oral suspensionsFriciu M, et al. Testing, 11(10), e0164577-e0164577 (2016)
Diazoxide in the treatment of hypertensive crisis a series of 23 patients and a review of the literature.D I Cameron East African medical journal, 53(7), 357-365 (1976-07-01)
NMR and fluorescence studies of drug binding to the first nucleotide binding domain of SUR2A.Jorge P López-Alonso et al.Biochemistry, 51(45), 9211-9222 (2012-10-20)
Na(+)-H+ exchange inhibition attenuates ischemic injury in rat random pattern skin flap: the role of mitochondrial ATP-sensitive potassium channels.Hamed Emami et al.European journal of pharmacology, 698(1-3), 330-334 (2012-11-06)
Congenital hyperinsulinism caused by hexokinase I expression or glucokinase-activating mutation in a subset of β-cells.Jean-Claude Henquin et al.Diabetes, 62(5), 1689-1696 (2013-01-01)
The treatment effect of diazoxide on 44 patients with congenital hyperinsulinism.Shuwen Hu et al.Journal of pediatric endocrinology & metabolism : JPEM, 25(11-12), 1119-1122 (2013-01-19)
Direct effects of diazoxide on mitochondria in pancreatic B-cells and on isolated liver mitochondria.T Grimmsmann et al.British journal of pharmacology, 123(5), 781-788 (1998-04-16)
[Pharmacodynamical and clinical experimental studies of the treatment of hypoglycemia by diazoxide].A Loubatières et al.La Presse medicale, 75(15), 725-729 (1967-03-25)
The neuroprotective effect of diazoxide is mediated by mitochondrial ATP-dependent potassium channels in a rat model of acute subdural hematoma.Ichiro Nakagawa et al.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 20(1), 144-147 (2012-10-06)
Topology-dependent, bifurcated mitochondrial quality control under starvation.Yanshuang Zhou et al.Autophagy, 16(3), 562-574 (2019-06-27)
KATP channel as well as SGLT1 participates in GIP secretion in the diabetic state.Hidetada Ogata et al.The Journal of endocrinology, 222(2), 191-200 (2014-06-04)
Islet O-GlcNAcylation Is Required for Lipid Potentiation of Insulin Secretion through SERCA2.Amber Lockridge et al.Cell reports, 31(5), 107609-107609 (2020-05-07)
CDK8 Regulates Insulin Secretion and Mediates Postnatal and Stress-Induced Expression of Neuropeptides in Pancreatic β Cells.Jing Xue et al.Cell reports, 28(11), 2892-2904 (2019-09-12)
Late anti-apoptotic effect of K(ATP) channel opening in skeletal muscle.Hossein Farahini et al.Clinical and experimental pharmacology & physiology, 39(11), 909-916 (2012-10-11)
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