
Azure B | CAS:531-55-5
Azure B
- 名称:天青 B; 天青 I | Azure B
- CAS号:531-55-5
- 别名:C.I. 52010; 3-Methylamino-7-dimethylaminophenothiazin-5-ium chloride
- 分子式:C15H16ClN3S
- 分子量:305.83
- EINESC号:208-511-2
产品描述
物理化学性质
熔点 | 205-210 ºC (dec.) |
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水溶性 | 溶解 |
安全数据
安全说明书 | S22;S24/25 |
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SDS
来源 | SDS样本 |
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没有数据 | 没有数据 |
产品合成路线
名称 | CAS号 |
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[Use of grandaxin in hypermotor dysfunction of the biliary ducts in young people].E Iu Plotnikova et al.Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology, (6)(6), 65-70 (2007-03-24)
[Tofisopam and melatonin attenuate the reorganization of circadian locomotor rhythm in rats under injection-induced stress conditions].E B Arushunian et al.Eksperimental'naia i klinicheskaia farmakologiia, 69(2), 14-17 (2006-07-19)
Analysis of tofisopam in human serum by column-switching semi-micro high-performance liquid chromatography and evaluation of tofisopam bioequivalency.Soo Kyoung Baek et al.Biomedical chromatography : BMC, 16(4), 277-281 (2002-04-05)
The atypical anxiolytic drug, tofisopam, selectively blocks phosphodiesterase isoenzymes and is active in the mouse model of negative symptoms of psychosis.Chris Rundfeldt et al.Journal of neural transmission (Vienna, Austria : 1996), 117(11), 1319-1325 (2010-10-23)
Histone deacetylase 6 inhibition restores autophagic flux to promote functional recovery after spinal cord injury.Zhilong Zheng et al.Experimental neurology, 324, 113138-113138 (2019-12-04)
Drug repositioning: identifying and developing new uses for existing drugs.Ted T Ashburn et al.Nature reviews. Drug discovery, 3(8), 673-683 (2004-08-03)
In vitro prediction and in vivo verification of enantioselective human tofisopam metabolite profiles.Michael D Cameron et al.Drug metabolism and disposition: the biological fate of chemicals, 35(10), 1894-1902 (2007-07-25)
In silico studies on potential MCF-7 inhibitors: a combination of pharmacophore and 3D-QSAR modeling, virtual screening, molecular docking, and pharmacokinetic analysis.Bharti Badhani et al.Journal of biomolecular structure & dynamics, 35(9), 1950-1967 (2016-07-13)
[Fluctuations of the antianxiety effect of valerian and grandaxin during daytime wakefulness in humans with different chronotypes].E B Arushaian et al.Fiziologiia cheloveka, 31(2), 135-137 (2005-05-14)
New PDE4 inhibitors based on pharmacophoric similarity between papaverine and tofisopam.Frédéric J J Bihel et al.Bioorganic & medicinal chemistry letters, 21(21), 6567-6572 (2011-09-17)
Effect of intracerebroventricular administration of two molecular forms of sulfated CCK octapeptide on anxiety-like behavior in the zebrafish danio rerio.Kouhei Matsuda et al.Peptides, 130, 170330-170330 (2020-05-24)
[Use of grandaxine in the treatment of patients with erosive-ulcerative stomach and gastroduodenal lesions].Ia M Vakhrushev et al.Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology, (4)(4), 21-24 (2004-12-01)
Effect of tofisopam on the single-oral-dose pharmacokinetics and pharmacodynamics of the cyp3a4 probe drug alprazolam.Sándor Drabant et al.European journal of clinical pharmacology, 62(7), 587-588 (2006-06-23)
Various effects of antidepressant drugs on bone microarchitectecture, mechanical properties and bone remodeling.N Bonnet et al.Toxicology and applied pharmacology, 221(1), 111-118 (2007-03-27)
Tenoten in the therapy of anxious disturbances in patients with essential hypertension and coronary heart disease.N P Vanchakova et al.Bulletin of experimental biology and medicine, 148(2), 343-345 (2009-12-23)
[The effect of tofisopam and tinctura leonuri on the color-discrimination function in young humans].K B Ovanesov Eksperimental'naia i klinicheskaia farmakologiia, 68(3), 56-59 (2005-07-29)
Application of drug repositioning strategy to TOFISOPAM.P Bernard et al.Current medicinal chemistry, 15(30), 3196-3203 (2008-12-17)
Emerging pharmacologic therapies for irritable bowel syndrome.Noriaki Manabe et al.Current gastroenterology reports, 12(5), 408-416 (2010-08-10)
Gas chromatography nitrogen phosphorous detection (GC-NPD) assay of tofisopam in human plasma for pharmacokinetic evaluation.Maria Tóth et al.Journal of pharmaceutical and biomedical analysis, 41(4), 1354-1359 (2006-05-10)
[A case in which tofisopam was effective for treatment of paroxysmal supraventricular tachycardia].Ryuji Kato et al.Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 123(5), 365-368 (2003-05-30)
Resveratrol-primed exosomes strongly promote the recovery of motor function in SCI rats by activating autophagy and inhibiting apoptosis via the PI3K signaling pathway.Yue Fan et al.Neuroscience letters, 736, 135262-135262 (2020-07-20)
Autoradiographic localization and quantitative determination of specific binding sites of anxiolytic homophthalazines (formerly called 2,3-benzodiazepines) in the striato-pallido-nigral system of rats.E J Horváth et al.Brain research. Molecular brain research, 22(1-4), 211-218 (1994-03-01)
Method validation and determination of enantiomers and conformers in tofisopam drug substances and drug products by chiral high-performance liquid chromatography and kinetic and thermodynamic study of the interconversion of the conformers.Mougang Hu et al.Journal of chromatography. A, 1129(1), 47-53 (2006-07-18)
Tofisopam inhibits the pharmacokinetics of CYP3A4 substrate midazolam.Mária Tóth et al.European journal of clinical pharmacology, 64(1), 93-94 (2007-11-09)
[Effect of tofisopam on CYP3A4 enzyme activity on human recombinant 3A4 supersome].Mária Tóth et al.Acta pharmaceutica Hungarica, 75(4), 195-198 (2006-05-23)
Bexarotene promotes microglia/macrophages - Specific brain - Derived Neurotrophic factor expression and axon sprouting after traumatic brain injury.Junchi He et al.Experimental neurology, 334, 113462-113462 (2020-09-12)
[Peculiarities in the effect of tofisopam and valerian extract on short-term memory and anxiety states in healthy humans].é B Arushanian et al.Eksperimental'naia i klinicheskaia farmakologiia, 67(6), 23-25 (2005-02-15)
[Climacteric disorders].Kazuya Makita et al.Nihon rinsho. Japanese journal of clinical medicine, 64 Suppl 4, 394-399 (2006-05-13)
Clinical trial: dextofisopam in the treatment of patients with diarrhoea-predominant or alternating irritable bowel syndrome.S M Leventer et al.Alimentary pharmacology & therapeutics, 27(2), 197-206 (2007-11-02)
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Products protected by valid patents are not offered for sale in countries where the sale of such products constitutes a patent infringement and its liability is at buyer's risk.
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271 +A13(1).
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