没有数据	没有数据

危险品标志	Xn
危险类别码	R22;R40
安全说明书	S22;S36

来源	SDS样本
没有数据	没有数据

产品合成路线

更多

名称	CAS号

更多

文章

同行评议文献

A decrease in NAMPT activity impairs basal PARP-1 activity in cytidine deaminase deficient-cells, independently of NAD.Sandra Cunha Silveira et al.Scientific reports, 10(1), 13907-13907 (2020-08-19) Pharmacological restoration of autophagy reduces hypertension-related stroke occurrence.Maurizio Forte et al.Autophagy, 16(8), 1468-1481 (2019-11-05) Targeting NAD+ Metabolism as Interventions for Mitochondrial Disease.Chi Fung Lee et al.Scientific reports, 9(1), 3073-3073 (2019-03-01) NAD metabolism: Implications in aging and longevity.Keisuke Yaku et al.Ageing research reviews, 47, 1-17 (2018-06-09) Subcellular Characterization of Nicotinamide Adenine Dinucleotide Biosynthesis in Metastatic Melanoma by Using Organelle-Specific Biosensors.Federica Gaudino et al.Antioxidants & redox signaling, 31(15), 1150-1165 (2019-08-29) Nicotinamide mononucleotide administration after sever hypoglycemia improves neuronal survival and cognitive function in rats.Xiaonan Wang et al.Brain research bulletin, 160, 98-106 (2020-05-08) An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers.Sophia E Airhart et al.PloS one, 12(12), e0186459-e0186459 (2017-12-07) ArsAB, a novel enzyme from Sporomusa ovata activates phenolic bases for adenosylcobamide biosynthesis.Chi Ho Chan et al.Molecular microbiology, 81(4), 952-967 (2011-06-24) Nicotinamide mononucleotide does not protect the ovarian reserve from cancer treatments.Jessica Stringer et al.Reproduction (Cambridge, England) (2019-11-22) The potential of the novel NAD+ supplementing agent, SNH6, as a therapeutic strategy for the treatment of Friedreich's ataxia.Shannon Chiang et al.Pharmacological research, 155, 104680-104680 (2020-02-08) Dissecting cobamide diversity through structural and functional analyses of the base-activating CobT enzyme of Salmonella enterica.Chi Ho Chan et al.Biochimica et biophysica acta, 1840(1), 464-475 (2013-10-15) Visualization and quantification of NAD(H) in brain sections by a novel histo-enzymatic nitrotetrazolium blue staining technique.Irina S Balan et al.Brain research, 1316, 112-119 (2009-12-29) Nicotinamide riboside protects against liver fibrosis induced by CCl4 via regulating the acetylation of Smads signaling pathway.Rui Jiang et al.Life sciences, 225, 20-28 (2019-04-01) Lipopolysaccharide Regulation of Intestinal Tight Junction Permeability Is Mediated by TLR4 Signal Transduction Pathway Activation of FAK and MyD88.Shuhong Guo et al.Journal of immunology (Baltimore, Md. : 1950), 195(10), 4999-5010 (2015-10-16) Identification of the Nicotinamide Salvage Pathway as a New Toxification Route for Antimetabolites.Daniela Buonvicino et al.Cell chemical biology, 25(4), 471-482 (2018-02-27) Pyrroloquinoline Quinone, a Redox-Active o-Quinone, Stimulates Mitochondrial Biogenesis by Activating the SIRT1/PGC-1α Signaling Pathway.Kazuhiro Saihara et al.Biochemistry, 56(50), 6615-6625 (2017-12-01) Reversal of endothelial dysfunction by nicotinamide mononucleotide via extracellular conversion to nicotinamide riboside.