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Azure B | CAS:531-55-5
Azure B
  • 名称:天青 B; 天青 I | Azure B
  • CAS号:531-55-5
  • 别名:C.I. 52010; 3-Methylamino-7-dimethylaminophenothiazin-5-ium chloride
  • 分子式:C15H16ClN3S
  • 分子量:305.83
  • EINESC号:208-511-2

产品描述

物理化学性质

熔点 205-210 ºC (dec.)
水溶性 溶解

安全数据

安全说明书 S22;S24/25

SDS

来源 SDS样本
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[Use of grandaxin in hypermotor dysfunction of the biliary ducts in young people].E Iu Plotnikova et al.Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology, (6)(6), 65-70 (2007-03-24) [Tofisopam and melatonin attenuate the reorganization of circadian locomotor rhythm in rats under injection-induced stress conditions].E B Arushunian et al.Eksperimental'naia i klinicheskaia farmakologiia, 69(2), 14-17 (2006-07-19) Analysis of tofisopam in human serum by column-switching semi-micro high-performance liquid chromatography and evaluation of tofisopam bioequivalency.Soo Kyoung Baek et al.Biomedical chromatography : BMC, 16(4), 277-281 (2002-04-05) The atypical anxiolytic drug, tofisopam, selectively blocks phosphodiesterase isoenzymes and is active in the mouse model of negative symptoms of psychosis.Chris Rundfeldt et al.Journal of neural transmission (Vienna, Austria : 1996), 117(11), 1319-1325 (2010-10-23) Histone deacetylase 6 inhibition restores autophagic flux to promote functional recovery after spinal cord injury.Zhilong Zheng et al.Experimental neurology, 324, 113138-113138 (2019-12-04) Drug repositioning: identifying and developing new uses for existing drugs.Ted T Ashburn et al.Nature reviews. Drug discovery, 3(8), 673-683 (2004-08-03) In vitro prediction and in vivo verification of enantioselective human tofisopam metabolite profiles.Michael D Cameron et al.Drug metabolism and disposition: the biological fate of chemicals, 35(10), 1894-1902 (2007-07-25) In silico studies on potential MCF-7 inhibitors: a combination of pharmacophore and 3D-QSAR modeling, virtual screening, molecular docking, and pharmacokinetic analysis.Bharti Badhani et al.Journal of biomolecular structure & dynamics, 35(9), 1950-1967 (2016-07-13) [Fluctuations of the antianxiety effect of valerian and grandaxin during daytime wakefulness in humans with different chronotypes].E B Arushaian et al.Fiziologiia cheloveka, 31(2), 135-137 (2005-05-14) New PDE4 inhibitors based on pharmacophoric similarity between papaverine and tofisopam.Frédéric J J Bihel et al.Bioorganic & medicinal chemistry letters, 21(21), 6567-6572 (2011-09-17) Effect of intracerebroventricular administration of two molecular forms of sulfated CCK octapeptide on anxiety-like behavior in the zebrafish danio rerio.Kouhei Matsuda et al.Peptides, 130, 170330-170330 (2020-05-24) [Use of grandaxine in the treatment of patients with erosive-ulcerative stomach and gastroduodenal lesions].Ia M Vakhrushev et al.Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology, (4)(4), 21-24 (2004-12-01) Effect of tofisopam on the single-oral-dose pharmacokinetics and pharmacodynamics of the cyp3a4 probe drug alprazolam.Sándor Drabant et al.European journal of clinical pharmacology, 62(7), 587-588 (2006-06-23) Various effects of antidepressant drugs on bone microarchitectecture, mechanical properties and bone remodeling.N Bonnet et al.Toxicology and applied pharmacology, 221(1), 111-118 (2007-03-27) Tenoten in the therapy of anxious disturbances in patients with essential hypertension and coronary heart disease.N P Vanchakova et al.Bulletin of experimental biology and medicine, 148(2), 343-345 (2009-12-23) [The effect of tofisopam and tinctura leonuri on the color-discrimination function in young humans].K B Ovanesov Eksperimental'naia i klinicheskaia farmakologiia, 68(3), 56-59 (2005-07-29) Application of drug repositioning strategy to TOFISOPAM.P Bernard et al.Current medicinal chemistry, 15(30), 3196-3203 (2008-12-17) Emerging pharmacologic therapies for irritable bowel syndrome.Noriaki Manabe et al.Current gastroenterology reports, 12(5), 408-416 (2010-08-10) Gas chromatography nitrogen phosphorous detection (GC-NPD) assay of tofisopam in human plasma for pharmacokinetic evaluation.Maria Tóth et al.Journal of pharmaceutical and biomedical analysis, 41(4), 1354-1359 (2006-05-10) [A case in which tofisopam was effective for treatment of paroxysmal supraventricular tachycardia].Ryuji Kato et al.Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 123(5), 365-368 (2003-05-30) Resveratrol-primed exosomes strongly promote the recovery of motor function in SCI rats by activating autophagy and inhibiting apoptosis via the PI3K signaling pathway.Yue Fan et al.Neuroscience letters, 736, 135262-135262 (2020-07-20) Autoradiographic localization and quantitative determination of specific binding sites of anxiolytic homophthalazines (formerly called 2,3-benzodiazepines) in the striato-pallido-nigral system of rats.E J Horváth et al.Brain research. Molecular brain research, 22(1-4), 211-218 (1994-03-01) Method validation and determination of enantiomers and conformers in tofisopam drug substances and drug products by chiral high-performance liquid chromatography and kinetic and thermodynamic study of the interconversion of the conformers.Mougang Hu et al.Journal of chromatography. A, 1129(1), 47-53 (2006-07-18) Tofisopam inhibits the pharmacokinetics of CYP3A4 substrate midazolam.Mária Tóth et al.European journal of clinical pharmacology, 64(1), 93-94 (2007-11-09) [Effect of tofisopam on CYP3A4 enzyme activity on human recombinant 3A4 supersome].Mária Tóth et al.Acta pharmaceutica Hungarica, 75(4), 195-198 (2006-05-23) Bexarotene promotes microglia/macrophages - Specific brain - Derived Neurotrophic factor expression and axon sprouting after traumatic brain injury.Junchi He et al.Experimental neurology, 334, 113462-113462 (2020-09-12) [Peculiarities in the effect of tofisopam and valerian extract on short-term memory and anxiety states in healthy humans].é B Arushanian et al.Eksperimental'naia i klinicheskaia farmakologiia, 67(6), 23-25 (2005-02-15) [Climacteric disorders].Kazuya Makita et al.Nihon rinsho. Japanese journal of clinical medicine, 64 Suppl 4, 394-399 (2006-05-13) Clinical trial: dextofisopam in the treatment of patients with diarrhoea-predominant or alternating irritable bowel syndrome.S M Leventer et al.Alimentary pharmacology & therapeutics, 27(2), 197-206 (2007-11-02) [Chronobiological peculiarities of tofisopam action on human heart rate variability].E B Arushanian et al.Eksperimental'naia i klinicheskaia farmakologiia, 68(4), 36-39 (2005-10-01) [Pineal hormone melatonin in low doses potentiates psychotropic and chronotropic activity of tofisopam in rats].É B Abrushanian et al.Eksperimental'naia i klinicheskaia farmakologiia, 76(4), 15-17 (2013-06-15) [Grandaxin in neurological practice].G M Diukova et al.Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 109(9), 44-48 (2009-11-17)
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