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A role for phospholipase D in angiotensin II-induced protein kinase D activation in adrenal glomerulosa cell models.Lawrence O Olala et al.Molecular and cellular endocrinology, 366(1), 31-37 (2012-11-28) 22-Hydroxycholesterols regulate lipid metabolism differently than T0901317 in human myotubes.Eili Tranheim Kase et al.Biochimica et biophysica acta, 1761(12), 1515-1522 (2006-10-24) Oxysterols inhibit differentiation and fusion of term primary trophoblasts by activating liver X receptors.I L M H Aye et al.Placenta, 32(2), 183-191 (2011-01-07) Induction of DKK1 by ox-LDL negatively regulates intracellular lipid accumulation in macrophages.Yu Zhang et al.FEBS letters, 589(1), 52-58 (2014-12-02) Antiproliferative effect of LXR agonists T0901317 and 22(R)-hydroxycholesterol on multiple human cancer cell lines.Chih-Pin Chuu et al.Anticancer research, 30(9), 3643-3648 (2010-10-15) Transport-metabolism interplay: LXRalpha-mediated induction of human ABC transporter ABCC2 (cMOAT/MRP2) in HepG2 cells.Tatsuhiko Adachi et al.Molecular pharmaceutics, 6(6), 1678-1688 (2009-07-11) Cholesterol side-chain cleavage by mitochondria from the human placenta. Studies using hydroxycholesterols as substrates.R C Tuckey The Journal of steroid biochemistry and molecular biology, 42(8), 883-890 (1992-09-01) Luciferase-based HMG-CoA reductase degradation assay for activity and selectivity profiling of oxy(lano)sterols.Ikuya Sagimori et al.Bioorganic & medicinal chemistry, 28(3), 115298-115298 (2020-01-07) Testosterone synthesized in cultured human SZ95 sebocytes derives mainly from dehydroepiandrosterone.WenChieh Chen et al.Experimental dermatology, 19(5), 470-472 (2010-03-27) Liver X receptor activation downregulates organic anion transporter 1 (OAT1) in the renal proximal tubule.Suticha Kittayaruksakul et al.American journal of physiology. Renal physiology, 302(5), F552-F560 (2011-12-16) Liver X receptor agonists decrease ENaC-mediated sodium transport in collecting duct cells.Sunhapas Soodvilai et al.American journal of physiology. Renal physiology, 303(12), F1610-F1616 (2012-10-19) 27-Hydroxycholesterol suppresses lipid accumulation by down-regulating lipogenic and adipogenic gene expression in 3T3-L1 cells.Bungo Shirouchi et al.Cytotechnology, 69(3), 485-492 (2016-03-18) Regulation of LXR by fatty acids, insulin, growth hormone and tumor necrosis factor-α in rainbow trout myocytes.Lourdes Cruz-Garcia et al.Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 160(2), 125-136 (2011-06-04) Cisplatin inhibits testosterone synthesis by a mechanism that includes the action of reactive oxygen species (ROS) at the level of P450scc.Mercedes Mori Sequeiros García et al.Chemico-biological interactions, 199(3), 185-191 (2012-09-04) 22R-Hydroxycholesterol protects neuronal cells from beta-amyloid-induced cytotoxicity by binding to beta-amyloid peptide.Zhi-Xing Yao et al.Journal of neurochemistry, 83(5), 1110-1119 (2002-11-20) Caprospinol: discovery of a steroid drug candidate to treat Alzheimer's disease based on 22R-hydroxycholesterol structure and properties.V Papadopoulos et al.Journal of neuroendocrinology, 24(1), 93-101 (2011-06-01) Altered levels of LXR-α: crucial implications in the pathogenesis of vitiligo.Ravinder Kumar et al.Experimental dermatology, 21(11), 853-858 (2012-11-21) Mechanism underlying apolipoprotein E (ApoE) isoform-dependent lipid efflux from neural cells in culture.Hirohisa Minagawa et al.Journal of neuroscience research, 87(11), 2498-2508 (2009-03-28) Modulators of the hedgehog signaling pathway.Philipp Heretsch et al.Bioorganic & medicinal chemistry, 18(18), 6613-6624 (2010-08-17) Identification of a hormone response element that mediates suppression of APOF by LXR and PPARα agonists.Yan Liu et al.Biochimica et biophysica acta. Molecular and cell biology of lipids, 1865(3), 158583-158583 (2019-12-10) Normal-phase liquid chromatography-atmospheric-pressure photoionization-mass spectrometry analysis of cholesterol and phytosterol oxidation products.Christian H Grün et al.Journal of chromatography. A, 1439, 74-81 (2016-01-18) Tumor necrosis factor alpha may act as an intraovarian mediator of luteinizing hormone-induced oocyte maturation in trout.Diego Crespo et al.Biology of reproduction, 86(1), 1-12 (2011-09-02) COMarko Tarvainen et al.Journal of agricultural and food chemistry, 64(51), 9653-9662 (2016-12-16) Structural insights into a key step of brassinosteroid biosynthesis and its inhibition.Keisuke Fujiyama et al.Nature plants, 5(6), 589-594 (2019-06-12) 22(R)-hydroxycholesterol and pioglitazone synergistically