熔点	219-221 ºC
比旋光度	104 º (c=1, H2O 25 ºC)
水溶性	620 g/L (20 ºC)

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来源	SDS样本
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The potent anti-tumor-promoting agent isoliquiritigenin.S Yamamoto et al.Carcinogenesis, 12(2), 317-323 (1991-02-01) S-allyl-L-cysteine and isoliquiritigenin improve mitochondrial function in cellular models of oxidative and nitrosative stress.Isabel Denzer et al.Food chemistry, 194, 843-848 (2015-10-17) Involvement of endoplasmic reticulum stress in isoliquiritigenin-induced SKOV-3 cell apoptosis.Xuan Yuan et al.Recent patents on anti-cancer drug discovery, 8(2), 191-199 (2012-09-12) Glycyrrhizin and isoliquiritigenin suppress the LPS sensor toll-like receptor 4/MD-2 complex signaling in a different manner.Hiroe Honda et al.Journal of leukocyte biology, 91(6), 967-976 (2012-03-17) Development of sample preparation method for isoliquiritigenin, liquiritin, and glycyrrhizic acid analysis in licorice by ionic liquids-ultrasound based extraction and high-performance liquid chromatography detection.Lei Yang et al.Food chemistry, 138(1), 173-179 (2012-12-26) Novel action of the chalcone isoliquiritigenin as a cystic fibrosis transmembrane conductance regulator (CFTR) inhibitor: potential therapy for cholera and polycystic kidney disease.Chatchai Muanprasat et al.Journal of pharmacological sciences, 118(1), 82-91 (2011-12-22) Antispasmodic effect of shakuyakukanzoto extract on experimental muscle cramps in vivo: role of the active constituents of Glycyrrhizae radix.Keiko K Lee et al.Journal of ethnopharmacology, 145(1), 286-293 (2012-11-21) Differential Effects of Glycyrrhiza Species on Genotoxic Estrogen Metabolism: Licochalcone A Downregulates P450 1B1, whereas Isoliquiritigenin Stimulates It.Tareisha L Dunlap et al.Chemical research in toxicology, 28(8), 1584-1594 (2015-07-03) Isoliquiritigenin-induced differentiation in mouse melanoma B16F0 cell line.Xiaoyu Chen et al.Oxidative medicine and cellular longevity, 2012, 534934-534934 (2013-01-11) The Flavone Luteolin Suppresses SREBP-2 Expression and Post-Translational Activation in Hepatic Cells.Tsz Yan Wong et al.PloS one, 10(8), e0135637-e0135637 (2015-08-25) Involvement of the mitochondrion-dependent and the endoplasmic reticulum stress-signaling pathways in isoliquiritigenin-induced apoptosis of HeLa cell.Xuan Yuan et al.Biomedical and environmental sciences : BES, 26(4), 268-276 (2013-03-29) Inhibitory effects of Glycyrrhizae radix and its active component, isoliquiritigenin, on Aβ(25-35)-induced neurotoxicity in cultured rat cortical neurons.Hong Kyu Lee et al.Archives of pharmacal research, 35(5), 897-904 (2012-05-31) Inhibitory effects of isoliquiritigenin on the migration and invasion of human breast cancer cells.Kai-Lee Wang et al.Expert opinion on therapeutic targets, 17(4), 337-349 (2013-01-19) Decrease of microRNA-122 causes hepatic insulin resistance by inducing protein tyrosine phosphatase 1B, which is reversed by licorice flavonoid.Yoon Mee Yang et al.Hepatology (Baltimore, Md.), 56(6), 2209-2220 (2012-07-19) Isoliquiritigenin isolated from Glycyrrhiza uralensis protects neuronal cells against glutamate-induced mitochondrial dysfunction.Eun-Ju Yang et al.Biochemical and biophysical research communications, 421(4), 658-664 (2012-04-28) Anti-platelet action of isoliquiritigenin, an aldose reductase inhibitor in licorice.M Tawata et al.European journal of pharmacology, 212(1), 87-92 (1992-02-25) Licorice isoliquiritigenin suppresses RANKL-induced osteoclastogenesis in vitro and prevents inflammatory bone loss in vivo.Lingxin Zhu et al.The international journal of biochemistry & cell biology, 44(7), 1139-1152 (2012-04-24) Molecular signatures in response to Isoliquiritigenin in lymphoblastoid cell lines.Jae-Eun Lee et al.Biochemical and biophysical research communications, 427(2), 392-397 (2012-09-22) Isoliquiritigenin treatment induces apoptosis by increasing intracellular ROS levels in HeLa cells.Xuan Yuan et al.Journal of Asian natural products research, 14(8), 789-798 (2012-06-15) Quercetin-induced apoptosis prevents EBV infection.Minjung