询 单
请 填 写 相 关 信 息
产品信息
产品名称
别名
CAS号
结构式 上传
联系方式
公司
联系人
电话
邮箱
内容
提交
中文版 English
请输入产品名称、CAS式、分子式
3,4-Difluorobenzyl chloride | CAS:698-80-6
3,4-Difluorobenzyl chloride
  • 名称:3,4-二氟氯苄 | 3,4-Difluorobenzyl chloride
  • CAS号:698-80-6
  • 别名:
  • 分子式:C7H5ClF2
  • 分子量:162.56
  • EINESC号:

产品描述

物理化学性质

没有数据没有数据

安全数据

危险品标志 C
危险类别码 R20/22;R34
安全说明书 S26;S36/37/39;S45

SDS

来源 SDS样本
Alfa-Aesar 浏览或下载
Acros-Organics 浏览或下载
Apollo 浏览或下载
产品合成路线
更多

名称 CAS号
更多
文章
同行评议文献
Palladium-catalyzed sp2 and sp3 C-H bond activation and addition to isatin toward 3-hydroxy-2-oxindoles.Gang-Wei Wang et al.Organic letters, 15(20), 5270-5273 (2013-10-05) QSAR study of isatin analogues as in vitro anti-cancer agents.Razieh Sabet et al.European journal of medicinal chemistry, 45(3), 1113-1118 (2010-01-09) PAC-1 and isatin derivatives are weak matrix metalloproteinase inhibitors.Stian Sjøli et al.Biochimica et biophysica acta, 1840(10), 3162-3169 (2014-07-22) Rabbit 3-hydroxyhexobarbital dehydrogenase is a NADPH-preferring reductase with broad substrate specificity for ketosteroids, prostaglandin D₂, and other endogenous and xenobiotic carbonyl compounds.Satoshi Endo et al.Biochemical pharmacology, 86(9), 1366-1375 (2013-09-03) Inhibition of monoamine oxidase by C5-substituted phthalimide analogues.Clarina I Manley-King et al.Bioorganic & medicinal chemistry, 19(16), 4829-4840 (2011-07-23) Versatile three component procedure for combinatorial synthesis of biologically relevant scaffold spiro[indole-thiazolidinones] under aqueous conditionsDandia, A.; et al. Green Chemistry, 13, 1852-1852 (2011) Ozil, M.; et al. J. Chem. Res. (M), 35, 268-268 (2011) Spirocyclic replacements for the isatin in the highly selective, muscarinic M1 PAM ML137: the continued optimization of an MLPCN probe molecule.Michael S Poslusney et al.Bioorganic & medicinal chemistry letters, 23(6), 1860-1864 (2013-02-19) Rhodium(II) catalyzed diastereoselective reactions of diazoacetamides with isatins: an efficient approach to 3-hydroxy-3,3'-bioxindoles.Ming Li et al.Organic & biomolecular chemistry, 10(44), 8808-8813 (2012-10-09) In vitro assessment of the cytotoxic, apoptotic, and mutagenic potentials of isatin.Priscila de Matos Cândido-Bacani et al.Journal of toxicology and environmental health. Part A, 76(6), 354-362 (2013-04-06) Docking studies on monoamine oxidase-B inhibitors: estimation of inhibition constants (K(i)) of a series of experimentally tested compounds.Mustafa Toprakçí et al.Bioorganic & medicinal chemistry letters, 15(20), 4438-4446 (2005-09-03) Isatin replacements applied to the highly selective, muscarinic M1 PAM ML137: continued optimization of an MLPCN probe molecule.Bruce J Melancon et al.Bioorganic & medicinal chemistry letters, 23(2), 412-416 (2012-12-15) Synthesis of new 4-thiazolidinone-, pyrazoline-, and isatin-based conjugates with promising antitumor activity.Dmytro Havrylyuk et al.Journal of medicinal chemistry, 55(20), 8630-8641 (2012-09-21) Synthesis and inhibitory activity against human monoamine oxidase of N1-thiocarbamoyl-3,5-di(hetero)aryl-4,5-dihydro-(1H)-pyrazole derivatives.Franco Chimenti et al.European journal of medicinal chemistry, 45(2), 800-804 (2009-11-21) Enzymatic detection and quantification assay of isatin, a putative stress biomarker in blood.Theis Sommer et al.ACS chemical neuroscience, 6(8), 1353-1360 (2015-04-22) Effect of affinity sorbent on proteomic profiling of isatin-binding proteins of mouse brain.O A Buneeva et al.Biochemistry. Biokhimiia, 77(11), 1326-1338 (2012-12-18) Face selective reduction of the exocyclic double bond in isatin derived spirocyclic lactones.Sandeep Rana et al.Organic & biomolecular chemistry, 11(2), 244-247 (2012-11-20) Synthesis and hydrolytic evaluation of acid-labile imine-linked cytotoxic isatin model systems.Lidia Matesic et al.Bioorganic & medicinal chemistry, 19(5), 1771-1778 (2011-02-11) Inhibition of monoamine oxidase by selected C5- and C6-substituted isatin analogues.Clarina I Manley-King et al.Bioorganic & medicinal chemistry, 19(1), 261-274 (2010-12-08) N-Heterocyclic-carbene-catalyzed reaction of α-bromo-α,β-unsaturated aldehyde or α,β-dibromoaldehyde with isatins: an efficient synthesis of spirocyclic oxindole-dihydropyranones.Changsheng Yao et al.Chemistry (Weinheim an der Bergstrasse, Germany), 19(2), 456-459 (2012-12-12) Synthesis, activity, and pharmacophore development for isatin-beta-thiosemicarbazones with selective activity toward multidrug-resistant cells.Matthew D Hall et al.Journal of medicinal chemistry, 52(10), 3191-3204 (2009-04-29) Synthesis and selective human monoamine oxidase inhibition of 3-carbonyl, 3-acyl, and 3-carboxyhydrazido coumarin derivatives.Daniela Secci et al.European journal of medicinal chemistry, 46(10), 4846-4852 (2011-08-30) Enantioselective construction of multifunctionalized spirocyclohexaneoxindoles through organocatalytic Michael-Aldol cyclization of isatin derived alkenes with linear dialdehydes.Xiao-Fei Huang et al.Organic & biomolecular chemistry, 10(44), 8794-8799 (2012-10-10) Asymmetric [3 + 2] annulation of N-protected isatins with but-3-yn-2-one catalyzed by DIOP: facile creation of enantioenriched spiro[furan-2,3'-indoline]-2',4(5H)-dione.Zhong Lian et al.Organic & biomolecular chemistry, 10(40), 8048-8050 (2012-08-30) Synthesis, in vitro and in vivo antitumor activity of symmetrical bis-Schiff base derivatives of isatin.Chengyuan Liang et al.European journal of medicinal chemistry, 74, 742-750 (2013-11-02) Characterization of a novel cometabolic degradation carbazole pathway by a phenol-cultivated Arthrobacter sp. W1.Shengnan Shi et al.Bioresource technology, 193, 281-287 (2015-07-06) Highly enantioselective addition of enals to isatin-derived ketimines catalyzed by N-heterocyclic carbenes: synthesis of spirocyclic γ-lactams.Hui Lv et al.Organic letters, 14(21), 5412-5415 (2012-10-16) Cytotoxic and anticancer activities of isatin and its derivatives: a comprehensive review from 2000-2008.K L Vine et al.Anti-cancer agents in medicinal chemistry, 9(4), 397-414 (2009-05-16) Isatin derivatives, a novel class of transthyretin fibrillogenesis inhibitors.Asensio González et al.Bioorganic & medicinal chemistry letters, 19(17), 5270-5273 (2009-08-05) Synthesis, semipreparative HPLC separation, biological evaluation, and 3D-QSAR of hydrazothiazole derivatives as human monoamine oxidase B inhibitors.Franco Chimenti et al.Bioorganic & medicinal chemistry, 18(14), 5063-5070 (2010-06-29) Cloning of Toluene 4-Monooxygenase Genes and Application of Two-Phase System to the Production of the Anticancer Agent, Indirubin.Lampet Wongsaroj et al.Molecular biotechnology, 57(8), 720-726 (2015-03-18) Total synthesis of (-)-isatisine A.Pitambar Patel et al.The Journal of organic chemistry, 77(23), 10509-10515 (2012-11-17) Investigations on the 2-thiazolylhydrazyne scaffold: synthesis and molecular modeling of selective human monoamine oxidase inhibitors.Franco Chimenti et al.Bioorganic & medicinal chemistry, 18(15), 5715-5723 (2010-07-10) Human NRDRB1, an alternatively spliced isoform of NADP(H)-dependent retinol dehydrogenase/reductase enhanced enzymatic activity of benzil.Yinxia Yan et al.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 30(6), 1371-1382 (2012-11-07) Stress and water balance: the roles of ANP, AVP and isatin.S K Bhattacharya et al.Indian journal of experimental biology, 36(12), 1195-1200 (1999-03-27) Convolutamydine A and synthetic analogues have antinociceptive properties in mice.Gabriela S M Figueiredo et al.Pharmacology, biochemistry, and behavior, 103(3), 431-439 (2012-10-11) Isatin--a new biological factor.V Glover et al.Indian journal of experimental biology, 29(1), 1-5 (1991-01-01) Demchuk, D. V.; et al. Mendeleev Communications, 21, 224-224 (2011) Chromone, a privileged scaffold for the development of monoamine oxidase inhibitors.Alexandra Gaspar et al.Journal of medicinal chemistry, 54(14), 5165-5173 (2011-06-24) Construction of spiro-fused 2-oxindole/α-methylene- γ-butyrolactone