熔点	-90 ºC
水溶性	2 g/100 mL
沸点	132 ºC
闪点	41 ºC
密度	0.8
折射率	1.41-1.412

危险品标志	Xi
危险类别码	R10;R37
安全说明书	S24/25

来源	SDS样本
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On the toxicity of kynurenic acid in vivo and in vitro.Waldemar A Turski et al.Pharmacological reports : PR, 66(6), 1127-1133 (2014-12-03) Decreased surface expression of the δ subunit of the GABAA receptor contributes to reduced tonic inhibition in dentate granule cells in a mouse model of fragile X syndrome.Nianhui Zhang et al.Experimental neurology, 297, 168-178 (2017-08-22) The synthetic cannabinoid 5F-AMB changes the balance between excitation and inhibition of layer V pyramidal neurons in the mouse medial prefrontal cortex.Masaki Domoto et al.Psychopharmacology, 235(8), 2367-2376 (2018-06-03) RBFOX3/NeuN is Required for Hippocampal Circuit Balance and Function.Han-Ying Wang et al.Scientific reports, 5, 17383-17383 (2015-12-02) Periaqueductal efferents to dopamine and GABA neurons of the VTA.Niels R Ntamati et al.PloS one, 13(1), e0190297-e0190297 (2018-01-06) Gene and protein expressions and metabolomics exhibit activated redox signaling and wnt/β-catenin pathway are associated with metabolite dysfunction in patients with chronic kidney disease.Dan-Qian Chen et al.Redox biology, 12, 505-521 (2017-03-28) Endocannabinoid Signaling Mediates Local Dendritic Coordination between Excitatory and Inhibitory Synapses.Hai Yin Hu et al.Cell reports, 27(3), 666-675 (2019-04-18) 3D Culture Method for Alzheimer's Disease Modeling Reveals Interleukin-4 Rescues Aβ42-Induced Loss of Human Neural Stem Cell Plasticity.Christos Papadimitriou et al.Developmental cell, 46(1), 85-101 (2018-07-06) Agmatine preferentially antagonizes GluN2B-containing N-methyl-d-aspartate receptors in spinal cord.Jonathan J Waataja et al.Journal of neurophysiology, 121(2), 662-671 (2018-11-15) Most vesicles in a central nerve terminal participate in recycling.Lei Xue et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(20), 8820-8826 (2013-05-17) The role of the optic tectum for visually evoked orienting and evasive movements.Daichi G Suzuki et al.Proceedings of the National Academy of Sciences of the United States of America, 116(30), 15272-15281 (2019-07-13) Relevance of Alternative Routes of Kynurenic Acid Production in the BrainRamos-Chavez LA, et al. Oxidative Medicine and Cellular Longevity, 2018 (2018) Kynurenine Pathway Activation in Human African Trypanosomiasis.Jeremy M Sternberg et al.The Journal of infectious diseases, 215(5), 806-812 (2016-12-26) Chronic dietary supplementation with kynurenic acid, a neuroactive metabolite of tryptophan, decreased body weight without negative influence on densitometry and mandibular bone biomechanical endurance in young rats.Ewa Tomaszewska et al.PloS one, 14(12), e0226205-e0226205 (2019-12-07) Ultrastructural Correlates of Presynaptic Functional Heterogeneity in Hippocampal Synapses.Lydia Maus et al.Cell reports, 30(11), 3632-3643 (2020-03-19) Neural stem and progenitor cells in the aged subependyma are activated by the young niche.David Piccin et al.Neurobiology of aging, 35(7), 1669-1679 (2014-02-25) Sensory lesioning induces microglial synapse elimination via ADAM10 and fractalkine signaling.Georgia Gunner et al.Nature neuroscience, 22(7), 1075-1088 (2019-06-19) Role of an excitatory preoptic-raphé pathway in febrile vasoconstriction of the rat's tail.Mutsumi Tanaka et al.American journal of physiology. Regulatory, integrative and comparative physiology, 305(12), R1479-R1489 (2013-10-18) Ketamine promotes rapid and transient activation of AMPA receptor-mediated synaptic transmission in the dorsal raphe nucleus.Nerea Llamosas et al.Progress in neuro-psychopharmacology & biological psychiatry, 88, 243-252 (2018-08-04) Hippocampal hyperexcitability and specific epileptiform activity in a mouse model of Dravet syndrome.Camille Liautard et al.Epilepsia, 54(7), 1251-1261 (2013-05-15) Simultaneous voltammetric analysis of tryptophan and kynurenine in culture medium from human cancer cells.Ilona Sadok et al.Talanta, 209, 120574-120574 (2020-01-02) Early Maternal and Social Deprivation Expands Neural Stem Cell Population Size and Reduces Hippocampus/Amygdala-Dependent Fear Memory.Kenny Anak Daun et al.Frontiers in neuroscience, 14, 22-22 (2020-02-18) Shifts in Ribosome Engagement Impact Key Gene Sets in Neurodevelopment and Ubiquitination in Rett Syndrome.Deivid C Rodrigues et al.Cell reports, 30(12), 4179-4196 (2020-03-27) Oxytocin increases inhibitory synaptic transmission and blocks development of long-term potentiation in the lateral amygdala.J W Crane et al.Journal of neurophysiology, 123(2), 587-599 (2020-01-01) Serum kynurenic acid: possible association with invasiveness of non-small cell lung cancer.Dariusz Sagan et al.Asian Pacific journal of cancer prevention : APJCP, 13(9), 4241-4244 (2012-11-22) Poor transcript-protein correlation in the brain: negatively correlating gene products reveal neuronal polarity as a potential cause.Christian P Moritz et al.Journal of neurochemistry, 149(5), 582-604 (2019-01-22) A non-target urinary and serum metabolomics strategy reveals therapeutical mechanism of Radix Astragali on adjuvant-induced arthritis rats.Tengfei Xu et al.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1048, 94-101 (2017-02-25) Non-neuronal, slow GABA signalling in the ventrobasal thalamus targets δ-subunit-containing GABA(A) receptors.Cristina Jiménez-González et al.The European journal of neuroscience, 33(8), 1471-1482 (2011-03-15) Increased Serotonin Transporter Expression Reduces Fear and Recruitment of Parvalbumin Interneurons of the Amygdala.Marco Bocchio et al.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 40(13), 3015-3026 (2015-06-09) Monitoring tryptophan metabolism after exposure to hexaconazole and the enantioselective metabolism of hexaconazole in rat hepatocytes in vitro.Yao Wang et al.Journal of hazardous materials, 295, 9-16 (2015-04-13) Neural Programmatic Role of Leptin, TNFα, Melanocortin, and Glutamate in Blood Pressure Regulation vs Obesity-Related Hypertension in Male C57BL/6 Mice.Bin Yu et al.Endocrinology, 158(6), 1766-1775 (2017-04-19) Protein-Bound Uremic Toxins in Hemodialysis Patients Relate to Residual Kidney Function, Are Not Influenced by Convective Transport, and Do Not Relate to Outcome.Maaike K van Gelder et al.Toxins, 12(4) (2020-04-11) Morphological and functional properties distinguish the substance P and gastrin-releasing peptide subsets of excitatory interneuron in the spinal cord dorsal horn.Allen C Dickie et al.Pain, 160(2), 442-462 (2018-09-25) Characteristic analyses of a neural differentiation model from iPSC-derived neuron according to morphology, physiology, and global gene expression pattern.Sai Kang et al.Scientific reports, 7(1), 12233-12233 (2017-09-28) The brain metabolite kynurenic acid inhibits alpha7 nicotinic receptor activity and increases non-alpha7 nicotinic receptor expression: physiopathological implications.C Hilmas et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 21(19), 7463-7473 (2001-09-22) Neuronal Chloride Regulation via KCC2 Is Modulated through a GABAB Receptor Protein Complex.Rebecca Wright et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 37(22), 5447-5462 (2017-04-30) LC-MS/MS-Based Profiling of Tryptophan-Related Metabolites in Healthy Plant Foods.Sara Vitalini et al.Molecules (Basel, Switzerland), 25(2) (2020-01-17) Lipocalin 2 modulates the cellular response to amyloid beta.S D Mesquita et al.Cell death and differentiation, 21(10), 1588-1599 (2014-05-24) Associations between tryptophan and iron metabolism observed in individuals with and without iron deficiency.Julian Wenninger et al.Scientific reports, 9(1), 14548-14548 (2019-10-12) Reduced tonic inhibition in the dentate gyrus contributes to chronic stress-induced impairments in learning and memory.Vallent Lee et al.Hippocampus, 26(10), 1276-1290 (2016-05-11) Central mineralocorticoid receptors and the role of angiotensin II and glutamate in the paraventricular nucleus of rats