Łukasz Mateuszuk et al.Biochemical pharmacology, 178, 114019-114019 (2020-05-12) Concerted Action of AMPK and Sirtuin-1 Induces Mitochondrial Fragmentation Upon Inhibition of Ca2+ Transfer to Mitochondria.Alenka Lovy et al.Frontiers in cell and developmental biology, 8, 378-378 (2020-06-12) NAMPT Inhibition Suppresses Cancer Stem-like Cells Associated with Therapy-Induced Senescence in Ovarian Cancer.Timothy Nacarelli et al.Cancer research, 80(4), 890-900 (2019-12-21) Recognition of nucleoside monophosphate substrates by Haemophilus influenzae class C acid phosphatase.Harkewal Singh et al.Journal of molecular biology, 404(4), 639-649 (2010-10-12) Enzymatic biofuel cells utilizing a biomimetic cofactor.Elliot Campbell et al.Chemical communications (Cambridge, England), 48(13), 1898-1900 (2012-01-10) Nicotinamide mononucleotide adenylyltransferase uses its NAD+ substrate-binding site to chaperone phosphorylated Tau.Xiaojuan Ma et al.eLife, 9 (2020-04-07) Simultaneous measurement of NAD metabolome in aged mice tissue using liquid chromatography tandem-mass spectrometry.Keisuke Yaku et al.Biomedical chromatography : BMC, 32(6), e4205-e4205 (2018-02-10) Monomeric eNAMPT in the development of experimental diabetes in mice: a potential target for type 2 diabetes treatment.Julius Kieswich et al.Diabetologia, 59(11), 2477-2486 (2016-08-20) Short-term administration of Nicotinamide Mononucleotide preserves cardiac mitochondrial homeostasis and prevents heart failure.Rongli Zhang et al.Journal of molecular and cellular cardiology, 112, 64-73 (2017-09-09) Niacin receptor activation improves human microvascular endothelial cell angiogenic function during lipotoxicity.Jennifer M Hughes-Large et al.Atherosclerosis, 237(2), 696-704 (2014-12-03) Structural and Functional Characterization of NadR from Lactococcus lactis.Artem Stetsenko et al.Molecules (Basel, Switzerland), 25(8) (2020-04-26) NAD metabolism in aging and cancer.John Wr Kincaid et al.Experimental biology and medicine (Maywood, N.J.), 245(17), 1594-1614 (2020-06-06) NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging.Daniel C Levine et al.Molecular cell, 78(5), 835-849 (2020-05-06) Highly sensitive LC-MS/MS analysis of catecholamines in plasma.Marianne L Bergmann et al.Clinical biochemistry, 82, 51-57 (2020-03-24) Nicotinamide mononucleotide and related metabolites induce disease resistance against fungal phytopathogens in Arabidopsis and barley.Akihiro Miwa et al.Scientific reports, 7(1), 6389-6389 (2017-07-27) Profiling of a wide range of neurochemicals in human urine by very-high-performance liquid chromatography-tandem mass spectrometry combined with in situ selective derivatization.Wonwoong Lee et al.Journal of chromatography. A, 1526, 47-57 (2017-10-17) Plasma free metanephrines for diagnosis of neuroblastoma patients.Sebastiano Barco et al.Clinical biochemistry, 66, 57-62 (2019-03-02) Ligand binding phenomena that pertain to the metabolic function of renalase.Brett A Beaupre et al.Archives of biochemistry and biophysics, 612, 46-56 (2016-11-05) Hyperthermophilic Archaeon Thermococcus kodakarensis Utilizes a Four-Step Pathway for NAD+ Salvage through Nicotinamide Deamination.Shin-Ichi Hachisuka et al.Journal of bacteriology, 200(11) (2018-03-21) NAMPT maintains mitochondria content via NRF2-PPARα/AMPKα pathway to promote cell survival under oxidative stress.An Yu et al.Cellular signalling, 66, 109496-109496 (2019-12-10) Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes.Kazuhiro Hasegawa et al.Nature medicine, 19(11), 1496-1504 (2013-10-22) Nicotinamide phosphoribosyltransferase/visfatin does not catalyze nicotinamide mononucleotide formation in blood plasma.Nobumasa Hara et al.PloS one, 6(8), e22781-e22781 (2011-08-10) The high-resolution crystal structure of periplasmic Haemophilus influenzae NAD nucleotidase reveals a novel enzymatic function of human CD73 related to NAD metabolism.Silvia Garavaglia et al.The Biochemical journal, 441(1), 131-141 (2011-09-22) Investigation of non-linear Mate1-mediated efflux