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Pyrazine | CAS:290-37-9
Pyrazine
  • 名称:吡嗪; 对二氮杂苯 | Pyrazine
  • CAS号:290-37-9
  • 别名:1,4-Diazine
  • 分子式:C4H4N2
  • 分子量:80.09
  • EINESC号:206-027-6

产品描述

物理化学性质

熔点 52-56 ºC
水溶性 溶解
沸点 115-116 ºC
闪点 55 ºC
密度 1.031

安全数据

危险品标志 F;Xi
危险类别码 R11;R36/37/38
安全说明书 S16;S26;S36

SDS

来源 SDS样本
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Mixed valent/geometry, linear, tetranuclear nickel complex bearing ONO pincer ligand exhibiting hitherto unknown ligation mode.Shalini C, et al. Polyhedron (2017) [Enzyme histochemical studies of the myocardium following acethydrazine poisoning].W Weinelt et al.Beitrage zur gerichtlichen Medizin, 45, 175-180 (1987-01-01) [Effect of monoacetylhydrazine on the rat liver].G B Sokolova et al.Problemy tuberkuleza, (5)(5), 64-68 (1986-01-01) Effects of rifampicin on pharmacokinetics of isoniazid and its metabolite acetylhydrazine in rats.R L Zhang et al.Zhongguo yao li xue bao = Acta pharmacologica Sinica, 13(6), 494-496 (1992-11-01) Cimetidine inhibits the formation of the reactive, toxic metabolite of isoniazid in rats but not in man.B H Lauterburg et al.Hepatology (Baltimore, Md.), 5(4), 607-609 (1985-07-01) Hepatic gene expression and lipid homeostasis in C57BL/6 mice exposed to hydrazine or acetylhydrazine.Victoria E Richards et al.Toxicological sciences : an official journal of the Society of Toxicology, 82(1), 318-332 (2004-07-30) Identification of novel hydrazine metabolites by 15N-NMR.N E Preece et al.Biochemical pharmacology, 41(9), 1319-1324 (1991-05-01) Analysis of the mechanism of isoniazid-induced developmental toxicity with frog embryo teratogenesis assay: Xenopus (FETAX).D J Fort et al.Teratogenesis, carcinogenesis, and mutagenesis, 10(6), 463-476 (1990-01-01) Activation of hydrazine derivatives to free radicals in the perfused rat liver: a spin-trapping study.B K Sinha Biochimica et biophysica acta, 924(2), 261-269 (1987-05-19) [Nonmedicinal prevention of liver involvement caused by isoniazid and monoacetylhydrazine in rats].V A Koriakin et al.Problemy tuberkuleza, (12)(12), 49-52 (1987-01-01) Highly selective and sensitive chemosensor for Al(III) based on isoquinoline Schiff base.Yu-Ying Huang et al.Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 243, 118754-118754 (2020-08-20) Inhibition of leukotriene omega-oxidation by isonicotinic acid hydrazide (isoniazid).S Parthé et al.European journal of biochemistry, 187(1), 119-124 (1990-01-12) Quantitative glycome analysis of N-glycan patterns in bladder cancer vs normal bladder cells using an integrated strategy.Ganglong Yang et al.Journal of proteome research, 14(2), 639-653 (2014-12-24) Human PXR modulates hepatotoxicity associated with rifampicin and isoniazid co-therapy.Feng Li et al.Nature medicine, 19(4), 418-420 (2013-03-12) Development and characterization of Haemophilus influenzae type b conjugate vaccine prepared using different polysaccharide chain lengths.R Rana et al.Vaccine, 33(23), 2646-2654 (2015-04-25) Isoniazid-related hepatotoxicity: a study of the effect of rifampicin administration on the metabolism of acetylisoniazid in man.P J Jenner et al.Tubercle, 70(2), 93-101 (1989-06-01) The effect of pyrazinamide and rifampicin on isoniazid metabolism in rats.Helene J De Rosa et al.Biopharmaceutics & drug disposition, 28(6), 291-296 (2007-06-16) Identification of N2 as a metabolite of acetylhydrazine in the rat.K Mörike et al.Archives of toxicology, 70(5), 300-305 (1996-01-01) The reaction of cyanoacetylhydrazine with omega-bromo(4-methyl)acetophenone: synthesis of heterocyclic