with angiotensin II-induced hypertension.Alexander Gabor et al.Hypertension (Dallas, Tex. : 1979), 61(5), 1083-1090 (2013-03-20) The L-type voltage-gated calcium channel CaStephanie J Temme et al.Learning & memory (Cold Spring Harbor, N.Y.), 24(11), 580-588 (2017-10-19) Protective activity of α-lactoalbumin (ALAC), a whey protein rich in tryptophan, in rodent models of epileptogenesis.E Russo et al.Neuroscience, 226, 282-288 (2012-09-25) Role of kynurenines in the neurotoxic actions of kainic acid.W M Behan et al.British journal of pharmacology, 129(8), 1764-1770 (2000-04-26) From Memory Impairment to Posttraumatic Stress Disorder-Like Phenotypes: The Critical Role of an Unpredictable Second Traumatic Experience.Charles Finsterwald et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(48), 15903-15915 (2015-12-04) SSRIs target prefrontal to raphe circuits during development modulating synaptic connectivity and emotional behavior.M Soiza-Reilly et al.Molecular psychiatry, 24(5), 726-745 (2018-10-04) Corticotropin-releasing factor enhances inhibitory synaptic transmission to type III neurons in the bed nucleus of the stria terminalis.Yusuke Nagano et al.Neuroscience letters, 600, 56-61 (2015-06-06) Bioorthogonal Labeling Reveals Different Expression of Glycans in Mouse Hippocampal Neuron Cultures during Their Development.Diana Soares da Costa et al.Molecules (Basel, Switzerland), 25(4) (2020-02-16) Morphine activation of mu opioid receptors causes disinhibition of neurons in the ventral tegmental area mediated by β-arrestin2 and c-Src.Fiona A Bull et al.Scientific reports, 7(1), 9969-9969 (2017-09-01) Biosynthesis of 8-hydroxyquinoline-2-carboxylic acid, an iron chelator from the gut of the lepidopteran Spodoptera littoralis.Jelena Pesek et al.Organic & biomolecular chemistry, 13(1), 178-184 (2014-10-31) Metabolism and neuropathologic significance of quinolinic acid and kynurenic acid.M P Heyes Biochemical Society transactions, 21(1), 83-89 (1993-02-01) Axonal organization defects in the hippocampus of adult conditional BACE1 knockout mice.Ming-Hsuan Ou-Yang et al.Science translational medicine, 10(459) (2018-09-21) Contributions of the Hippocampal CA3 Circuitry to Acute Seizures and Hyperexcitability Responses in Mouse Models of Brain Ischemia.Hongmei Song et al.Frontiers in cellular neuroscience, 12, 278-278 (2018-09-14) Minocycline Directly Enhances the Self-Renewal of Adult Neural Precursor Cells.Anri Kuroda et al.Neurochemical research, 43(1), 219-226 (2017-10-31) Repeated toluene exposure alters the synaptic transmission of layer 5 medial prefrontal cortex.Silvia L Cruz et al.Neurotoxicology and teratology, 73, 9-14 (2019-03-04) Overactivity of Liver-Related Neurons in the Paraventricular Nucleus of the Hypothalamus: Electrophysiological Findings inHong Gao et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 37(46), 11140-11150 (2017-10-19) Delta glutamate receptor conductance drives excitation of mouse dorsal raphe neurons.Stephanie C Gantz et al.eLife, 9 (2020-04-03) NMDA Receptors Regulate the Development of Neuronal Intrinsic Excitability through Cell-Autonomous Mechanisms.Guoqiang Hou et al.Frontiers in cellular neuroscience, 11, 353-353 (2017-11-23) Spinal Neuropeptide Y1 Receptor-Expressing Neurons Form an Essential Excitatory Pathway for Mechanical Itch.David Acton et al.Cell reports, 28(3), 625-639 (2019-07-18) Dysregulated expression of monoacylglycerol lipase is a marker for anti-diabetic drug metformin-targeted therapy to correct impaired neurogenesis and spatial memory in Alzheimer's disease.Charvi Syal et al.Theranostics, 10(14), 6337-6360 (2020-06-03) Role of ventral medullary catecholaminergic neurons for respiratory modulation of sympathetic outflow in rats.Davi J A Moraes et al.Scientific reports, 7(1), 16883-16883 (2017-12-06) Caudal ventrolateral medulla mediates baroreceptor afferent inputs to subfornical organ angiotensin II responsive neurons.John Ciriello Brain research, 1491, 127-135 (2012-11-13) Muscarinic M1 receptors regulate propofol modulation of GABAergic transmission in rat ventrolateral preoptic neurons.Yu Zhang et al.Journal of molecular neuroscience : MN, 55(4), 830-835 (2014-10-09) RE1 silencing transcription factor/neuron-restrictive silencing factor regulates expansion of adult mouse subventricular zone-derived neural stem/progenitor cells in vitro.Chiara Soldati et al.Journal of neuroscience research, 93(8), 1203-1214 (2015-02-19) Egr-1 Maintains NSC Proliferation and Its Overexpression Counteracts Cell Cycle Exit Triggered by the Withdrawal of Epidermal Growth Factor.Arcangela Anna Cera et al.Developmental neuroscience, 40(3), 223-233 (2018-07-06) Oral Glucose Tolerance and Tryptophan Metabolism in Non-Obese and Non-Insulin-Dependent Diabetic Goto-Kakizaki Rats Fed High-Tryptophan Diets.Eri Imai et al.Journal of nutritional science and vitaminology, 64(1), 48-55 (2018-03-02) Dlx1 and Dlx2 Promote Interneuron GABA Synthesis, Synaptogenesis, and Dendritogenesis.Ramon Pla et al.Cerebral cortex (New York, N.Y. : 1991), 28(11), 3797-3815 (2017-10-14) Pathological modeling of TBEV infection reveals differential innate immune responses in human neurons and astrocytes that correlate with their susceptibility to infection.Mazigh Fares et al.Journal of neuroinflammation, 17(1), 76-76 (2020-03-05) Development of simultaneous analysis of tryptophan metabolites in serum and gastric juice - an investigation towards establishing a biomarker test for gastric cancer diagnosis.Jong Min Choi et al.Biomedical chromatography : BMC, 30(12), 1963-1974 (2016-05-31) Hypoglycemia-induced alterations in hippocampal intrinsic rhythms: Decreased inhibition, increased excitation, seizures and spreading depression.C M Florez et al.Neurobiology of disease, 82, 213-225 (2015-06-21) Metabolite profile analysis reveals association of vitamin B-6 with metabolites related to one-carbon metabolism and tryptophan catabolism but not with biomarkers of inflammation in oral contraceptive users and reveals the effects of oral contraceptives on these processes.Luisa Rios-Avila et al.The Journal of nutrition, 145(1), 87-95 (2014-12-21) Mannitol decreases neocortical epileptiform activity during early brain development via cotransport of chloride and water.J Glykys et al.Neurobiology of disease, 125, 163-175 (2019-02-04) Global Metabolomic Identification of Long-Term Dose-Dependent Urinary Biomarkers in Nonhuman Primates Exposed to Ionizing Radiation.Evan L Pannkuk et al.Radiation research, 184(2), 121-133 (2015-08-01) Aging decreases L-type calcium channel currents and pacemaker firing fidelity in substantia nigra dopamine neurons.Sarah Y Branch et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(28), 9310-9318 (2014-07-11) Inhibiting Stearoyl-CoA Desaturase Ameliorates alpha-Synuclein CytotoxicityVincent BM, et al. Cell Reports, 25(10), 2742-2754 (2018) Methamphetamine abuse impairs motor cortical plasticity and function.X Huang et al.Molecular psychiatry, 22(9), 1274-1281 (2017-08-24) BDNF increases synaptic NMDA receptor abundance by enhancing the local translation of Pyk2 in cultured hippocampal neurons.Pedro Afonso et al.Science signaling, 12(586) (2019-06-20) Metabolite profile analysis reveals functional effects of 28-day vitamin B-6 restriction on one-carbon metabolism and tryptophan catabolic pathways in healthy men and women.Vanessa R da Silva et al.The Journal of nutrition, 143(11), 1719-1727 (2013-08-24) Prefrontal Cortex Corticotropin-Releasing Factor Neurons Control Behavioral Style Selection under Challenging Situations.Peng Chen et al.Neuron, 106(2), 301-315 (2020-02-27) Kynurenic acid in brain and cerebrospinal fluid of fetal, newborn, and adult sheep and effects of placental embolization.D W Walker et al.Pediatric research, 45(6), 820-826 (1999-06-15) The pretectal connectome in lamprey.Lorenza Capantini et al.The Journal of comparative neurology, 525(4), 753-772 (2016-08-26) Excitatory VTA to DH projections provide a valence signal to memory circuits.Yuan Han et al.Nature communications, 