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Effect of terfenadine on nasal provocation.R Jankowski et al.International archives of allergy and immunology, 101(3), 311-317 (1993-01-01) Involvement of unique mechanisms in the induction of scratching behavior in BALB/c mice by compound 48/80.Naoki Inagaki et al.European journal of pharmacology, 448(2-3), 175-183 (2002-07-30) [Long QT interval. Interaction of terfenadine and itraconazole].Cornelia Rufke et al.Medizinische Monatsschrift fur Pharmazeuten, 29(1), 22-24 (2006-02-09) Different effects of the selective serotonin reuptake inhibitors fluvoxamine, paroxetine, and sertraline on the pharmacokinetics of fexofenadine in healthy volunteers.Junji Saruwatari et al.Journal of clinical psychopharmacology, 32(2), 195-199 (2012-03-01) Development of recombinant cell line co-expressing mutated Nav1.5, Kir2.1, and hERG for the safety assay of drug candidates.Masato Fujii et al.Journal of biomolecular screening, 17(6), 773-784 (2012-04-14) Comparison of nasal steroid with antihistamine in prophylactic treatment against pollinosis using an environmental challenge chamber.Heizaburo Yamamoto et al.Allergy and asthma proceedings, 33(5), 397-403 (2012-10-03) Phase separation in coamorphous systems: in silico prediction and the experimental challenge of detection.Katja Pajula et al.Molecular pharmaceutics, 11(7), 2271-2279 (2014-05-16) Terfenadine, a nonsedating antihistamine.C A Carter et al.Drug intelligence & clinical pharmacy, 19(11), 812-817 (1985-11-01) Comparative effects of terfenadine and loratadine in the treatment of hay fever.G Ciprandi et al.Journal of investigational allergology & clinical immunology, 1(6), 368-372 (1991-12-01) Effect of coadministration of single and multiple doses of rifampicin on the pharmacokinetics of fexofenadine enantiomers in healthy subjects.Hiroyuki Kusuhara et al.Drug metabolism and disposition: the biological fate of chemicals, 41(1), 206-213 (2012-11-02) Inhibitory effects of the antihistamines epinastine, terfenadine, and ebastine on potassium currents in rat ventricular myocytes.H Ohtani et al.The Journal of pharmacy and pharmacology, 51(9), 1059-1063 (1999-10-21) Targeting TMEM176B Enhances Antitumor Immunity and Augments the Efficacy of Immune Checkpoint Blockers by Unleashing Inflammasome Activation.Mercedes Segovia et al.Cancer cell, 35(5), 767-781 (2019-05-16) Characterization of a highly sensitive and selective novel trapping reagent, stable isotope labeled glutathione ethyl ester, for the detection of reactive metabolites.Toshikazu Yamaoka et al.Journal of pharmacological and toxicological methods, 76, 83-95 (2015-09-01) Enhanced systemic exposure of fexofenadine via the intranasal administration of chitosan-coated liposome.Fu Qiang et al.International journal of pharmaceutics, 430(1-2), 161-166 (2012-04-25) Adenylate kinase release as a high-throughput-screening-compatible reporter of bacterial lysis for identification of antibacterial agents.Anna C Jacobs et al.Antimicrobial agents and chemotherapy, 57(1), 26-36 (2012-10-03) TerfenadineMcTavish D, et al. Drugs, 39, 552-574 (1990) Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.Jing Yuan et al.Nature chemical biology, 5(10), 765-771 (2009-09-08) [Multicenter studies of terfenadine-containing suspensions in children with hayfever].L Endre et al.Orvosi hetilap, 139(1), 11-15 (1998-02-07) Quantitative benefit-risk assessment using only qualitative information on utilities.Ola Caster et al.Medical decision making : an international journal of the Society for Medical Decision Making, 32(6), E1-15 (2012-09-01) H1-antihistamines exacerbate high-fat diet-induced hepatic steatosis in wild-type but not in apolipoprotein E knockout mice.Vineesh V Raveendran et al.American journal of physiology. Gastrointestinal and liver physiology, 307(2), G219-G228 (2014-05-24) Antihistamines modulate the integrin signaling pathway in h9c2 rat cardiomyocytes: Possible association with cardiotoxicity.J S Yun et al.Human & experimental toxicology, 34(8), 796-807 (2014-11-27) H(1)-antihistamines and urticaria: how can we predict the best drug for our patient?M K Church et al.