decrease cholesterol ester via the PPARγ-LXRα-ABCA1 pathway in cholesterosis of the gallbladder.Jing-Min Wang et al.Biochemical and biophysical research communications, 447(1), 152-157 (2014-04-08) LXR agonists and ABCG1-dependent cholesterol efflux in MCF-7 breast cancer cells: relation to proliferation and apoptosis.Ali El Roz et al.Anticancer research, 32(7), 3007-3013 (2012-07-04) Structural basis for three-step sequential catalysis by the cholesterol side chain cleavage enzyme CYP11A1.Natalia Mast et al.The Journal of biological chemistry, 286(7), 5607-5613 (2010-12-17) The human placenta expresses CYP17 and generates androgens de novo.J C Escobar et al.The Journal of clinical endocrinology and metabolism, 96(5), 1385-1392 (2011-02-11) CINPA1 is an inhibitor of constitutive androstane receptor that does not activate pregnane X receptor.Milu T Cherian et al.Molecular pharmacology, 87(5), 878-889 (2015-03-13) Cholesterol negatively regulates IL-9-producing CD8+ T cell differentiation and antitumor activity.Xingzhe Ma et al.The Journal of experimental medicine, 215(6), 1555-1569 (2018-05-11) Dysregulation of SREBP2 induces BACE1 expression.Raffaella Mastrocola et al.Neurobiology of disease, 44(1), 116-124 (2011-07-06) Activation of liver X receptors inhibits hedgehog signaling, clonogenic growth, and self-renewal in multiple myeloma.Jasmin R Agarwal et al.Molecular cancer therapeutics, 13(7), 1873-1881 (2014-05-09) LXRα is uniquely required for maximal reverse cholesterol transport and atheroprotection in ApoE-deficient mice.Cynthia Hong et al.Journal of lipid research, 53(6), 1126-1133 (2012-03-29) A steroid isolated from the water mold Achlya heterosexualis induces neurogenesis in vitro and in vivo.Laurent Lecanu et al.Steroids, 77(3), 224-232 (2011-12-06) A Dioxygenase Catalyzes Steroid 16α-Hydroxylation in Steroidal Glycoalkaloid Biosynthesis.Masaru Nakayasu et al.Plant physiology, 175(1), 120-133 (2017-07-30) Oxysterol-induced soluble endoglin release and its involvement in hypertension.Ana C Valbuena-Diez et al.Circulation, 126(22), 2612-2624 (2012-11-01) Activators of PPARs and LXR decrease the adverse effects of exogenous glucocorticoids on the epidermis.Marianne Demerjian et al.Experimental dermatology, 18(7), 643-649 (2009-02-25) Liver X receptor antagonist reduces lipid formation and increases glucose metabolism in myotubes from lean, obese and type 2 diabetic individuals.E T Kase et al.Diabetologia, 50(10), 2171-2180 (2007-07-31) Stereo specific platelet inhibition by the natural LXR agonist 22(R)-OH-cholesterol and its fluorescence labelling with preserved bioactivity and chiral handling in macrophages.Stephanie Schaffer et al.Biochemical pharmacology, 86(2), 279-285 (2013-05-15) Dietary supplementation with 22-S-hydroxycholesterol to rats reduces body weight gain and the accumulation of liver triacylglycerol.Eili Tranheim Kase et al.Lipids, 47(5), 483-493 (2012-03-20) The liver X receptor modulator 22(S)-hydroxycholesterol exerts cell-type specific effects on lipid and glucose metabolism.Nina Pettersen Hessvik et al.The Journal of steroid biochemistry and molecular biology, 128(3-5), 154-164 (2011-11-05) Immunosteroid as a regulator for Th1/Th2 balance: its possible role in autoimmune diseases.Junko Matsuzaki et al.Autoimmunity, 38(5), 369-375 (2005-10-18) Reduced cholesterol levels impair Smoothened activation in Smith-Lemli-Opitz syndrome.Robert Blassberg et al.Human molecular genetics, 25(4), 693-705 (2015-12-20) Apolipoprotein A-I activates cellular cAMP signaling through the ABCA1 transporter.Bassam Haidar et al.The Journal of biological chemistry, 279(11), 9963-9969 (2004-01-01) LXR-activating oxysterols induce the expression of inflammatory markers in endothelial cells through LXR-independent mechanisms.Fulvio Morello et al.Atherosclerosis, 207(1), 38-44 (2009-05-12) Gene-selective modulation by a synthetic oxysterol ligand of the liver X receptor.Elaine M Quinet et al.Journal of lipid research, 45(10), 1929-1942 (2004-08-05) Mesenchymal stem cells differentiate into renin-producing juxtaglomerular (JG)-like cells under the control of liver X receptor-alpha.Kenichi Matsushita et al.The Journal of biological chemistry, 285(16), 11974-11982 (2010-02-02) Autoregulation of the human liver X receptor alpha promoter.B A Laffitte et al.Molecular and cellular biology, 21(22), 7558-7568 (2001-10-18) Oxysterols induce differentiation in human keratinocytes and increase Ap-1-dependent involucrin transcription.K Hanley et al.The Journal of investigative dermatology, 114(3), 545-553 (2000-02-26)

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