熔点	-93 ºC
水溶性	分解. 5-10 g/100 mL at 23 ºC
沸点	97 ºC
闪点	6 ºC
密度	0.77
折射率	1.365-1.367

危险品标志	F;T
危险类别码	R11;R23/24/25
安全说明书	S16;S27;S45

来源	SDS样本
没有数据	没有数据

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Negative effects of long-term feeding of high-grain diets to lactating goats on milk fat production and composition by regulating gene expression and DNA methylation in the mammary gland.Ping Tian et al.Journal of animal science and biotechnology, 8, 74-74 (2017-10-14) Anticodon domain methylated nucleosides of yeast tRNA(Phe) are significant recognition determinants in the binding of a phage display selected peptide.P Mucha et al.Biochemistry, 40(47), 14191-14199 (2001-11-21) Monitoring of urinary excretion of modified nucleosides in cancer patients using a set of six monoclonal antibodies.C Reynaud et al.Cancer letters, 61(3), 255-262 (1992-01-31) Sequence- and base-specific delivery of nitric oxide to cytidine and 5-methylcytidine leading to efficient deamination.Md Monsur Ali et al.Journal of the American Chemical Society, 126(29), 8864-8865 (2004-07-22) Accurate measurement of DNA methylation that is traceable to the international system of units.Daniel G Burke et al.Analytical chemistry, 81(17), 7294-7301 (2009-09-01) DNA Methyltransferases - Role and Function, 30-30 (2016) A prominent and conserved role for YY1 in Xist transcriptional activation.Mélanie Makhlouf et al.Nature communications, 5, 4878-4878 (2014-09-12) Electrochemical DNA methylation detection for enzymatically digested CpG oligonucleotides.Dai Kato et al.Analytical chemistry, 83(20), 7595-7599 (2011-09-13) Three serum metabolite signatures for diagnosing low-grade and high-grade bladder cancer.Guangguo Tan et al.Scientific reports, 7, 46176-46176 (2017-04-07) Using Accurate Mass Gas Chromatography-Mass Spectrometry with the MINE Database for Epimetabolite Annotation.Zijuan Lai et al.Analytical chemistry, 89(19), 10171-10180 (2017-09-07) Photophysical properties of 5-methylcytidine.Alexei Sharonov et al.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2(4), 362-364 (2003-05-23) Exploitation of Synthetic mRNA To Drive Immune Effector Cell Recruitment and Functional Reprogramming In Vivo.Yitian Xu et al.Journal of immunology (Baltimore, Md. : 1950), 202(2), 608-617 (2018-12-14) Prevention of age-related changes in hippocampal levels of 5-methylcytidine by caloric restriction.Leonidas Chouliaras et al.Neurobiology of aging, 33(8), 1672-1681 (2011-07-19) Viable Mice with Extensive Gene Humanization (25-kbp) Created Using Embryonic Stem Cell/Blastocyst and CRISPR/Zygote Injection Approaches.Tiffany Leidy-Davis et al.Scientific reports, 8(1), 15028-15028 (2018-10-12) Kilo-scale synthesis process for 2'-O-(2-methoxyethyl)-pyrimidine derivatives.Bruce S Ross et al.Nucleosides, nucleotides & nucleic acids, 24(5-7), 815-818 (2005-10-27) Selective derivatization of cytosine and methylcytosine moieties with 2-bromoacetophenone for submicrogram DNA methylation analysis by reversed phase HPLC with spectrofluorimetric detection.Adolfo Lopez Torres et al.Analytical chemistry, 83(20), 7999-8005 (2011-09-13) Epigenetic alterations in TRAMP mice: epigenome DNA methylation profiling using MeDIP-seq.Wenji Li et al.Cell & bioscience, 8, 3-3 (2018-01-19) Chemically-induced DNA de-methylation alters the effectiveness of microspore embryogenesis in triticale.Anna Nowicka et al.Plant science : an international journal of experimental plant biology, 287, 110189-110189 (2019-09-05) Measurement of genome wide DNA methylation by reversed-phase high-performance liquid chromatography.B H Ramsahoye Methods (San Diego, Calif.), 27(2), 156-161 (2002-07-04) PEA15 regulates the DNA damage-induced cell cycle checkpoint and oncogene-directed transformation.Arvindhan Nagarajan et al.Molecular and cellular biology, 34(12), 