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 42(10), 1423-1429 (2012-09-22) A pharmacophore hypothesis for P-glycoprotein substrate recognition using GRIND-based 3D-QSAR.Giovanni Cianchetta et al.Journal of medicinal chemistry, 48(8), 2927-2935 (2005-04-15) Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).Zhichao Liu et al.PLoS computational biology, 7(12), e1002310-e1002310 (2011-12-24) Development and validation of an ultra-performance liquid chromatography method for simultaneous analysis of 20 antihistaminics in dietary supplements.Jung Yeon Kim et al.Biomedical chromatography : BMC, 29(3), 465-474 (2014-08-01) Differential thermodynamic driving force of first- and second-generation antihistamines to determine their binding affinity for human H1 receptors.Shigeru Hishinuma et al.Biochemical pharmacology, 91(2), 231-241 (2014-07-30) Torsades de pointes induced by erythromycin and terfenadine.D G Paris et al.The American journal of emergency medicine, 12(6), 636-638 (1994-11-01) Optimization of the adult zebrafish ECG method for assessment of drug-induced QTc prolongation.Girish Hari Chaudhari et al.Journal of pharmacological and toxicological methods, 67(2), 115-120 (2013-01-29) LuxR-dependent quorum sensing: computer aided discovery of new inhibitors structurally unrelated to N-acylhomoserine lactones.Laurent Soulère et al.Bioorganic & medicinal chemistry letters, 20(15), 4355-4358 (2010-07-10) Structure determination of fexofenadine-α-cyclodextrin complex by quantitative 2D ROESY analysis and molecular mechanics studies.Syed Mashhood Ali et al.Magnetic resonance in chemistry : MRC, 50(4), 299-304 (2012-03-15) Poorly soluble marketed drugs display solvation limited solubility.Christel A S Bergström et al.Journal of medicinal chemistry, 50(23), 5858-5862 (2007-10-13) Physical characterization of drug:polymer dispersion behavior in polyethylene glycol 4000 solid dispersions using a suite of complementary analytical techniques.Dipy M Vasa et al.Journal of pharmaceutical sciences, 103(9), 2911-2923 (2014-05-16) Danazol Inhibits Cytochrome P450 2J2 Activity in a Substrate-independent Manner.Eunyoung Lee et al.Drug metabolism and disposition: the biological fate of chemicals, 43(8), 1250-1253 (2015-06-07) Potential of decursin to inhibit the human cytochrome P450 2J2 isoform.Boram Lee et al.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 70, 94-99 (2014-05-03) [Treatment with terfenadine and ketoconazole or itraconazole can cause torsades de pointes ventricular tachycardia].S Pohjola-Sintonen Duodecim; laaketieteellinen aikakauskirja, 109(2), 164-166 (1993-01-01) In vitro model for assessing arrhythmogenic properties of drugs based on high-resolution impedance measurements.Filomain Nguemo et al.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 29(5-6), 819-832 (2012-05-23) Discovery of new cholesteryl ester transfer protein inhibitors via ligand-based pharmacophore modeling and QSAR analysis followed by synthetic exploration.Reema Abu Khalaf et al.European journal of medicinal chemistry, 45(4), 1598-1617 (2010-02-02) [Excessive terfenadine level due to drinking grapefruit juice].J N van den Anker et al.Nederlands tijdschrift voor geneeskunde, 141(41), 1976-1978 (1998-04-29) Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).Giulia Caron et al.Journal of medicinal chemistry, 48(9), 3269-3279 (2005-04-29) Integrating constitutive gene expression and chemoactivity: mining the NCI60 anticancer screen.David G Covell PloS one, 7(10), e44631-e44631 (2012-10-12) Comment: the new macrolide antibiotics and terfenadine.L M Cortese et al.The Annals of pharmacotherapy, 26(7-8), 1019-1019 (1992-07-01) Association between arterial stiffness and serum L-octanoylcarnitine and lactosylceramide in overweight middle-aged subjects: 3-year follow-up study.Minjoo Kim et al.PloS one, 10(3), e0119519-e0119519 (2015-03-18) Hypaconitine-induced QT prolongation mediated through inhibition of KCNH2 (hERG) potassium channels in conscious dogs.Shuilin Xie et al.Journal of ethnopharmacology, 166, 375-379 (2015-03-25) Hydrophilic interaction chromatography versus reversed phase liquid chromatography coupled to mass spectrometry: effect of electrospray ionization source geometry on sensitivity.Aurélie Periat et al.Journal of chromatography. A, 1356, 211-220 (2014-07-16) Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.Johannes Kornhuber et al.Journal of medicinal chemistry, 51(2), 219-237 (2007-11-22) Cardiac ion channels and antihistamines: possible mechanisms of cardiotoxicity.M Taglialatela et al.