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1-Amino-1-deoxy-D-sorbitol | CAS:488-43-7
1-Amino-1-deoxy-D-sorbitol
  • 名称:1-氨基-1-脱氧-D-山梨糖醇 | 1-Amino-1-deoxy-D-sorbitol
  • CAS号:488-43-7
  • 别名:
  • 分子式:C6H15NO5
  • 分子量:181.19
  • EINESC号:207-677-3

产品描述

物理化学性质

熔点 127 ºC
闪点 230 ºC

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Acetaminophen, via its reactive metabolite N-acetyl-p-benzo-quinoneimine and transient receptor potential ankyrin-1 stimulation, causes neurogenic inflammation in the airways and other tissues in rodents.Romina Nassini et al.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 24(12), 4904-4916 (2010-08-20) Use of a systems model of drug-induced liver injury (DILIsym(®)) to elucidate the mechanistic differences between acetaminophen and its less-toxic isomer, AMAP, in mice.Brett A Howell et al.Toxicology letters, 226(2), 163-172 (2014-02-25) Glutathione-S-transferase pi as a model protein for the characterisation of chemically reactive metabolites.Rosalind E Jenkins et al.Proteomics, 8(2), 301-315 (2008-01-19) A 1H NMR-based metabolomics approach for mechanistic insight into acetaminophen-induced hepatotoxicity.Kiyoshi Fukuhara et al.Drug metabolism and pharmacokinetics, 26(4), 399-406 (2011-06-15) In-source formation of N-acetyl-p-benzoquinone imine (NAPQI), the putatively toxic acetaminophen (paracetamol) metabolite, after derivatization with pentafluorobenzyl bromide and GC-ECNICI-MS analysis.Dimitrios Tsikas et al.Journal of chromatography. 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B, Analytical technologies in the biomedical and life sciences, 859(2), 147-156 (2007-10-05) Structural and kinetic analyses of macrophage migration inhibitory factor active site interactions.Gregg V Crichlow et al.Biochemistry, 48(1), 132-139 (2008-12-19) Monitoring paracetamol metabolism after single and repeated administration in pediatric patients with neoplastic diseases.S Koling et al.International journal of clinical pharmacology and therapeutics, 45(9), 496-503 (2007-10-03) Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury.Jean-Matthieu Prot et al.Toxicology and applied pharmacology, 259(3), 270-280 (2012-01-11)
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