没有数据	没有数据

危险品标志	Xn
危险类别码	R20/21/22
安全说明书	S36

来源	SDS样本
没有数据	没有数据

产品合成路线

更多

名称	CAS号

更多

文章

同行评议文献

Clozapine-induced salivation: interaction with N-desmethylclozapine and amisulpride in an experimental rat model.Tania Godoy et al.European journal of oral sciences, 119(4), 275-281 (2011-07-06) Gastrointestinal hypomotility: an under-recognised life-threatening adverse effect of clozapine.R J Flanagan et al.Forensic science international, 206(1-3), e31-e36 (2010-08-20) Correlation Between Serum Concentrations of N-Desmethylclozapine and Granulocyte Levels in Patients with Schizophrenia: A Retrospective Observational Study.Robert L Smith et al.CNS drugs, 31(11), 991-997 (2017-09-28) The GABAB positive allosteric modulators CGP7930 and GS39783 stimulate ERK1/2 signalling in cells lacking functional GABAB receptors.Maria C Olianas et al.European journal of pharmacology, 794, 135-146 (2016-11-24) Discovery of Procognitive Antipsychotics by Combining Muscarinic M1 Receptor Structure-Activity Relationship with Systems Response Profiles in Zebrafish Larvae.Karin Hellman et al.ACS chemical neuroscience, 11(2), 173-183 (2019-12-19) The impact of hospital smoking ban on clozapine and norclozapine levels.Lori Murayama-Sung et al.Journal of clinical psychopharmacology, 31(1), 124-126 (2010-12-31) Toxicological screening of human plasma by on-line SPE-HPLC-DAD: identification and quantification of basic drugs and metabolites.Ludmila Mut et al.Biomedical chromatography : BMC, 29(6), 935-952 (2014-11-18) Modulation of the Tryptophan Hydroxylase 1/Monoamine Oxidase-A/5-Hydroxytryptamine/5-Hydroxytryptamine Receptor 2A/2B/2C Axis Regulates Biliary Proliferation and Liver Fibrosis During Cholestasis.Konstantina Kyritsi et al.Hepatology (Baltimore, Md.), 71(3), 990-1008 (2019-07-26) Plasma levels of clozapine and norclozapine in Mexican schizophrenia patients.Dinora F González-Esquivel et al.Arzneimittel-Forschung, 61(6), 335-339 (2011-08-11) Functional activation of G-proteins coupled with muscarinic acetylcholine receptors in rat brain membranes.Yuji Odagaki et al.Journal of pharmacological sciences, 125(2), 157-168 (2014-05-23) Segmental analysis of antidepressant and antipsychotic drugs in the hair of schizophrenic patients.Xin Wang et al.Drug testing and analysis, 12(4), 472-484 (2019-12-26) Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors.B L Roth et al.The Journal of pharmacology and experimental therapeutics, 268(3), 1403-1410 (1994-03-01) Inhibition of Epstein-Barr Virus Lytic Reactivation by the Atypical Antipsychotic Drug Clozapine.Abbie G Anderson et al.Viruses, 11(5) (2019-05-22) The clozapine metabolite N-desmethylclozapine displays variable activity in diverse functional assays at human dopamine D₂ and serotonin 5-HT₁A receptors.Peter Heusler et al.European journal of pharmacology, 669(1-3), 51-58 (2011-08-13) Microdialysis evaluation of clozapine and N-desmethylclozapine pharmacokinetics in rat brain.Thomas I F H Cremers et al.Drug metabolism and disposition: the biological fate of chemicals, 40(10), 1909-1916 (2012-06-28) Pharmacology of N-desmethylclozapine.Jelveh Lameh et al.Pharmacology & therapeutics, 115(2), 223-231 (2007-06-23) Development of a SPE-HPLC-MS/MS method for the determination of most prescribed pharmaceuticals and related metabolites in urban sewage samples.Robert Gurke et al.