熔点	130-131 ºC**
密度	1.178±0.06 g/cm3 (20 º

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Expression and function of aminopeptidase N/CD13 produced by fibroblast-like synoviocytes in rheumatoid arthritis: role of CD13 in chemotaxis of cytokine-activated T cells independent of enzymatic activity.Rachel Morgan et al.Arthritis & rheumatology (Hoboken, N.J.), 67(1), 74-85 (2014-09-16) Autoimmune disease-associated variants of extracellular endoplasmic reticulum aminopeptidase 1 induce altered innate immune responses by human immune cells.Yasser A Aldhamen et al.Journal of innate immunity, 7(3), 275-289 (2015-01-17) Azorella compacta methanolic extract induces apoptosis via activation of mitogen-activated protein kinase.Min Hee Sung et al.Molecular medicine reports, 12(5), 6821-6828 (2015-09-24) Metabolic characterization of meso-dihydroguaiaretic acid in liver microsomes and in mice.Jang Su Jeon et al.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 76, 94-102 (2014-12-24) 3-Phenylcoumarin derivatives selectively modulate different steps of reactive oxygen species production by immune complex-stimulated human neutrophils.Micássio F Andrade et al.International immunopharmacology, 15(2), 387-394 (2013-01-22) Cinnamon and its Components Suppress Vascular Smooth Muscle Cell Proliferation by Up-Regulating Cyclin-Dependent Kinase Inhibitors.Hyeeun Kwon et al.The American journal of Chinese medicine, 43(4), 621-636 (2015-06-30) Gemcitabine-coumarin-biotin conjugates: a target specific theranostic anticancer prodrug.Sukhendu Maiti et al.Journal of the American Chemical Society, 135(11), 4567-4572 (2013-03-07) The antitumor activity of PNA modified vinblastine cationic liposomes on Lewis lung tumor cells: In vitro and in vivo evaluation.Xue-Tao Li et al.International journal of pharmaceutics, 487(1-2), 223-233 (2015-04-22) A case of coumarin necrosis with penile and pedal involvement.Y Harmanyeri et al.Journal of the European Academy of Dermatology and Venereology : JEADV, 10(3), 248-252 (1998-06-27) Species differences in the metabolism of ritobegron in vitro and assessment of potential interactions with transporters and cytochrome P450 enzymes.Y Abe et al.Die Pharmazie, 70(1), 38-46 (2015-05-16) Synthesis and biological evaluation of novel coumarin-pyrazoline hybrids endowed with phenylsulfonyl moiety as antitumor agents.Kamilia M Amin et al.European journal of medicinal chemistry, 60, 187-198 (2013-01-08) Characterization of laminar extrudates manufactured at room temperature in the absence of solvents for the delivery of drugs.G Oliveira et al.International journal of pharmaceutics, 454(1), 90-98 (2013-07-13) New Coumarin Derivatives as Potent Selective COX-2 Inhibitors: Synthesis, Anti-Inflammatory, QSAR, and Molecular Modeling Studies.Dina H Dawood et al.Archiv der Pharmazie, 348(12), 875-888 (2015-10-16) Ectopic expression of a stress-inducible glycosyltransferase from saffron enhances salt and oxidative stress tolerance in Arabidopsis while alters anchor root formation.Oussama Ahrazem et al.Plant science : an international journal of experimental plant biology, 234, 60-73 (2015-03-26) An updated review of the clinical development of coumarin (1,2-benzopyrone) and 7-hydroxycoumarin.M E Marshall et al.Journal of cancer research and clinical oncology, 120 Suppl, S39-S42 (1994-01-01) High-throughput fluorescence assay of cytochrome P450 3A4.Qian Cheng et al.Methods in molecular biology (Clifton, N.J.), 987, 157-162 (2013-03-12) A comprehensive review on synthesis and designing aspects of coumarin derivatives as monoamine oxidase inhibitors for depression and Alzheimer's disease.Pravin O Patil et al.Bioorganic & medicinal chemistry, 21(9), 2434-2450 (2013-03-23) Coumarin attenuates hepatic steatosis by down-regulating lipogenic gene expression in mice fed a high-fat diet.Min Young Um et al.The British journal of nutrition, 109(9), 1590-1597 (2013-04-20) Effects of 8-methoxypsoralen on the metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mice.Mingfei Feng et al.Drug metabolism and pharmacokinetics, 30(4), 314-320 (2015-07-27) Fluorescent protein-tagged Vpr dissociates from HIV-1 core after viral fusion and rapidly enters the cell nucleus.Tanay M Desai et al.Retrovirology, 12, 88-88 (2015-10-30) Molecular insight into affinities of drugs and their metabolites to lipid bilayers.Markéta Paloncýová et al.The journal of physical chemistry. 