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Dibenzo[f,h]quinoxaline | CAS:217-68-5
Dibenzo[f,h]quinoxaline
  • 名称:二苯并[f,h]喹喔啉 | Dibenzo[f,h]quinoxaline
  • CAS号:217-68-5
  • 别名:1,4-Diazatriphenylene; 5,6:7,8-Dibenzoquinoxaline; NSC 74769; Phenanthro[9,10-b]pyrazine
  • 分子式:C16H10N2
  • 分子量:230.26
  • EINESC号:

产品描述

物理化学性质

熔点 180 ºC**
密度 1.291±0.06 g/cm3 (20 º

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A new strategy towards the total synthesis of phenanthridone alkaloids: synthesis of (+)-2,7-dideoxypancratistatin as a model study.Ganesh Pandey et al.Chemical communications (Cambridge, England), (6)(6), 624-625 (2002-07-18) Hepatoprotective effects of 6(5H)-phenanthridinone from chemical-induced centrilobular necrosis.Marek Banasik et al.Research communications in molecular pathology and pharmacology, 115-116, 15-20 (2007-06-15) PARP-1 inhibitors sensitize HNSCC cells to APR-246 by inactivation of thioredoxin reductase 1 (TrxR1) and promotion of ROS accumulation.Zhi-Xian Yin et al.Oncotarget, 9(2), 1885-1897 (2018-02-09) Exclusive destruction of mitotic spindles in human cancer cells.Leonid Visochek et al.Oncotarget, 8(13), 20813-20824 (2017-02-18) PARP-1 inhibition prevents CNS migration of dendritic cells during EAE, suppressing the encephalitogenic response and relapse severity.Leonardo Cavone et al.Multiple sclerosis (Houndmills, Basingstoke, England), 17(7), 794-807 (2011-02-24) Effects of 6(5H)-phenanthridinone, an inhibitor of poly(ADP-ribose)polymerase-1 activity (PARP-1), on locomotor networks of the rat isolated spinal cord.Sara Ebrahimi Nasrabady et al.Cellular and molecular neurobiology, 31(4), 503-508 (2011-02-19) 6,(5H)-phenanthridinone protects against carbon tetrachloride-induced cytotoxicity in human HepG2 cells.Paul C Grivas et al.Research communications in molecular pathology and pharmacology, 120-121(1-6), 117-126 (2007-01-01) Stereoselective synthesis of functionalised carbocyclic amides: construction of the syn-(4aS,10bS)-phenanthridone skeleton.Sajjad Ahmad et al.Organic & biomolecular chemistry, 10(19), 3937-3945 (2012-04-06) A novel spectrophotometric method for determination of kinetic constants of aldehyde oxidase using multivariate calibration method.Mohammad-Hossein Sorouraddin et al.Journal of biochemical and biophysical methods, 70(6), 999-1005 (2007-10-16) A highly sensitive RP-HPLC-fluorescence method to study aldehyde oxidase activity.Mohammad-Reza Rashidi et al.Journal of AOAC International, 94(2), 550-554 (2011-05-14) Novel phenanthridinone inhibitors of poly (adenosine 5'-diphosphate-ribose) synthetase: potent cytoprotective and antishock agents.Prakash Jagtap et al.Critical care medicine, 30(5), 1071-1082 (2002-05-15) Attenuation of bromobenzene-induced hepatotoxicity by poly(ADP-ribose) polymerase inhibitors.Kelly W Hall et al.Research communications in molecular pathology and pharmacology, 122-123(1-6), 79-95 (2009-01-01) Chronic exposure of the oligochaete Lumbriculus variegatus to polycyclic aromatic compounds (PACs): bioavailability and effects on reproduction.Miriam León Paumen et al.Environmental science & technology, 42(9), 3434-3440 (2008-06-05) Molecular design, synthesis and docking study of benz[b]oxepines and 12-oxobenzo[c]phenanthridinones as topoisomerase 1 inhibitors.Suh-Hee Lee et al.Bioorganic & medicinal chemistry letters, 19(9), 2444-2447 (2009-04-07) Effect of 6(5H)-phenanthridinone, a poly (ADP-ribose)polymerase inhibitor, and ionizing radiation on the growth of cultured lymphoma cells.D Weltin et al.International journal of radiation biology, 72(6), 685-692 (1998-01-07) Synthesis and evaluation of C-ring aromatized analogues of phenanthridone alkaloids.Seokwoo Lee et al.Archives of pharmacal research, 34(7), 1065-1070 (2011-08-04) Poly(ADP-ribose) polymerase inhibitors attenuate necrotic but not apoptotic neuronal death in experimental models of cerebral ischemia.F Moroni et al.Cell death and differentiation, 8(9), 921-932 (2001-08-30) Inhibitors of poly(ADP-ribose) polymerase-1 suppress transcriptional activation in lymphocytes and ameliorate autoimmune encephalomyelitis in rats.Alberto Chiarugi British journal of pharmacology, 137(6), 761-770 (2002-11-02) The monofunctional alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine triggers apoptosis through p53-dependent and -independent pathways.Wan-Ju Kim et al.Toxicology and applied pharmacology, 202(1), 84-98 (2004-12-14) Nicotinamide is a potent inhibitor of proinflammatory cytokines.J S Ungerstedt et al.Clinical and experimental immunology, 131(1), 48-52 (2003-01-10) Modulation of the antiproliferative activity of anticancer drugs in hematopoietic tumor cell lines by the poly(ADP-ribose) polymerase inhibitor 6(5H)-phenanthridinone.V Holl et al.Anticancer research, 20(5A), 3233-3241 (2000-11-04) One-pot formation of C-C and C-N bonds through palladium-catalyzed dual C-H activation: synthesis of phenanthridinones.Guan-Wu Wang et al.Angewandte Chemie (International ed. in English), 50(6), 1380-1383 (2011-02-04) Synthesis of some members of the hydroxylated phenanthridone subclass of the Amaryllidaceae alkaloid family.Albert Padwa et al.The Journal of organic chemistry, 72(7), 2570-2582 (2007-03-07) Effect of 6(5H)-phenanthridinone, an inhibitor of poly(ADP-ribose) polymerase, on cultured tumor cells.D Weltin et al.Oncology research, 6(9), 399-403 (1994-01-01) Novel isoquinolinone-derived inhibitors of poly(ADP-ribose) polymerase-1: pharmacological characterization and neuroprotective effects in an in vitro model of cerebral ischemia.Alberto Chiarugi et al.The Journal of pharmacology and experimental therapeutics, 305(3), 943-949 (2003-02-28) Total synthesis of 7-deoxypancratistatin-1-carboxaldehyde and carboxylic acid via solvent-free intramolecular aziridine opening: phenanthrene to phenanthridone cyclization strategy.Jonathan Collins et al.Organic letters, 10(3), 361-364 (2008-01-01) Novel inhibitors of poly(ADP-ribose) polymerase/PARP1 and PARP2 identified using a cell-based screen in yeast.E Perkins et al.Cancer research, 61(10), 4175-4183 (2001-05-19) Inhibition of poly(ADP-ribose) polymerase down-regulates BRCA1 and RAD51 in a pathway mediated by E2F4 and p130.Denise Campisi Hegan et al.Proceedings of the National Academy of Sciences of the United States of America, 107(5), 2201-2206 (2010-02-06) Inhibition of poly(ADP-ribose) polymerase-1 attenuates the toxicity of carbon tetrachloride.Marek Banasik et al.Journal of enzyme inhibition and medicinal chemistry, 26(6), 883-889 (2011-03-15)
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