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N,N-Diethylaniline | CAS:91-66-7
N,N-Diethylaniline
  • 名称:N,N-二乙基苯胺 | N,N-Diethylaniline
  • CAS号:91-66-7
  • 别名:N,N-diethylaminobenzene; N,N-diethylbenzenamine; DEA
  • 分子式:C10H15N
  • 分子量:149.23
  • EINESC号:202-088-8

产品描述

物理化学性质

熔点 -38 ºC
水溶性 14 g/L (12 ºC)
沸点 215-217 ºC
闪点 88 ºC
密度 0.938
折射率 1.541-1.543

安全数据

危险品标志 T;N
危险类别码 R23/24/25;R33;R51/53
安全说明书 S28A;S37;S45;S61

SDS

来源 SDS样本
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B, Analytical technologies in the biomedical and life sciences, 968, 69-78 (2014-01-30) Phenylbutazone and the horse--a review.L B Jeffcott et al.Equine veterinary journal, 9(3), 105-110 (1977-07-01) Fast targeted analysis of 132 acidic and neutral drugs and poisons in whole blood using LC-MS/MS.Matthew Di Rago et al.Forensic science international, 243, 35-43 (2014-05-06) Synthesis of biologically active N-methyl derivatives of amidines and cyclized five-membered products of amidines with oxalyl chloride.Sham M Sondhi et al.European journal of medicinal chemistry, 43(12), 2824-2830 (2007-11-21) Focal experimental injury leads to widespread gene expression and histologic changes in equine flexor tendons.Else Jacobson et al.PloS one, 10(4), e0122220-e0122220 (2015-04-04) Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.Francisco J Prado-Prado et al.Bioorganic & medicinal chemistry, 18(6), 2225-2231 (2010-02-27) Developing structure-activity relationships for the prediction of hepatotoxicity.Nigel Greene et al.Chemical research in toxicology, 23(7), 1215-1222 (2010-06-18) Diffusion coefficients of phenylbutazone in supercritical CO2 and in ethanol.Chang Yi Kong et al.Journal of chromatography. 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EPAM.Stuart C Clark-Price et al.Journal of the American Veterinary Medical Association, 240(1), 40-44 (2011-12-17) In Vitro Evaluation of the Effect of 7-Methyl Substitution on Glucuronidation of Daphnetin: Metabolic Stability, Isoform Selectivity, and Bioactivity Analysis.Si-Cheng Liang et al.Journal of pharmaceutical sciences, 104(10), 3557-3564 (2015-06-25) The Japanese toxicogenomics project: application of toxicogenomics.Takeki Uehara et al.Molecular nutrition & food research, 54(2), 218-227 (2009-12-31) The use of phenylbutazone in the horse.L R Soma et al.Journal of veterinary pharmacology and therapeutics, 35(1), 1-12 (2011-06-15) A medium-term gpt delta rat model as an in vivo system for analysis of renal carcinogenesis and the underlying mode of action.Kohei Matsushita et al.Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 67(1), 31-39 (2014-12-03) [Multiple manifestations of intolerance in association with anti-inflammatory agents. 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Part A, Molecular and biomolecular spectroscopy, 74(1), 1-9 (2009-07-21) 4-thiazolidinone--a biologically active scaffold.Amit Verma et al.European journal of medicinal chemistry, 43(5), 897-905 (2007-09-18) Effects of phenylbutazone on gene expression of cyclooxygenase-1 and -2 in the oral, glandular gastric, and bladder mucosae of healthy horses.Jorge E Nieto et al.American journal of veterinary research, 73(1), 98-104 (2011-12-30) Spectroscopic analysis on structure-affinity relationship in the interactions of different oleanane-type triterpenoids with bovine serum albumin.Jia Hou et al.Luminescence : the journal of biological and chemical luminescence, 30(6), 780-789 (2014-11-28) Expression of pleiotrophin, an important regulator of cell migration, is inhibited in intestinal epithelial cells by treatment with non-steroidal anti-inflammatory drugs.Kristopher Silver et al.Growth factors (Chur, Switzerland), 30(4), 258-266 (2012-06-14) Toxicogenomic biomarkers for renal papillary injury in rats.Takeki Uehara et al.Toxicology, 303, 1-8 (2012-11-13) "Bute" in horse meat presents very low risk to health, says England's chief medical officer.Jacqui Wise BMJ (Clinical research ed.), 346, f1066-f1066 (2013-02-19) The EpiOcular Eye Irritation Test (EIT) for hazard identification and labelling of eye irritating chemicals: protocol optimisation for solid materials and the results after extended shipment.Yulia Kaluzhny et al.Alternatives to laboratory animals : ATLA, 43(2), 101-127 (2015-05-23) Effects of meloxicam and phenylbutazone on equine gastric mucosal permeability.E D'Arcy-Moskwa et al.Journal of veterinary internal medicine, 26(6), 1494-1499 (2012-10-23) Phenylbutazone in the horse: a review.T Tobin et al.Journal of veterinary pharmacology and therapeutics, 9(1), 1-25 (1986-03-01) UDP-glucuronosyltransferases and clinical drug-drug interactions.Tony K L Kiang et al.Pharmacology & therapeutics, 106(1), 97-132 (2005-03-23) Food and Chemical Toxicology, 2010, Association of phenylbutazone usage in horses bought for slaughter: a public health risk.Don Henneke et al.