11(1), 1466-1466 (2020-03-21) Role of kynurenines in the neurotoxic actions of kainic acidBehan WMH and Stone TW British Journal of Pharmacology, 129(8), 1764-1770 (2000) Kynurenic Acid and Its Analogs Are Beneficial Physiologic Attenuators in Bdelloid Rotifers.Zsolt Datki et al.Molecules (Basel, Switzerland), 24(11) (2019-06-13) Perifornical hypothalamic pathway to the adrenal gland: Role for glutamatergic transmission in the glucose counter-regulatory response.A Sabetghadam et al.Autonomic neuroscience : basic & clinical, 203, 67-73 (2017-02-09) Specific urinary metabolites in canine mammary gland tumors.Marcela Valko-Rokytovská et al.Journal of veterinary science, 21(2), e23-e23 (2020-04-02) Mitochondrial Regulation of the Hippocampal Firing Rate Set Point and Seizure Susceptibility.Boaz Styr et al.Neuron, 102(5), 1009-1024 (2019-05-03) A functional coupling between extrasynaptic NMDA receptors and A-type K+ channels under astrocyte control regulates hypothalamic neurosecretory neuronal activity.Krishna Naskar et al.The Journal of physiology, 592(13), 2813-2827 (2014-05-20) Rhubarb Protect Against Tubulointerstitial Fibrosis by Inhibiting TGF-β/Smad Pathway and Improving Abnormal Metabolome in Chronic Kidney Disease.Zhi-Hao Zhang et al.Frontiers in pharmacology, 9, 1029-1029 (2018-10-03) IDO1 and Kynurenine Pathway Metabolites Activate PI3K-Akt Signaling in the Neoplastic Colon Epithelium to Promote Cancer Cell Proliferation and Inhibit Apoptosis.Kumar S Bishnupuri et al.Cancer research, 79(6), 1138-1150 (2019-01-27) Quinolinic acid and kynurenic acid in the mammalian brain.R Schwarcz et al.Advances in experimental medicine and biology, 294, 185-199 (1991-01-01) Integrated Organotypic Slice Cultures and RT-QuIC (OSCAR) Assay: Implications for Translational Discovery in Protein Misfolding Diseases.Naveen Kondru et al.Scientific reports, 7, 43155-43155 (2017-02-25) Characterization of microbial dysbiosis and metabolomic changes in dogs with acute diarrhea.Blake C Guard et al.PloS one, 10(5), e0127259-e0127259 (2015-05-23) MAP6 interacts with Tctex1 and Cav 2.2/N-type calcium channels to regulate calcium signalling in neurons.Jacques Brocard et al.The European journal of neuroscience, 46(11), 2754-2767 (2017-11-03) Combination of a δ-opioid Receptor Agonist and Loperamide Produces Peripherally-mediated Analgesic Synergy in Mice.Daniel J Bruce et al.Anesthesiology, 131(3), 649-663 (2019-07-26) NPY Induces Stress Resilience via Downregulation of Ih in Principal Neurons of Rat Basolateral Amygdala.Heika Silveira Villarroel et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 38(19), 4505-4520 (2018-04-14) Manipulating midbrain dopamine neurons and reward-related behaviors with light-controllable nicotinic acetylcholine receptors.Romain Durand-de Cuttoli et al.eLife, 7 (2018-09-05) Prevention of postoperative fatigue syndrome in rat model by ginsenoside Rb1 via down-regulation of inflammation along the NMDA receptor pathway in the hippocampus.Wei-Zhe Chen et al.Biological & pharmaceutical bulletin, 38(2), 239-247 (2015-03-10) Munc13 genotype regulates secretory amyloid precursor protein processing via postsynaptic glutamate receptors.Maike Hartlage-Rübsamen et al.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 31(1), 36-45 (2012-10-17) Vasopressin V1a receptors mediate the hypertensive effects of [PyrPhilip R Griffiths et al.The Journal of physiology, 595(11), 3303-3318 (2017-03-04) Iron-sulfur glutaredoxin 2 protects oligodendrocytes against damage induced by nitric oxide release from activated microglia.Klaudia Lepka et al.Glia, 65(9), 1521-1534 (2017-06-16) ATP stimulates rat hypothalamic sympathetic neurons by enhancing AMPA receptor-mediated currents.Hildebrando Candido Ferreira-Neto et al.Journal of neurophysiology, 114(1), 159-169 (2015-04-24) Transient Hypoxemia Chronically Disrupts Maturation of Preterm Fetal Ovine Subplate Neuron Arborization and Activity.Evelyn McClendon et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 37(49), 11912-11929 (2017-11-02) Targeting the Brain with a Neuroprotective Omega-3 Fatty Acid to Enhance Neurogenesis in Hypoxic Condition in Culture.Amanda Lo Van et al.Molecular neurobiology, 56(2), 986-999 (2018-06-03) Trypanosoma brucei metabolite indolepyruvate decreases HIF-1α and glycolysis in macrophages as a mechanism of innate immune evasion.Anne F McGettrick et al.Proceedings of the National Academy of Sciences of the United States of America, 113(48), E7778-E7787 (2016-11-20) Comprehensive analysis of the tryptophan metabolome in urine of patients with acute intermittent porphyria.Alex Gomez-Gomez et al.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1060, 347-354 (2017-07-01) PI3K-Akt signaling activates mTOR-mediated epileptogenesis in organotypic hippocampal culture model of post-traumatic epilepsy.Yevgeny Berdichevsky et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(21), 9056-9067 (2013-05-24) Distinctive Modulation of Dopamine Release in the Nucleus Accumbens Shell Mediated by Dopamine and Acetylcholine Receptors.Jung Hoon Shin et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 37(46), 11166-11180 (2017-10-17) The activation of metabotropic glutamate 5 receptors in the rat ventral tegmental area increases dopamine extracellular levels.Carla Ferrada et al.Neuroreport, 28(1), 28-34 (2016-11-22) Female-specific decreases in alcohol binge-like drinking resulting from GABAA receptor delta-subunit knockdown in the VTA.L M Darnieder et al.Scientific reports, 9(1), 8102-8102 (2019-05-31) Increasing the Receptor Tyrosine Kinase EphB2 Prevents Amyloid-β-induced Depletion of Cell Surface Glutamate Receptors by a Mechanism That Requires the PDZ-binding Motif of EphB2 and Neuronal Activity.Takashi Miyamoto et al.The Journal of biological chemistry, 291(4), 1719-1734 (2015-11-22) In Vitro and In Vivo Identification of Novel Positive Allosteric Modulators of the Human Dopamine D2 and D3 Receptor.Martyn Wood et al.Molecular pharmacology, 89(2), 303-312 (2015-12-15) Vitamin B1 deficiency inhibits the increased conversion of tryptophan to nicotinamide in severe food-restricted rats.Katsumi Shibata et al.Bioscience, biotechnology, and biochemistry, 79(1), 103-108 (2014-09-26) Stress-induced increase in kynurenic acid as a potential biomarker for patients with schizophrenia and distress intolerance.Joshua Chiappelli et al.JAMA psychiatry, 71(7), 761-768 (2014-05-09) Human metabolic responses to chronic environmental polycyclic aromatic hydrocarbon exposure by a metabolomic approach.Zhonghua Wang et al.Journal of proteome research, 14(6), 2583-2593 (2015-05-21) Role of the paraventricular nucleus in the reflex diuresis to pulmonary lymphatic obstruction in rabbits.Rishabh Charan Choudhary et al.Canadian journal of physiology and pharmacology, 94(1), 18-27 (2015-10-27) Role of dopamine projections from ventral tegmental area to nucleus accumbens and medial prefrontal cortex in reinforcement behaviors assessed using optogenetic manipulation.Xiao Han et al.Metabolic brain disease, 32(5), 1491-1502 (2017-05-20) Visual experience prevents dysregulation of GABAB receptor-dependent short-term depression in adult superior colliculus.Timothy S Balmer et al.Journal of neurophysiology, 113(7), 2049-2061 (2015-01-09) Insulin-Like Growth Factor II Targets the mTOR Pathway to Reverse Autism-Like Phenotypes in Mice.Adam B Steinmetz et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 38(4), 1015-1029 (2017-12-09) Stem cell-derived interneuron transplants as a treatment for schizophrenia: preclinical validation in a rodent model.J J Donegan et al.Molecular psychiatry, 22(10), 1492-1501 (2016-08-03) Synaptic properties of SOM- and CCK-expressing cells in dentate gyrus interneuron networks.Shakuntala Savanthrapadian et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(24), 8197-8209 (2014-06-13) RORβ Spinal Interneurons Gate Sensory Transmission during Locomotion to Secure a Fluid Walking Gait.Stephanie C Koch et al.Neuron, 96(6), 1419-1431 (2017-12-12) A systemically-available