熔点	54-59 ºC
水溶性	溶解 0.68 g/L
沸点	65-66 ºC (8 mmHg)

危险品标志	Xn
危险类别码	R22;R36/37/38
安全说明书	S26;S36/37/39

来源	SDS样本
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Novel HCV NS5B polymerase inhibitors: discovery of indole 2-carboxylic acids with C3-heterocycles.Gopinadhan N Anilkumar et al.Bioorganic & medicinal chemistry letters, 21(18), 5336-5341 (2011-08-16) Synthesis and biological activities of novel aryl indole-2-carboxylic acid analogs as PPARgamma partial agonists.James F Dropinski et al.Bioorganic & medicinal chemistry letters, 15(22), 5035-5038 (2005-09-13) In vitro and in vivo assessment of the antioxidant activity of melatonin and related indole derivatives.V Stetinová et al.General physiology and biophysics, 21(2), 153-162 (2002-09-19) Tricyclic quinoxalinediones, aza-kynurenic acids, and indole-2-carboxylic acids as in vivo active NMDA-glycine antagonists.Ryu Nagata et al.Current topics in medicinal chemistry, 6(7), 733-745 (2006-05-25) Synthesis and SAR of 2-carboxylic acid indoles as inhibitors of plasminogen activator inhibitor-1.Baihua Hu et al.Bioorganic & medicinal chemistry letters, 15(15), 3514-3518 (2005-06-29) Formation of indigo and related compounds from indolecarboxylic acids by aromatic acid-degrading bacteria: chromogenic reactions for cloning genes encoding dioxygenases that act on aromatic acids.R W Eaton et al.Journal of bacteriology, 177(23), 6983-6988 (1995-12-01) Evidence that d-cysteine protects mice from gastric damage via hydrogen sulfide produced by d-amino acid oxidase.Luan Kelves M Souza et al.Nitric oxide : biology and chemistry, 64, 1-6 (2017-02-01) Synthetic cannabinoid BB-22 (QUCHIC): Human hepatocytes metabolism with liquid chromatography-high resolution mass spectrometry detection.Jeremy Carlier et al.Journal of pharmaceutical and biomedical analysis, 157, 27-35 (2018-05-14) The discovery of fused pyrrole carboxylic acids as novel, potent D-amino acid oxidase (DAO) inhibitors.Tim Sparey et al.Bioorganic & medicinal chemistry letters, 18(11), 3386-3391 (2008-05-06) Spectral and thermal studies of divalent transition metal complexes with indole-2-carboxylic acid and 4-substituted hydrazinethiocarbamide.Iman T Ahmed Spectrochimica acta. 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Part A, Molecular and biomolecular spectroscopy, 65(1), 5-10 (2006-08-01) In vitro scavenging activity for reactive oxygen species by N-substituted indole-2-carboxylic acid esters.Irena Kruk et al.Luminescence : the journal of biological and chemical luminescence, 22(4), 379-386 (2007-05-02) Asc-1 Transporter Regulation of Synaptic Activity via the Tonic Release of d-Serine in the Forebrain.Hagit Sason et al.Cerebral cortex (New York, N.Y. : 1991), 27(2), 1573-1587 (2016-01-23) Substituted analogues of GV150526 as potent glycine binding site antagonists in animal models of cerebral ischemia.R Di Fabio et al.Journal of medicinal chemistry, 42(18), 3486-3493 (1999-09-10) Effect of dimerization on vibrational spectra of eumelanin precursors.Stephen P Nighswander-Rempel et al.Photochemistry and photobiology, 84(3), 613-619 (2008-01-23) Gold(III) chloride catalyzed regioselective synthesis of pyrano[3,4-b]indol-1(9H)-ones and evaluation of anticancer potential towards human cervix adenocarcinoma.Chandrasekaran Praveen et al.Bioorganic & medicinal chemistry letters, 21(14), 4170-4173 (2011-06-21) The discovery and structure-activity relationships of indole-based inhibitors of glutamate carboxypeptidase II.Brian Grella et al.Bioorganic & medicinal chemistry letters, 20(24), 7222-7225 (2010-11-16) Palladium-catalyzed annulation of allenes with indole-2-carboxylic acid derivatives: synthesis of indolo[2,3-c]pyrane-1-ones via Ar-I reactivity or C-H functionalization.R Rama Suresh et al.The Journal of organic chemistry, 77(16), 6959-6969 (2012-07-26) Cooperative binding interactions of glycopeptide antibiotics.Hideyuki Shiozawa et al.Journal of the American Chemical Society, 124(15), 3914-3919 (2002-04-11) Discovery and SAR of indole-2-carboxylic acid benzylidene-hydrazides as a new series of potent apoptosis inducers using a cell-based HTS assay.Han-Zhong Zhang et al.Bioorganic & medicinal chemistry, 12(13), 3649-3655 (2004-06-10) Synthesis and receptor docking studies of N-substituted indole-2-carboxylic acid esters as a search for COX-2 selective enzyme inhibitors.S Olgen et al.European journal of medicinal chemistry, 36(9), 747-770 (2001-10-24) Pacemaker activity in hydra is modulated by glycine receptor ligands.R D Ruggieri et al.Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 138(2), 193-202 (2004-07-28) Molecular modifications on carboxylic acid derivatives as potent histone deacetylase inhibitors: Activity and docking studies.Gamze Bora-Tatar et al.Bioorganic & medicinal chemistry, 17(14), 5219-5228 (2009-06-13) Metabonomic analysis of quercetin against the toxicity of acrylamide in rat urine.Wei Bao et al.Food & function, 8(3), 1204-1214 (2017-02-23) Assembly of indole-2-carboxylic acid esters through a ligand-free copper-catalysed cascade process.Qian Cai et al.Chemical communications (Cambridge, England), (48)(48), 7581-7583 (2009-12-22) Protonated carbonic acid and reactive intermediates in the acidic decarboxylation of indolecarboxylic acids.Adelle A Vandersteen et al.The Journal of organic chemistry, 77(15), 6505-6509 (2012-07-19) Novel indole-2-carboxamide and cycloalkeno[1,2-b]indole derivatives. Structure-activity relationships for high inhibition of human LDL peroxidation.C Kuehm-Caubere et al.Journal of medicinal chemistry, 40(8), 1201-1210 (1997-04-11) Synthesis of tricyclic indole-2-carboxylic [correction of caboxylic] acids as potent NMDA-glycine antagonists.S Katayama et al.The Journal of organic chemistry, 66(10), 3474-3483 (2001-05-12) Substituted indole-2-carboxylates as in vivo potent antagonists acting as the strychnine-insensitive glycine binding site.R Di Fabio et al.Journal of medicinal chemistry, 40(6), 841-850 (1997-03-14)

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