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4-Bromo-3-iodo-toluene | CAS:858841-53-9
4-Bromo-3-iodo-toluene
  • 名称:4-溴-3-碘-甲苯 | 4-Bromo-3-iodo-toluene
  • CAS号:858841-53-9
  • 别名:
  • 分子式:C7H6BrI
  • 分子量:296.93
  • EINESC号:

产品描述

物理化学性质

沸点 271.5±20.0 ºC (760 Tor
闪点 118.0±21.8 ºC, 计算值*
密度 2.062±0.06 g/cm3 (20 º

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journal of pharmaceutics, 443(1-2), 279-287 (2013-01-08) Kuijieyuan Decoction Improved Intestinal Barrier Injury of Ulcerative Colitis by Affecting TLR4-Dependent PI3K/AKT/NF-κB Oxidative and Inflammatory Signaling and Gut Microbiota.Baohai Liu et al.Frontiers in pharmacology, 11, 1036-1036 (2020-08-28) Exploring therapeutic potentials of baicalin and its aglycone baicalein for hematological malignancies.Haijun Chen et al.Cancer letters, 354(1), 5-11 (2014-08-17) AKT serine/threonine protein kinase modulates baicalin-triggered autophagy in human bladder cancer T24 cells.Chingju Lin et al.International journal of oncology, 42(3), 993-1000 (2013-01-29) New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin.Min Li-Weber Cancer treatment reviews, 35(1), 57-68 (2008-11-14) Baicalin inhibits autophagy induced by influenza A virus H3N2.Hai-yan Zhu et al.Antiviral research, 113, 62-70 (2014-12-03) [Cellular absorption of the active ingredients in different compatibilities of gegenqinlian decoction in human intestinal Caco-2 cells].Bo-sha Zhang et al.Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 35(9), 1460-1463 (2013-03-05) [Preparation of baicalin nanocrystal pellets and preliminary study on its pharmacokinetics].Shi-Ying Jin et al.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(8), 1156-1159 (2013-08-16) Research Article Flavocoxid Protects Against Cadmium-Induced Disruption of the Blood-Testis Barrier and Improves Testicular Damage and Germ Cell Impairment in Mice.Letteria Minutoli et al.Toxicological sciences : an official journal of the Society of Toxicology, 148(1), 311-329 (2015-10-02) Protective effects of baicalin on LPS-induced injury in intestinal epithelial cells and intercellular tight junctions.Jian Chen et al.Canadian journal of physiology and pharmacology, 93(4), 233-237 (2015-02-11) [Optimization of the extraction process for qingrejiedu oral liquid with synthesizing multiple guidelines grading method].Hong Liu et al.Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 35(8), 1326-1330 (2013-01-17) Hydrophobic flavonoids from Scutellaria baicalensis induce colorectal cancer cell apoptosis through a mitochondrial-mediated pathway.Chong-Zhi Wang et al.International journal of oncology, 42(3), 1018-1026 (2013-01-23) Synergistic interactions among flavonoids and acetogenins in Graviola (Annona muricata) leaves confer protection against prostate cancer.Chunhua Yang et al.Carcinogenesis, 36(6), 656-665 (2015-04-12) Baicalin attenuates fibrogenic process in human renal proximal tubular cells (HK-2) exposed to diabetic milieu.Jung Eun Nam et al.Life sciences, 254, 117742-117742 (2020-05-04) Anti-inflammatory effects of Baicalin, Baicalein, and Wogonin in vitro and in vivo.Wonhwa Lee et al.Inflammation, 38(1), 110-125 (2014-09-25) Effects of San-Huang-Xie-Xin-tang, a traditional Chinese prescription for clearing away heat and toxin, on the pacemaker activities of interstitial cells of Cajal from the murine small intestine.Byung Joo Kim et al.Journal of ethnopharmacology, 155(1), 744-752 (2014-06-24) [Effect of baicalin on expression of TLR4 in RAW264.7 cells infected by ESBLs Escherichia coli].Yun Yun et al.