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Description of route of synthesis:
Add 6-Aza-spiro [2.5] octane hydrochloride and 2-fluoro-4-nitrobenzoic acid to dimethyl sulfoxide, then add potassium carbonate as an acid binding agent, and heat up for aromatic nucleophilic substitution reaction. The fluorine atom is replaced by the amino group on the pyridine ring; After the reaction is complete, the system is poured into water to acidify and precipitate a solid. After filtration, washing with water, and refining, 2- (6-Azaspiro [2.5] Octan-6-yl) -4-Nitrobenzoic acid is obtained.
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