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水溶性	12.2 g/L 20 ºC

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危险类别码	R20/21/22
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Acquisition of analgesic properties by the cholecystokinin (CCK)/CCK2 receptor system within the amygdala in a persistent inflammatory pain condition.Olivier Roca-Lapirot et al.Pain, 160(2), 345-357 (2018-10-04) Anxiety-induced hyperalgesia in female rats is mediated by cholecystokinin 2 receptor in rostral ventromedial medulla and spinal 5-hydroxytryptamine 2B receptor.Ming Jiang et al.Journal of pain research, 12, 2009-2026 (2019-07-17) Cholecystokinin and thermoregulation--a minireview.Z Szelényi Peptides, 22(8), 1245-1250 (2001-07-18) Cholecystokinin-8 inhibits methamphetamine-induced neurotoxicity via an anti-oxidative stress pathway.Di Wen et al.Neurotoxicology, 57, 31-38 (2016-11-05) The role of CCK2 receptors in energy homeostasis: insights from the CCK2 receptor-deficient mouse.Tracey J Weiland et al.Physiology & behavior, 82(2-3), 471-476 (2004-07-28) Behavioral profile of CCK2 receptor-deficient mice.V Daugé et al.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 25(5), 690-698 (2001-10-30) Rimonabant attenuates amphetamine sensitisation in a CCK2 receptor-dependent manner.Kertu Rünkorg et al.Behavioural brain research, 226(1), 335-339 (2011-09-20) Reduced anxious behavior in mice lacking the CCK2 receptor gene.Yukiko Horinouchi et al.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 14(2), 157-161 (2004-03-12) Is the CCK2 receptor essential for normal regulation of body weight and adiposity?Hui Chen et al.The European journal of neuroscience, 24(5), 1427-1433 (2006-09-13) The G-protein-coupled CCK2 receptor associates with phospholipase Cgamma1.Marika Arnould et al.FEBS letters, 568(1-3), 89-93 (2004-06-16) Distribution of CCK1 and CCK2 receptors in normal and diseased human pancreatic tissue.Jean Claude Reubi et al.Gastroenterology, 125(1), 98-106 (2003-07-10) CCK2 gastrin receptor as a potential target for therapy in leukaemia cell lines.M Stubbs et al.Oncology reports, 14(4), 1055-1058 (2005-09-06) Deletion of CCK2 receptor in mice results in an upregulation of the endogenous opioid system.Blandine Pommier et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 22(5), 2005-2011 (2002-03-07) Effects of CCK2 receptor blockade on growth parameters in gastrointestinal tract and pancreas in rats.M Björkqvist et al.Pharmacology & toxicology, 89(4), 208-213 (2002-03-08) Expression of CCK2 receptors in the murine pancreas: proliferation, transdifferentiation of acinar cells, and neoplasia.Pascal Clerc et al.Gastroenterology, 122(2), 428-437 (2002-02-08) Mechanism for Src activation by the CCK2 receptor: Patho-physiological functions of this receptor in pancreas.Audrey Ferrand et al.World journal of gastroenterology, 12(28), 4498-4503 (2006-07-29) CCK1 and CCK2 receptors are expressed on pancreatic stellate cells and induce collagen production.Marc J Berna et al.The Journal of biological chemistry, 285(50), 38905-38914 (2010-09-17) Targeted mutation of CCK2 receptor gene modifies the behavioural effects of diazepam in female mice.Sirli Raud et al.Psychopharmacology, 168(4), 417-425 (2003-04-24) CCK2 receptor antagonists: pharmacological tools to study the gastrin-ECL cell-parietal cell axis.R Håkanson et al.Regulatory peptides, 80(1-2), 1-12 (1999-05-11) Gastrin increases its own synthesis in gastrointestinal cancer cells via the CCK2 receptor.Suzana Kovac et al.FEBS letters, 584(21), 4413-4418 (2010-10-12) Gastrin suppresses growth of CCK2 receptor expressing colon cancer cells by inducing apoptosis in vitro and in vivo.Susanne Müerköster et al.Gastroenterology, 129(3), 952-968 (2005-09-07) Gender specific effects of ethanol in mice, lacking CCK2 receptors.Urho Abramov et al.Behavioural brain research, 175(1), 149-156 (2006-09-15) Maternal deprivation increases behavioural reactivity to stressful situations in adulthood: suppression by the CCK2 antagonist L365,260.Vincent Vazquez et al.Psychopharmacology, 181(4), 706-713 (2005-07-21) Exogenous melatonin delays gastric emptying rate in rats: role of CCK2 and 5-HT3 receptors.O Kasimay et al.Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 56(4), 543-553 (2006-01-05) Protecting-group-free synthesis of a dual CCK1/CCK2 receptor antagonistLiu J, et al. 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Slice et al.Journal of cellular physiology, 196(3), 454-463 (2003-08-02) Transgenic expression of CCK2 receptors sensitizes murine pancreatic acinar cells to carcinogen-induced preneoplastic lesions formation.Anne Mathieu et al.International journal of cancer, 115(1), 46-54 (2005-02-03) CCK2 receptor-deficient mice have increased sensitivity of dopamine D2 receptors.S Kõks et al.Neuropeptides, 37(1), 25-29 (2003-03-15) Distinct changes in the behavioural effects of morphine and naloxone in CCK2 receptor-deficient mice.Kertu Rünkorg et al.Behavioural brain research, 144(1-2), 125-135 (2003-08-30) Agonist-independent activation of Src tyrosine kinase by a cholecystokinin-2 (CCK2) receptor splice variant.Barbara Olszewska-Pazdrak et al.The Journal of biological chemistry, 279(39), 40400-40404 (2004-08-05) Secretory organelles in ECL cells: effects of pharmacological blockade of the gastrin/CCK2 receptor versus its elimination by gene targeting.Chun-Mei Zhao et al.Inflammopharmacology, 13(1-3), 75-82 (2005-11-02) Synthesis, characterization and in vitro evaluation of new oxorhenium- and oxotechnetium-CCK4 derivatives as molecular imaging agents for CCK2-receptor targeting.Sandra Dorbes et al.European journal of medicinal chemistry, 45(2), 423-429 (2009-10-27) An ITIM-like motif within the CCK2 receptor sequence required for interaction with SHP-2 and the activation of the AKT pathway.Sébastien Vatinel et al.Biochimica et biophysica acta, 1763(10), 1098-1107 (2006-09-12) Temperature dependence of the sodium pump is altered in the cerebral cortex of CCK2 receptor-deficient mice.T Salum et al.Neurochemical research, 35(5), 688-692 (2010-01-09) Deletion of the CCK2 receptor gene reduces mechanical sensitivity and abolishes the development of hyperalgesia in mononeuropathic mice.Kaido Kurrikoff et al.The European journal of neuroscience, 20(6), 1577-1586 (2004-09-10) Cholecystokinin (CCK) stimulates aldosterone secretion from human adrenocortical cells via CCK2 receptors coupled to the adenylate cyclase/protein kinase A signaling cascade.G Mazzocchi et al.The Journal of clinical endocrinology and metabolism, 89(3), 1277-1284 (2004-03-06) Cell cycle dependent expression of the CCK2 receptor by gastrointestinal myofibroblasts: putative role in determining cell migration.Akos Varga et al.Physiological reports, 5(19) (2017-10-19) Anthranilic sulfonamide CCK1/CCK2 dual receptor antagonists II: tuning of receptor selectivity and in vivo efficacy.Marna Pippel et al.Bioorganic & medicinal chemistry letters, 19(22), 6376-6378 (2009-10-10) Cell-type-specific CCK2 receptor signaling underlies the cholecystokinin-mediated selective excitation of hippocampal parvalbumin-positive fast-spiking basket cells.Soo Yeun Lee et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(30), 10993-11002 (2011-07-29) CCK2 receptor expression transforms non-tumorigenic human NCM356 colonic epithelial cells into tumor forming cells.Celia Chao et al.International journal of cancer, 126(4), 864-875 (2009-08-22) Environmental enrichment reduces mechanical hypersensitivity in neuropathic mice, but fails to abolish the phenotype of CCK2 receptor deficient mice.Urho Abramov et al.Neuroscience letters, 467(3), 230-233 (2009-10-21) Differences in behavioural effects of amphetamine and dopamine-related gene expression in wild-type and homozygous CCK2 receptor deficient mice.Kertu Rünkorg et al.Neuroscience letters, 406(1-2), 17-22 (2006-08-19) Targeted invalidation of CCK2 receptor gene induces anxiolytic-like action in light-dark exploration, but not in fear conditioning test.Sirli Raud et al.Psychopharmacology, 181(2), 347-357 (2005-04-15) Constitutively active CCK2 receptor splice variant increases Src-dependent HIF-1 alpha expression and tumor growth.C Chao et al.Oncogene, 26(7), 1013-1019 (2006-08-16) Cholecystokinin CCK2 receptors mediate the peptide's inhibitory actions on the contractile activity of human distal colon via the nitric oxide pathway.M Fornai et al.British journal of pharmacology, 151(8), 1246-1253 (2007-06-19) Significant increase in the aggressive behavior of transgenic mice overexpressing peripheral progastrin peptides: associated changes in CCK2 and serotonin receptors in the CNS.Qian Li et al.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 32(8), 1813-1821 (2007-01-18) Comparison of the binding and internalization properties of 12 DOTA-coupled and ¹¹¹In-labelled CCK2/gastrin receptor binding peptides: a collaborative project under COST Action BM0607.Luigi Aloj et al.European journal of nuclear medicine and molecular imaging, 38(8), 1417-1425 (2011-04-28) Anthranilic sulfonamide CCK1/CCK2 dual receptor antagonists I: discovery of CCKR1 selectivity in a previously CCKR2-selective lead series.Marna Pippel et al.Bioorganic & medicinal chemistry letters, 19(22), 6373-6375 (2009-10-09) The cholecystokinin CCK2 receptor antagonist, JNJ-26070109, inhibits gastric acid secretion and prevents omeprazole-induced acid rebound in the rat.T D Barrett et al.British journal of pharmacology, 166(5), 1684-1693 (2012-02-04) CCK receptors-related signaling involved in nitric oxide production caused by gastrin 17 in porcine coronary endothelial cells.Elena Grossini et al.Molecular and cellular endocrinology, 350(1), 20-30 (2011-12-06) Mutant mice lacking the cholecystokinin2 receptor show a dopamine-dependent hyperactivity and a behavioral sensitization to morphine.V Daugé et al.Neuroscience letters, 306(1-2), 41-44 (2001-06-19) Haemodynamic and exocrine effects of caerulein at submaximal and supramaximal levels on the rat pancreas: role of cholecystokinin receptor subtypes.Thomas Griesbacher et al.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... 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A histochemical, electron-microscopic and chemical study.D Chen et al.Cell and tissue research, 299(1), 81-95 (2000-02-02) The cholecystokinin receptor agonist, CCK-8, induces adiponectin production in rat white adipose tissue.Adrián Plaza et al.British journal of pharmacology, 176(15), 2678-2690 (2019-04-24) Essential interaction of Egr-1 at an islet-specific response element for basal and gastrin-dependent glucagon gene transactivation in pancreatic alpha-cells.Stéphane Leung-Theung-Long et al.The Journal of biological chemistry, 280(9), 7976-7984 (2004-12-22) Cholecystokinin receptors regulate sperm protein tyrosine phosphorylation via uptake of HCO3-.Yuchuan Zhou et al.Reproduction (Cambridge, England), 150(4), 257-268 (2015-07-16) The role of luminal gastrin in the regulation of pancreatic juice secretion in preruminant calves.Romuald Zabielski et al.Regulatory peptides, 119(3), 169-176 (2004-05-04) Necessity of intracellular cyclic AMP in inducing gastric