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(10), 1590-1594 (2013-08-21) Unexpected retention behavior of baicalin: Hydrophilic interaction like properties of a reversed-phase column.Balázs Magda et al.Journal of pharmaceutical and biomedical analysis, 111, 119-125 (2015-04-17) Baicalein upregulates DDIT4 expression which mediates mTOR inhibition and growth inhibition in cancer cells.Yujun Wang et al.Cancer letters, 358(2), 170-179 (2014-12-30) Study on formability of solid nanosuspensions during solidification: II novel roles of freezing stress and cryoprotectant property.Peng-Fei Yue et al.International journal of pharmaceutics, 475(1-2), 35-48 (2014-08-27) Baicalin alleviates TNBS-induced colitis by inhibiting PI3K/AKT pathway activation.Lei Zhu et al.Experimental and therapeutic medicine, 20(1), 581-590 (2020-06-17) [Protective effect of baicalin against LPS-induced intestinal injury].Qiong Wu et al.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(17), 2854-2858 (2014-01-02) [Effect on different concentrations of exogenous hormones on baicalin in Scutellaria baicalensis callus].Gui-Xiang Wan et al.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 37(24), 3799-3802 (2013-05-01) Extraction and Bioactivity Analysis of Major Flavones Compounds from Scutellaria baicalensis Using In Vitro Assay and Online Screening HPLC-ABTS System.Kwang Jin Lee et al.Journal of analytical methods in chemistry, 2014, 563702-563702 (2014-09-27) Baicalin regulates neuronal fate decision in neural stem/progenitor cells and stimulates hippocampal neurogenesis in adult rats.Peng-Wei Zhuang et al.CNS neuroscience & therapeutics, 19(3), 154-162 (2013-01-11) Baicalin inhibits the fenton reaction by enhancing electron transfer from Fe (2+) to dissolved oxygen.Daisuke Nishizaki et al.The American journal of Chinese medicine, 43(1), 87-101 (2015-02-03) [Preparation of flavonoid reference standards from Scutellariae Radix under the guidance of high performance liquid chromatography-mass spectrometry analysis].Henan Guo et al.Se pu = Chinese journal of chromatography, 30(7), 690-695 (2012-11-30) Rapid determination of baicalin and total baicalein content in Scutellariae radix by ATR-IR and NIR spectroscopy.M Navarro Escamilla et al.Talanta, 114, 304-310 (2013-08-21) Involvement of the inhibition of intestinal glucuronidation in enhancing the oral bioavailability of resveratrol by labrasol containing nanoemulsions.Jing Zhou et al.Molecular pharmaceutics, 12(4), 1084-1095 (2015-02-28) Baicalin is an inhibitor of subgroup J avian leukosis virus infection.Kun Qian et al.Virus research, 248, 63-70 (2018-02-27) Concentration-dependent inhibitory effect of Baicalin on the plasma protein binding and metabolism of chlorzoxazone, a CYP2E1 probe substrate, in rats in vitro and in vivo.Na Gao et al.PloS one, 8(1), e53038-e53038 (2013-01-10) Baicalin, a flavonoid, affects the activity of human dermal papilla cells and promotes anagen induction in mice.Seung Hyun Shin et al.Naunyn-Schmiedeberg's archives of pharmacology, 388(5), 583-586 (2014-12-02) Studies on the antioxidant properties of extracts from the roots and shoots of two Scutellaria species in human blood plasma.Izabela Grzegorczyk-Karolak et al.Acta biochimica Polonica, 62(2), 253-258 (2015-05-28) A stable fixed-dose combination tablet of pseudoephedrine and KOB extracts for the extended release.C-J Hwang et al.Drug research, 63(11), 572-578 (2013-06-20) A Scutellaria baicalensis radix water extract inhibits 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a component of Scutellaria baicalensis, alleviates anorexia and inhibits skeletal muscle atrophy in experimental cancer cachexia.Bin Li et al.