熔点	78-82 ºC
沸点	280 ºC
密度	0.899

危险品标志	Xi
危险类别码	R36/37/38
安全说明书	S26;S37/39

来源	SDS样本
没有数据	没有数据

产品合成路线

更多

名称	CAS号

更多

文章

同行评议文献

Gas Chromatography/Mass Spectrometry Metabolomics of Urine and Serum from Nonhuman Primates Exposed to Ionizing Radiation: Impacts on the Tricarboxylic Acid Cycle and Protein Metabolism.Evan L Pannkuk et al.Journal of proteome research, 16(5), 2091-2100 (2017-03-30) Biomarker Profiling for Pyridoxine Dependent Epilepsy in Dried Blood Spots by HILIC-ESI-MS.Elizabeth Mary Mathew et al.International journal of analytical chemistry, 2018, 2583215-2583215 (2018-08-30) Comparative rates of metabolism of pipecolic acid in several animal species.J Dancis et al.Comparative biochemistry and physiology. B, Comparative biochemistry, 73(4), 1011-1012 (1982-01-01) A Role for Tocopherol Biosynthesis in Arabidopsis Basal Immunity to Bacterial Infection.Elia Stahl et al.Plant physiology, 181(3), 1008-1028 (2019-09-14) Diagnosis of tuberculous meningitis by detection of tuberculostearic acid in cerebrospinal fluid.G L French et al.Lancet (London, England), 2(8551), 117-119 (1987-07-18) The effects of acute falciparum malaria on the disposition of caffeine and the comparison of saliva and plasma-derived pharmacokinetic parameters in adult Nigerians.O O Akinyinka et al.European journal of clinical pharmacology, 56(2), 159-165 (2000-07-06) Stable isotope dilution analysis of pipecolic acid in cerebrospinal fluid, plasma, urine and amniotic fluid using electron capture negative ion mass fragmentography.R M Kok et al.Clinica chimica acta; international journal of clinical chemistry, 168(2), 143-152 (1987-09-30) Stereoselective access to fluorinated and non-fluorinated quaternary piperidines: synthesis of pipecolic acid and iminosugar derivatives.Santos Fustero et al.Chemistry (Weinheim an der Bergstrasse, Germany), 18(12), 3753-3764 (2012-02-16) Effects of Maerua subcordata (Gilg) DeWolf on electrophile-responsive element (EpRE)-mediated gene expression in vitro.Mebrahtom Gebrelibanos Hiben et al.PloS one, 14(4), e0215155-e0215155 (2019-04-16) Hyperpipecolic acidemia: clinical and biochemical observations in two male siblings.B K Burton et al.The Journal of pediatrics, 99(5), 729-734 (1981-11-01) Proton MR CSF analysis and a new software as predictors for the differentiation of meningitis in children.Arunachalam Subramanian et al.NMR in biomedicine, 18(4), 213-225 (2005-01-01) An efficient lipase-catalyzed enantioselective hydrolysis of (R,S)-azolides derived from N-protected proline, pipecolic acid, and nipecotic acid.Chia-Hui Wu et al.Applied microbiology and biotechnology, 97(4), 1581-1587 (2012-03-31) Global host metabolic response to Plasmodium vivax infection: a 1H NMR based urinary metabonomic study.Arjun Sengupta et al.Malaria journal, 10, 384-384 (2011-12-27) Effect of a carboxyl group on the chemiluminescent reaction of tris(2,2'-bipyridine)ruthenium(III) with aliphatic amines.Hitoshi Kodamatani et al.Talanta, 78(1), 227-232 (2009-01-29) Transport and signaling via the amino acid binding site of the yeast Gap1 amino acid transceptor.Griet Van Zeebroeck et al.Nature chemical biology, 5(1), 45-52 (2008-12-09) Cerebro-hepato-renal syndrome of Zellweger. A report of eight cases with comments upon the incidence, the liver lesion, and a fault in pipecolic acid metabolism.D M Danks et al.The Journal of pediatrics, 86(3), 382-387 (1975-03-01) Infantile Refsum's disease: biochemical findings suggesting multiple peroxisomal dysfunction.B T Poll-The et al.Journal of inherited metabolic disease, 9(2), 169-174 (1986-01-01) Simultaneous determination of alpha-aminoadipic semialdehyde, piperideine-6-carboxylate and pipecolic acid by LC-MS/MS for pyridoxine-dependent seizures and folinic acid-responsive seizures.Katerina Sadilkova et al.Journal of neuroscience methods, 184(1), 136-141 (2009-07-28) Metabolism of phytanic acid and 3-methyl-adipic acid excretion in patients with adult Refsum disease.Anthony S Wierzbicki et al.Journal of lipid research, 44(8), 1481-1488 (2003-04-18) Primary Metabolite Responses to Oxidative Stress in Early-Senescing and Paraquat Resistant Arabidopsis thaliana rcd1 (Radical-Induced Cell Death1).Nina Sipari et al.Frontiers in plant science, 11, 194-194 (2020-03-18) Algicidal activity of a dibenzofuran-degrader Rhodococcus sp.Meng-Hui Wang et al.Journal of microbiology and biotechnology, 23(2), 260-266 (2013-02-16) Origin of D- and L-pipecolic acid in human physiological fluids: a study of the catabolic mechanism to pipecolic acid using the lysine loading test.T Fujita et al.Clinica chimica acta; international journal of clinical chemistry, 287(1-2), 145-156 (1999-10-06) Heat-induced formation of mepiquat by decarboxylation of pipecolic acid and its betaine derivative. Part 1: Model system studies.Yuan Yuan et al.Food chemistry, 227, 173-178 (2017-03-10) Metabolites of the kynurenine pathway of tryptophan metabolism in the cerebrospinal fluid of Malawian children with malaria.Isabelle M Medana et al.The Journal of infectious diseases, 188(6), 844-849 (2003-09-10) Cerebrospinal fluid taurine after traumatic brain injury.Yukio Seki et al.Neurochemical research, 30(1), 123-128 (2005-03-11) A metabolomic strategy revealed the role of JA and SA balance in Clematis terniflora DC. Response to UVB radiation and dark.Bingxian Yang et al.Physiologia plantarum, 167(2), 232-249 (2018-11-24) Intramolecular hydroamination of dithioketene acetals: an easy route to cyclic amino acid derivatives.Hai-Chao Xu et al.Organic letters, 12(22), 5174-5177 (2010-10-16) Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression.Arun Sreekumar et al.Nature, 457(7231), 910-914 (2009-02-13) Identification and quantification of amino acids and related compounds based on Differential Mobility Spectrometry.Francis Berthias et al.The Analyst, 145(14), 4889-4900 (2020-06-02) Lysine restricted diet for pyridoxine-dependent epilepsy: first evidence and future trials.Clara D M van Karnebeek et al.Molecular genetics and metabolism, 107(3), 335-344 (2012-10-02) Syntheses of (-)-pelletierine and (-)-homopipecolic acid.Wen-Hua Chiou et al.Organic & biomolecular chemistry, 10(13), 2518-2520 (2012-02-22) Metabolomic Analysis of Diet-Induced Obese Mice Supplemented with Eicosapentaenoic Acid.Shigeki Nishitani et al.Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 128(8), 548-555 (2018-12-12) Analogues of arginine vasopressin modified in the N-terminal part of the molecule with pipecolic acid isomers.Dariusz Sobolewski et al.Advances in experimental medicine and biology, 611, 501-502 (2009-04-30) Aphid-Responsive Defense Networks in Hybrid Switchgrass.Kyle G Koch et al.Frontiers in plant science, 11, 1145-1145 (2020-08-28) A one-pot, reductive amination/6-endo-trig cyclisation for the stereoselective synthesis of 6-substituted-4-oxopipecolic acids.Lindsay S Fowler et al.Chemical communications (Cambridge, England), 47(23), 6569-6571 (2011-05-17) Chiral separation of the clinically important compounds fucose and pipecolic acid using CE: determination of the most effective chiral selector.Christoforos A Hadjistasi et al.Chirality, 25(9), 556-560 (2013-06-13) Zellweger syndrome: report of one case.H F Lee et al.Acta paediatrica Taiwanica = Taiwan er ke yi xue hui za zhi, 42(1), 53-56 (2001-03-29) Induction of peroxisome proliferator activated receptor γ (PPARγ) mediated gene expression and inhibition of induced nitric oxide production by Maerua subcordata (Gilg) DeWolf.Mebrahtom Gebrelibanos Hiben et al.BMC complementary medicine and therapies, 20(1), 80-80 (2020-03-14) Determination of pipecolic acid in urine and plasma by isotope dilution mass fragmentography.G A van den Berg et al.Clinica chimica acta; international journal of clinical chemistry, 159(3), 229-237 (1986-09-30) Hyperpipecolic acidemia associated with hepatomegaly, mental retardation, optic nerve dysplasia and progressive neurological disease.G H Thomas et al.Clinical genetics, 8(5), 376-382 (1975-11-01) Metabolomics reveals attenuation of the SLC6A20 kidney transporter in nonhuman primate and mouse models of type 2 diabetes mellitus.Andrew D Patterson et al.The Journal of biological chemistry, 286(22), 19511-19522 (2011-04-14) Vitamin D Switches BAF Complexes to Protect β Cells.Zong Wei et al.Cell, 173(5), 1135-1149 (2018-05-15) Pipecolic acid