2264-2282 (2014-04-09) NAIL-MS reveals the repair of 2-methylthiocytidine by AlkB in E. coli.Valentin F Reichle et al.Nature communications, 10(1), 5600-5600 (2019-12-08) Advances in Carbohydrate Chemistry, Volume 14, 291-291 (1959) Co-delivery of nucleoside-modified mRNA and TLR agonists for cancer immunotherapy: Restoring the immunogenicity of immunosilent mRNA.Rein Verbeke et al.Journal of controlled release : official journal of the Controlled Release Society, 266, 287-300 (2017-10-11) Alteration of DNA demethylation dynamics by in vitro culture conditions in rabbit pre-implantation embryos.Adriana R Reis e Silva et al.Epigenetics, 7(5), 440-446 (2012-03-16) Role of RNA methyltransferases in tissue renewal and pathology.Sandra Blanco et al.Current opinion in cell biology, 31, 1-7 (2014-07-12) Maternal dietary manganese protects chick embryos against maternal heat stress via epigenetic-activated antioxidant and anti-apoptotic abilities.Yongwen Zhu et al.Oncotarget, 8(52), 89665-89680 (2017-11-23) 5-Methyldeoxycytidine monophosphate deaminase and 5-methylcytidyl-DNA deaminase activities are present in human mature sperm cells.Jean Pierre Jost et al.FEBS letters, 519(1-3), 128-134 (2002-05-23) Least absolute shrinkage and selection operator and dimensionality reduction techniques in quantitative structure retention relationship modeling of retention in hydrophilic interaction liquid chromatography.Emilia Daghir-Wojtkowiak et al.Journal of chromatography. A, 1403, 54-62 (2015-06-04) A rapid and sensitive method for quantitation of nucleosides in human urine using liquid chromatography/mass spectrometry with direct urine injection.Sang Hee Lee et al.Rapid communications in mass spectrometry : RCM, 18(9), 973-977 (2004-04-30) Feeders facilitate telomere maintenance and chromosomal stability of embryonic stem cells.Renpeng Guo et al.Nature communications, 9(1), 2620-2620 (2018-07-07) Modified Foxp3 mRNA protects against asthma through an IL-10-dependent mechanism.Lauren E Mays et al.The Journal of clinical investigation, 123(3), 1216-1228 (2013-02-09) Contribution of AT-, GC-, and methylated cytidine-rich DNA to chromatin composition in Malpighian tubule cell nuclei of Panstrongylus megistus (Hemiptera, Reduviidae).Elenice M Alvarenga et al.Acta histochemica, 114(7), 665-672 (2011-12-27) The interfering effects of superovulation and vitrification upon some important epigenetic biomarkers in mouse blastocyst.Azizollah Bakhtari et al.Cryobiology, 69(3), 419-427 (2014-10-14) In Vitro Transcribed mRNA Vaccines with Programmable Stimulation of Innate Immunity.Kristin H Loomis et al.Bioconjugate chemistry, 29(9), 3072-3083 (2018-08-02) Association of hypomethylation of LINE-1 repetitive element in blood leukocyte DNA with an increased risk of hepatocellular carcinoma.Di JZ, Han XD, Gu WY, et al. Journal of Zhejiang University. Science, 12, 805-811 (2011) Sex-specific chromatin landscapes in an ultra-compact chordate genome.Pavla Navratilova et al.Epigenetics & chromatin, 10, 3-3 (2017-01-25) Protective effects of zinc on rat sperm chromatin integrity involvement: DNA methylation, DNA fragmentation, ubiquitination and protamination after bleomycin etoposide and cis-platin treatment.Farnaz Khadivi et al.Theriogenology, 142, 177-183 (2019-10-11) The nature of cancer and the mechanisms of its control: a review.L C Strong Cytobios, 28(111-112), 187-208 (1980-01-01) Nucleotide Modification Alters MicroRNA-Dependent Silencing of MicroRNA Switches.John Lockhart et al.Molecular therapy. Nucleic acids, 14, 339-350 (2019-01-22) Observing the fate of tRNA and its modifications by nucleic acid isotope labeling mass spectrometry: NAIL-MS.Matthias Heiss et al.RNA biology, 14(9), 1260-1268 (2017-05-11) The Primary Structure of Transfer RNA, 252-252 (2012) The involvement of