物理化学性质
| 沸点 |
199 ºC |
| 闪点 |
96 ºC |
| 密度 |
0.974 |
产品合成路线
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同行评议文献
Palladium-Catalysed Direct Desulfitative Arylation of Pyrroles using Benzenesulfonyl Chlorides as Alternative Coupling Partners. Jin R, et al. Advanced Synthesis & Catalysis, 356(18), 3831-3841 (2014)
"Benzenesulfonyl chlorides: new reagents for access to alternative regioisomers in palladium-catalysed direct arylations of thiophenes"Yuan K, et al. Chemical Science, 5(1), 392-396 (2014)
"C-H Functionalization of Enamides: Synthesis of ?-Amidovinyl Sulfones via Visible-Light Photoredox Catalysis"Jiang H, et al. Advanced Synthesis & Catalysis, 355(4), 809-813 (2013)
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Description for route of synthesis:
Under inert gas protection, using tetrahydrofuran as the solvent, methyl triphenylphosphine bromide is first reacted with n-butyl lithium at low temperature to prepare Wittig reagent; Subsequently, acetic acid was added to the system and the Wittig reaction was carried out at controlled temperature to convert the ketone carbonyl group into olefins; After the reaction is completed, the target product 4-methyl-4-pentenoic acid is obtained by quenching, extraction, washing, drying, and purification through vacuum distillation or recrystallization.
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