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A, 1371, 244-256 (2014-12-03) Systematic and practical solvent system selection strategy based on the nonrandom two-liquid segment activity coefficient model for real-life counter-current chromatography separation.Da-Bing Ren et al.Journal of chromatography. A, 1393, 47-56 (2015-03-31) Synthesis and luminescence properties of iridium complexes chelated with coumarin ligands.Hye Rim Park et al.Journal of nanoscience and nanotechnology, 13(5), 3441-3445 (2013-07-19) Species variation in the enantioselective metabolism of tegafur to 5-fluorouracil among rats, dogs and monkeys.Ikuo Yamamiya et al.The Journal of pharmacy and pharmacology, 66(12), 1686-1697 (2014-08-15) Recent progress in the development of coumarin derivatives as potent anti-HIV agents.Donglei Yu et al.Medicinal research reviews, 23(3), 322-345 (2003-03-21) Polycaprolactone/maltodextrin nanocarrier for intracellular drug delivery: formulation, uptake mechanism, internalization kinetics, and subcellular localization.Maxwell Korang-Yeboah et al.International journal of nanomedicine, 10, 4763-4781 (2015-08-08) Phenotyping of CYP450 in human liver microsomes using the cocktail approach.Dany Spaggiari et al.Analytical and bioanalytical chemistry, 406(20), 4875-4887 (2014-06-05) Induction of ROS-independent JNK-activation-mediated apoptosis by a novel coumarin-derivative, DMAC, in human colon cancer cells.Lin MH, Cheng CH, Chen KC, et al. Chemico-Biological Interactions, 218, 42-49 (2014) Toward prediction of alkane/water partition coefficients.Anita Toulmin et al.Journal of medicinal chemistry, 51(13), 3720-3730 (2008-06-19) Photo responsive monoolein cubic phase containing coumarin-Tween 20 conjugates.Jing Dai et al.Drug development and industrial pharmacy, 39(9), 1457-1463 (2013-08-02) Benzene, coumarin and quinolinone derivatives from roots of Citrus hystrix.Kanda Panthong et al.Phytochemistry, 88, 79-84 (2013-01-29) 2-Phenylethynesulfonamide (PES) uncovers a necrotic process regulated by oxidative stress and p53.Paolo Mattiolo et al.Biochemical pharmacology, 91(3), 301-311 (2014-08-21) Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.Lei Du-Cuny et al.Bioorganic & medicinal chemistry, 17(19), 6983-6992 (2009-09-08) Curcumin induces p53-independent necrosis in H1299 cells via a mitochondria-associated pathway.Feie Li et al.Molecular medicine reports, 12(5), 7806-7814 (2015-10-16) Ultrasound accelerated gelation of novel L-lysine based hydrogelators.Shangfeng Pan et al.Chemical communications (Cambridge, England), 49(73), 8045-8047 (2013-08-02) Quercetin and Coumarin Inhibit Dipeptidyl Peptidase-IV and Exhibits Antioxidant Properties: In Silico, In Vitro, Ex Vivo.Anand-Krishna Singh et al.Biomolecules, 10(2) (2020-02-07) Anti-inflammatory actions of herbal formula Gyejibokryeong-hwan regulated by inhibiting chemokine production and STAT1 activation in HaCaT cells.Soo-Jin Jeong et al.Biological & pharmaceutical bulletin, 38(3), 425-434 (2015-03-12) Extension of a dynamic headspace multi-volatile method to milliliter injection volumes with full sample evaporation: Application to green tea.Nobuo Ochiai et al.Journal of chromatography. A, 1421, 103-113 (2015-08-16) QSAR study on permeability of hydrophobic compounds with artificial membranes.Masaaki Fujikawa et al.Bioorganic & medicinal chemistry, 15(11), 3756-3767 (2007-04-10) Enantioselective N-demethylation and hydroxylation of sibutramine in human liver microsomes and recombinant cytochrome p-450 isoforms.Dhananjay D Shinde et al.Journal of toxicology and environmental health. Part A, 77(22-24), 1419-1430 (2014-10-25) Metabolic drug-drug interaction potential of macrolactin A and 7-O-succinyl macrolactin A assessed by evaluating cytochrome P450 inhibition and induction and UDP-glucuronosyltransferase inhibition in vitro.Soo Hyeon Bae et al.Antimicrobial agents and chemotherapy, 58(9), 5036-5046 (2014-06-04) In silico methods for physiologically based biokinetic models describing bioactivation and detoxification of coumarin and estragole: implications for risk assessment.Ivonne M C M Rietjens et al.Molecular nutrition & food research, 54(2), 195-207 (2009-11-28) A review of coumarin derivatives in pharmacotherapy of breast cancer.Musiliyu A Musa et al.Current medicinal chemistry, 15(26), 2664-2679 (2008-11-11) Low cost referenced luminescent imaging of oxygen and pH with a 2-CCD colour near infrared camera.Josef Ehgartner et al.The Analyst, 139(19), 4924-4933 (2014-08-07) Reduction of lipid peroxidation products and advanced glycation end-product precursors by cyanobacterial aldo-keto reductase AKR3G1—a founding member of the AKR3G subfamily.Jan Hintzpeter et al.