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 50(3-4), 603-603 (2012-01-17) Bute residues of low concern for consumers, say EFSA and EMA. The Veterinary record, 172(16), 407-407 (2013-04-23) HET-CAM bioassay in comparison to the croton oil test for investigating steroidal and non-steroidal compoundsBrandtner AH, et al. ALTEX, 19(2), 51-56 (2016) Competitive binding to plasma thyroid hormone transport proteins and thyroid disruption by phenylbutazone used as a probe.Véronique Gayrard et al.General and comparative endocrinology, 174(2), 225-231 (2011-09-22) Is phenylbutazone a genotoxic carcinogen? A weight-of-evidence assessment.Robert D Combes Alternatives to laboratory animals : ATLA, 41(3), 235-248 (2013-08-27) Chemosensory Cell-Derived Acetylcholine Drives Tracheal Mucociliary Clearance in Response to Virulence-Associated Formyl Peptides.Alexander Perniss et al.Immunity, 52(4), 683-699 (2020-04-16) Comparison of generation 3 polyamidoamine dendrimer and generation 4 polypropylenimine dendrimer on drug loading, complex structure, release behavior, and cytotoxicity.Naimin Shao et al.International journal of nanomedicine, 6, 3361-3372 (2012-01-24) [Biological availability and solubility of phenylbutazone].L Krówczyński et al.Folia medica Cracoviensia, 21(1), 141-147 (1979-01-01) EC seeks advice on risks from phenylbutazone in horsemeat. The Veterinary record, 172(12), 306-306 (2013-03-26) [Mechanism of the ulcerogenic effects of phenylbutazone and indomethacin].M Valentík et al.Ceskoslovenska gastroenterologie a vyziva, 32(8), 494-500 (1978-12-01) Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).Zhichao Liu et al.PLoS computational biology, 7(12), e1002310-e1002310 (2011-12-24) A review and assessment of drug-induced parotitis.Krista G Brooks et al.The Annals of pharmacotherapy, 46(12), 1688-1699 (2012-12-20) Ulcerative cystitis associated with phenylbutazone administration in two horses.Monica Aleman et al.Journal of the American Veterinary Medical Association, 239(4), 499-503 (2011-08-16) Microwave-assisted synthesis of N-substituted cyclic imides and their evaluation for anticancer and anti-inflammatory activities.Sham M Sondhi et al.Bioorganic & medicinal chemistry letters, 19(5), 1534-1538 (2009-02-10) Preliminary investigation of concurrent administration of phenylbutazone and romifidine in healthy horses.Karin Kruger et al.Veterinary anaesthesia and analgesia, 38(5), 505-509 (2011-08-13) Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.Jing Yuan et al.Nature chemical biology, 5(10), 765-771 (2009-09-08) Circumferential hoof clamp method of lameness induction in the horse.M E Swaab et al.Veterinary journal (London, England : 1997), 205(1), 81-86 (2015-06-06) Synthesis and anti-inflammatory activity of newer quinazolin-4-one derivatives.Ashok Kumar et al.European journal of medicinal chemistry, 44(1), 83-90 (2008-05-27) Bone marrow depression due to mianserin, phenylbutazone, oxyphenbutazone, and chloramphenicol--Part II.S Chaplin Adverse drug reactions and acute poisoning reviews, 5(3), 181-196 (1986-01-01) Binding of diuretic antihypertensive bendroflumethiazide to human serum albumin studied by ¹⁹F nuclear magnetic resonance method.K Kitamura et al.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 45(1-2), 195-200 (2011-11-26) [Phenylbutazone and its analogs. Synthesis, chemical and pharmaceutical properties].M I Santoro et al.Revista de farmacia e bioquimica da Universidade de Sao Paulo, 11(2), 117-141 (1973-07-01) Synthesis and anti-inflammatory activity of 2-(2-aroylaroxy)-4,6-dimethoxy pyrimidines.T D Venu et al.Bioorganic & medicinal chemistry letters, 18(15), 4409-4412 (2008-07-16) Phenylbutazone induces expression of MBNL1 and suppresses formation of MBNL1-CUG RNA foci in a mouse model of myotonic dystrophyChen G, et al. Scientific Reports, 6, 25317-25317 (2016)
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