Lee et al.Oncotarget, 6(14), 12603-12624 (2015-06-11) Analgesic and uterine relaxant effects of isoliquiritigenin, a flavone from Glycyrrhiza glabra.Yulu Shi et al.Phytotherapy research : PTR, 26(9), 1410-1417 (2012-03-06) Isoliquiritigenin, a chalcone compound, is a positive allosteric modulator of GABAA receptors and shows hypnotic effects.Suengmok Cho et al.Biochemical and biophysical research communications, 413(4), 637-642 (2011-09-29) The isolation of bioactive flavonoids from Jacaranda obtusifolia H. B. K. ssp. rhombifolia (G. F. W. Meijer) Gentry.Sorachai Khamsan et al.Acta pharmaceutica (Zagreb, Croatia), 62(2), 181-190 (2012-07-04) Small molecule modifier screen for kit-dependent functions in zebrafish embryonic melanocytesHultman KA, et al. Zebrafish, 5(4), 279-287 (2008) Isoliquiritigenin enhances radiosensitivity of HepG2 cells via disturbance of redox status.Chao Sun et al.Cell biochemistry and biophysics, 65(3), 433-444 (2012-10-23) Vasorelaxant effect of isoliquiritigenin, a novel soluble guanylate cyclase activator, in rat aorta.S M Yu et al.British journal of pharmacology, 114(8), 1587-1594 (1995-04-01) Isoliquiritigenin inhibits the growth of multiple myeloma via blocking IL-6 signaling.Xiangzheng Chen et al.Journal of molecular medicine (Berlin, Germany), 90(11), 1311-1319 (2012-06-01) Quercetin-induced apoptosis prevents EBV infectionLee M, et al. Testing, 6(14), 12603-12603 (2015) Isoliquiritigenin isolated from licorice Glycyrrhiza uralensis prevents 6-hydroxydopamine-induced apoptosis in dopaminergic neurons.Cheol Kyu Hwang et al.Bioscience, biotechnology, and biochemistry, 76(3), 536-543 (2012-03-28) Effects of phytochemicals on in vitro anti-inflammatory activity of Bifidobacterium adolescentis.Kyuichi Kawabata et al.Bioscience, biotechnology, and biochemistry, 79(5), 799-807 (2015-02-28) Isoliquiritigenin showed strong inhibitory effects towards multiple UDP-glucuronosyltransferase (UGT) isoform-catalyzed 4-methylumbelliferone (4-MU) glucuronidation.Hang Lu et al.Fitoterapia, 84, 208-212 (2012-12-15) Determination of isoliquiritigenin and its distribution in mice by synchronous fluorescence spectrometry.Bo Han et al.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 27(11), 1115-1119 (2011-11-15) Mammalian target of rapamycin regulates isoliquiritigenin-induced autophagic and apoptotic cell death in adenoid cystic carcinoma cells.Gang Chen et al.Apoptosis : an international journal on programmed cell death, 17(1), 90-101 (2011-10-01) Novel plant-derived target drugs: a step forward from licorice?Vito Lorusso et al.Expert opinion on therapeutic targets, 17(4), 333-335 (2013-02-22) Isoliquiritigenin attenuates oxidative hepatic damage induced by carbon tetrachloride with or without buthionine sulfoximine.ZhengLin Zhao et al.Chemico-biological interactions, 225, 13-20 (2014-12-03) Flavonoids and Auxin Transport Inhibitors Rescue Symbiotic Nodulation in the Medicago truncatula Cytokinin Perception Mutant cre1.Jason Liang Pin Ng et al.The Plant cell, 27(8), 2210-2226 (2015-08-09) NADPH oxidase-derived reactive oxygen species are involved in the HL-60 cell monocytic differentiation induced by isoliquiritigenin.Hongmei Chen et al.Molecules (Basel, Switzerland), 17(11), 13424-13438 (2012-11-14) Isoliquiritigenin is a potent inhibitor of NLRP3 inflammasome activation and diet-induced adipose tissue inflammation.Hiroe Honda et al.Journal of leukocyte biology, 96(6), 1087-1100 (2014-09-12) Comparative evaluation of two structurally related flavonoids, isoliquiritigenin and liquiritigenin, for their oral infection therapeutic potential.Mark Feldman et al.Journal of natural products, 74(9), 1862-1867 (2011-08-27) Downregulation of COX-2 and CYP 4A signaling by isoliquiritigenin inhibits human breast cancer metastasis through preventing anoikis resistance, migration and invasion.Zheng H, Li Y, Wang Y, et al. Toxicology and Applied Pharmacology, 280(1), 10-20 (2014) Wdr68 mediates dorsal and ventral patterning events for craniofacial developmentAlvarado E, et al. PLoS ONE, 11(11), e0166984-e0166984 (2016)

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