DNA and histone methylation in the repression of IL-1β-induced MCP-1 production by hypoxia.Yoko Aoi et al.Biochemical and biophysical research communications, 414(1), 252-258 (2011-09-29) AlkB Homologue 1 Demethylates N3-Methylcytidine in mRNA of Mammals.Cheng-Jie Ma et al.ACS chemical biology, 14(7), 1418-1425 (2019-06-13) A novel method to assess the full genome methylation profile using monoclonal antibody combined with the high throughput based microarray approach.Ashwin Kelkar et al.Epigenetics, 4(6), 415-420 (2009-09-17) Flow-dependent epigenetic DNA methylation regulates endothelial gene expression and atherosclerosis.Jessilyn Dunn et al.The Journal of clinical investigation, 124(7), 3187-3199 (2014-05-29) Epigenetic and SP1-mediated regulation is involved in the repression of galactokinase 1 gene in the liver of neonatal piglets born to betaine-supplemented sows.Demin Cai et al.European journal of nutrition, 56(5), 1899-1909 (2016-06-03) Exogenous Delivery of Link N mRNA into Chondrocytes and MSCs-The Potential Role in Increasing Anabolic Response.Gauri Tendulkar et al.International journal of molecular sciences, 20(7) (2019-04-10) Exploring the protective effects of schizandrol A in acute myocardial ischemia mice by comprehensive metabolomics profiling integrated with molecular mechanism studies.Qiong Lai et al.Acta pharmacologica Sinica, 41(8), 1058-1072 (2020-03-04) QSEA-modelling of genome-wide DNA methylation from sequencing enrichment experiments.Matthias Lienhard et al.Nucleic acids research, 45(6), e44-e44 (2016-12-04) Distinct nuclear organization, DNA methylation pattern and cytokinin distribution mark juvenile, juvenile-like and adult vegetative apical meristems in peach (Prunus persica (L.) Batsch).Maria Beatrice Bitonti et al.Journal of experimental botany, 53(371), 1047-1054 (2002-04-25) Genome-wide screening of aberrant DNA methylation which associated with gene expression in mouse skin cancers.Kyoko Fujiwara et al.Molecular carcinogenesis, 54(3), 178-188 (2013-10-12) Transcriptome-wide mapping of 5-methylcytidine RNA modifications in bacteria, archaea, and yeast reveals m5C within archaeal mRNAs.Sarit Edelheit et al.PLoS genetics, 9(6), e1003602-e1003602 (2013-07-05) Experience-dependent DNA methylation regulates plasticity in the developing visual cortex.Paola Tognini et al.Nature neuroscience, 18(7), 956-958 (2015-05-26) Successful reprogramming of cellular protein production through mRNA delivered by functionalized lipid nanoparticles.Marianna Yanez Arteta et al.Proceedings of the National Academy of Sciences of the United States of America, 115(15), E3351-E3360 (2018-03-29) DNA Damage Signaling-Induced Cancer Cell Reprogramming as a Driver of Tumor Relapse.Doria Filipponi et al.Molecular cell, 74(4), 651-663 (2019-04-08) Effect of vitrification onJianfeng Yao et al.Reproduction (Cambridge, England), 154(3), 97-105 (2017-07-12) A 5-methylcytosine DNA glycosylase/lyase demethylates the retrotransposon Tos17 and promotes its transposition in rice.Honggui La et al.Proceedings of the National Academy of Sciences of the United States of America, 108(37), 15498-15503 (2011-09-08) Incorporation of two modified nucleosides allows selective platination of an oligonucleotide making it suitable for duplex cross-linking.Berta Algueró et al.