elevation in plasma and cerebrospinal fluid of two patients with pyridoxine-dependent epilepsy.B Plecko et al.Annals of neurology, 48(1), 121-125 (2000-07-14) Enantioselective allylation of imines catalyzed by newly developed (-)-β-pinene-based π-allylpalladium catalyst: an efficient synthesis of (R)-α-propylpiperonylamine and (R)-pipecolic acid.Rodney A Fernandes et al.Organic & biomolecular chemistry, 10(38), 7789-7800 (2012-08-23) Neuron-specific enolase, nucleotides, nucleosides, purine bases, oxypurines and uric acid concentrations in cerebrospinal fluid of children with meningitis.Antonio Rodríguez-Núñez et al.Brain & development, 25(2), 102-106 (2003-02-13) Phytochemical analysis of Ononis arvensis L. by liquid chromatography coupled with mass spectrometry.Nóra Gampe et al.Journal of mass spectrometry : JMS, 54(2), 121-133 (2018-11-09) Fluctuating Light Interacts with Time of Day and Leaf Development Stage to Reprogram Gene Expression.Trang Schneider et al.Plant physiology, 179(4), 1632-1657 (2019-02-06) Pipecolic acid, an endogenous mediator of defense amplification and priming, is a critical regulator of inducible plant immunity.Hana Návarová et al.The Plant cell, 24(12), 5123-5141 (2012-12-12) Pipecolic Acid Is Induced in Barley upon Infection and Triggers Immune Responses Associated with Elevated Nitric Oxide Accumulation.Miriam Lenk et al.Molecular plant-microbe interactions : MPMI, 32(10), 1303-1313 (2019-06-14) Peroxisomal bifunctional enzyme deficiency.P A Watkins et al.The Journal of clinical investigation, 83(3), 771-777 (1989-03-01) Metabolism of lysine in alpha-aminoadipic semialdehyde dehydrogenase-deficient fibroblasts: evidence for an alternative pathway of pipecolic acid formation.Eduard A Struys et al.FEBS letters, 584(1), 181-186 (2009-11-26) Analytical considerations for postmortem metabolomics using GC-high-resolution MS.Lana Brockbals et al.Analytical and bioanalytical chemistry, 412(24), 6241-6255 (2019-11-24) Biochemical Principles and Functional Aspects of Pipecolic Acid Biosynthesis in Plant Immunity.Michael Hartmann et al.Plant physiology, 174(1), 124-153 (2017-03-24) ECNI GC-MS analysis of picolinic and quinolinic acids and their amides in human plasma, CSF, and brain tissue.George A Smythe et al.Advances in experimental medicine and biology, 527, 705-712 (2004-06-23) Differential 12C-/13C-isotope dansylation labeling and fast liquid chromatography/mass spectrometry for absolute and relative quantification of the metabolome.Kevin Guo et al.Analytical chemistry, 81(10), 3919-3932 (2009-03-25) Assessment of antioxidant reserves and oxidative stress in cerebrospinal fluid after severe traumatic brain injury in infants and children.Hulya Bayir et al.Pediatric research, 51(5), 571-578 (2002-04-30) Intramolecular anodic olefin coupling reactions and the synthesis of cyclic amines.Hai-Chao Xu et al.Journal of the American Chemical Society, 132(8), 2839-2844 (2010-02-06) The clinical significance of cerebrospinal fluid levels of kynurenine pathway metabolites and lactate in severe malaria.Isabelle M Medana et al.The Journal of infectious diseases, 185(5), 650-656 (2002-02-28) Yun-Chu Chen et al.Proceedings of the National Academy of Sciences of the United States of America, 115(21), E4920-E4929 (2018-05-08)Systemic acquired resistance (SAR) is a global response in plants induced at the site of infection that leads to long-lasting and broad-spectrum disease resistance at distal, uninfected tissues. Despite the importance of this priming mechanism, the identity and complexity of... Determination of pipecolic acid following trimethylsilyl and trifluoroacyl derivatisation on plasma filter paper by stable isotope GC-MS for peroxisomal disorders.Hye-Ran Yoon et al.Archives of pharmacal research, 33(2), 317-323 (2010-03-03) Chromatin Accessibility Dynamics and a Hierarchical Transcriptional Regulatory Network Structure for Plant Somatic Embryogenesis.Fu-Xiang Wang et al.Developmental cell, 54(6), 742-757 (2020-08-07) Lysine catabolism in Haemonchus contortus and Teladorsagia circumcincta.S Umair et al.Experimental parasitology, 131(1), 101-106 (2012-03-31) Clinical significance of