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 29 Suppl 3, 182-189 (1999-08-12) Chemical Library Screening and Structure-Function Relationship Studies Identify Bisacodyl as a Potent and Selective Cytotoxic Agent Towards Quiescent Human Glioblastoma Tumor Stem-Like Cells.Maria Zeniou et al.PloS one, 10(8), e0134793-e0134793 (2015-08-14) A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.Motoi Tobita et al.Bioorganic & medicinal chemistry letters, 15(11), 2886-2890 (2005-05-25) Support vector machines classification of hERG liabilities based on atom types.Lei Jia et al.Bioorganic & medicinal chemistry, 16(11), 6252-6260 (2008-05-02) Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).Jenny M Pedersen et al.Journal of medicinal chemistry, 51(11), 3275-3287 (2008-05-07) Sustained postexercise vasodilatation and histamine receptor activation following small muscle-mass exercise in humans.Zachary Barrett-O'Keefe et al.Experimental physiology, 98(1), 268-277 (2012-08-01) Strategic proposals to avoid drug interactions during drug development: a lesson from a terfenadine-related drug interaction.T Ishizaki The Journal of toxicological sciences, 21(5), 301-303 (1996-12-01) A two-state homology model of the hERG K+ channel: application to ligand binding.Ramkumar Rajamani et al.Bioorganic & medicinal chemistry letters, 15(6), 1737-1741 (2005-03-05) Enantioselective uptake of fexofenadine by Caco-2 cells as model intestinal epithelial cells.Kohei Togami et al.The Journal of pharmacy and pharmacology, 65(1), 22-29 (2012-12-12) A predictive ligand-based Bayesian model for human drug-induced liver injury.Sean Ekins et al.Drug metabolism and disposition: the biological fate of chemicals, 38(12), 2302-2308 (2010-09-17) Effects of terfenadine on psychomotor performance. An overview.D W Aaronson Drug safety, 8(4), 321-329 (1993-04-01) Design and synthesis of selective, high-affinity inhibitors of human cytochrome P450 2J2.Pierre Lafite et al.Bioorganic & medicinal chemistry letters, 16(10), 2777-2780 (2006-02-24) On the potential of in vitro organ-chip models to define temporal pharmacokinetic-pharmacodynamic relationships.Christopher W McAleer et al.Scientific reports, 9(1), 9619-9619 (2019-07-05) You're the flight surgeon: nasal congestion and Eustachian tube dysfunction.Yvette Guzman Aviation, space, and environmental medicine, 84(3), 268-269 (2013-03-22) GRIND-based 3D-QSAR and CoMFA to investigate topics dominated by hydrophobic interactions: the case of hERG K+ channel blockers.Giuseppe Ermondi et al.European journal of medicinal chemistry, 44(5), 1926-1932 (2008-12-27) Marine algal toxin azaspiracid is an open-state blocker of hERG potassium channelsTwiner MJ, et al. Chemical Research in Toxicology, 25(9), 1975-1984 (2012) A two-state homology model of the hERG K+ channel: application to ligand binding.Ramkumar Rajamani et al.Bioorganic & medicinal chemistry letters, 15(6), 1737-1741 (2005-03-05) Enantioselective uptake of fexofenadine by Caco-2 cells as model intestinal epithelial cells.Kohei Togami et al.The Journal of pharmacy and pharmacology, 65(1), 22-29 (2012-12-12) Effects of terfenadine on psychomotor performance. An overview.D W Aaronson Drug safety, 8(4), 321-329 (1993-04-01) Strategic proposals to avoid drug interactions during drug development: a lesson from a terfenadine-related drug interaction.T Ishizaki The Journal of toxicological sciences, 21(5), 301-303 (1996-12-01) Anti-IL-31 receptor antibody is shown to be a potential therapeutic option for treating itch and dermatitis in mice.K