4-Methyl-5-hydroxymethyluracil | CAS:147-61-5
4-Methyl-5-hydroxymethyluracil
- 名称:4-甲基-5-羟基甲基尿嘧啶 | 4-Methyl-5-hydroxymethyluracil
- CAS号:147-61-5
- 别名:5-Hydroxymethyl-6-methyluracil; NSC 13202; NSC 667247; Pentoxil; Pentoxyl
- 分子式:C6H8N2O3
- 分子量:156.14
- EINESC号:205-694-0
产品描述
物理化学性质
熔点 | 314-315 ºC** |
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密度 | 1.308±0.06 g/cm3 (20 º |
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Characterization of relaxant mechanism of H2 S in mouse corpus cavernosum.Fatma Aydinoglu et al.Clinical and experimental pharmacology & physiology, 43(4), 503-511 (2016-02-05)
Inhibition of adenylate cyclase attenuates muscarinic Ca²(+) signaling by a PKA-independent mechanism in rat carotid body Type I cells.Carrie M Thompson et al.Respiratory physiology & neurobiology, 175(1), 90-96 (2010-09-28)
Inhibition of adenylyl cyclase in amygdala blocks the effect of audiogenic seizure kindling in genetically epilepsy-prone rats.Srinivasan Tupal et al.Neuropharmacology, 59(1-2), 107-111 (2010-04-27)
[The role of serine/threonine and tyrosine protein kinases in the depression of cholinosensitivity in Helix lucorum neurons in the cellular correlate of habituation].D A Makhnovskiĭ et al.Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova, 61(4), 459-475 (2011-10-04)
β-Endorphin inhibits phagocytic activity of lizard splenic phagocytes through μ receptor-coupled adenylate cyclase-protein kinase A signaling pathway.Sunil Kumar et al.General and comparative endocrinology, 171(3), 301-308 (2011-03-01)
Inhibition of adenylate cyclase of catfish and rat hepatocyte membranes by 9-(tetrahydro-2-furyl)adenine (SQ 22536).E Fabbri et al.Journal of enzyme inhibition, 5(2), 87-98 (1991-01-01)
Functional and molecular characterization of prostaglandin E2 dilatory receptors in the rat craniovascular system in relevance to migraine.Maja Myren et al.Cephalalgia : an international journal of headache, 30(9), 1110-1122 (2010-08-18)
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GABAB Receptors Regulate Extrasynaptic GABAA Receptors.William M Connelly et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(9), 3780-3785 (2013-03-01)
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Mirabegron, a β3-adrenoceptor agonist reduced platelet aggregation through cyclic adenosine monophosphate accumulation.Camila Bitencourt Mendes-Silvério et al.European journal of pharmacology, 829, 79-84 (2018-04-15)
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Prostaglandin E2 promotes liver cancer cell growth by the upregulation of FUSE-binding protein 1 expression.Juan Ma et al.International journal of oncology, 42(3), 1093-1104 (2013-01-23)
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Increase nitric oxide synthase activity in parotid glands from rats with experimental periodontitis.V Miozza et al.Oral diseases, 16(8), 801-806 (2010-06-22)
Multiple effects of gymnopilin on circulatory system of the rat.Aiko Nishio et al.Biological & pharmaceutical bulletin, 35(8), 1300-1305 (2012-08-07)
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