of trimethoprim in the mouse kidney as the mechanism underlying drug-drug interactions between trimethoprim and organic cations in the kidney.Tomoko Kito et al.Drug metabolism and pharmacokinetics, 34(1), 87-94 (2018-12-12) SIRT1 regulates macrophage self-renewal.Francesco Imperatore et al.The EMBO journal, 36(16), 2353-2372 (2017-07-14) A fluorometric assay for high-throughput screening targeting nicotinamide phosphoribosyltransferase.Ruo-Yu Zhang et al.Analytical biochemistry, 412(1), 18-25 (2011-01-08) p53 prevents doxorubicin cardiotoxicity independently of its prototypical tumor suppressor activities.Jie Li et al.Proceedings of the National Academy of Sciences of the United States of America, 116(39), 19626-19634 (2019-09-07) Regulation of Nampt expression by transcriptional coactivator NCOA6 in pancreatic β-cells.Jin Yoon et al.Biochemical and biophysical research communications, 487(3), 600-606 (2017-04-25) Structure-functional changes in eNAMPT at high concentrations mediate mouse and human beta cell dysfunction in type 2 diabetes.Sophie R Sayers et al.Diabetologia, 63(2), 313-323 (2019-11-17) Dermoscopic patterns of fungal melanonychia: A comparative study with other causes of melanonychia.Jungyoon Ohn et al.Journal of the American Academy of Dermatology, 76(3), 488-493 (2016-10-30) Nicotinamide mononucleotide inhibits JNK activation to reverse Alzheimer disease.Zhiwen Yao et al.Neuroscience letters, 647, 133-140 (2017-03-24) Sirt2 facilitates hepatic glucose uptake by deacetylating glucokinase regulatory protein.Hitoshi Watanabe et al.Nature communications, 9(1), 30-30 (2018-01-04) Nicotinamide Phosphoribosyltransferase Acts as a Metabolic Gate for Mobilization of Myeloid-Derived Suppressor Cells.Cristina Travelli et al.Cancer research, 79(8), 1938-1951 (2019-02-20) Characterization of human nicotinate phosphoribosyltransferase: Kinetic studies, structure prediction and functional analysis by site-directed mutagenesis.Lucia Galassi et al.Biochimie, 94(2), 300-309 (2011-07-12) A neuroprotective agent that inactivates prodegenerative TrkA and preserves mitochondria.Konstantin Feinberg et al.The Journal of cell biology, 216(11), 3655-3675 (2017-09-08) Characterization of Leber Congenital Amaurosis-associated NMNAT1 Mutants.Yo Sasaki et al.The Journal of biological chemistry, 290(28), 17228-17238 (2015-05-29) Assessment of NAD+metabolism in human cell cultures, erythrocytes, cerebrospinal fluid and primate skeletal muscle.Tyler G Demarest et al.Analytical biochemistry, 572, 1-8 (2019-03-02) Structural and Mechanistic Regulation of the Pro-degenerative NAD Hydrolase SARM1.Matthew Bratkowski et al.Cell reports, 32(5), 107999-107999 (2020-08-07) Investigation of NADH binding, hydride transfer, and NAD(+) dissociation during NADH oxidation by mitochondrial complex I using modified nicotinamide nucleotides.James A Birrell et al.Biochemistry, 52(23), 4048-4055 (2013-05-21) Effects of visfatin on brown adipose tissue energy regulation using T37i cells.Georgios K Dimitriadis et al.Cytokine, 113, 248-255 (2018-08-01) Sympathetic activity induced by naloxone-precipitated morphine withdrawal is blocked in genetically engineered mice lacking functional CRF1 receptor.Juan-Antonio García-Carmona et al.Toxicology and applied pharmacology, 283(1), 42-49 (2015-01-15) NAD+ precursor modulates post-ischemic mitochondrial fragmentation and reactive oxygen species generation via SIRT3 dependent mechanisms.Nina Klimova et al.Experimental neurology, 325, 113144-113144 (2019-12-15) A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline.Mariana