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 12(6), 901-911 (2007-05-31) USP7 negatively controls global DNA methylation by attenuating ubiquitinated histone-dependent DNMT1 recruitment.Jialun Li et al.Cell discovery, 6, 58-58 (2020-09-05) Comparative dynamics of 5-methylcytosine reprogramming and TET family expression during preimplantation mammalian development in mouse and sheep.F Jafarpour et al.Theriogenology, 89, 86-96 (2017-01-04) Nanomechanical recognition measurements of individual DNA molecules reveal epigenetic methylation patterns.Rong Zhu et al.Nature nanotechnology, 5(11), 788-791 (2010-11-03) Antioxidant responses and deregulation of epigenetic writers and erasers link oxidative stress and DNA methylation in bovine blastocysts.Monalisa M Bomfim et al.Molecular reproduction and development, 84(12), 1296-1305 (2017-11-07) Identification of epigenetically altered genes in sporadic amyotrophic lateral sclerosis.Claudia Figueroa-Romero et al.PloS one, 7(12), e52672-e52672 (2013-01-10) Regulatory network decoded from epigenomes of surface ectoderm-derived cell types.Rebecca F Lowdon et al.Nature communications, 5, 5442-5442 (2014-11-26) The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes.Tian-Peng Gu et al.Nature, 477(7366), 606-610 (2011-09-06) Maternal dietary zinc supplementation enhances the epigenetic-activated antioxidant ability of chick embryos from maternal normal and high temperatures.Yongwen Zhu et al.Oncotarget, 8(12), 19814-19824 (2017-02-09) Transgenerational Inheritance of Betaine-Induced Epigenetic Alterations in Estrogen-Responsive IGF-2/IGFBP2 Genes in Rat Hippocampus.Yang Yang et al.Molecular nutrition & food research, 64(8), e1900823-e1900823 (2020-02-06) CMP substitutions preferentially inhibit polysialic acid synthesis.Tatsuo Miyazaki et al.Glycobiology, 18(2), 187-194 (2007-12-14) High-resolution ion mobility spectrometry-mass spectrometry of isomeric/isobaric ribonucleotide variants.Thomas Kenderdine et al.Journal of mass spectrometry : JMS, 55(2), e4465-e4465 (2019-11-08) A Molecular Tool Targeting the Base-Flipping Activity of Human UHRF1.Liliyana Zaayter et al.Chemistry (Weinheim an der Bergstrasse, Germany), 25(58), 13363-13375 (2019-07-20) DNA methylation and differential gene regulation in photoreceptor cell death.P Farinelli et al.Cell death & disease, 5, e1558-e1558 (2014-12-06) WUSCHEL triggers innate antiviral immunity in plant stem cells.Haijun Wu et al.Science (New York, N.Y.), 370(6513), 227-231 (2020-10-10) AZA-MS: a novel multiparameter mass spectrometry method to determine the intracellular dynamics of azacitidine therapy in vivo.A Unnikrishnan et al.Leukemia, 32(4), 900-910 (2017-12-19) Molecular biology. Demystifying DNA demethylation.Christopher S Nabel et al.Science (New York, N.Y.), 333(6047), 1229-1230 (2011-09-03) rRNA adenine methylation requires T07A9.8 gene as rram-1 in Caenorhabditis elegans.Wataru Yokoyama et al.Journal of biochemistry, 163(6), 465-474 (2018-02-01) Cystine-glutamate antiporter xCT deficiency suppresses tumor growth while preserving antitumor immunity.Michael D Arensman et al.Proceedings of the National Academy of Sciences of the United States of America, 116(19), 9533-9542 (2019-04-26) Embryonic development, locomotor behavior, biochemical, and epigenetic effects of the pharmaceutical drugs paracetamol and ciprofloxacin in larvae and embryos of Danio rerio when exposed to environmental realistic levels of both drugs.Ana F Nogueira et al.Environmental toxicology, 34(11), 1177-1190 (2019-07-20) Global DNA methylation is altered by neoadjuvant chemoradiotherapy in rectal cancer and may predict response to treatment - A pilot study.J S Tsang et al.European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 40(11), 1459-1466 (2014-08-12) Heavy Metals Induce Decline of Derivatives of 5-Methycytosine in Both DNA and RNA of Stem Cells.Jun Xiong et al.ACS chemical biology, 12(6), 1636-1643 (2017-04-28) Activation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: implications for epigenetic reprogramming.Hugh D Morgan et al.The Journal of biological chemistry, 279(50), 52353-52360 (2004-09-28) In Ovo injection of betaine affects hepatic cholesterol metabolism through epigenetic gene regulation in newly hatched chicks.Yun Hu et al.PloS one, 10(4), e0122643-e0122643 (2015-04-11) Elongator mutation in mice induces neurodegeneration and ataxia-like behavior.Marija Kojic et al.Nature communications, 9(1), 3195-3195 (2018-08-12) MicroRNAs Induce a Permissive Chromatin Environment that Enables Neuronal Subtype-Specific Reprogramming of Adult Human Fibroblasts.Daniel G Abernathy et al.Cell stem cell, 21(3), 332-348 (2017-09-09) Role of urinary cations in the etiology of interstitial cystitis: A multisite study.C Lowell Parsons et al.International journal of urology : official journal of the Japanese Urological Association, 27(9), 731-735 (2020-07-18) Immunochemical detection of urinary 5-methyl-2'-deoxycytidine as a potential biologic marker for leukemia.K Itoh et al.Clinica chimica acta; international journal of clinical chemistry, 234(1-2), 37-45 (1995-01-31) Allium cepa L. Response to Sodium Selenite (Se(IV)) Studied in Plant Roots by a LC-MS-Based Proteomic Approach.Jakub Karasinski et al.Journal of agricultural and food chemistry, 65(19), 3995-4004 (2017-05-04) Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA.Katalin Karikó et al.Nucleic acids research, 39(21), e142-e142 (2011-09-06) Inhibition of a G9a/DNMT network triggers immune-mediated bladder cancer regression.Cristina Segovia et al.Nature medicine, 25(7), 1073-1081 (2019-07-05) Global DNA Methylation and Histone Posttranslational Modifications in Human and Nonhuman Primate Brain in Association with Prenatal Alcohol Exposure.Jessica S Jarmasz et al.Alcoholism, clinical and experimental research, 43(6), 1145-1162 (2019-05-11) Treatment with mRNA coding for the necroptosis mediator MLKL induces antitumor immunity directed against neo-epitopes.Lien Van Hoecke et al.Nature communications, 9(1), 3417-3417 (2018-08-26) Modulation of the immune system during postpartum uterine inflammation.Caroline G Walker et al.Physiological genomics, 47(4), 89-101 (2015-01-22) Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients.Leonidas Chouliaras et al.Neurobiology of aging, 34(9), 2091-2099 (2013-04-16) N 1-Methylpseudouridine substitution enhances the performance of synthetic mRNA switches in cells.Callum J C Parr et al.Nucleic acids research, 48(6), e35-e35 (2020-02-25) Determination of ribavirin in human serum and plasma by capillary electrophoresis.Michael C Breadmore et al.Electrophoresis, 25(10-11), 1615-1622 (2004-06-10) Chemical allergen induced perturbations of the mouse lymph node DNA methylome.Victoria Louise Chapman et al.Toxicological sciences : an official journal of the Society of Toxicology, 139(2), 350-361 (2014-03-29) Label-free DNA methylation analysis using opto-fluidic ring resonators.Jonathan D Suter et al.Biosensors & bioelectronics, 26(3), 1016-1020 (2010-09-18) Global DNA methylation as a possible biomarker for diabetic retinopathyMaghbooli Z, et al. Diabetes/metabolism Research and Reviews, 31(2), 183-189 (2015) Multi-site-specific 16S rRNA methyltransferase RsmF from Thermus thermophilus.Hasan Demirci et al.RNA (New York, N.Y.), 16(8), 1584-1596 (2010-06-19) A cross-talk between DNA methylation and H3 lysine 9 dimethylation at the KvDMR1 region controls the induction of Cdkn1c in muscle cells.Oriella Andresini et al.Epigenetics, 11(11), 791-803 (2016-10-25) Metabolic profiling of asthma in mice and the interventional effects of SPA using liquid chromatography and Q-TOF mass spectrometry.Li Su et al.Molecular bioSystems, 13(6), 1172-1181 (2017-05-04) tRNAHis 5-methylcytidine levels increase in response to several growth arrest conditions in Saccharomyces cerevisiae.Melanie A Preston et al.RNA (New York, N.Y.), 19(2), 243-256 (2012-12-20) Titrimetric immunohistochemical evaluation of DNA hypomethylation in uterine tumours.M Wolk et al.Journal of clinical pathology, 62(11), 1039-1042 (2009-10-29)

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