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Spermine hydrochloride | CAS:306-67-2
Spermine hydrochloride
  • 名称:精胺盐酸盐 | Spermine hydrochloride
  • CAS号:306-67-2
  • 别名:N1,N4-Bis(3-aminopropyl)-1,4-butanediamine hydrochloride; Spermine tetrahydrochloride
  • 分子式:C10H26N4.4(HCl)
  • 分子量:348.19
  • EINESC号:206-189-8

产品描述

物理化学性质

熔点 310-311 ºC (dec.)

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SDS

来源 SDS样本
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Affinity labeling with bromopyruvate.I Kameshita et al.Journal of biochemistry, 86(5), 1251-1257 (1979-11-01) Over-expression of GAPDH in human colorectal carcinoma as a preferred target of 3-bromopyruvate propyl ester.Zhenjie Tang et al.Journal of bioenergetics and biomembranes, 44(1), 117-125 (2012-02-22) Flow cytometric evaluation of the effects of 3-bromopyruvate (3BP) and dichloracetate (DCA) on THP-1 cells: a multiparameter analysis.Harrie A Verhoeven et al.Journal of bioenergetics and biomembranes, 44(1), 91-99 (2012-02-10) Casiopeina II-gly and bromo-pyruvate inhibition of tumor hexokinase, glycolysis, and oxidative phosphorylation.Alvaro Marín-Hernández et al.Archives of toxicology, 86(5), 753-766 (2012-02-22) A translational study "case report" on the small molecule "energy blocker" 3-bromopyruvate (3BP) as a potent anticancer agent: from bench side to bedside.Y H Ko et al.Journal of bioenergetics and biomembranes, 44(1), 163-170 (2012-02-14) Aerosolized 3-bromopyruvate inhibits lung tumorigenesis without causing liver toxicity.Qi Zhang et al.Cancer prevention research (Philadelphia, Pa.), 5(5), 717-725 (2012-03-10) Effect of the antitumoral alkylating agent 3-bromopyruvate on mitochondrial respiration: role of mitochondrially bound hexokinase.Clara Rodrigues-Ferreira et al.Journal of bioenergetics and biomembranes, 44(1), 39-49 (2012-02-11) Butyrate activates the monocarboxylate transporter MCT4 expression in breast cancer cells and enhances the antitumor activity of 3-bromopyruvate.Odília Queirós et al.Journal of bioenergetics and biomembranes, 44(1), 141-153 (2012-02-22) The extreme hyper-reactivity of Cys94 in lysozyme avoids its amorphous aggregation.Alessio Bocedi et al.Scientific reports, 8(1), 16050-16050 (2018-10-31) Glutamine deprivation enhances antitumor activity of 3-bromopyruvate through the stabilization of monocarboxylate transporter-1.Simone Cardaci et al.Cancer research, 72(17), 4526-4536 (2012-07-10) D-Amino acid oxidase-induced oxidative stress, 3-bromopyruvate and citrate inhibit angiogenesis, exhibiting potent anticancer effects.S M El Sayed et al.Journal of bioenergetics and biomembranes, 44(5), 513-523 (2012-07-18) Human hepatocellular carcinoma in a mouse model: assessment of tumor response to percutaneous ablation by using glyceraldehyde-3-phosphate dehydrogenase antagonists.Shanmugasundaram Ganapathy-Kanniappan et al.Radiology, 262(3), 834-845 (2012-02-24) Insights into the carboxyltransferase reaction of pyruvate carboxylase from the structures of bound product and intermediate analogs.Adam D Lietzan et al.Biochemical and biophysical research communications, 441(2), 377-382 (2013-10-26) Enhancement of hexokinase II inhibitor-induced apoptosis in hepatocellular carcinoma cells via augmenting ER stress and anti-angiogenesis by protein disulfide isomerase inhibition.Su Jong Yu et al.Journal of bioenergetics and biomembranes, 44(1), 101-115 (2012-02-22) 3-Bromopyruvate alleviates the development of monocrotaline-induced rat pulmonary arterial hypertension by decreasing aerobic glycolysis, inducing apoptosis, and suppressing inflammation.Jie Liu et al.Chinese medical journal, 133(1), 49-60 (2020-01-11) Blockade of N-Glycosylation Promotes Antitumor Immune Response of T Cells.Shigemi Sasawatari et al.Journal of immunology (Baltimore, Md. : 1950), 204(5), 1373-1385 (2020-01-24) 3-Bromopyruvate: a novel antifungal agent against the human pathogen Cryptococcus neoformans.Mariusz Dyląg et al.Biochemical and biophysical research communications, 434(2), 322-327 (2013-04-02) Nitrogen Trapping as a Therapeutic Strategy in Tumors with Mitochondrial Dysfunction.Hanumantha Rao Madala et al.Cancer research, 80(17), 3492-3506 (2020-07-12) Regulation of the proliferation of colon cancer cells by compounds that affect glycolysis, including 3-bromopyruvate, 2-deoxyglucose and biguanides.Michael A Lea et al.Anticancer research, 33(2), 401-407 (2013-02-09) Inhibition of glucose turnover by 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glyceraldehyde-3-phosphate dehydrogenase antagonists?S Nahum Goldberg Radiology, 262(3), 737-739 (2012-02-24) Kinetics of inactivation of bovine pancreatic ribonuclease A by bromopyruvic acid.M H Wang et al.The Biochemical journal, 320 ( Pt 1), 187-192 (1996-11-15) Bromopyruvate as an affinity label for baker's yeast flavocytochrome b2. Stoichiometry of incorporation and localization on the peptide chain.P M Alliel et al.European journal of biochemistry, 105(2), 343-351 (1980-04-01) Bromopyruvate mediates autophagy and cardiolipin degradation to monolyso-cardiolipin in GL15 glioblastoma cells.Magdalena Davidescu et al.Journal of bioenergetics and biomembranes, 44(1), 51-60 (2012-02-10) Ultra-rapid glutathionylation of chymotrypsinogen in its molten globule-like conformation: A comparison to archaeal proteins.Alessio Bocedi et al.Scientific reports, 10(1), 8943-8943 (2020-06-04) Experimental results using 3-bromopyruvate in mesothelioma: in vitro and in vivo studies.Philippe Icard et al.Journal of bioenergetics and biomembranes, 44(1), 81-90 (2012-02-11) Anticancer efficacy of the metabolic blocker 3-bromopyruvate: specific molecular targeting.Shanmugasundaram Ganapathy-Kanniappan et al.Anticancer research, 33(1), 13-20 (2012-12-26) 3-Bromopyruvate inhibits calcium uptake by sarcoplasmic reticulum vesicles but not SERCA ATP hydrolysis activity.Douglas Jardim-Messeder et al.The international journal of biochemistry & cell biology, 44(5), 801-807 (2012-02-22) A new reaction useful for chemical cross-linking between nucleic acids and proteins.N Nitta et al.FEBS letters, 166(1), 194-198 (1984-01-23) Deprive to kill: glutamine closes the gate to anticancer monocarboxylic drugs.Simone Cardaci et al.Autophagy, 8(12), 1830-1832 (2012-08-31) Glycolysis inhibitors as a potential therapeutic option to treat aggressive neuroblastoma expressing GLUT1.Kohei Matsushita et al.Journal of pediatric surgery, 47(7), 1323-1330 (2012-07-21) Transport and cytotoxicity of the anticancer drug 3-bromopyruvate in the yeast Saccharomyces cerevisiae.Paweł Lis et al.Journal of bioenergetics and biomembranes, 44(1), 155-161 (2012-02-24) Peroxiredoxin 6 is the primary antioxidant enzyme for the maintenance of viability and DNA integrity in human spermatozoa.Maria C Fernandez et al.Human reproduction (Oxford, England) (2018-06-19) MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors.Kivanç Birsoy et al.Nature genetics, 45(1), 104-108 (2012-12-04) Repeated cisplatin treatment can lead to a multiresistant tumor cell population with stem cell features and sensitivity to 3-bromopyruvate.My Wintzell et al.Cancer biology & therapy, 13(14), 1454-1462 (2012-09-08) Targeting aerobic glycolysis: 3-bromopyruvate as a promising anticancer drug.Simone Cardaci et al.Journal of bioenergetics and biomembranes, 44(1), 17-29 (2012-02-14) 3-Bromopyruvate (3BP) a fast acting, promising, powerful, specific, and effective "small molecule" anti-cancer agent taken from labside to bedside: introduction to a special issue.Peter L Pedersen Journal of bioenergetics and biomembranes, 44(1), 1-6 (2012-03-03)
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