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 35(12), 12415-12425 (2014-09-10) Biotransformation of baicalin to baicalein significantly strengthens the inhibition potential towards UDP-glucuronosyltransferases (UGTs) isoforms.Yanjie Teng et al.Die Pharmazie, 68(9), 763-767 (2013-10-24) Baicalin relieves inflammation stimulated by lipopolysaccharide via upregulating TUG1 in liver cells.Yanqiu Huang et al.Journal of physiology and biochemistry, 75(4), 463-473 (2019-08-10) The effects of coenzyme Q10 and baicalin in cisplatin-induced lipid peroxidation and nitrosative stress.Ewa Sawicka et al.Acta poloniae pharmaceutica, 70(6), 977-985 (2014-01-05) Reduced system exposures of total rhein and baicalin after combinatory oral administration of rhein, baicalin and berberine to beagle dogs and rats.Zhanguo Wang et al.Journal of ethnopharmacology, 145(2), 442-449 (2012-11-20) [Effect of different developmental stage on plant growth and active compounds in Scutellaria baicalensis].Guo-Qiang Hu et al.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 37(24), 3793-3798 (2013-05-01) [Study on in situ intestinal absorption of baicalin contained in Tiangou Jiangya capsules].Ling-Jun Li et al.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(6), 894-898 (2013-05-31) Therapeutic effects of baicalin on monocrotaline-induced pulmonary arterial hypertension by inhibiting inflammatory response.Yun Luan et al.International immunopharmacology, 26(1), 188-193 (2015-01-21) Liquid Chromatography-Tandem Mass Spectrometry Screening Method for the Detection of Radical-Scavenging Natural Antioxidants from the Whole Scutellariae (Radix, Stem and Leaf).Gao-Feng Shi et al.Journal of chromatographic science, 53(7), 1140-1146 (2015-01-09) [Effect of baicalin on pattern recognition receptor TLR2/4-NOD2 and its significance of druggability].Yu-Shuang Chai et al.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(16), 2639-2644 (2013-11-16) Baicalin promotes embryo adhesion and implantation by upregulating fucosyltransferase IV (FUT4) via Wnt/beta-catenin signaling pathway.Yu-Mei Zhang et al.FEBS letters, 589(11), 1225-1233 (2015-04-22) [The study on baicalin in China].Y Zhu Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 13(9), 567-569 (1993-09-01) Transdermal baicalin delivery using diethylene glycol monoethyl ether-mediated cubic phase gel.Yongtai Zhang et al.International journal of pharmaceutics, 479(1), 219-226 (2014-12-30) Baicalin relieves hypoxia-aroused H9c2 cell apoptosis by activating Nrf2/HO-1-mediated HIF1α/BNIP3 pathway.Hailiang Yu et al.Artificial cells, nanomedicine, and biotechnology, 47(1), 3657-3663 (2019-09-04) Identification of a nitric oxide generation-stimulative principle in Scutellariae radix.Ziyang Chen et al.Bioscience, biotechnology, and biochemistry, 77(3), 657-659 (2013-03-09) Baicalin Attenuates YAP Activity to Suppress Ovarian Cancer Stemness.Yucong Li et al.OncoTargets and therapy, 13, 7151-7163 (2020-08-18) Antiviral activity of baicalin against influenza A (H1N1/H3N2) virus in cell culture and in mice and its inhibition of neuraminidase.Yue Ding et al.Archives of virology, 159(12), 3269-3278 (2014-08-01) Tanshinone IIA and Baicalin inhibiting the formation of benzo[a]pyrene and benzo[a]pyrene induced cytotoxicity: correlation with scavenging free radical.Shixiang Wang et al.Environmental toxicology and pharmacology, 36(2), 403-410 (2013-06-15) Baicalin, an emerging multi-therapeutic agent: pharmacodynamics, pharmacokinetics, and considerations from drug development perspectives.N R Srinivas Xenobiotica; the fate of foreign compounds in biological systems, 40(5), 357-367 (2010-03-17) Baicalin inhibits breast cancer development via inhibiting IĸB kinase activation in vitro and in vivo.Yang Gao et al.International journal of oncology, 53(6), 2727-2736 (2018-10-16) [In vitro effect of banxiaxiexin-decoction and different combinations on the metabolic activities of baicalin and baicalein in rat liver microsomes].Qiao-Ling Cai et al.Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 35(8), 1286-1290 (2013-01-17) Baicalin augments the differentiation of osteoblasts via enhancement of microRNA-217.Qi Wang et al.Molecular and cellular biochemistry, 463(1-2), 91-100 (2019-10-14) [Antitumor effect of baicalin on rat brain glioma].Yong-zhen Hu et al.Zhonghua zhong liu za zhi [Chinese journal of oncology], 35(1), 11-16 (2013-05-08) Chrysin, baicalein and galangin are indirect activators of the human constitutive androstane receptor (CAR).Alejandro Carazo Fernández et al.Toxicology letters, 233(2), 68-77 (2015-01-28) [Drug delivery systems of baicalin, baicalin-phospholipid complex and self-microemulsifying drug across Caco-2 cell model].Li Chen et al.Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 35(5), 757-761 (2012-12-12) Comparative pharmacokinetics of baicalin in normal and the type 2 diabetic rats after oral administration of the Radix scutellariae extract.Yuan-Xiong Deng et al.Fitoterapia, 83(8), 1435-1442 (2013-01-23) Design, synthesis and evaluation of a baicalin and berberine hybrid compound as therapeutic agent for ulcerative colitis.Dan Jia et al.Bioorganic & medicinal chemistry, 28(20), 115697-115697 (2020-10-18) Baicalin Attenuates Hypoxia-Induced Pulmonary Arterial Hypertension to Improve Hypoxic Cor Pulmonale by Reducing the Activity of the p38 MAPK Signaling Pathway and MMP-9.Yan S, et al. Evidence-Based Complementary and Alternative Medicine : ECAM, 2016 (2016) Quantitative assessment of traditional Oriental herbal formulation Samhwangsasim-tang using UPLC technique.Amrit Poudel et al.Journal of chromatographic science, 52(2), 176-185 (2013-02-14) Regulating effect of baicalin on IKK/IKB/NF-kB signaling pathway and apoptosis-related proteins in rats with ulcerative colitis.Jian Shen et al.International immunopharmacology, 73, 193-200 (2019-05-20) Baicalin influences the dendritic morphology of newborn neurons in the hippocampus of chronically stressed rats.Jiang X, et al. Neural Regeneration Research, 8(6), 496-496 (2013) [Construction on the chitosan microparticles of baicalin and comparison of transdermal diffusion in vitro of baicalin in chitosan microparticles and cream].Huan Wang et al.Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 35(5), 800-803 (2012-12-12) A practical application of wavelet moment method on the quantitative analysis of Shuanghuanglian oral liquid based on three-dimensional fingerprint spectra.Jing Chen et al.Journal of chromatography. A, 1352, 55-61 (2014-06-11) Crystal structure of the human ecto-5'-nucleotidase (CD73): insights into the regulation of purinergic signaling.Karen Knapp et al.Structure (London, England : 1993), 20(12), 2161-2173 (2012-11-13) Baicalin induces apoptosis in hepatic cancer cells in vitro and suppresses tumor growth in vivo.Yang Yu et al.International journal of clinical and experimental medicine, 8(6), 8958-8967 (2015-08-27) Baicalin downregulates Porphyromonas gingivalis lipopolysaccharide-upregulated IL-6 and IL-8 expression in human oral keratinocytes by negative regulation of TLR signaling.Wei Luo et al.PloS one, 7(12), e51008-e51008 (2012-12-15) A dual inhibitor of cyclooxygenase and 5-lipoxygenase protects against kainic acid-induced brain injury.Letteria Minutoli et al.Neuromolecular medicine, 17(2), 192-201 (2015-04-22) Comparative pharmacokinetics of a marker compound, baicalin in KOB extract after oral administration to normal and allergic-induced rats.Jong-Suep Baek et al.Drug delivery, 21(6), 453-458 (2014-01-23) [Determination of chlorogenic acid and baicalin in Yinhuang film-coated tablets by HPLC isocratic elution].Mei Xu et al.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(5), 691-693 (2013-06-04) Concentration-dependent inhibitory effects of baicalin on the metabolism of dextromethorphan, a dual probe of CYP2D and CYP3A, in rats.Xin Tian et al.Chemico-biological interactions, 203(2), 522-529 (2013-03-06) Baicalin Protects Mice from Aristolochic Acid I-Induced Kidney Injury by Induction of CYP1A through the Aromatic Hydrocarbon Receptor.Ke Wang et al.International journal of molecular sciences, 16(7), 16454-16468 (2015-07-25)
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