熔点	116-117 ºC**
沸点	194.9±23.0 ºC (760 Tor
闪点	71.7±22.6 ºC, 计算值*
密度	1.14±0.1 g/cm3 (20 ºC

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来源	SDS样本
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Stability-indicating spectrophotometric and spectrodensitometric methods for the determination of diacerein in the presence of its degradation product.Marianne Nebsen et al.Drug testing and analysis, 3(4), 221-227 (2011-04-19) Diacerein for osteoarthritis.T S A Fidelix et al.The Cochrane database of systematic reviews, (1)(1), CD005117-CD005117 (2006-01-27) [Management of osteoarthritis: oral therapies].Pascal Richette La Revue du praticien, 62(5), 654-660 (2012-06-27) Effects of diacerein on biosynthesis activities of chondrocytes in culture.J P Pujol et al.Biorheology, 37(1-2), 177-184 (2000-07-27) Combined effect of subchondral drilling and hyaluronic acid with/without diacerein in full-thickness articular cartilage lesion in rabbits.Wanwisa Suwannaloet et al.TheScientificWorldJournal, 2012, 310745-310745 (2012-06-06) Clinical pharmacokinetics of diacerein.P Nicolas et al.Clinical pharmacokinetics, 35(5), 347-359 (1998-12-05) Self-reported prevalence of psoriasis and evaluation of the impact on the natural history of hip osteoarthritis: results of a 10 years follow-up study of 507 patients (ECHODIAH study).Umut Kalyoncu et al.Joint, bone, spine : revue du rhumatisme, 76(4), 389-393 (2009-02-17) Diacerein decreases TNF-alpha and IL-1beta levels in peritoneal fluid and prevents Baker's yeast-induced fever in young rats.Juliana Saibt Martins Pasin et al.Inflammation research : official journal of the European Histamine Research Society ... [et al.], 59(3), 189-196 (2009-09-05) Anti-inflammatory and anti-peroxidative roles of diacerein are possibly mediated through an alteration in thyroid functions in animal model of inflammation.Rameshwar Jatwa et al.Fundamental & clinical pharmacology, 23(4), 465-471 (2009-06-09) Development of lipid nanoparticles of diacerein, an antiosteoarthritic drug for enhancement in bioavailability and reduction in its side effects.Achint Jain et al.Journal of biomedical nanotechnology, 9(5), 891-900 (2013-06-28) Evaluation of symptomatic slow-acting drugs in osteoarthritis using the GRADE system.Olivier Bruyère et al.BMC musculoskeletal disorders, 9, 165-165 (2008-12-18) Effect of diacerein on insulin secretion and metabolic control in drug-naive patients with type 2 diabetes: a randomized clinical trial.Maria G Ramos-Zavala et al.Diabetes care, 34(7), 1591-1594 (2011-05-26) Diacerein.C M Spencer et al.Drugs, 53(1), 98-106 (1997-01-01) Diacerhein improves glucose tolerance and insulin sensitivity in mice on a high-fat diet.Natália Tobar et al.Endocrinology, 152(11), 4080-4093 (2011-09-08) Diacerein as adjuvant to diclofenac sodium in osteoarthritis knee.Kuljinder Singh et al.International journal of rheumatic diseases, 15(1), 69-77 (2012-02-14) Efficacy and safety of diacerein in early knee osteoarthritis: a randomized placebo-controlled trial.Ballari Brahmachari et al.Clinical rheumatology, 28(10), 1193-1198 (2009-07-15) Diacerein: a potential therapeutic drug for periodontal disease.Ren-Yeong Huang et al.Medical hypotheses, 79(2), 165-167 (2012-05-16) Are FoxO transcription factors implicated in osteoarthritis? Influence of Diacerhein.N de Isla et al.Bio-medical materials and engineering, 20(3), 227-233 (2010-10-12) Chondromodulating chimeric prodrugs of diacetylrhein: synthesis and evaluation in monoiodoacetate-induced hyperalgesia.Suneela Dhaneshwar et al.Medicinal chemistry (Shariqah (United Arab Emirates)), 9(3), 449-458 (2012-08-28) Changes of body weight and inflammatory markers after 12-week intervention trial: results of a double-blind, placebo-control pilot study.Nam-Seok Joo et al.Yonsei medical journal, 52(2), 242-248 (2011-02-15) Isolation and structural elucidation of two impurities from a diacerein bulk drug.Chaudhari Ashok et al.Journal of pharmaceutical and biomedical analysis, 49(2), 525-528 (2009-01-10) Studies on synthesis, stability, release and pharmacodynamic profile of a novel diacerein-thymol prodrug.Suneela Dhaneshwar et al.Bioorganic & medicinal chemistry letters, 23(1), 55-61 (2012-12-12) Physico-chemical and structural characterization of diacerhein.Massimo Bambagiotti-Alberti et al.Journal of pharmaceutical and biomedical analysis, 49(4), 1065-1069 (2009-02-14) In vitro effects of diacerein on NO production by chondrocytes in response to proinflammatory mediators.N G de Isla et al.Bio-medical materials and engineering, 18(1 Suppl), S99-104 (2008-05-06) [Pharmacological therapies for osteoarthritis].Pascal Richette Therapie, 66(5), 383-390 (2011-10-28) The pathogenetic role of IL-1β in severe epidermolysis bullosa simplex.Verena Wally et al.The Journal of investigative dermatology, 133(7), 1901-1903 (2013-01-25) Diacerein decreases visceral pain through inhibition of glutamatergic neurotransmission and cytokine signaling in mice.Vinícius Maria Gadotti et al.Pharmacology, biochemistry, and behavior, 102(4), 549-554 (2012-07-04) Symptomatic efficacy and safety of diacerein in the treatment of osteoarthritis: a meta-analysis of randomized placebo-controlled trials.E M Bartels et al.Osteoarthritis and cartilage, 18(3), 289-296 (2009-10-28) [Mechanisms of action of diacerein, the first inhibitor of interleukin-1 in osteoarthritis].Marie Solignac Presse medicale (Paris, France : 1983), 33(9 Pt 2), S10-S12 (2004-07-01) [Treatment of osteoarthritis with drugs and other modalities].P Härle et al.Der Internist, 49(12), 1458-1462 (2008-11-18) [Diacerein].G Passiu Annali italiani di medicina interna : organo ufficiale della Societa italiana di medicina interna, 1(2), 172-174 (1986-06-01) Diacerein as a disease-modulating agent in osteoarthritis.G Falgarone et al.Current rheumatology reports, 3(6), 479-483 (2001-11-16) Physicochemical characterization and dissolution study of solid dispersions of diacerein with polyethylene glycol 6000.Amit Kumar Aggarwal et al.Drug development and industrial pharmacy, 37(10), 1181-1191 (2011-04-01) Rhein, the metabolite of diacerhein, reduces the proliferation of osteoarthritic chondrocytes and synoviocytes without inducing apoptosis.F Legendre et al.Scandinavian journal of rheumatology, 38(2), 104-111 (2009-03-11) [Efficacy of diacerein on the symptoms and radiographic progression of osteoarthritis].D Provvedini et al.Presse medicale (Paris, France : 1983), 31(39 Pt 2), 4S13-4S15 (2003-01-09)

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