G Tarragó et al.Cell metabolism, 27(5), 1081-1095 (2018-05-03) Kynurenine pathway, NAD+ synthesis, and mitochondrial function: Targeting tryptophan metabolism to promote longevity and healthspan.Raul Castro-Portuguez et al.Experimental gerontology, 132, 110841-110841 (2020-01-20) Catalysis-based inhibitors of the calcium signaling function of CD38.Anna Ka Yee Kwong et al.Biochemistry, 51(1), 555-564 (2011-12-07) Tailoring RNA modular units on a common scaffold: a modular ribozyme with a catalytic unit for beta-nicotinamide mononucleotide-activated RNA ligation.Yuki Fujita et al.RNA (New York, N.Y.), 15(5), 877-888 (2009-03-25) Nampt-mediated spindle sizing secures a post-anaphase increase in spindle speed required for extreme asymmetry.Zhe Wei et al.Nature communications, 11(1), 3393-3393 (2020-07-09) Evolutionary optimization of a modular ligase ribozyme: a small catalytic unit and a hairpin motif masking an element that could form an inactive structure.Yuki Fujita et al.Nucleic acids research, 38(10), 3328-3339 (2010-01-30) Specific cyclic ADP-ribose phosphohydrolase obtained by mutagenic engineering of MnJoão Meireles Ribeiro et al.Scientific reports, 8(1), 1036-1036 (2018-01-20) Catecholamine excretion profiles identify clinical subgroups of neuroblastoma patients.I R N Verly et al.European journal of cancer (Oxford, England : 1990), 111, 21-29 (2019-02-25) Wld(S) reduces paraquat-induced cytotoxicity via SIRT1 in non-neuronal cells by attenuating the depletion of NAD.Qiujing Yu et al.PloS one, 6(7), e21770-e21770 (2011-07-14) Targeting the NAD+ salvage pathway suppresses APC mutation-driven colorectal cancer growth and Wnt/β-catenin signaling via increasing Axin level.Chenyang Ye et al.Cell communication and signaling : CCS, 18(1), 16-16 (2020-02-02) Crystallization and preliminary X-ray crystallographic analysis of quinolinate phosphoribosyltransferase from porcine kidney in complex with nicotinate mononucleotide.Hyung-Seop Youn et al.Acta crystallographica. Section F, Structural biology and crystallization communications, 68(Pt 12), 1488-1490 (2012-11-30) Oxyresveratrol stimulates mucin production in an NAD+-dependent manner in human intestinal goblet cells.Dahyun Hwang et al.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 118, 880-888 (2018-06-24) NAD+ metabolism governs the proinflammatory senescence-associated secretome.Timothy Nacarelli et al.Nature cell biology, 21(3), 397-407 (2019-02-20) Induced fit and the catalytic mechanism of isocitrate dehydrogenase.Susana Gonçalves et al.Biochemistry, 51(36), 7098-7115 (2012-08-16) Effects of B Vitamins Overload on Plasma Insulin Level and Hydrogen Peroxide Generation in Rats.Wuping Sun et al.The Chinese journal of physiology, 60(4), 207-214 (2017-08-30) NAD metabolic dependency in cancer is shaped by gene amplification and enhancer remodelling.Sudhir Chowdhry et al.Nature, 569(7757), 570-575 (2019-04-26) Simple, rapid, and cost-effective microextraction by the packed sorbent method for quantifying of urinary free catecholamines and metanephrines using liquid chromatography-tandem mass spectrometry and its application in clinical analysis.Xin Xiong et al.Analytical and bioanalytical chemistry, 412(12), 2763-2775 (2020-03-05) Identification of Isn1 and Sdt1 as glucose- and vitamin-regulated nicotinamide mononucleotide and nicotinic acid mononucleotide [corrected] 5'-nucleotidases responsible for production of nicotinamide riboside and nicotinic acid riboside.Katrina L Bogan et al.The Journal of biological chemistry, 284(50), 34861-34869 (2009-10-23) Identification