
Metanicotine | CAS:538-79-4
Metanicotine
- 名称:位变异烟碱 | Metanicotine
- CAS号:538-79-4
- 别名:N-Methyl-4-(3-pyridinyl)-3-buten-1-amine; NSC 66331
- 分子式:C10H14N2
- 分子量:162.23
- EINESC号:
产品描述
物理化学性质
沸点 | 292 ºC |
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闪点 | 130 ºC |
密度 | 0.980 |
安全数据
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SDS
来源 | SDS样本 |
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The diagnosis of GH deficiency in obese patients: a reappraisal with GHRH plus arginine testing after pharmacological blockade of lipolysis.Massimo Scacchi et al.European journal of endocrinology, 163(2), 201-206 (2010-05-13)
Acyl ghrelin induces insulin resistance independently of GH, cortisol, and free fatty acidsVestergaard ET, et al. Scientific Reports, 7, 42706-42706 (2017)
Acipimox attenuates atherosclerosis and enhances plaque stability in ApoE-deficient mice fed a palmitate-rich diet.Feipeng Jin et al.Biochemical and biophysical research communications, 428(1), 86-92 (2012-10-13)
Inhibition of lipolysis in Type 2 diabetes normalizes glucose disposal without change in muscle glycogen synthesis rates.Ee L Lim et al.Clinical science (London, England : 1979), 121(4), 169-177 (2011-03-11)
Pharmacokinetics and bioequivalence evaluation of two acipimox tablets: a single-dose, randomized-sequence, two-way crossover study in healthy Chinese male volunteers.J Huang et al.Drug research, 63(2), 79-83 (2013-03-01)
Effect of the antilipolytic nicotinic acid analogue acipimox on whole-body and skeletal muscle glucose metabolism in patients with non-insulin-dependent diabetes mellitus.Vaag A, et al. The Journal of Clinical Investigation, 88(4), 1282-1290 (1991)
Acipimox, an inhibitor of lipolysis, attenuates atherogenesis in LDLR-null mice treated with HIV protease inhibitor ritonavir.Wen Guo et al.Arteriosclerosis, thrombosis, and vascular biology, 29(12), 2028-2032 (2009-09-19)
Acipimox-enhanced ¹⁸F-fluorodeoxyglucose positron emission tomography for characterizing and predicting early remodeling in the rat infarct model.Mélanie Bousquenaud et al.The international journal of cardiovascular imaging, 28(6), 1407-1415 (2011-11-26)
Inflammation and lipid accumulation in xanthoma disseminatum: Therapeutic considerations.Klaus Eisendle et al.Journal of the American Academy of Dermatology, 58(2 Suppl), S47-S49 (2008-01-23)
The assessment of human regional drug absorption of free acid and sodium salt forms of acipimox, in healthy volunteers, to direct modified release formulation strategy.Rajeev Menon et al.Biopharmaceutics & drug disposition, 30(9), 508-516 (2009-10-03)
Nicotinic acid receptor subtypes and their ligands.Willem Soudijn et al.Medicinal research reviews, 27(3), 417-433 (2007-01-24)
Paradoxical changes in muscle gene expression in insulin-resistant subjects after sustained reduction in plasma free fatty acid concentration.Mandeep Bajaj et al.Diabetes, 56(3), 743-752 (2007-03-01)
Free fatty acids decrease circulating ghrelin concentrations in humans.Lars C Gormsen et al.European journal of endocrinology, 154(5), 667-673 (2006-04-29)
Acipimox during exercise points to an inhibitory feedback of GH on ghrelin secretion in bulimic and healthy women.Jara Nedvidkova et al.Regulatory peptides, 167(1), 134-139 (2011-01-18)
The lowering of hepatic fatty acid uptake improves liver function and insulin sensitivity without affecting hepatic fat content in humans.Sara Rigazio et al.American journal of physiology. Endocrinology and metabolism, 295(2), E413-E419 (2008-05-29)
Short-term flexibility of myocardial triglycerides and diastolic function in patients with type 2 diabetes mellitus.Sebastiaan Hammer et al.American journal of physiology. Endocrinology and metabolism, 295(3), E714-E718 (2008-07-17)
Acipimox--a nicotinic acid analogue for hyperlipidaemia. Drug and therapeutics bulletin, 29(15), 57-59 (1991-07-22)