acid secretion via muscarinic M3 and cholecystokinin2 receptors on parietal cells in isolated mouse stomach.Yasuo Ochi et al.Life sciences, 77(16), 2040-2050 (2005-05-28) Expression of cholecystokinin-2/gastrin receptor in the murine pancreas modulates cell adhesion and cell differentiation in vivo.Christiane Bierkamp et al.The American journal of pathology, 165(6), 2135-2145 (2004-12-08) Intermolecular interactions between cholecystokinin-8 and the third extracellular loop of the cholecystokinin-2 receptor.Craig Giragossian et al.Biochemistry, 41(14), 4560-4566 (2002-04-03) Involvement of cholecystokinin 2 receptor in food intake regulation: hyperphagia and increased fat deposition in cholecystokinin 2 receptor-deficient mice.Pascal Clerc et al.Endocrinology, 148(3), 1039-1049 (2006-11-24) The apoptosis-inducing effect of gastrin on colorectal cancer cells relates to an increased IEX-1 expression mediating NF-kappa B inhibition.S Sebens Müerköster et al.Oncogene, 27(8), 1122-1134 (2007-08-21) Preclinical evaluation of 68Ga-DOTA-minigastrin for the detection of cholecystokinin-2/gastrin receptor-positive tumors.Maarten Brom et al.Molecular imaging, 10(2), 144-152 (2011-03-29) SR146131: a new potent, orally active, and selective nonpeptide cholecystokinin subtype 1 receptor agonist. 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In vitro studies.E Bignon et al.The Journal of pharmacology and experimental therapeutics, 289(2), 742-751 (1999-04-24) Cholecystokinin2 receptor-deficient mice display altered function of brain dopaminergic system.S Kõks et al.Psychopharmacology, 158(2), 198-204 (2001-11-10) Cholecystokinin in the rostral ventromedial medulla mediates opioid-induced hyperalgesia and antinociceptive tolerance.Jennifer Y Xie et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 25(2), 409-416 (2005-01-14) A novel mechanism for JAK2 activation by a G protein-coupled receptor, the CCK2R: implication of this signaling pathway in pancreatic tumor models.Audrey Ferrand et al.The Journal of biological chemistry, 280(11), 10710-10715 (2005-01-11) Cholecystokinin: role in thermoregulation and other aspects of energetics.Zoltán Szelényi Clinica chimica acta; international journal of clinical chemistry, 411(5-6), 329-335 (2009-12-29) Effects of exogenous cholecystokinin octapeptide on acquisition of naloxone precipitated withdrawal induced conditioned place aversion in rats.Hailei Yu et al.PloS one, 7(7), e41860-e41860 (2012-08-01) Influence of a novel, versatile bifunctional chelator on theranostic properties of a minigastrin analogue.Joachim Pfister et al.EJNMMI research, 5(1), 74-74 (2015-12-17) Molecular cloning, expression and pharmacological characterization of the canine cholecystokinin 1 receptor.Magda Francesca Morton et al.British journal of pharmacology, 145(3), 374-384 (2005-03-15) Involvement of capsaicin-sensitive afferent nerves and cholecystokinin 2/gastrin receptors in gastroprotection and adaptation of gastric mucosa to Helicobacter pylori-lipopolysaccharide.Tomasz Brzozowski et al.The Journal of pharmacology and experimental therapeutics, 310(1), 116-125 (2004-03-17) Protective effect of cholecystokinin octapeptide on angiotensin II-induced apoptosis in H9c2 cardiomyoblast cells.Can Wang et al.Journal of cellular biochemistry, 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American College of Neuropsychopharmacology, 38(9), 1816-1824 (2013-04-09) Immunohistochemical examination of cholecystokinin and gastrin receptors (CCK-2/gastrin-R) expression in normal and exocrine cancerous human pancreatic tissues.Feriel Sellam et al.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... 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