systems with extremely high enantioselectivity via indium-catalyzed amide allylation of N-methyl isatin.Yusuke Murata et al.Organic letters, 15(24), 6182-6185 (2013-11-15) Yb(NTf2)3-catalyzed [3 + 3] cycloaddition between isatin ketonitrones and cyclopropanes to construct novel spiro[tetrahydro-1,2-oxazine]oxindoles.Hai-Bin Yang et al.Organic & biomolecular chemistry, 10(41), 8236-8243 (2012-09-15) Structure-activity relationship of flavonoids as potent inhibitors of carbonyl reductase 1 (CBR1).Yuki Arai et al.Fitoterapia, 101, 51-56 (2015-01-01) Synthesis of novel 1H-1,2,3-triazole tethered C-5 substituted uracil-isatin conjugates and their cytotoxic evaluation.Kewal Kumar et al.European journal of medicinal chemistry, 58, 153-159 (2012-11-06) Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.Janice L Hyatt et al.Journal of medicinal chemistry, 50(8), 1876-1885 (2007-03-24) Reactivity of dinuclear copper(II) complexes towards melanoma cells: Correlation with its stability, tyrosinase mimicking and nuclease activity.Cléia Justino Nunes et al.Journal of inorganic biochemistry, 149, 49-58 (2015-05-30) Novel Synthesis of Some Phthalazinone DerivativesMahmoud, M. R.; et al. Chin. J. Chem., 29, 1446-1450 (2011) Identification and further development of thiazolidinones spiro-fused to indolin-2-ones as potent and selective inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase BVintonyak, V. V.; et al. Tetrahedron, 67, 6713-6729 (2011) Isatin: role in stress and anxiety.Alexei Medvedev et al.Stress (Amsterdam, Netherlands), 8(3), 175-183 (2005-10-21) Acylideneoxoindoles: a new class of reversible inhibitors of human transglutaminase 2.Cornelius Klöck et al.Bioorganic & medicinal chemistry letters, 21(9), 2692-2696 (2011-01-11) Designing and characterization of copper (II) ion-imprinted adsorbent based on isatin functionalized chitosan.M Monier et al.International journal of biological macromolecules, 155, 795-804 (2020-04-02) Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators.Eduard Dolusić et al.Journal of medicinal chemistry, 54(15), 5320-5334 (2011-07-06) CaCl(2) as a bifunctional reusable catalyst: diversity-oriented synthesis of 4H-pyran library under ultrasonic irradiation.Hamid Reza Safaei et al.Molecular diversity, 16(4), 669-683 (2012-09-13) Synthesis, and docking studies of some fused-quinazolines and quinazolines carrying biological active isatin moiety as cell-cycle inhibitors of breast cancer cell lines.A A Radwan et al.Drug research, 63(3), 129-136 (2013-02-28) In vitro cytotoxicity evaluation of some substituted isatin derivatives.Kara L Vine et al.Bioorganic & medicinal chemistry, 15(2), 931-938 (2006-11-08) Biochemical and pharmacological characterization of isatin and its derivatives: from structure to activity.Parvaneh Pakravan et al.Pharmacological reports : PR, 65(2), 313-335 (2013-06-08) Palladium-catalyzed oxidative cycloaddition through C-H/N-H activation: access to benzazepines.Lei Wang et al.Angewandte Chemie (International ed. in English), 52(6), 1768-1772 (2013-01-03) Step-economic, efficient, ZnS nanoparticle-catalyzed synthesis of spirooxindole derivatives in aqueous medium viaKnoevenagel condensation followed by Michael additionDandia, A.; et al. Green Chemistry, 13, 2135-2145 (2011) Synthesis of new fluorinated, 2-substituted 5-pyrrolidinylsulfonyl isatin derivatives as caspase-3 and caspase-7 inhibitors: nonradioactive counterparts of putative PET-compatible apoptosis imaging agents.Panupun Limpachayaporn et al.Bioorganic & medicinal chemistry, 21(7), 2025-2036 (2013-02-16) Sensitive Determination of C-Alkylated Flavonoids by HPLC-ESI-MS/MS Using Multiple Reaction Monitoring Approach: Pseudarthria hookeri as a Case Study.Ina Faraz et al.Journal of chromatographic science, 57(10), 944-949 (2019-11-02) Novel rearrangements in the reactions directed toward preparation of spiro-N,N-ketals: reactions of naphthalene-1,8-diamine with ninhydrin and isatin.Motoko Akita et al.Molecules (Basel, Switzerland), 17(12), 13879-13890 (2012-11-24) Dual behavior of isatin-based cyclic ketimines with dicarbomethoxy carbene: expedient synthesis of highly functionalized spirooxindolyl oxazolidines and pyrrolines.T Rajasekaran et al.Organic letters, 15(7), 1512-1515 (2013-03-13) Comparison of the antiplasmodial and falcipain-2 inhibitory activity of beta-amino alcohol thiolactone-chalcone and isatin-chalcone hybrids.Renate H Hans et al.Bioorganic & medicinal chemistry letters, 20(7), 2234-2237 (2010-03-09) From Maya Blue to "Maya Yellow": a connection between ancient nanostructured materials from the voltammetry of microparticles.Antonio Doménech et al.Angewandte Chemie (International ed. in English), 50(25), 5741-5744 (2011-05-11) Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators.Eduard Dolusić et al.Journal of medicinal chemistry, 54(15), 5320-5334 (2011-07-06) Structure-activity relationship of flavonoids as potent inhibitors of carbonyl reductase 1 (CBR1).Yuki Arai et al.Fitoterapia, 101, 51-56 (2015-01-01) Synthesis of novel 1H-1,2,3-triazole tethered C-5 substituted uracil-isatin conjugates and their cytotoxic evaluation.Kewal Kumar et al.European journal of medicinal chemistry, 58, 153-159 (2012-11-06) Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.Janice L Hyatt et al.Journal of medicinal chemistry, 50(8), 1876-1885 (2007-03-24) [Isatin: possible role in functional interaction of natriuretic peptides and monoamines].V Glover et al.Voprosy meditsinskoi khimii, 43(6), 515-521 (1998-03-21) The endogenous oxindole isatin induces apoptosis of MCF‑7 breast cancer cells through a mitochondrial pathway.Zhongliang Ma et al.Oncology reports, 32(5), 2111-2117 (2014-09-02) Dual behavior of isatin-based cyclic ketimines with dicarbomethoxy carbene: expedient synthesis of highly functionalized spirooxindolyl oxazolidines and pyrrolines.T Rajasekaran et al.Organic letters, 15(7), 1512-1515 (2013-03-13) [Pharmacological role of isatin, an endogenous MAO inhibitor].N Hamaue Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 120(4), 352-362 (2000-04-25) [Isatin: possible role in functional interaction of natriuretic peptides and monoamines].V Glover et al.Voprosy meditsinskoi khimii, 43(6), 515-521 (1998-03-21) The endogenous oxindole isatin induces apoptosis of MCF‑7 breast cancer cells through a mitochondrial pathway.Zhongliang Ma et al.Oncology reports, 32(5), 2111-2117 (2014-09-02) Cascade reaction of isatins with heterocyclic ketene aminals: synthesis of imidazopyrroloquinoline derivatives.Fuchao Yu et al.Organic letters, 13(18), 4782-4785 (2011-08-19) Isatins as privileged molecules in design and synthesis of spiro-fused cyclic frameworks.Girija S Singh et al.Chemical reviews, 112(11), 6104-6155 (2012-09-07) Synthesis and structure-activity evaluation of isatin-β-thiosemicarbazones with improved selective activity toward multidrug-resistant cells expressing P-glycoprotein.Matthew D Hall et al.Journal of medicinal chemistry, 54(16), 5878-5889 (2011-07-05) Unprecedented one-pot, domino tertiary alcohol protection-Michael type addition of halides to Morita-Baylis-Hillman adduct of isatin with RCOX/K2CO3: diastereoselective synthesis of oxindole appended β-halo esters.Rajarethinam Solaiselvi et al.Organic letters, 15(6), 1186-1189 (2013-03-07) Synthesis and molecular modelling studies of prenylated pyrazolines as MAO-B inhibitors.Rossella Fioravanti et al.Bioorganic & medicinal chemistry letters, 20(22), 6479-6482 (2010-10-12) [Monoamine oxidase, tribulin, isatin: basic and applied medical aspects].A E Medvedev Vestnik Rossiiskoi akademii meditsinskikh nauk, (10)(10), 45-48 (1999-12-01)
备注

Products protected by valid patents are not offered for sale in countries where the sale of such products constitutes a patent infringement and its liability is at buyer's risk.

Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271 +A13(1).

名称 CAS号

相关产品

相关资讯

热门标签
询 单
请 填 写 相 关 信 息
产品信息
产品名称
别名
CAS号
结构式 上传
联系方式
公司
联系人
电话
邮箱
内容
提交