Kinetics and utilization of lipid sources during acute exercise and acipimox.Birgitte Nellemann et al.American journal of physiology. Endocrinology and metabolism, 307(2), E199-E208 (2014-06-05)
Suppression of circulating free fatty acids with acipimox in chronic heart failure patients changes whole body metabolism but does not affect cardiac function.Mads Halbirk et al.American journal of physiology. Heart and circulatory physiology, 299(4), H1220-H1225 (2010-08-17)
Impaired growth hormone secretion in obese subjects is partially reversed by acipimox-mediated plasma free fatty acid depressionCordido F, et al. The Journal of clinical endocrinology and metabolism, 81(3), 914-918 (1996)
Mechanisms of insulin resistance after insulin-induced hypoglycemia in humans: the role of lipolysis.Paola Lucidi et al.Diabetes, 59(6), 1349-1357 (2010-03-20)
ECG-triggered 18F-fluorodeoxyglucose positron emission tomography imaging of the rat heart is dramatically enhanced by acipimox.Sylvain Poussier et al.European journal of nuclear medicine and molecular imaging, 37(9), 1745-1750 (2010-04-16)
Effects on insulin secretion and insulin action of a 48-h reduction of plasma free fatty acids with acipimox in nondiabetic subjects genetically predisposed to type 2 diabetes.Kenneth Cusi et al.American journal of physiology. Endocrinology and metabolism, 292(6), E1775-E1781 (2007-02-15)
Dose-response effects of free fatty acids on amino acid metabolism and ureagenesis.L C Gormsen et al.Acta physiologica (Oxford, England), 192(3), 369-379 (2007-11-02)
Intense [18F]FDG tongue uptake in a case of acipimox-related angio-oedema during FDG-PET myocardial viability study.Georgios Arsos et al.European journal of nuclear medicine and molecular imaging, 34(8), 1320-1321 (2007-06-05)
Effects of prolonged fasting and sustained lipolysis on insulin secretion and insulin sensitivity in normal subjects.B Salgin et al.American journal of physiology. Endocrinology and metabolism, 296(3), E454-E461 (2008-12-25)
Acipimox reduces circulating levels of insulin and associated neutrophilic inflammation in metabolic syndrome.Fabrizio Montecucco et al.American journal of physiology. Endocrinology and metabolism, 300(4), E681-E690 (2011-01-27)
Comparison of rat and dog models of vasodilatation and lipolysis for the calculation of a therapeutic index for GPR109A agonists.Ester Carballo-Jane et al.Journal of pharmacological and toxicological methods, 56(3), 308-316 (2007-07-24)
Effects of acute and one-week fatty acid lowering on cardiac function and insulin sensitivity in relation with myocardial and muscle fat and adiponectin levels.Hanna-Riikka Lehto et al.The Journal of clinical endocrinology and metabolism, 97(9), 3277-3284 (2012-07-05)
Effects of acipimox on serum lipids, lipoproteins and lipolytic enzymes in hypertriglyceridemiaTaskinen MR and Nikkila EA Atherosclerosis, 69(2-3), 249-255 (1988)
[Effect of acipimox on diabetes mellitus-associated hyperlipoproteinemia].G Paragh et al.Orvosi hetilap, 134(3), 121-124 (1993-01-17)
Inhibition of lipolysis stimulates peripheral glucose uptake but has no effect on endogenous glucose production in HIV lipodystrophy.Birgitte Lindegaard et al.Diabetes, 56(8), 2070-2077 (2007-07-03)
Anti-inflammatory effects of nicotinic acid in human monocytes are mediated by GPR109A dependent mechanisms.Janet E Digby et al.Arteriosclerosis, thrombosis, and vascular biology, 32(3), 669-676 (2012-01-24)
Effects of growth hormone and free fatty acids on insulin sensitivity in patients with type 1 diabetes.Burak Salgin et al.The Journal of clinical endocrinology and metabolism, 94(9), 3297-3305 (2009-07-02)
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Products protected by valid patents are not offered for sale in countries where the sale of such products constitutes a patent infringement and its liability is at buyer's risk.
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271 +A13(1).
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