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(1), 263-273 (2014-11-08) In Vitro Inhibition of Human Placental Glutathione S-Transferase by 3-Arylcoumarin Derivatives.Mustafa Muhlis Alparslan et al.Archiv der Pharmazie, 348(9), 635-642 (2015-07-25) Mitochondrial targeting of bilirubin regulatory enzymes: An adaptive response to oxidative stress.Siti Nur Fadzilah Muhsain et al.Toxicology and applied pharmacology, 282(1), 77-89 (2014-12-06) Metabolic characterization of meso-dihydroguaiaretic acid in liver microsomes and in mice.Jang Su Jeon et al.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 76, 94-102 (2014-12-24) Chemopreventive potential of coumarin in 7, 12-dimethylbenz[a] anthracene induced hamster buccal pouch carcinogenesis.Nagarethinam Baskaran et al.Asian Pacific journal of cancer prevention : APJCP, 13(10), 5273-5279 (2012-12-19) Versatile fluorescence resonance energy transfer-based mesoporous silica nanoparticles for real-time monitoring of drug release.Jinping Lai et al.ACS nano, 7(3), 2741-2750 (2013-03-01) Synthesis of hydroxycoumarins and hydroxybenzo[f]- or [h]coumarins as lipid peroxidation inhibitors.Theodoros Symeonidis et al.Bioorganic & medicinal chemistry letters, 19(4), 1139-1142 (2009-01-20) Coumarin-conjugated multiwalled carbon nanotubes for potential biological applications: development and characterization.D Lannazzo et al.Journal of nanoscience and nanotechnology, 12(6), 5030-5038 (2012-08-22) Coumarins as new matrices for matrix-assisted laser-desorption/ionization Fourier transform ion cyclotron resonance mass spectrometric analysis of hydrophobic compounds.Hang Wang et al.Analytica chimica acta, 882, 49-57 (2015-06-05) Comparison of xenobiotic metabolizing enzyme activities in ex vivo human skin and reconstructed human skin models from SkinEthic.Joan Eilstein et al.Archives of toxicology, 88(9), 1681-1694 (2014-03-25) Quality evaluation and pattern recognition analyses of marker compounds from five medicinal drugs of Rutaceae family by HPLC/PDA.Bing Tian Zhao et al.Archives of pharmacal research, 38(8), 1512-1520 (2015-03-04) Targeted omics analyses, and metabolic enzyme activity assays demonstrate maintenance of key mucociliary characteristics in long term cultures of reconstituted human airway epithelia.Andrew Baxter et al.Toxicology in vitro : an international journal published in association with BIBRA, 29(5), 864-875 (2015-04-12) Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.Alfonso Maresca et al.Journal of medicinal chemistry, 53(1), 335-344 (2009-11-17) Design, synthesis, and evaluation of coumarin-based molecular probes for imaging of myelination.Changning Wang et al.Journal of medicinal chemistry, 54(7), 2331-2340 (2011-03-12) Coumarins incorporating hydroxy- and chloro-moieties selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II.Alfonso Maresca et al.Bioorganic & medicinal chemistry letters, 20(15), 4511-4514 (2010-06-29) CYP2A6 polymorphisms: is there a role for pharmacogenomics in preventing coumarin-induced hepatotoxicity in lymphedema patients?Nicholas Farinola et al.Pharmacogenomics, 8(2), 151-158 (2007-02-09) Application of physiologically-based toxicokinetic modelling in oral-to-dermal extrapolation of threshold doses of cosmetic ingredients.M Gajewska et al.Toxicology letters, 227(3), 189-202 (2014-04-16) Inhibitory effects of Hwang-Ryun-Hae-Dok-Tang on cytochrome P450 in human liver microsomes.Sang Yoon Lee et al.Xenobiotica; the fate of foreign compounds in biological systems, 45(2), 131-138 (2014-08-26) Fluorescence Dynamics of Monocyclodextrin- and Bis(thiol-cyclodextrin)-Coumarin C153 Complexes.Marianna Gregova Trencanova et al.Chemphyschem : a European