kynurenine aminotransferase II (KAT II) inhibitor restores nicotine-evoked glutamatergic activity in the cortex of rats.Ajeesh Koshy Cherian et al.Neuropharmacology, 82, 41-48 (2014-03-22) Discovery of Kynurenines Containing Oligopeptides as Potent Opioid Receptor Agonists.Edina Szűcs et al.Biomolecules, 10(2) (2020-02-16) Supplementing healthy women with up to 5.0 g/d of L-tryptophan has no adverse effects.Chiaki Hiratsuka et al.The Journal of nutrition, 143(6), 859-866 (2013-04-26) Electrophysiological characterization of spino-sciatic and cortico-sciatic associative plasticity: modulation by trans-spinal direct current and effects on recovery after spinal cord injury in mice.Zaghloul Ahmed The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(11), 4935-4946 (2013-03-15) Glycine aggravates ischemia reperfusion-induced acute kidney injury through N-Methyl-D-Aspartate receptor activation in rats.Shiyana Arora et al.Molecular and cellular biochemistry, 393(1-2), 123-131 (2014-04-18) Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites.Hao Guo et al.Science (New York, N.Y.), 370(6516) (2020-10-31) Synaptic Activity Drives a Genomic Program That Promotes a Neuronal Warburg Effect.Carlos Bas-Orth et al.The Journal of biological chemistry, 292(13), 5183-5194 (2017-02-16) Determination of kynurenic acid in rat cerebrospinal fluid by HPLC with fluorescence detection.Ye Bao et al.Biomedical chromatography : BMC, 30(1), 62-67 (2015-05-13) A covalent small molecule inhibitor of glutamate-oxaloacetate transaminase 1 impairs pancreatic cancer growth.Tomohiro Yoshida et al.Biochemical and biophysical research communications, 522(3), 633-638 (2019-12-04) Gq-Coupled Muscarinic Receptor Enhancement of KCNQ2/3 Channels and Activation of TRPC Channels in Multimodal Control of Excitability in Dentate Gyrus Granule Cells.Chase M Carver et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 39(9), 1566-1587 (2018-12-30) Transthyretin provides trophic support via megalin by promoting neurite outgrowth and neuroprotection in cerebral ischemia.J R Gomes et al.Cell death and differentiation, 23(11), 1749-1764 (2016-10-19) Cyclosporin A enhances neural precursor cell survival in mice through a calcineurin-independent pathway.Nadia Sachewsky et al.Disease models & mechanisms, 7(8), 953-961 (2014-07-25) The projections from the anterior cingulate cortex to the nucleus accumbens and ventral tegmental area contribute to neuropathic pain-evoked aversion in rats.Shi-Hao Gao et al.Neurobiology of disease, 140, 104862-104862 (2020-04-07) Impaired adult neurogenesis is an early event in Alzheimer's disease neurodegeneration, mediated by intracellular Aβ oligomers.Chiara Scopa et al.Cell death and differentiation, 27(3), 934-948 (2019-10-09) Integration of Hypernatremia and Angiotensin II by the Organum Vasculosum of the Lamina Terminalis Regulates Thirst.Brian J Kinsman et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(10), 2069-2079 (2020-02-02) Increased CRF signalling in a ventral tegmental area-interpeduncular nucleus-medial habenula circuit induces anxiety during nicotine withdrawal.Rubing Zhao-Shea et al.Nature communications, 6, 6770-6770 (2015-04-22) A systems-level framework for drug discovery identifies Csf1R as an anti-epileptic drug target.Prashant K Srivastava et al.Nature communications, 9(1), 3561-3561 (2018-09-05) TARP mediation of accelerated and more regular locus coeruleus network bursting in neonatal rat brain slices.Bijal Rawal et al.Neuropharmacology, 148, 169-177 (2019-01-11) Modulation of multidrug resistance-associated proteins function in erythrocytes in glycerol-induced acute renal failure rats.Aoi Matsushima et al.The Journal of pharmacy and pharmacology, 69(2), 172-181 (2016-11-20) Kynurenic acid is a nutritional cue that enables behavioral plasticityLemieux GA, et al. Cell, 160(1), 119-131 (2015) Modulation of epileptogenesis: A paradigm for the integration of enzyme-based microelectrode arrays and optogenetics.Corwin R Butler et al.Epilepsy research, 159, 106244-106244 (2019-12-10) A mathematical model of tryptophan metabolism via the kynurenine pathway provides insights into the effects of vitamin B-6 deficiency, tryptophan loading, and induction of tryptophan 2,3-dioxygenase on tryptophan metabolites.Luisa Rios-Avila et al.The Journal of nutrition, 143(9), 1509-1519 (2013-08-02) Opposing roles of corticotropin-releasing factor and neuropeptide Y within the dorsolateral bed nucleus of the stria terminalis in the negative affective component of pain in rats.Soichiro Ide et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(14), 5881-5894 (2013-04-05) Changes in Tryptophan Catabolite (TRYCAT) Pathway Patterning Are Associated with Mild Impairments in Declarative Memory in Schizophrenia and Deficits in Semantic and Episodic Memory Coupled with Increased False-Memory Creation in Deficit Schizophrenia.Buranee Kanchanatawan et al.Molecular neurobiology, 55(6), 5184-5201 (2017-09-07) Early-life adversity selectively impairs α2-GABAA receptor expression in the mouse nucleus accumbens and influences the behavioral effects of cocaine.Scott J Mitchell et al.Neuropharmacology, 141, 98-112 (2018-08-24) Vulnerability of invasive glioblastoma cells to lysosomal membrane destabilization.Vadim Le Joncour et al.EMBO molecular medicine, 11(6) (2019-05-10) Etomidate blocks LTP and impairs learning but does not enhance tonic inhibition in mice carrying the N265M point mutation in the beta3 subunit of the GABA(A) receptor.E D Zarnowska et al.Neuropharmacology, 93, 171-178 (2015-02-15) Curiosity to kill the KAT (kynurenine aminotransferase): structural insights into brain kynurenic acid synthesis.Franca Rossi et al.Current opinion in structural biology, 18(6), 748-755 (2008-10-28) Time-dependent effects of L-tryptophan administration on urinary excretion of L-tryptophan metabolites.Chiaki Hiratsuka et al.Journal of nutritional science and vitaminology, 60(4), 255-260 (2014-10-10) The Safety and Tolerability of Topically Delivered Kynurenic Acid in Humans. A Phase 1 Randomized Double-Blind Clinical Trial.Anthony Papp et al.Journal of pharmaceutical sciences, 107(6), 1572-1576 (2018-02-09) PTEN Loss Increases the Connectivity of Fast Synaptic Motifs and Functional Connectivity in a Developing Hippocampal Network.Caitlynn M Barrows et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 37(36), 8595-8611 (2017-07-29) Syntheses, transformations and pharmaceutical applications of kynurenic acid derivatives.F Fülöp et al.Current medicinal chemistry, 16(36), 4828-4842 (2009-11-26) Identification of Urine Metabolites as Biomarkers of Early Lyme Disease.Adoracion Pegalajar-Jurado et al.Scientific reports, 8(1), 12204-12204 (2018-08-17) Regulation of lifespan by neural excitation and REST.Joseph M Zullo et al.Nature, 574(7778), 359-364 (2019-10-18) Activation of mu-opioid receptors in the ventrolateral orbital cortex inhibits the GABAergic miniature inhibitory postsynaptic currents in rats.Chao-Ling Qu et al.Neuroscience letters, 592, 64-69 (2015-02-26) Kynurenic acid antagonists and kynurenine pathway inhibitors.T W Stone Expert opinion on investigational drugs, 10(4), 633-645 (2001-04-03) Kynurenic acid as an antagonist of α7 nicotinic acetylcholine receptors in the brain: facts and challenges.Edson X Albuquerque et al.Biochemical pharmacology, 85(8), 1027-1032 (2012-12-29) Electrochemical deposition of conductive polymers onto magnesium microwires for neural electrode applications.Chaoxing Zhang et al.Journal of biomedical materials research. Part A, 106(7), 1887-1895 (2018-03-10) Erythropoietin Induces Homeostatic Plasticity at Hippocampal Synapses.Raquel B Dias et al.Cerebral cortex (New York, N.Y. : 1991), 28(8), 2795-2809 (2017-10-21) Anatomically Defined and Functionally Distinct Dorsal Raphe Serotonin Sub-systems.Jing Ren et al.Cell, 175(2), 472-487 (2018-08-28) [New findings in the study of the pathogenesis and treatment of endogenous depression].A S Tiganov et al.Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 112(11), 65-72 (2013-02-05) Long-Lasting Impairment of mGluR5-Activated Intracellular Pathways in the Striatum After Withdrawal of Cocaine Self-Administration.Hanne Mette Hoffmann et al.The international journal of neuropsychopharmacology, 20(1), 72-82 (2016-10-17) Study of BDE-47 induced Parkinson's disease-like metabolic changes in C57BL/6 mice by integrated metabolomic, lipidomic and proteomic analysis.Fenfen Ji et al.Journal of hazardous materials, 378, 120738-120738 (2019-06-17) Sonic Hedgehog promotes proliferation of Notch-dependent monociliated choroid plexus tumour cells.Li Li et al.Nature cell biology, 18(4), 418-430 (2016-03-22) Recreational concentrations of alcohol enhance synaptic inhibition of cerebellar unipolar brush cells via pre- and postsynaptic mechanisms.Ben D Richardson et al.Journal of neurophysiology, 118(1), 267-279 (2017-04-07) Role of β2/3-specific GABA-A receptor isoforms in the development of hippocampus kindling epileptogenesis.Doodipala Samba Reddy et al.Epilepsy & behavior : E&B, 82, 57-63 (2018-03-28) Cholinergic neurons in the pedunculopontine tegmental nucleus modulate breathing in rats by direct projections to the retrotrapezoid nucleus.Janayna D Lima et al.The Journal of physiology, 597(7), 1919-1934 (2019-02-07) Investigation of the aryl hydrocarbon receptor and the intrinsic tumoral component of the kynurenine pathway of tryptophan metabolism in primary brain tumors.Anthony R Guastella et al.Journal of neuro-oncology, 139(2), 239-249 (2018-04-19) A wide-targeted urinary and serum metabolomics strategy reveals the effective substance of the Wu-tou decoction.Xiaoxu Cheng et al.Journal of separation science, 43(4), 727-735 (2019-11-26) Nicotine enhances GABAergic inhibition of oxytocin mRNA-expressing neuron in the hypothalamic paraventricular nucleus in vitro in rats.Ke-Min Zhang et al.Neuroscience letters, 638, 5-11 (2016-12-08) Tonic Suppression of the Mesolimbic Dopaminergic System by Enhanced Corticotropin-Releasing Factor Signaling Within the Bed Nucleus of the Stria Terminalis in Chronic Pain Model Rats.Daiki Takahashi et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 39(42), 8376-8385 (2019-08-28) α6 subunit-containing nicotinic receptors mediate low-dose ethanol effects on ventral tegmental area neurons and ethanol reward.Scott C Steffensen et al.Addiction biology (2017-09-14) Synergistic effect of the L-tryptophan and kynurenic acid with dipyrone or paracetamol in mice.Nayrton Flávio Moura Rocha et al.Chemico-biological interactions, 205(2), 148-156 (2013-07-23) [Na+] Increases in Body Fluids Sensed by Central Nax Induce Sympathetically Mediated Blood Pressure Elevations via H+-Dependent Activation of ASIC1a.Kengo Nomura et al.Neuron, 101(1), 60-75 (2018-12-07) Targeted expression of step-function opsins in transgenic rats for optogenetic studies.Hiroyuki Igarashi et al.Scientific reports, 8(1), 5435-5435 (2018-04-05) Isolation and generation of neurosphere cultures from embryonic and adult mouse brain.Henrik Ahlenius et al.Methods in molecular biology (Clifton, N.J.), 633, 241-252 (2010-03-06) Kynurenic acid content in selected culinary herbs and spicesTurski MP, et al. Journal of Chemistry, 2015, 1386-1397 (2015) Chemogenetic Recruitment of Specific Interneurons Suppresses Seizure Activity.Alexandru Cǎlin et al.Frontiers in cellular neuroscience, 12, 293-293 (2018-09-21) Expanding the Optogenetics Toolkit by Topological Inversion of Rhodopsins.Jennifer Brown et al.Cell, 175(4), 1131-1140 (2018-10-23) Kynurenic acid and its analogue can alter the opioid receptor G-protein signaling after acute treatment via NMDA receptor in rat cortex and striatum.Reza Samavati et al.Journal of the neurological sciences, 376, 63-70 (2017-04-23) Urinary metabolic disturbance in the olfactory bulbectomized rats and the modulatory effects of fluoxetine.Yun-Feng Zhou et al.Life sciences, 234, 116751-116751 (2019-08-16) A neural basis for tonic suppression of sodium appetite.Seahyung Park et al.Nature neuroscience, 23(3), 423-432 (2020-01-22) Mild Traumatic Brain Injury Leads to Decreased Inhibition and a Differential Response of Calretinin Positive Interneurons in the Injured Cortex.Mariana Brizuela et al.Journal of neurotrauma, 34(17), 2504-2517 (2017-05-04) Overexpression of angiotensin-converting enzyme 2 attenuates tonically active glutamatergic input to the rostral ventrolateral medulla in hypertensive rats.Yang-Kai Wang et al.American journal of physiology. Heart and circulatory physiology, 307(2), H182-H190 (2014-05-20) Potentiation of Acetylcholine-Mediated Facilitation of Inhibitory Synaptic Transmission by an Azaindolizione Derivative, ZSET1446 (ST101), in the Rat Hippocampus.Kentaro Takeda et al.The Journal of pharmacology and experimental therapeutics, 356(2), 445-455 (2015-11-19) MicroRNA134 of Ventral Hippocampus Is Involved in Cocaine Extinction-Induced Anxiety-like and Depression-like Behaviors in Mice.Yuehan Li et al.Molecular therapy. Nucleic acids, 19, 937-950 (2020-02-01) Organic anion transporting polypeptides 1B1 and 1B3 play an important role in uremic toxin handling and drug-uremic toxin interactions in the liver.Toshihiro Sato et al.Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 17(4), 475-484 (2015-01-13) The fate of technical-grade chlordane in mice fed a high-fat diet and its roles as a candidate obesogen.Dezhen Wang et al.Environmental pollution (Barking, Essex : 1987), 222, 532-542 (2017-01-04) Zinc reduces antiseizure activity of neurosteroids by selective blockade of extrasynaptic GABA-A receptor-mediated tonic inhibition in the hippocampus.Shu-Hui Chuang et al.Neuropharmacology, 148, 244-256 (2018-11-25) Kynurenine pathway metabolism following prenatal KMO inhibition and in Mecp2Caroline M Forrest et al.Neurochemistry international, 100, 110-119 (2016-09-14) Valnoctamide enhances phasic inhibition: a potential target mechanism for the treatment of benzodiazepine-refractory status epilepticus.Jay Spampanato et al.Epilepsia, 55(9), e94-e98 (2014-07-06) Central Amygdala Circuits Mediate Hyperalgesia in Alcohol-Dependent Rats.Elizabeth M Avegno et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 38(36), 7761-7773 (2018-07-29) The paracetamol metabolite N-acetylp-benzoquinone imine reduces excitability in first- and second-order neurons of the pain pathway through actions on KV7 channels.Sutirtha Ray et al.Pain, 160(4), 954-964 (2019-01-03) Targeting of NF-κB to Dendritic Spines Is Required for Synaptic Signaling and Spine Development.Erica C Dresselhaus et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 38(17), 4093-4103 (2018-03-21) Metabotropic NMDA receptor function is required for NMDA receptor-dependent long-term depression.Sadegh Nabavi et al.Proceedings of the National Academy of Sciences of the United States of America, 110(10), 4027-4032 (2013-02-23) A community-based study on determinants of circulating markers of cellular immune activation and kynurenines: the Hordaland Health Study.D Theofylaktopoulou et al.Clinical and experimental immunology, 173(1), 121-130 (2013-04-24) Dietary and Microbial Oxazoles Induce Intestinal Inflammation by Modulating Aryl Hydrocarbon Receptor ResponsesIyer SS, et al. Cell, 173(5), 1123-1134 (2018) Glio-and neuro-protection by prosaposin is mediated by orphan G-protein coupled receptors GPR37L1 and GPR37Liu B, et al. Glia, 66(11), 2414-2426 (2018) Isobolographic Analysis of Antiseizure Activity of the GABA Type A Receptor-Modulating Synthetic Neurosteroids Brexanolone and Ganaxolone with Tiagabine and Midazolam.Shu-Hui Chuang et al.The Journal of pharmacology and experimental therapeutics, 372(3), 285-298 (2019-12-18) Dentate cannabinoid-sensitive interneurons undergo unique and selective strengthening of mutual synaptic inhibition in experimental epilepsy.Jiandong Yu et al.Neurobiology of disease, 89, 23-35 (2016-01-26) Markers of Inflammation and Monoamine Metabolism Indicate Accelerated Aging in Bipolar Disorder.Seline van den Ameele et al.Frontiers in psychiatry, 9, 250-250 (2018-07-03) The inhibitory