derivatives with antitumor activity.Rafat M Mohareb et al.Molecules (Basel, Switzerland), 15(5), 3602-3617 (2010-07-27) Acetylation of acetylhydrazine, the toxic metabolite of isoniazid, in humans. Inhibition by concomitant administration of isoniazid.E Peretti et al.The Journal of pharmacology and experimental therapeutics, 243(2), 686-689 (1987-11-01) Analysis of isoniazid, acetylhydrazine and [15N2]acetylhydrazine in serum by capillary gas chromatography-ammonia chemical ionization mass spectrometry.G Karlaganis et al.Journal of chromatography, 420(1), 171-177 (1987-09-04) Determination of the isoniazid metabolite monoacetylhydrazine in urine by high-performance liquid chromatography.P J Jenner et al.Journal of chromatography, 415(1), 188-196 (1987-03-20) The effect of vitamin B6 deficiency on acetylhydrazine hepatic necrosis.C J Ganley et al.Pharmacology & toxicology, 74(4-5), 303-304 (1994-04-01) The role of oxygen free radicals in isoniazid-induced hepatotoxicity.A Walubo et al.Methods and findings in experimental and clinical pharmacology, 20(8), 649-655 (1999-01-29) Role of hydrazine in the mechanism of isoniazid hepatotoxicity in rabbits.T C Sarich et al.Archives of toxicology, 70(12), 835-840 (1996-01-01) Redox Imbalance and Oxidative DNA Damage During Isoniazid Treatment of HIV-Associated Tuberculosis: A Clinical and Translational Pharmacokinetic Study.Isaac Zentner et al.Frontiers in pharmacology, 11, 1103-1103 (2020-08-28) Reaction of pregnenolone with cyanoacetylhydrazine: novel synthesis of hydrazide-hydrazone, pyrazole, pyridine, thiazole, thiophene derivatives and their cytotoxicity evaluations.Rafat M Mohareb et al.Steroids, 77(14), 1551-1559 (2012-10-16) Stable isotopic labeling-based quantitative targeted glycomics (i-QTaG).Kyoung-Jin Kim et al.Biotechnology progress, 31(3), 840-848 (2015-04-03) The Isoniazid Metabolites Hydrazine and Pyridoxal Isonicotinoyl Hydrazone Modulate Heme Biosynthesis.Christopher Trent Brewer et al.Toxicological sciences : an official journal of the Society of Toxicology, 168(1), 209-224 (2018-12-06) Simultaneous quantitation of hydrazine and acetylhydrazine in human plasma by high performance liquid chromatography-tandem mass spectrometry after derivatization with p-tolualdehyde.Lu Song et al.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1063, 189-195 (2017-09-08) Identification of aberrantly expressed glycans in gastric cancer by integrated lectin microarray and mass spectrometric analyses.Xiang Li et al.Oncotarget, 7(52), 87284-87300 (2016-11-30) Simultaneous kinetic-spectrophotometric determination of hydrazine and acetylhydrazine in micellar media using the H-point standard addition method.Abbas Afkhami et al.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 20(8), 1199-1203 (2004-09-09) Pharmacokinetics of the toxic hydrazino metabolites formed from isoniazid in humans.B H Lauterburg et al.The Journal of pharmacology and experimental therapeutics, 235(3), 566-570 (1985-12-01) Determination of hydrazine in biofluids by capillary gas chromatography with nitrogen-sensitive or mass spectrometric detection.N E Preece et al.Journal of chromatography, 573(2), 227-234 (1992-01-17) Role of hydrazine in isoniazid-induced hepatotoxicity in a hepatocyte inflammation model.Shahrzad Tafazoli et al.Toxicology and applied pharmacology, 229(1), 94-101 (2008-02-26) The effect of ageing on isoniazid pharmacokinetics and hepatotoxicity in Fischer 344 rats.John Mach et al.Fundamental & clinical pharmacology, 30(1), 23-34 (2015-10-11)
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