of mitochondrial electron transport chain-mediated NADH radical formation by EPR spin-trapping techniques.Satoshi Matsuzaki et al.Biochemistry, 50(50), 10792-10803 (2011-11-19) Nicotinamide mononucleotide protects against pro-inflammatory cytokine-mediated impairment of mouse islet function.P W Caton et al.Diabetologia, 54(12), 3083-3092 (2011-09-09) Identification of the nicotinamide mononucleotide adenylyltransferase of Trypanosoma cruzi.Carlos H Niño et al.Memorias do Instituto Oswaldo Cruz, 110(7), 890-897 (2015-11-13) Bacteria Boost Mammalian Host NAD Metabolism by Engaging the Deamidated Biosynthesis Pathway.Igor Shats et al.Cell metabolism, 31(3), 564-579 (2020-03-05) PPARδ modulation rescues mitochondrial fatty acid oxidation defects in the mdx model of muscular dystrophy.Eric L Bell et al.Mitochondrion, 46, 51-58 (2018-02-20) Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures.Yasir S Elhassan et al.Cell reports, 28(7), 1717-1728 (2019-08-15) Inflammatory macrophage dependence on NAD+ salvage is a consequence of reactive oxygen species-mediated DNA damage.Alanna M Cameron et al.Nature immunology, 20(4), 420-432 (2019-03-13) RNA aptamers that bind flavin and nicotinamide redox cofactors.C T Lauhon et al.Journal of the American Chemical Society, 117(4), 1246-1257 (1995-02-01) Mitochondria-localized NAD biosynthesis by nicotinamide mononucleotide adenylyltransferase in Jerusalem artichoke (Helianthus tuberosus L.) heterotrophic tissues.Catello Di Martino et al.Planta, 234(4), 657-670 (2011-05-21) Functional analysis of the nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase (CobT) enzyme, involved in the late steps of coenzyme B12 biosynthesis in Salmonella enterica.Kathy R Claas et al.Journal of bacteriology, 192(1), 145-154 (2009-11-03) Comparative genomics of NAD(P) biosynthesis and novel antibiotic drug targets.Jicai Bi et al.Journal of cellular physiology, 226(2), 331-340 (2010-09-22) Real-time monitoring of PARP1-dependent PARylation by ATR-FTIR spectroscopy.Annika Krüger et al.Nature communications, 11(1), 2174-2174 (2020-05-03) Effects of long-acting somatostatin analogues on adrenal growth and phosphoribosyl pyrophosphate formation in experimental diabetes.Sirilaksana Kunjara et al.International journal of experimental pathology, 93(1), 56-69 (2012-01-24) Nicotinamide Mononucleotide Administration Prevents Experimental Diabetes-Induced Cognitive Impairment and Loss of Hippocampal Neurons.Krish Chandrasekaran et al.International journal of molecular sciences, 21(11) (2020-05-30) NAMPT/PBEF1 enzymatic activity is indispensable for myeloma cell growth and osteoclast activity.Sathisha Upparahalli Venkateshaiah et al.Experimental hematology, 41(6), 547-557 (2013-02-26) The Cytokine Nicotinamide Phosphoribosyltransferase (eNAMPT; PBEF; Visfatin) Acts as a Natural Antagonist of C-C Chemokine Receptor Type 5 (CCR5).Simone Torretta et al.Cells, 9(2) (2020-02-27) Ionic liquids based on imidazole for online concentration of catecholamines in capillary electrophoresis.Elena Bessonova et al.Journal of separation science, 40(10), 2304-2311 (2017-04-04) Independent AMP and NAD signaling regulates C2C12 differentiation and metabolic adaptation.Chia George Hsu et al.Journal of physiology and biochemistry, 72(4), 689-697 (2016-07-10) CD73 protein as a source of extracellular precursors for sustained NAD+ biosynthesis in FK866-treated tumor cells.Alessia Grozio et al.The Journal of biological chemistry, 288(36), 25938-25949 (2013-07-25) Direct electrochemical measurement of metanephrines in spot urine samples for the diagnosis of phaeochromocytomas.Zheng-Hu Shi et al.Scientific reports, 7(1), 8041-8041 (2017-08-16) NAD+ consumption by PARP1 in response to DNA damage triggers metabolic shift critical for damaged cell survival.Michael M Murata et al.Molecular biology of the cell, 30(20), 2584-2597 (2019-08-08) Detection of spot urinary free metanephrines and 3-methoxytyramine with internal reference correction for the diagnosis of pheochromocytomas and paragangliomas.Haoran Wang et al.