journal of chemical physics and physical chemistry, 16(11), 2466-2473 (2015-06-03) Toward establishing structure-activity relationships for oxygenated coumarins as differentiation inducers of promonocytic leukemic cells.María E Riveiro et al.Bioorganic & medicinal chemistry, 17(18), 6547-6559 (2009-09-01) Bioassay-Guided Chromatographic Isolation and Identification of Antibacterial Compounds from Artemisia annua L. That Inhibit Clostridium perfringens Growth.Elise Ivarsen et al.Journal of AOAC International, 97(5), 1282-1290 (2015-04-24) Targeting proapoptotic protein BAD inhibits survival and self-renewal of cancer stem cells.K S R Sastry et al.Cell death and differentiation, 21(12), 1936-1949 (2014-09-13) Protective effects of coumarin and coumarin derivatives against carbon tetrachloride-induced acute hepatotoxicity in rats.Hakkı Murat Bilgin et al.Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 63(4), 325-330 (2010-03-09) Synthetic human serum albumin Sudlow I binding site mimics.Björn C G Karlsson et al.Journal of medicinal chemistry, 53(22), 7932-7937 (2010-10-27) Effects of artemisinin antimalarials on Cytochrome P450 enzymes in vitro using recombinant enzymes and human liver microsomes: potential implications for combination therapies.Therese Ericsson et al.Xenobiotica; the fate of foreign compounds in biological systems, 44(7), 615-626 (2014-01-10) Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure.Larry J Jolivette et al.Journal of pharmaceutical sciences, 94(7), 1467-1483 (2005-05-28) NMR and MD Studies Reveal That the Isolated Dengue NS3 Protease Is an Intrinsically Disordered Chymotrypsin Fold Which Absolutely Requests NS2B for Correct Folding and Functional Dynamics.Garvita Gupta et al.PloS one, 10(8), e0134823-e0134823 (2015-08-11) Evaluation of a water extract of So-Cheong-Ryong-Tang for acute toxicity and genotoxicity using in vitro and in vivo tests.Mee-Young Lee et al.BMC complementary and alternative medicine, 15, 235-235 (2015-07-17) CYP2A7 pseudogene transcript affects CYP2A6 expression in human liver by acting as a decoy for miR-126.Masataka Nakano et al.Drug metabolism and disposition: the biological fate of chemicals, 43(5), 703-712 (2015-02-25) Synthesis and in vitro evaluation of 3-(4-nitrophenyl)coumarin derivatives in tumor cell lines.Musiliyu A Musa et al.Bioorganic chemistry, 58, 96-103 (2015-01-02) Quercetin improves the activity of the ubiquitin-proteasomal system in 150Q mutated huntingtin-expressing cells but exerts detrimental effects on neuronal survivability.J Chakraborty et al.Journal of neuroscience research, 93(10), 1581-1591 (2015-07-15) Development and validation of a simple LC method for the determination of phenacetin, coumarin, tolbutamide, chlorzoxazone, testosterone and their metabolites as markers of cytochromes 1A2, 2A6, 2C11, 2E1 and 3A2 in rat microsomal medium.Xuejia Zhai et al.Die Pharmazie, 68(1), 19-26 (2013-03-01) Natural history and management of cervical spine disease in chondrodysplasia punctata and coumarin embryopathy.Timothy W Vogel et al.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 28(4), 609-619 (2012-01-26) Identification and functional characterization of novel feline cytochrome P450 2A.Gaku Okamatsu et al.Xenobiotica; the fate of foreign compounds in biological systems, 45(6), 503-510 (2014-12-31) One-step fabrication of multifunctional micromotors.Wenlong Gao et al.Nanoscale, 7(33), 13918-13923 (2015-07-30) Pharmacogenetics-based coumarin therapy.Brian F Gage Hematology. American Society of Hematology. Education Program, 467-473 (2006-11-25) Synthesis and biological evaluation of (2,5-dihydro-1H-pyrrol-1-yl)-2H-chromen-2-ones as free radical scavengers.Anna Balabani et al.European journal of medicinal chemistry, 46(12), 5894-5901 (2011-10-18) Coumarin: an alternative candidate for the treatment of non-alcoholic steatohepatitis?Jian Wu The British journal of nutrition, 109(9), 1542-1543 (2013-01-24) Evaluation of the in vitro/in vivo drug interaction potential of BST204, a purified dry extract of ginseng, and its four bioactive ginsenosides through cytochrome P450 inhibition/induction and UDP-glucuronosyltransferase inhibition.Yu Fen Zheng et al.