neurotransmitter GABA evokes long-lasting Ca(2+) oscillations in cortical astrocytes.Letizia Mariotti et al.Glia, 64(3), 363-373 (2015-10-27) Distress intolerance, kynurenic acid, and schizophrenia.Daniel C Javitt JAMA psychiatry, 71(7), 749-750 (2014-05-09) Determination of tryptophan derivatives in kynurenine pathway in fermented foods using liquid chromatography tandem mass spectrometry.Cemile Yılmaz et al.Food chemistry, 243, 420-427 (2017-11-18) Cerebrospinal fluid kynurenic acid is associated with manic and psychotic features in patients with bipolar I disorder.Sara K Olsson et al.Bipolar disorders, 14(7), 719-726 (2012-10-04) Hypoxia-induced hypothermia mediated by the glutamatergic transmission in the lateral preoptic area.T Osaka Neuroscience, 226, 73-80 (2012-09-25) Defining the Adult Neural Stem Cell Niche Proteome Identifies Key Regulators of Adult Neurogenesis.Jacob Kjell et al.Cell stem cell, 26(2), 277-293 (2020-02-08) Aldosterone-Sensing Neurons in the NTS Exhibit State-Dependent Pacemaker Activity and Drive Sodium Appetite via Synergy with Angiotensin II Signaling.Jon M Resch et al.Neuron, 96(1), 190-206 (2017-09-29) Oligophrenin-1 regulates number, morphology and synaptic properties of adult-born inhibitory interneurons in the olfactory bulb.Nelly Redolfi et al.Human molecular genetics, 25(23), 5198-5211 (2016-10-16) Perturbed Wnt signaling leads to neuronal migration delay, altered interhemispheric connections and impaired social behavior.Riccardo Bocchi et al.Nature communications, 8(1), 1158-1158 (2017-10-29) CaV2.1 α1 Subunit Expression Regulates Presynaptic CaV2.1 Abundance and Synaptic Strength at a Central Synapse.Matthias Lübbert et al.Neuron, 101(2), 260-273 (2018-12-14) Plasma Tryptophan-Kynurenine Metabolites Are Altered in Human Immunodeficiency Virus Infection and Associated With Progression of Carotid Artery Atherosclerosis.Qibin Qi et al.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 67(2), 235-242 (2018-02-08) Connecting inflammation with glutamate agonism in suicidality.Sophie Erhardt et al.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 38(5), 743-752 (2013-01-10) The CAN-In network: A biologically inspired model for self-sustained theta oscillations and memory maintenance in the hippocampus.Francesco Giovannini et al.Hippocampus, 27(4), 450-463 (2017-01-05) Chronic Intermittent Ethanol Exposure Enhances the Excitability and Synaptic Plasticity of Lateral Orbitofrontal Cortex Neurons and Induces a Tolerance to the Acute Inhibitory Actions of Ethanol.Sudarat Nimitvilai et al.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 41(4), 1112-1127 (2015-08-20) Activation of GABAergic Neurons in the Nucleus Accumbens Mediates the Expression of Cocaine-Associated Memory.Tong Zhang et al.Biological & pharmaceutical bulletin, 41(7), 1084-1088 (2018-07-03) Amyloid-Beta1-42 -Induced Increase in GABAergic Tonic Conductance in Mouse Hippocampal CA1 Pyramidal Cells.Beatriz Calvo-Flores Guzmán et al.Molecules (Basel, Switzerland), 25(3) (2020-02-12) Validation of a global quantitative analysis methodology of tryptophan metabolites in mice using LC-MS.Antoine Lefèvre et al.Talanta, 195, 593-598 (2019-01-11) Sensitivity of GABAergic Tonic Currents to Acute Ethanol in Cerebellar Granule Neurons is Not Age- or δ Subunit-Dependent in Developing Rats.Marvin R Diaz et al.Alcoholism, clinical and experimental research, 40(1), 83-92 (2016-01-05) Effects of intrathecal kynurenate on arterial pressure during chronic osmotic stress in conscious rats.Britta Veitenheimer et al.American journal of physiology. Heart and circulatory physiology, 304(2), H303-H310 (2012-11-20) CAST/ELKS Proteins Control Voltage-Gated Ca2+ Channel Density and Synaptic Release Probability at a Mammalian Central Synapse.Wei Dong et al.Cell reports, 24(2), 284-293 (2018-07-12) Development and therapeutic potential of kynurenic acid and kynurenine derivatives for neuroprotection.T W Stone Trends in pharmacological sciences, 21(4), 149-154 (2000-03-31) ProNGF Is a Cell-Type-Specific Mitogen for Adult Hippocampal and for Induced Neural Stem Cells.Valerio Corvaglia et al.Stem cells (Dayton, Ohio), 37(9), 1223-1237 (2019-05-28) Dietary and Microbial Oxazoles Induce Intestinal Inflammation by Modulating Aryl Hydrocarbon Receptor Responses.Shankar S Iyer et al.Cell, 173(5), 1123-1134 (2018-05-19) Kynurenine pathway inhibition as a therapeutic strategy for neuroprotectionStone TW, et al. FEBS Journal, 279(8), 1386-1397 (2012) Single-Cell RNA Analysis of Type I Spiral Ganglion Neurons Reveals a Lmx1a Population in the Cochlea.Fiorella Carla Grandi et al.Frontiers in molecular neuroscience, 13, 83-83 (2020-06-12) Control of Amygdala Circuits by 5-HT Neurons via 5-HT and Glutamate Cotransmission.Ayesha Sengupta et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 37(7), 1785-1796 (2017-01-15) Enantioselective Metabolism and Interference on Tryptophan Metabolism of Myclobutanil in Rat Hepatocytes.Yao Wang et al.Chirality, 27(9), 643-649 (2015-06-27) The superior paraolivary nucleus shapes temporal response properties of neurons in the inferior colliculus.Richard A Felix et al.Brain structure & function, 220(5), 2639-2652 (2014-06-30) Interaction of Intrinsic and Synaptic Currents Mediate Network Resonance Driven by Layer V Pyramidal Cells.Stephen L Schmidt et al.Cerebral cortex (New York, N.Y. : 1991), 27(9), 4396-4410 (2016-09-01) Hyperuricemia influences tryptophan metabolism via inhibition of multidrug resistance protein 4 (MRP4) and breast cancer resistance protein (BCRP).Anita C A Dankers et al.Biochimica et biophysica acta, 1832(10), 1715-1722 (2013-05-15) Expansion of retinal stem cells and their progeny using cell microcarriers in a bioreactor.Tahani Baakdhah et al.Biotechnology progress, 35(3), e2800-e2800 (2019-03-07) Reduction of brain kynurenic acid improves cognitive function.Rouba Kozak et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(32), 10592-10602 (2014-08-08) Mixed-species RNA-seq for elucidation of non-cell-autonomous control of gene transcriptionQiu J, et al. Nature Protocols, 13(10), 2176-2176 (2018) cAMP-dependent insulin modulation of synaptic inhibition in neurons of the dorsal motor nucleus of the vagus is altered in diabetic mice.Camille B Blake et al.American journal of physiology. Regulatory, integrative and comparative physiology, 307(6), R711-R720 (2014-07-06) Epilepsy and intellectual disability linked protein Shrm4 interaction with GABAJonathan Zapata et al.Nature communications, 8, 14536-14536 (2017-03-07) Activation of nicotinamide adenine dinucleotide phosphate oxidase is the primary trigger of epileptic seizures in rodent models.Anton Malkov et al.Annals of neurology, 85(6), 907-920 (2019-04-03) 3β-Methyl-Neurosteroid Analogs Are Preferential Positive Allosteric Modulators and Direct Activators of Extrasynaptic δ-Subunit γ-Aminobutyric Acid Type A Receptors in the Hippocampus Dentate Gyrus Subfield.Shu-Hui Chuang et al.The Journal of pharmacology and experimental therapeutics, 365(3), 583-601 (2018-04-01) Isolation and generation of neurosphere cultures from embryonic and adult mouse brain.Henrik Ahlenius et al.Methods in molecular biology (Clifton, N.J.), 633, 241-252 (2010-03-06) Repeated toluene exposure increases the excitability of layer 5 pyramidal neurons in the prefrontal cortex of adolescent rats.Monserrat Armenta-Resendiz et al.Neurotoxicology and teratology, 68, 27-35 (2018-05-02) Bidirectional modulation of cocaine expectancy by phasic glutamate fluctuations in the nucleus accumbens.Nobuyoshi Suto et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(21), 9050-9055 (2013-05-24) Comparison of peak-picking workflows for untargeted liquid chromatography/high-resolution mass spectrometry metabolomics data analysis.Atefeh Rafiei et al.Rapid communications in mass spectrometry : RCM, 29(1), 119-127 (2014-12-03) α2δ-2 Protein Controls Structure and Function at the Cerebellar Climbing Fiber Synapse.Kathleen A Beeson et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(12), 