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1156, 122306-122306 (2020-08-24) β-nicotinamide mononucleotide (NMN) production in Escherichia coli.George Cătălin Marinescu et al.Scientific reports, 8(1), 12278-12278 (2018-08-18) NAD+ cellular redox and SIRT1 regulate the diurnal rhythms of tyrosine hydroxylase and conditioned cocaine reward.Ryan W Logan et al.Molecular psychiatry, 24(11), 1668-1684 (2018-05-08) Monocyte-derived extracellular Nampt-dependent biosynthesis of NAD(+) protects the heart against pressure overload.Masamichi Yano et al.Scientific reports, 5, 15857-15857 (2015-11-03) Plasma metanephrins are associated with myocardial hypertrophy and cardiac diastolic function in patients with essential hypertension.Ying Zhou et al.Clinical and investigative medicine. Medecine clinique et experimentale, 43(1), E22-E29 (2020-04-06) Cardioprotection by nicotinamide mononucleotide (NMN): Involvement of glycolysis and acidic pH.Sergiy M Nadtochiy et al.Journal of molecular and cellular cardiology, 121, 155-162 (2018-07-01) Detection and pharmacological modulation of nicotinamide mononucleotide (NMN) in vitro and in vivo.Laura Formentini et al.Biochemical pharmacology, 77(10), 1612-1620 (2009-05-12) N(1)-methylnicotinamide as an endogenous probe for drug interactions by renal cation transporters: studies on the metformin-trimethoprim interaction.Fabian Müller et al.European journal of clinical pharmacology, 71(1), 85-94 (2015-01-02) Melatonin and Nicotinamide Mononucleotide Attenuate Myocardial Ischemia/Reperfusion Injury via Modulation of Mitochondrial Function and Hemodynamic Parameters in Aged Rats.Leila Hosseini et al.Journal of cardiovascular pharmacology and therapeutics, 25(3), 240-250 (2019-10-28) Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice.Jun Yoshino et al.Cell metabolism, 14(4), 528-536 (2011-10-11) Chromogranin A in the Laboratory Diagnosis of Pheochromocytoma and Paraganglioma.Radovan Bílek et al.Cancers, 11(4) (2019-04-28) A pre-steady state and steady state kinetic analysis of the N-ribosyl hydrolase activity of hCD157.Frank Preugschat et al.Archives of biochemistry and biophysics, 564, 156-163 (2014-09-25) Endogenous Nampt upregulation is associated with diabetic nephropathy inflammatory-fibrosis through the NF-κB p65 and Sirt1 pathway; NMN alleviates diabetic nephropathy inflammatory-fibrosis by inhibiting endogenous Nampt.Ye Chen et al.Experimental and therapeutic medicine, 14(5), 4181-4193 (2017-11-07) Effect of nicotinamide mononucleotide on insulin secretion and gene expressions of PDX-1 and FoxO1 in RIN-m5f cells.Feifeng Sheng et al.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 36(10), 958-963 (2011-11-17) A possibility of nutriceuticals as an anti-aging intervention: activation of sirtuins by promoting mammalian NAD biosynthesis.Shin-Ichiro Imai Pharmacological research, 62(1), 42-47 (2010-01-21) The compensatory antioxidant response system with a focus on neuroprogressive disorders.Gerwyn Morris et al.Progress in neuro-psychopharmacology & biological psychiatry, 95, 109708-109708 (2019-07-28)

备注