询 单
请 填 写 相 关 信 息
产品信息
产品名称
别名
CAS号
结构式 上传
联系方式
公司
联系人
电话
邮箱
内容
提交
中文版 English
请输入产品名称、CAS式、分子式
2,3,4,9-Tetrahydro-2-[2-(methylamino)benzoyl]-1H-pyrido[3,4-b]indol-1-one | CAS:526-43-2
2,3,4,9-Tetrahydro-2-[2-(methylamino)benzoyl]-1H-pyrido[3,4-b]indol-1-one
  • 名称:2,3,4,9-四氢-2-[2-(甲基氨基)苯甲酰基]-1H-吡啶并[3,4-b]吲哚-1-酮 | 2,3,4,9-Tetrahydro-2-[2-(methylamino)benzoyl]-1H-pyrido[3,4-b]indol-1-one
  • CAS号:526-43-2
  • 别名:Rhetsinine
  • 分子式:C19H17N3O2
  • 分子量:319.36
  • EINESC号:

产品描述

物理化学性质

密度 1.372±0.06 g/cm3 (20 º

安全数据

没有数据没有数据

SDS

来源 SDS样本
没有数据没有数据
产品合成路线
更多

名称 CAS号
更多
文章
同行评议文献
Furosemide increases plasma oxypurinol without lowering serum urate--a complex drug interaction: implications for clinical practice.Lisa K Stamp et al.Rheumatology (Oxford, England), 51(9), 1670-1676 (2012-04-28) Allopurinol and oxypurinol promote osteoblast differentiation and increase bone formationOrriss I R, et al. Experimental Cell Research, 342(2), 166-174 (2016) A repeated oral administration study of febuxostat (TMX-67), a non-purine-selective inhibitor of xanthine oxidase, in patients with impaired renal function in Japan: pharmacokinetic and pharmacodynamic study.Tatsuo Hosoya et al.Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, 17(4 Suppl 2), S27-S34 (2011-07-01) Tissue protective effect of xanthine oxidase inhibitor, polymer conjugate of (styrene-maleic acid copolymer) and (4-amino-6-hydroxypyrazolo[3,4-d]pyrimidine), on hepatic ischemia-reperfusion injury.Jun Fang et al.Experimental biology and medicine (Maywood, N.J.), 235(4), 487-496 (2010-04-22) Genome-wide association study identifies ABCG2 (BCRP) as an allopurinol transporter and a determinant of drug response.C C Wen et al.Clinical pharmacology and therapeutics, 97(5), 518-525 (2015-02-14) Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.Denis Fourches et al.Chemical research in toxicology, 23(1), 171-183 (2009-12-18) Xanthine dehydrogenase downregulation promotes TGF beta signaling and cancer stem cell-related gene expression in hepatocellular carcinomaChen GL, et al. Oncogenesis, 6(9), e382-e382 (2017) Febuxostat inhibition of endothelial-bound XO: implications for targeting vascular ROS production.Umair Z Malik et al.Free radical biology & medicine, 51(1), 179-184 (2011-05-11) Evaluation of neuronal protective effects of xanthine oxidoreductase inhibitors on severe whole-brain ischemia in mouse model and analysis of xanthine oxidoreductase activity in the mouse brain.Go Suzuki et al.Neurologia medico-chirurgica, 55(1), 77-85 (2015-03-07) Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.Denis Fourches et al.Chemical research in toxicology, 23(1), 171-183 (2009-12-18) Lack of effect of hydrochlorothiazide and low-dose aspirin on the renal clearance of urate and oxypurinol after a single dose of allopurinol in normal volunteers.Daniel Y Ng et al.European journal of clinical pharmacology, 67(7), 709-713 (2010-12-25) Oxypurinol, allopurinol and allopurinol-1-riboside in plasma following an acute overdose of allopurinol in a patient with advanced chronic kidney disease.Diluk R W Kannangara et al.British journal of clinical pharmacology, 73(5), 828-829 (2011-11-22) Oxypurinol directly and immediately activates the drug-specific T cells via the preferential use of HLA-B*58:01.James Yun et al.Journal of immunology (Baltimore, Md. : 1950), 192(7), 2984-2993 (2014-03-05) The pharmacokinetics of oxypurinol in people with gout.Sophie L Stocker et al.British journal of clinical pharmacology, 74(3), 477-489 (2012-02-04) Clinical pharmacokinetics and pharmacodynamics of allopurinol and oxypurinol.Richard O Day et al.Clinical pharmacokinetics, 46(8), 623-644 (2007-07-28) Genome-wide association study identifies ABCG2 (BCRP) as an allopurinol transporter and a determinant of drug response.C C Wen et al.Clinical pharmacology and therapeutics, 97(5), 518-525 (2015-02-14) Hypoxia and reoxygenation induce endothelial nitric oxide synthase uncoupling in endothelial cells through tetrahydrobiopterin depletion and S-glutathionylation.Francesco De Pascali et al.Biochemistry, 53(22), 3679-3688 (2014-04-25) Dietary inhibition of xanthine oxidase attenuates radiation-induced endothelial dysfunction in rat aorta.Kevin G Soucy et al.Journal of applied physiology (Bethesda, Md. : 1985), 108(5), 1250-1258 (2010-02-20) Oxypurinol-Specific T Cells Possess Preferential TCR Clonotypes and Express Granulysin in Allopurinol-Induced Severe Cutaneous Adverse Reactions.Wen-Hung Chung et al.The Journal of investigative dermatology, 135(9), 2237-2248 (2015-05-07) Docetaxel Facilitates Endothelial Dysfunction through Oxidative Stress via Modulation of Protein Kinase C Beta: The Protective Effects of Sotrastaurin.Ching-Hsia Hung et al.Toxicological sciences : an official journal of the Society of Toxicology, 145(1), 59-67 (2015-01-31) Inhibition of xanthine oxidase reduces hyperglycemia-induced oxidative stress and improves mitochondrial alterations