2403-2415 (2020-02-23) Optical mapping of neuronal activity during seizures in zebrafish.L Turrini et al.Scientific reports, 7(1), 3025-3025 (2017-06-10) In Silico Labeling: Predicting Fluorescent Labels in Unlabeled Images.Eric M Christiansen et al.Cell, 173(3), 792-803 (2018-04-17) Parvalbumin-Positive Inhibitory Interneurons Oppose Propagation But Favor Generation of Focal Epileptiform Activity.Michele Sessolo et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(26), 9544-9557 (2015-07-03) Improving AM ester calcium dye loading efficiency.Mohammad I K Hamad et al.Journal of neuroscience methods, 240, 48-60 (2014-12-03) Urinary metabonomics elucidate the therapeutic mechanism of Orthosiphon stamineus in mouse crystal-induced kidney injury.Songyan Gao et al.Journal of ethnopharmacology, 166, 323-332 (2015-03-22) A high mitochondrial transport rate characterizes CNS neurons with high axonal regeneration capacity.Romain Cartoni et al.PloS one, 12(9), e0184672-e0184672 (2017-09-20) Kynurenic acid and kynurenine aminotransferases in retinal aging and neurodegeneration.Robert Rejdak et al.Pharmacological reports : PR, 63(6), 1324-1334 (2012-02-24) Synergistic effect of the L-tryptophan and kynurenic acid with dipyrone or paracetamol in mice.Nayrton Flávio Moura Rocha et al.Chemico-biological interactions, 205(2), 148-156 (2013-07-23) Changes in GABAergic inputs in the paraventricular nucleus maintain sympathetic vasomotor tone in chronic heart failure.B A Carillo et al.Autonomic neuroscience : basic & clinical, 171(1-2), 41-48 (2012-11-14) Pharmacological manipulation of kynurenic acid: potential in the treatment of psychiatric disorders.Sophie Erhardt et al.CNS drugs, 23(2), 91-101 (2009-01-29) Amyloid-Beta1-42 -Induced Increase in GABAergic Tonic Conductance in Mouse Hippocampal CA1 Pyramidal Cells.Beatriz Calvo-Flores Guzmán et al.Molecules (Basel, Switzerland), 25(3) (2020-02-12) Effect of feed supplementation with kynurenic acid on the morphology of the liver, kidney and gills in rainbow trout (Oncorhynchus mykiss Walbaum, 1792), healthy and experimentally infected with Yersinia ruckeri.E Kaczorek et al.Journal of fish diseases, 40(7), 873-884 (2016-10-01) Sensitivity of GABAergic Tonic Currents to Acute Ethanol in Cerebellar Granule Neurons is Not Age- or δ Subunit-Dependent in Developing Rats.Marvin R Diaz et al.Alcoholism, clinical and experimental research, 40(1), 83-92 (2016-01-05) Effects of intrathecal kynurenate on arterial pressure during chronic osmotic stress in conscious rats.Britta Veitenheimer et al.American journal of physiology. Heart and circulatory physiology, 304(2), H303-H310 (2012-11-20) Activation of GABAergic Neurons in the Nucleus Accumbens Mediates the Expression of Cocaine-Associated Memory.Tong Zhang et al.Biological & pharmaceutical bulletin, 41(7), 1084-1088 (2018-07-03) Chronic Intermittent Ethanol Exposure Enhances the Excitability and Synaptic Plasticity of Lateral Orbitofrontal Cortex Neurons and Induces a Tolerance to the Acute Inhibitory Actions of Ethanol.Sudarat Nimitvilai et al.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 41(4), 1112-1127 (2015-08-20) Enantioselective Metabolism and Interference on Tryptophan Metabolism of Myclobutanil in Rat Hepatocytes.Yao Wang et al.Chirality, 27(9), 643-649 (2015-06-27) The superior paraolivary nucleus shapes temporal response properties of neurons in the inferior colliculus.Richard A Felix et al.Brain structure & function, 220(5), 2639-2652 (2014-06-30) Interaction of Intrinsic and Synaptic Currents Mediate Network Resonance Driven by Layer V Pyramidal Cells.Stephen L Schmidt et al.Cerebral cortex (New York, N.Y. : 1991), 27(9), 4396-4410 (2016-09-01) Downregulation of GABAMiranda Mele et al.Molecular neurobiology, 54(1), 45-57 (2016-01-07) Kynurenic acid: a metabolite with multiple actions and multiple targets in brain and periphery.Flavio Moroni et al.Journal of neural transmission (Vienna, Austria : 1996), 119(2), 133-139 (2012-01-05) Hyperuricemia influences tryptophan metabolism via inhibition of multidrug resistance protein 4 (MRP4) and breast cancer resistance protein (BCRP).Anita C A Dankers et al.Biochimica et biophysica acta, 1832(10), 1715-1722 (2013-05-15) Expansion of retinal stem cells and their progeny using cell microcarriers in a bioreactor.Tahani Baakdhah et al.Biotechnology progress, 35(3), e2800-e2800 (2019-03-07) Validation of a global quantitative analysis methodology of tryptophan metabolites in mice using LC-MS.Antoine Lefèvre et al.Talanta, 195, 593-598 (2019-01-11) ProNGF Is a Cell-Type-Specific Mitogen for Adult Hippocampal and for Induced Neural Stem Cells.Valerio Corvaglia et al.Stem cells (Dayton, Ohio), 37(9), 1223-1237 (2019-05-28) The CAN-In network: A biologically inspired model for self-sustained theta oscillations and memory maintenance in the hippocampus.Francesco Giovannini et al.Hippocampus, 27(4), 450-463 (2017-01-05) The effect of low dose rate on metabolomic response to radiation in mice.Maryam Goudarzi et al.Radiation and environmental biophysics, 53(4), 645-657 (2014-07-23) Presynaptic Mitochondria Volume and Abundance Increase during Development of a High-Fidelity Synapse.Connon I Thomas et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 39(41), 7994-8012 (2019-08-29) Non-chemosensitive parafacial neurons simultaneously regulate active expiration and airway patency under hypercapnia in rats.Alan A de Britto et al.The Journal of physiology, 595(6), 2043-2064 (2016-12-23) Adolescent cocaine exposure enhances the GABAergic transmission in the prelimbic cortex of adult mice.Pengbo Shi et al.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(7), 8614-8622 (2019-04-30) Astroglial Connexin 43 Hemichannels Modulate Olfactory Bulb Slow Oscillations.Lisa Roux et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(46), 15339-15352 (2015-11-21) Restoration of Kv7 Channel-Mediated Inhibition Reduces Cued-Reinstatement of Cocaine Seeking.Jeffrey Parrilla-Carrero et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 38(17), 4212-4229 (2018-04-11) NH125 reduces the level of CPEB3, an RNA binding protein, to promote synaptic GluA2 expression.Crhistian L Bender et al.Neuropharmacology, 101, 531-537 (2015-04-07) Opening of KATP Channel Regulates Tonic Currents From Pyramidal Neurons in Rat Brain.Zhongxia Li et al.The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 44(6), 718-725 (2017-06-21) The niacin required for optimum growth can be synthesized from L-tryptophan in growing mice lacking tryptophan-2,3-dioxygenase.Miki Terakata et al.The Journal of nutrition, 143(7), 1046-1051 (2013-05-24) Estimation of Current and Future Physiological States in Insular Cortex.Yoav Livneh et al.Neuron, 105(6), 1094-1111 (2020-01-21) Context-Dependent Modulation of GABAAR-Mediated Tonic Currents.Bijal Patel et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(2), 607-621 (2016-01-14) Conditional Single Vector CRISPR/SaCas9 Viruses for Efficient Mutagenesis in the Adult Mouse Nervous System.Avery C Hunker et al.Cell reports, 30(12), 4303-4316 (2020-03-27) V1 interneurons regulate the pattern and frequency of locomotor-like activity in the neonatal mouse spinal cord.Melanie Falgairolle et al.PLoS biology, 17(9), e3000447-e3000447 (2019-09-13) Reducing cannabinoid abuse and preventing relapse by enhancing endogenous brain levels of kynurenic acid.Zuzana Justinova et al.Nature neuroscience, 16(11), 1652-1661 (2013-10-15) Metabonomic analysis of quercetin against the toxicity of acrylamide in rat urine.Wei Bao et al.Food & function, 8(3), 1204-1214 (2017-02-23) Neurosteroid Structure-Activity Relationships for Functional Activation of Extrasynaptic δGABA(A) Receptors.Chase Matthew Carver et al.The Journal of pharmacology and experimental therapeutics, 357(1), 188-204 (2016-02-10) Mechanisms of Metabolism Interaction Between p-Cresol and Mycophenolic Acid.Yan Rong et al.Toxicological sciences : an official journal of the Society of Toxicology, 173(2), 267-279 (2019-11-20) Development and therapeutic potential