circulating tumor cells and metabolic signatures in lung cancer after surgical removal.Dawei Yang et al.Journal of translational medicine, 18(1), 243-243 (2020-06-20) Discovery of 23 natural tubulysins from Angiococcus disciformis An d48 and Cystobacter SBCb004.Yi Chai et al.Chemistry & biology, 17(3), 296-309 (2010-03-27) Synthesis of methyl N-Boc-(2S,4R)-4-methylpipecolate.Kuo-Yuan Hung et al.The Journal of organic chemistry, 75(24), 8728-8731 (2010-11-26) Normalization of proliferation and tight junction formation in bladder epithelial cells from patients with interstitial cystitis/painful bladder syndrome by d-proline and d-pipecolic acid derivatives of antiproliferative factor.Susan Keay et al.Chemical biology & drug design, 77(6), 421-430 (2011-03-01) iPSC-derived familial Alzheimer's PSEN2 N141I cholinergic neurons exhibit mutation-dependent molecular pathology corrected by insulin signaling.Cesar L Moreno et al.Molecular neurodegeneration, 13(1), 33-33 (2018-06-28) Postmortem metabolomics: Correlating time-dependent concentration changes of xenobiotic and endogenous compounds.Lana Brockbals et al.Drug testing and analysis, 12(8), 1171-1182 (2020-05-07) Reduction of FR900525 using an S-(2-aminoethyl) l-cysteine-resistant mutant.Shiho Shimizu et al.Journal of bioscience and bioengineering, 123(6), 685-691 (2017-02-12) Isochorismate-derived biosynthesis of the plant stress hormone salicylic acid.Dmitrij Rekhter et al.Science (New York, N.Y.), 365(6452), 498-502 (2019-08-03) Plasma levels of pipecolic acid in patients with chronic liver disease.H Kawasaki et al.Hepatology (Baltimore, Md.), 8(2), 286-289 (1988-03-01) Cell Death Triggered by the YUCCA-like Bs3 Protein Coincides with Accumulation of Salicylic Acid and Pipecolic Acid But Not of Indole-3-Acetic Acid.Christina Krönauer et al.Plant physiology, 180(3), 1647-1659 (2019-05-10) Automated screening of urine samples for carbohydrates, organic and amino acids after treatment with urease.J D Shoemaker et al.Journal of chromatography, 562(1-2), 125-138 (1991-01-02) Transcriptional analysis of defense mechanisms in upland tetraploid switchgrass to greenbugs.Teresa Donze-Reiner et al.BMC plant biology, 17(1), 46-46 (2017-02-18) Effects of cigarette smoking on quinine pharmacokinetics in malaria.S Pukrittayakamee et al.European journal of clinical pharmacology, 58(5), 315-319 (2002-08-20) Plasma pipecolic acid is frequently elevated in non-peroxisomal disease.J C M Baas et al.Journal of inherited metabolic disease, 25(8), 699-701 (2003-04-23) Plasma levels of pipecolic acid in patients with chronic liver disease.H Kawasaki et al.Hepatology (Baltimore, Md.), 8(2), 286-289 (1988-03-01) Highly sensitive quantification for human plasma-targeted metabolomics using an amine derivatization reagent.Naoko Arashida et al.Analytica chimica acta, 954, 77-87 (2017-01-14) A simple and highly sensitive HPLC method with fluorescent detection for determination of pipecolic acid in mouse brain areas.Hirofumi Inoue et al.Biological & pharmaceutical bulletin, 34(2), 287-289 (2011-03-19) 2,6-Dimethyloctanedioic acid--a metabolite of phytanic acid in Refsum's disease.J Greter et al.Clinical chemistry, 29(3), 434-437 (1983-03-01) Highly enantioselective catalytic dynamic resolution of N-Boc-2-lithiopiperidine: synthesis of (R)-(+)-N-Boc-pipecolic acid, (S)-(-)-coniine, (S)-(+)-pelletierine, (+)-beta-conhydrine, and (S)-(-)-ropivacaine and formal synthesis of (-)-lasubine II and (+)-cermizine C.Timothy K Beng et al.Journal of the American Chemical Society, 132(35), 12216-12217 (2010-09-03) Occurrence of pipecolic acid and pipecolic acid betaine (homostachydrine) in Citrus genus plants.Luigi Servillo et al.Journal of agricultural and food chemistry, 60(1), 315-321 (2012-01-03) Lysine metabolism in the human and the monkey: demonstration of pipecolic acid formation in the brain and other organs.Y F Chang Neurochemical research, 7(5), 577-588 (1982-05-01) Localization of pipecolic acid metabolism in rat liver peroxisomes: probable explanation for hyperpipecolataemia in Zellweger syndrome.J M Trijbels et al.Journal of inherited metabolic disease, 10(2), 128-134 (1987-01-01)

备注