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 68, 117-127 (2014-03-19) Mechanism for different fluorescence response of a coumarin-amide-dipicolylamine linkage to Zn(II) and Cd(II) in water.Shigehiro Sumiya et al.The journal of physical chemistry. 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Continuous vs. segmented second-dimension system gradients for comprehensive two-dimensional liquid chromatography of sugarcane (Saccharum spp.).Gabriel Mazzi Leme et al.Analytical and bioanalytical chemistry, 406(18), 4315-4324 (2014-06-22) Searching the cytochrome p450 enzymes for the metabolism of meranzin hydrate: a prospective antidepressant originating from Chaihu-Shugan-San.Xi Huang et al.PloS one, 9(11), e113819-e113819 (2014-11-27) Development of validated determination of the eleven marker compounds in Gyejibokryeong-hwan for the quality assessment using HPLC analysis.Jung-Hoon Kim et al.Archives of pharmacal research, 38(1), 52-62 (2014-03-13) Novel coumarins and 2-thioxo-coumarins as inhibitors of the tumor-associated carbonic anhydrases IX and XII.Fabrizio Carta et al.Bioorganic & medicinal chemistry, 20(7), 2266-2273 (2012-03-02) Photoaffinity casting of a coumarin flag for rapid identification of ligand-binding sites within protein.Shota Morimoto et al.Chemical communications (Cambridge, England), 49(18), 1811-1813 (2013-01-26) Development of functional molecules for elucidation of the physiological roles of several nuclear receptors and their endogenous ligands.Tomoya Hirano Chemical & pharmaceutical bulletin, 61(2), 111-120 (2013-02-02) Live-cell multiphoton fluorescence correlation spectroscopy with an improved large Stokes shift fluorescent protein.Yinghua Guan et al.Molecular biology of the cell, 26(11), 2054-2066 (2015-04-17) Natural and synthetic coumarin derivatives with anti-inflammatory/ antioxidant activities.Konstantina C Fylaktakidou et al.Current pharmaceutical design, 10(30), 3813-3833 (2004-12-08) Coumarin therapy in thrombosis.Graham Pineo et al.Hematology/oncology clinics of North America, 17(1), 201-216 (2003-03-12) Randomised trial of a clinical dosing algorithm to start anticoagulation with phenprocoumon.Angela Caduff Good et al.Swiss medical weekly, 143, w13709-w13709 (2013-01-10) Coumarin derivatives, but not coumarin itself, cause skin irritation via topical delivery.Tai-Long Pan et al.Toxicology letters, 226(2), 173-181 (2014-02-25) Proteasome functioning in breast cancer: connection with clinical-pathological factors.Elena E Shashova et al.PloS one, 9(10), e109933-e109933 (2014-10-21) Multiplexed immunohistochemistry, imaging, and quantitation: a review, with an assessment of Tyramide signal amplification, multispectral imaging and multiplex analysis.Edward C Stack et al.Methods (San Diego, Calif.), 70(1), 46-58 (2014-09-23) On the mechanism of nanoparticulate CeO2 toxicity to freshwater algae.Brad M Angel et al.Aquatic toxicology (Amsterdam, Netherlands), 168, 90-97 (2015-10-16) Prenylcoumarin with Rev-export inhibitory activity from Cnidii Monnieris Fructus.Satoru Tamura et al.Bioorganic & medicinal chemistry letters, 20(12), 3717-3720 (2010-05-25) A fluorescence high throughput screening method for the detection of reactive electrophiles as potential skin sensitizers.Cristina Avonto et al.Toxicology and applied pharmacology, 289(2), 177-184 (2015-10-13) Inhibition of cytochrome P450 by ethambutol in human liver microsomes.Sang Yoon Lee et al.Toxicology letters, 229(1), 33-40 (2014-06-10) Coumarin metabolism, toxicity and carcinogenicity: relevance for human risk assessment.B G Lake Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 37(4), 423-453 (1999-07-27) Antiinflammatory and antioxidant evaluation of novel coumarin derivatives.Christos A Kontogiorgis et al.Journal of enzyme inhibition and medicinal chemistry, 21(1), 21-29 (2006-03-31) Effect of CYP2A6 genetic polymorphism on the metabolic conversion of tegafur to 5-fluorouracil and its enantioselectivity.Ikuo Yamamiya et al.Drug metabolism and disposition: the biological fate of chemicals, 42(9), 1485-1492 (2014-07-09) Parallel dual secondary column-dual detection: a further way of enhancing the informative potential of two-dimensional comprehensive gas chromatography.Luca Nicolotti et al.Journal of chromatography. 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