of kynurenic acid and kynurenine derivatives for neuroprotection.T W Stone Trends in pharmacological sciences, 21(4), 149-154 (2000-03-31) BDNF-dependent plasticity induced by peripheral inflammation in the primary sensory and the cingulate cortex triggers cold allodynia and reveals a major role for endogenous BDNF as a tuner of the affective aspect of pain.Karine Thibault et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(44), 14739-14751 (2014-10-31) Acute restraint stress augments the rewarding memory of cocaine through activation of α1 adrenoceptors in the medial prefrontal cortex of mice.Shintaro Wada et al.Neuropharmacology, 166, 107968-107968 (2020-02-10) Genomic Decoding of Neuronal Depolarization by Stimulus-Specific NPAS4 Heterodimers.G Stefano Brigidi et al.Cell, 179(2), 373-391 (2019-10-05) Manipulating kynurenic acid levels in the brain - on the edge between neuroprotection and cognitive dysfunction.Levente Szalardy et al.Current topics in medicinal chemistry, 12(16), 1797-1806 (2012-10-04) Sexual congruency in the connectome and translatome of VTA dopamine neurons.Amanda S Chung et al.Scientific reports, 7(1), 11120-11120 (2017-09-13) Kynurenine pathway inhibition as a therapeutic strategy for neuroprotectionStone TW, et al. FEBS Journal, 279(8), 1386-1397 (2012) CAST/ELKS Proteins Control Voltage-Gated Ca2+ Channel Density and Synaptic Release Probability at a Mammalian Central Synapse.Wei Dong et al.Cell reports, 24(2), 284-293 (2018-07-12) Reduction of brain kynurenic acid improves cognitive function.Rouba Kozak et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(32), 10592-10602 (2014-08-08) Dietary and Microbial Oxazoles Induce Intestinal Inflammation by Modulating Aryl Hydrocarbon Receptor Responses.Shankar S Iyer et al.Cell, 173(5), 1123-1134 (2018-05-19) Single-Cell RNA Analysis of Type I Spiral Ganglion Neurons Reveals a Lmx1a Population in the Cochlea.Fiorella Carla Grandi et al.Frontiers in molecular neuroscience, 13, 83-83 (2020-06-12) Control of Amygdala Circuits by 5-HT Neurons via 5-HT and Glutamate Cotransmission.Ayesha Sengupta et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 37(7), 1785-1796 (2017-01-15) Impairment of adenylyl cyclase-mediated glutamatergic synaptic plasticity in the periaqueductal grey in a rat model of neuropathic pain.Yu-Cheng Ho et al.The Journal of physiology, 593(13), 2955-2973 (2015-04-14) Neuropharmacology of quinolinic and kynurenic acids.T W Stone Pharmacological reviews, 45(3), 309-379 (1993-09-01) Multimodal Analysis of Cell Types in a Hypothalamic Node Controlling Social Behavior.Dong-Wook Kim et al.Cell, 179(3), 713-728 (2019-10-19) The cardiovascular functions of salusin-β mediated by muscarinic receptors, glutamate receptors or L-type calcium channels within the rostral ventrolateral medulla of rats.Fu-Jia Xie et al.Microscopy research and technique, 80(7), 812-819 (2017-04-04) Branched-chain amino acids alter neurobehavioral function in rats.Anna Coppola et al.American journal of physiology. Endocrinology and metabolism, 304(4), E405-E413 (2012-12-20) Microbiota-Derived Metabolites Suppress Arthritis by Amplifying Aryl-Hydrocarbon Receptor Activation in Regulatory B Cells.Elizabeth C Rosser et al.Cell metabolism, 31(4), 837-851 (2020-03-28) Conserved contributions of NMDA receptor subtypes to synaptic responses in lamina II spinal neurons across early postnatal development.Hadir Mahmoud et al.Molecular brain, 13(1), 31-31 (2020-03-07) Deficit schizophrenia is a discrete diagnostic category defined by neuro-immune and neurocognitive features: results of supervised machine learning.Buranee Kanchanatawan et al.Metabolic brain disease, 33(4), 1053-1067 (2018-03-13) A metabonomic study of adjuvant-induced arthritis in rats using ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry.Yao Qi et al.Molecular bioSystems, 10(10), 2617-2625 (2014-07-22) Plasma sample based analysis of gastric cancer progression using targeted metabolomics.Sergio Lario et al.Scientific reports, 7(1), 17774-17774 (2017-12-21) A-type KSoledad Pitra et al.American journal of physiology. Heart and circulatory physiology, 313(3), H548-H557 (2017-06-20) Brief optogenetic inhibition of dopamine neurons mimics endogenous negative reward prediction errors.Chun Yun Chang et al.Nature neuroscience, 19(1), 111-116 (2015-12-08) Altered NMDAR signaling underlies autistic-like features in mouse models of CDKL5 deficiency disorder.Sheng Tang et al.Nature communications, 10(1), 2655-2655 (2019-06-16) Inhibition of opioid receptor mediated G-protein activity after chronic administration of kynurenic acid and its derivative without direct binding to opioid receptors.Ferenc Zador et al.CNS & neurological disorders drug targets, 13(9), 1520-1529 (2014-12-06) Suppressive effects of morphine injected into the ventral bed nucleus of the stria terminalis on the affective, but not sensory, component of pain in rats.Chikashi Maruyama et al.The European journal of neuroscience, 47(1), 40-47 (2017-11-14) [Kynurenic acid--a new tool in the treatment of hiperhomocysteinemia and its consequences?].Patrycja Nowicka-Stążka et al.Postepy higieny i medycyny doswiadczalnej (Online), 66, 431-436 (2012-08-28) Enduring changes in tonic GABAA receptor signaling in dentate granule cells after controlled cortical impact brain injury in mice.Jeffery A Boychuk et al.Experimental neurology, 277, 178-189 (2016-01-17) Transient Deregulation of Canonical Wnt Signaling in Developing Pyramidal Neurons Leads to Dendritic Defects and Impaired Behavior.Beatrice Viale et al.Cell reports, 27(5), 1487-1502 (2019-05-03) TMEM16B Calcium-Activated Chloride Channels Regulate Action Potential Firing in Lateral Septum and Aggression in Male Mice.Lynn Wang et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 39(36), 7102-7117 (2019-07-20) Establishment of an in Vitro Human Blood-Brain Barrier Model Derived from Induced Pluripotent Stem Cells and Comparison to a Porcine Cell-Based System.Annalise Di Marco et al.Cells, 9(4) (2020-04-23) Supragranular Pyramidal Cells Exhibit Early Metabolic Alterations in the 3xTg-AD Mouse Model of Alzheimer's Disease.Juliette Piquet et al.Frontiers in cellular neuroscience, 12, 216-216 (2018-08-04) Quantification of free and protein bound uremic toxins in human serum by LC-MS/MS: Comparison of rapid equilibrium dialysis and ultrafiltration.Nicolas Fabresse et al.Clinica chimica acta; international journal of clinical chemistry, 507, 228-235 (2020-05-07) Loss of CDKL5 in Glutamatergic Neurons Disrupts Hippocampal Microcircuitry and Leads to Memory Impairment in Mice.Sheng Tang et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 37(31), 7420-7437 (2017-07-05) Role of the dorsomedial medulla in suppression of cough by codeine in cats.Ivan Poliacek et al.Respiratory physiology & neurobiology, 246, 59-66 (2017-08-06) Charge-Balanced Electrical Stimulation Can Modulate Neural Precursor Cell Migration in the Presence of Endogenous Electric Fields in Mouse Brains.Stephanie N Iwasa et al.eNeuro, 6(6) (2019-11-28) Microtubule-associated tau contributes to intra-dendritic trafficking of AMPA receptors in multiple ways.Mamiko Suzuki et al.Neuroscience letters, 653, 276-282 (2017-05-31) Electrophysiological effects of exogenous and endogenous kynurenic acid in the rat brain: studies in vivo and in vitro.H E Scharfman et al.Amino acids, 19(1), 283-297 (2000-10-12) Experimental Evidence that 3-Methylglutaric Acid Disturbs Mitochondrial Function and Induced Oxidative Stress in Rat Brain Synaptosomes: New Converging Mechanisms.Ana Laura Colín-González et al.Neurochemical research, 41(10), 2619-2626 (2016-06-10) Fezf2 expression in layer 5 projection neurons of mature mouse motor cortex.Malinda L S Tantirigama et al.The Journal of comparative neurology, 524(4), 829-845 (2015-08-04) Impairment of Glycolysis-Derived l-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer's Disease.Juliette Le Douce et al.Cell metabolism, 31(3), 503-517 (2020-03-05)

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