in skeletal muscle of diabetic mice.Amélie Bravard et al.American journal of physiology. Endocrinology and metabolism, 300(3), E581-E591 (2011-01-13) Effects of bovine milk ingestion on urinary excretion of oxypurinol and uric acid.M Kurajoh et al.International journal of clinical pharmacology and therapeutics, 49(6), 366-370 (2011-05-27) Amelioration of ischemia-reperfusion injury in an isolated rabbit lung model using OXANOH.Nahidh W Hasaniya et al.Vascular and endovascular surgery, 45(7), 581-591 (2011-10-11) Effect of xanthine oxidase-generated extracellular superoxide on skeletal muscle force generation.M C Gomez-Cabrera et al.American journal of physiology. Regulatory, integrative and comparative physiology, 298(1), R2-R8 (2009-10-16) 4-Amino-6-hydroxypyrazolo [3,4-d]pyrimidine (AHPP) conjugated PEG micelles: water soluble polymeric xanthine oxidase inhibitor.Gahininath Y Bharate et al.Journal of drug targeting, 19(10), 954-966 (2011-11-15) Eicosapentaenoic acid and oxypurinol in the treatment of muscle wasting in a mouse model of cancer cachexia.Vanessa C Vaughan et al.PloS one, 7(9), e45900-e45900 (2012-10-03) Regulation of high glucose-mediated mucin expression by matrix metalloproteinase-9 in human airway epithelial cells.Hongmei Yu et al.Experimental cell research, 333(1), 127-135 (2015-02-24) Improving the use of allopurinol in chronic gout: monitoring oxypurinol levels to guide therapy.M P Keith et al.Clinical pharmacology and therapeutics, 90(3), 363-364 (2011-08-25) Modelling the reduced xanthine oxidase in active sulfo and inactive desulfo forms.Joyee Mitra et al.Dalton transactions (Cambridge, England : 2003), 42(9), 3050-3058 (2013-01-10) Nox2 dependent redox-regulation of Akt and ERK1/2 to promote left ventricular hypertrophy in dietary obesity of mice.Sunbal N Bhatti et al.Biochemical and biophysical research communications, 528(3), 506-513 (2020-06-09) Relationships among hyperuricemia, endothelial dysfunction and cardiovascular disease: molecular mechanisms and clinical implications.Paolo Puddu et al.Journal of cardiology, 59(3), 235-242 (2012-03-09) Myeloperoxidase and oxidation of uric acid in gout: implications for the clinical consequences of hyperuricaemia.Lisa K Stamp et al.Rheumatology (Oxford, England), 53(11), 1958-1965 (2014-06-06) Inhibition of XO or NOX attenuates diethylstilbestrol-induced endothelial nitric oxide deficiency without affecting its effects on LNCaP cell invasion and apoptosis.Ji-Youn Youn et al.Clinical science (London, England : 1979), 123(8), 509-518 (2012-05-10) Recent onset of rash, dehydration, and nonbloody diarrhea in an elderly man.Tahirah Tyrell et al.The Journal of family practice, 62(9), E1-E5 (2013-10-02) Inhibition of xanthine oxidase reduces wasting and improves outcome in a rat model of cancer cachexia.Jochen Springer et al.International journal of cancer, 131(9), 2187-2196 (2012-02-18) Crystallographic and docking studies of purine nucleoside phosphorylase from Mycobacterium tuberculosis.Rodrigo G Ducati et al.Bioorganic & medicinal chemistry, 18(13), 4769-4774 (2010-06-24) Oxidative and nitrosative stress in acute pancreatitis. Modulation by pentoxifylline and oxypurinol.Javier Escobar et al.Biochemical pharmacology, 83(1), 122-130 (2011-10-18) Adenosine causes read-through into the late region of the HPV16 genome in a guanosine-dependent mannerYu H, et al. Virology, 521(9), 1-19 (2018) Systematic and Molecular Basis of the Antibacterial Action of Quinoxaline 1,4-Di-N-Oxides against Escherichia coli.Guyue Cheng et al.PloS one, 10(8), e0136450-e0136450 (2015-08-22) Allopurinol reduces oxidative stress in the ovine fetal cardiovascular system after repeated episodes of ischemia-reperfusion.Jan B Derks et al.Pediatric research, 68(5), 374-380 (2010-07-09) Relationship between serum urate and plasma oxypurinol in the management of gout: determination of minimum plasma oxypurinol concentration to achieve a target serum urate level.L K Stamp et al.Clinical pharmacology and therapeutics, 90(3), 392-398 (2011-07-29) Measurement of urinary oxypurinol by high performance liquid chromatography-tandem mass spectrometry.Sophie L Stocker et al.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 878(25), 2363-2368 (2010-08-13) Pharmacokinetic and pharmacodynamic interaction between allopurinol and probenecid in patients with gout.Sophie L Stocker et al.The Journal of rheumatology, 38(5), 904-910 (2011-02-03) HZE ⁵⁶Fe-ion irradiation induces endothelial dysfunction in rat aorta: role of xanthine oxidase.Kevin G Soucy et al.Radiation research, 176(4), 474-485 (2011-07-27)
备注

Products protected by valid patents are not offered for sale in countries where the sale of such products constitutes a patent infringement and its liability is at buyer's risk.

Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271 +A13(1).

名称 CAS号

相关产品

相关资讯

热门标签
询 单
请 填 写 相 关 信 息
产品信息
产品名称
别名
CAS号
结构式 上传
联系方式
公司
联系人
电话
邮箱
内容
提交