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Pyrithiamine hydrobromide | CAS:534-64-5
Pyrithiamine hydrobromide
  • 名称:吡啶硫胺氢溴酸盐 | Pyrithiamine hydrobromide
  • CAS号:534-64-5
  • 别名:Neopyrithiamine; Pyrithiamin; Pyrithiamin hydrobromide; Pyrithiamine; Pyrithiamine bromide hydrobromide
  • 分子式:C14H19N4O.HBr.Br
  • 分子量:419.14
  • EINESC号:208-604-8

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物理化学性质

熔点 247 ºC*

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Benefits of butyrylcholinesterase reactivability testing in organophosphate poisoning.Laurenţiu Sorodoc et al.Human & experimental toxicology, 30(11), 1769-1776 (2011-04-12) In vitro effects of acetylcholinesterase reactivators on monoamine oxidase activity.Zdeněk Fišar et al.Toxicology letters, 201(2), 176-180 (2011-01-05) Syntheses and in vitro evaluations of uncharged reactivators for human acetylcholinesterase inhibited by organophosphorus nerve agents.Julien Renou et al.Chemico-biological interactions, 203(1), 81-84 (2012-11-01) Oximes as pretreatment before acute exposure to paraoxon.Dietrich E Lorke et al.Journal of applied toxicology : JAT, 39(11), 1506-1515 (2019-07-03) Percutaneous exposure to the nerve agent VX: Efficacy of combined atropine, obidoxime and diazepam treatment.Marloes J A Joosen et al.Chemico-biological interactions, 188(1), 255-263 (2010-07-06) Effect of different oximes on rat and human cholinesterases inhibited by methamidophos: a comparative in vitro and in silico study.Thiago Henrique Lugokenski et al.Basic & clinical pharmacology & toxicology, 111(6), 362-370 (2012-06-19) Investigation of kinetic interactions between approved oximes and human acetylcholinesterase inhibited by pesticide carbamates.Timo Wille et al.Chemico-biological interactions, 206(3), 569-572 (2013-08-22) Development and validation of a FIA/UV-vis method for pK(a) determination of oxime based acetylcholinesterase reactivators.Karel Musil et al.Journal of pharmaceutical and biomedical analysis, 117, 240-246 (2015-09-21) Review of oximes available for treatment of nerve agent poisoning.R M Dawson Journal of applied toxicology : JAT, 14(5), 317-331 (1994-09-01) Using MRI for the assessment of paraoxon-induced brain damage and efficacy of antidotal treatment.Yossi Rosman et al.Journal of applied toxicology : JAT, 32(6), 409-416 (2011-08-24) A comparison of tabun-inhibited rat brain acetylcholinesterase reactivation by three oximes (HI-6, obidoxime, and K048) in vivo detected by biochemical and histochemical techniques.Jiri Bajgar et al.Journal of enzyme inhibition and medicinal chemistry, 25(6), 790-797 (2010-11-09) A comparison of the reactivating and therapeutic efficacy of newly developed oximes (K347, K628) with commonly used oximes (obidoxime, HI-6) against tabun in rats and mice.Jiri Kassa et al.Drug and chemical toxicology, 33(3), 227-232 (2010-05-01) [Studying kinetics of oxime-induced reactivation of malathion-inhibited cholinesterase].M A Iudin et al.Eksperimental'naia i klinicheskaia farmakologiia, 76(1), 21-24 (2013-03-07) Reactivation of organophosphate-inhibited human AChE by combinations of obidoxime and HI 6 in vitro.F Worek et al.Journal of applied toxicology : JAT, 27(6), 582-588 (2007-03-21) Kinetic analysis of interactions of paraoxon and oximes with human, Rhesus monkey, swine, rabbit, rat and guinea pig acetylcholinesterase.Franz Worek et al.Toxicology letters, 200(1-2), 19-23 (2010-10-26) Incorporation of obidoxime into human serum albumin nanoparticles: optimisation of preparation parameters for the development of a stable formulation.Jürgen Kufleitner et al.Journal of microencapsulation, 27(7), 594-601 (2010-10-07) A comparison of the potency of a novel bispyridinium oxime K203 and currently available oximes (obidoxime, HI-6) to counteract the acute neurotoxicity of sarin in rats.Jiri Kassa et al.Basic & clinical pharmacology & toxicology, 111(5), 333-338 (2012-04-28) A comparison of reactivating and therapeutic efficacy of bispyridinium acetylcholinesterase reactivator KR-22934 with the oxime K203 and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice.Jiri Kassa et al.Toxicology mechanisms and methods, 21(3), 241-245 (2010-12-15) Characterization of the anticholinergic properties of obidoxime; functional examinations of the rat atria and the urinary bladder.Ondrej Soukup et al.Toxicology mechanisms and methods, 20(7), 428-433 (2010-07-07) A common mechanism for resistance to oxime reactivation of acetylcholinesterase inhibited by organophosphorus compounds.Donald M Maxwell et al.Chemico-biological interactions, 203(1), 72-76 (2012-09-18) Prevention of organophosphate-induced chronic epilepsy by early benzodiazepine treatment.Shai Shrot et al.Toxicology, 323, 19-25 (2014-06-03) Pharmacokinetics of obidoxime in patients poisoned with organophosphorus compounds.H Thiermann et al.Toxicology letters, 197(3), 236-242 (2010-06-15) Oxime reactivators and their in vivo and in vitro effects on nicotinic receptors.O Soukup et al.Physiological research, 60(4), 679-686 (2011-05-18) In vitro evaluation of bis-pyridinium oximes bearing methoxy alkane linker as reactivators of sarin inhibited human acetylcholinesterase.Jyotiranjan Acharya et al.Toxicology in vitro : an international journal published in association with BIBRA, 24(6), 1797-1802 (2010-07-06) sec-Butyl-propylacetamide (SPD) and two of its stereoisomers rapidly terminate paraoxon-induced status epilepticus in rats.Guy Bar-Klein et al.Epilepsia, 55(12), 1953-1958 (2014-11-08) A comparison of neuroprotective efficacy of the oxime K203 and its fluorinated analogue (KR-22836) with obidoxime in Tabun-poisoned rats.Jiri Kassa et al.Basic & clinical pharmacology & toxicology, 107(5), 861-867 (2010-11-01) [Antidotal effect of combinations obidoxime/HI-6 and memantine in mice poisoned with soman, dichlorvos or heptenophos].Biljana Antonijević et al.Vojnosanitetski pregled, 68(12), 1033-1040 (2012-02-23) The efficacy of obidoxime 72 hours after intoxication by organophosphates.Sergio Emilio Prieto-Miranda et al.The American journal of emergency medicine, 29(2), 244-244 (2010-09-10) First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase.Guillaume Mercey et al.Chemical communications (Cambridge, England), 47(18), 5295-5297 (2011-04-01) Treatment efficacy in a soman-poisoned guinea pig model: added value of physostigmine?Marloes J A Joosen et al.Archives of toxicology, 85(3), 227-237 (2010-09-16) Atropine dosage in patients with severe organophosphate pesticide poisoning.Hossein Sanaei-Zadeh The American journal of emergency medicine, 30(4), 628-628 (2012-02-07) New original in vitro method to assess cholinesterase reactivity in organophosphate poisoning.L Sorodoc et al.Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi, 114(3), 757-763 (2011-01-18)
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