Kasutani et al.British journal of pharmacology, 171(22), 5049-5058 (2014-06-20) Design and synthesis of selective, high-affinity inhibitors of human cytochrome P450 2J2.Pierre Lafite et al.Bioorganic & medicinal chemistry letters, 16(10), 2777-2780 (2006-02-24) A predictive ligand-based Bayesian model for human drug-induced liver injury.Sean Ekins et al.Drug metabolism and disposition: the biological fate of chemicals, 38(12), 2302-2308 (2010-09-17) The effect of antihistamines on seizures induced by increasing-current electroshocks: ketotifen, but not olopatadine, promotes the seizures in infant rats.Koji Yamada et al.Biological & pharmaceutical bulletin, 35(5), 693-697 (2012-06-13) Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.Nandita Sinha et al.European journal of medicinal chemistry, 46(2), 618-630 (2010-12-28) Piperlongumine restores the balance of autophagy and apoptosis by increasing BCL2 phosphorylation in rotenone-induced Parkinson disease models.Jia Liu et al.Autophagy, 14(5), 845-861 (2018-02-13) Some pharmacokinetic aspects of the lipophilic terfenadine and zwitterionic fexofenadine in humans.Chen Chen Drugs in R&D, 8(5), 301-314 (2007-09-05) Effect of intestinal first-pass hydrolysis on the oral bioavailability of an ester prodrug of fexofenadine.Kayoko Ohura et al.Journal of pharmaceutical sciences, 101(9), 3264-3274 (2012-05-26) Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.Denis Fourches et al.Chemical research in toxicology, 23(1), 171-183 (2009-12-18) Side chain flexibilities in the human ether-a-go-go related gene potassium channel (hERG) together with matched-pair binding studies suggest a new binding mode for channel blockers.Ulrich Zachariae et al.Journal of medicinal chemistry, 52(14), 4266-4276 (2009-06-19) Dipeptidyl nitriles as human dipeptidyl peptidase I inhibitors.Jon Bondebjerg et al.Bioorganic & medicinal chemistry letters, 16(13), 3614-3617 (2006-05-02) Delineation of the protective action of zinc sulfate on ulcerative colitis in rats.Ho H Luk et al.European journal of pharmacology, 443(1-3), 197-204 (2002-06-05) Terfenadine: a mixture of equipotent antihistamine enantiomers without a clear 'isomeric ballast'.M Q Zhang et al.Pharmacy world & science : PWS, 15(5), 186-192 (1993-10-15) Modeling K(m) values using electrotopological state: substrates for cytochrome P450 3A4-mediated metabolism.Yong-Hua Wang et al.Bioorganic & medicinal chemistry letters, 15(18), 4076-4084 (2005-07-02) You're the flight surgeon: nasal congestion and Eustachian tube dysfunction.Yvette Guzman Aviation, space, and environmental medicine, 84(3), 268-269 (2013-03-22) On the potential of in vitro organ-chip models to define temporal pharmacokinetic-pharmacodynamic relationships.Christopher W McAleer et al.Scientific reports, 9(1), 9619-9619 (2019-07-05) Structural determinants for histamine H(1) affinity, hERG affinity and QTc prolongation in a series of terfenadine analogs.Robert Aslanian et al.Bioorganic & medicinal chemistry letters, 19(17), 5043-5047 (2009-08-08) Adaptation and validation of the Urticaria Patient Daily Diary for adolescents.Susan D Mathias et al.Allergy and asthma proceedings, 33(2), 186-190 (2012-04-25) Long-lasting inhibitory effect of apple and orange juices, but not grapefruit juice, on OATP2B1-mediated drug absorption.Yoshiyuki Shirasaka et al.Drug metabolism and disposition: the biological fate of chemicals, 41(3), 615-621 (2012-12-25) Docking model of drug binding to the human ether-à-go-go potassium channel guided by tandem dimer mutant patch-clamp data: a synergic approach.Yumi N Imai et al.Journal of medicinal chemistry, 52(6), 1630-1638 (2009-03-06) Novel indolylindazolylmaleimides as inhibitors of protein kinase C-beta: synthesis, biological activity, and cardiovascular safety.Han-Cheng Zhang et al.Journal of medicinal chemistry, 48(6), 1725-1728 (2005-03-18) GRIND-based 3D-QSAR and CoMFA to investigate topics dominated by hydrophobic interactions: the case of hERG K+ channel blockers.Giuseppe Ermondi et al.European journal of medicinal chemistry, 44(5), 1926-1932 (2008-12-27) A pharmacologically validated, high-capacity, functional thallium flux assay for the human Ether-à-go-go related gene potassium channel.William A Schmalhofer et al.Assay and drug development technologies, 8(6), 714-726 (2010-12-17) Exploring novel colon-targeting antihistaminic prodrug for colitis.S Dhaneshwar et al.Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 63(4), 327-337 (2012-10-17) Potent farnesyltransferase inhibitors with 1,4-diazepane scaffolds as novel destabilizing microtubule agents in hormone-resistant prostate cancer.Nicolas Wlodarczyk et al.Journal of medicinal chemistry, 54(5), 1178-1190 (2011-02-09) A pharmacologically validated, high-capacity, functional thallium flux assay for the human Ether-à-go-go related gene potassium channel.William A Schmalhofer et al.Assay and drug development technologies, 8(6), 714-726 (2010-12-17) Effect of terfenadine and pentamidine on the HERG channel and its intracellular trafficking: combined analysis with automated voltage clamp and confocal microscopy.Hikaru Tanaka et al.Biological & pharmaceutical bulletin, 37(11), 1826-1830 (2014-11-05) Characterization of A-935142, a hERG enhancer, in the presence and absence of standard hERG blockers.Xiaoqin Liu et al.Life sciences, 90(15-16), 607-611 (2012-03-13) The effect of antihistamines on seizures induced by increasing-current electroshocks: ketotifen, but not olopatadine, promotes the seizures in infant rats.Koji Yamada et al.Biological & pharmaceutical bulletin, 35(5), 693-697 (2012-06-13) Docking model of drug binding to the human ether-à-go-go potassium channel guided by tandem dimer mutant patch-clamp data: a synergic approach.Yumi N Imai et al.Journal of medicinal chemistry, 52(6), 1630-1638 (2009-03-06) Side chain flexibilities in the human ether-a-go-go related gene potassium channel (hERG) together with matched-pair binding studies suggest a new binding mode for channel blockers.Ulrich Zachariae et al.Journal of medicinal chemistry, 52(14), 4266-4276 (2009-06-19) Erythromycin and ketoconazole (Nizoral) associated with terfenadine (Seldane)-induced ventricular arrhythmias.R L Wynn General dentistry, 41(1), 27-29 (1993-01-01) Development of an in silico model for human skin permeation based on a Franz cell skin permeability assay.Pil H Lee et al.Bioorganic & medicinal chemistry letters, 20(1), 69-73 (2009-12-08) Chemical genetics reveals a complex functional ground state of neural stem cells.Phedias Diamandis et al.Nature chemical biology, 3(5), 268-273 (2007-04-10) Development of a highly sensitive methodology for quantitative determination of fexofenadine in a microdose study by multiple injection method using ultra-high performance liquid chromatography with tandem mass spectrometry.Yukari Tanaka et al.Biological & pharmaceutical bulletin, 35(5), 698-704 (2012-06-13) Identifying off-target effects and hidden phenotypes of drugs in human cells.Marnie L MacDonald et al.Nature chemical biology, 2(6), 329-337 (2006-05-09) Long-lasting inhibition of the intestinal absorption of fexofenadine by cyclosporin A in rats.Kei Suzuki et al.Journal of pharmaceutical sciences, 101(7), 2606-2615 (2012-04-28) Structural and functional screening in human induced-pluripotent stem cell-derived cardiomyocytes accurately identifies cardiotoxicity of multiple drug types.Kimberly R Doherty et al.Toxicology and applied pharmacology, 285(1), 51-60 (2015-04-07) Involvement of leukotriene B4 in itching in a mouse model of ocular allergy.Tsugunobu Andoh et al.Experimental eye research, 98, 97-103 (2012-04-17) Investigating the contribution of CYP2J2 to ritonavir metabolism in vitro and in vivo.Rüdiger Kaspera et al.Biochemical pharmacology, 91(1), 109-118 (2014-06-29) Profile of ragweed hay fever symptom control with terfenadine started before or after symptoms are established.C D Brooks et al.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 20(1), 21-26 (1990-01-01) Terfenadine. A review of its pharmacodynamic properties and therapeutic efficacy.E M Sorkin et al.Drugs, 29(1), 34-56 (1985-01-01)

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