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 990, 23-30 (2015-04-05) Behavioral effects of N-desmethylclozapine on locomotor activity and sensorimotor gating function in mice-Possible involvement of muscarinic receptors.Shunsuke Maehara et al.Brain research, 1418, 111-119 (2011-09-16) Ameliorative effect of N-desmethylclozapine in animal models of social deficits and cognitive functions.Shunsuke Maehara et al.Brain research bulletin, 86(3-4), 146-151 (2011-08-23) Antipsychotics for treatment of delirium in hospitalised non-ICU patients.Lisa Burry et al.The Cochrane database of systematic reviews, 6, CD005594-CD005594 (2018-06-20) Elevated clozapine serum levels in combination with perazine.M Fischer et al.Psychopharmacology, 226(3), 623-625 (2013-02-12) Design and synthesis of novel derivatives of the muscarinic agonist tetra(ethylene glycol)(3-methoxy-1,2,5-thiadiazol-4-yl) [3-(1-methyl-1,2,5,6-tetrahydropyrid-3-yl)-1,2,5-thiadiazol-4-yl] ether (CDD-0304): effects of structural modifications on the binding and activity at muscarinic receptor subtypes and chimeras.Frederick R Tejada et al.Journal of medicinal chemistry, 49(25), 7518-7531 (2006-12-08) Plasma clozapine levels and clinical response in treatment-refractory Chinese schizophrenic patientsWong JO, et al. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 30(2), 251-264 (2006) Frontiers in Clinical Drug Research- Central Nervous System, 19-19 (2013) Sensitive quantification of clozapine and its main metabolites norclozapine and clozapine-N-oxide in serum and urine using LC-MS/MS after simple liquid-liquid extraction work-up.Ariane Wohlfarth et al.Analytical and bioanalytical chemistry, 400(3), 737-746 (2011-03-12) Effects of clozapine and N-desmethylclozapine on synaptic transmission at hippocampal inhibitory and excitatory synapses.Takako Ohno-Shosaku et al.Brain research, 1421, 66-77 (2011-09-29) Atypical Antipsychotics-Advances in Research and Application (2012) Exploring binding properties of agonists interacting with a δ-opioid receptor.Francesca Collu et al.PloS one, 7(12), e52633-e52633 (2013-01-10) Clozapine and N-desmethylclozapine are potent 5-HT1C receptor antagonists.M Kuoppamäki et al.European journal of pharmacology, 245(2), 179-182 (1993-04-15) Quantification of the steady-state plasma concentrations of clozapine and N-desmethylclozapine in Japanese patients with schizophrenia using a novel HPLC method and the effects of CYPs and ABC transporters polymorphisms.Yumiko Akamine et al.Annals of clinical biochemistry, 54(6), 677-685 (2016-12-10) Regulation of PI3K/Akt signaling by N-desmethylclozapine through activation of δ-opioid receptor.Maria C Olianas et al.European journal of pharmacology, 660(2-3), 341-350 (2011-04-26) Involvement of decreased muscarinic receptor function in prepulse inhibition deficits in mice reared in social isolation.K Koda et al.British journal of pharmacology, 162(3), 763-772 (2010-10-21) Automated Analysis of Clozapine and Norclozapine in Human Plasma Using Novel Extraction Plate Technology and Flow-Injection Tandem Mass Spectrometry.Lewis Couchman et al.Therapeutic drug monitoring, 38(1), 42-49 (2015-09-09) Clozapine--a dangerous drug in a clozapine-naïve subject.D Stanworth et al.Forensic science international, 214(1-3), e23-e25 (2011-08-13) Multimodal Imaging for DREADD-Expressing Neurons in Living Brain and Their Application to Implantation of iPSC-Derived Neural Progenitors.Bin Ji et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(45), 11544-11558 (2016-12-03) Impact of clozapine, N-desmethylclozapine and chlorpromazine on thromboxane production in vitro.Hubertus Himmerich et al.Medicinal chemistry (Shariqah (United Arab Emirates)), 8(6), 1032-1038 (2012-07-05) N-desmethylclozapine: is there evidence for its antipsychotic potential?Maria Cristina Mendoza et al.Clinical neuropharmacology, 32(3), 154-157 (2009-06-02) Use of Phenotypically Poor Metabolizer Individual Donor Human Liver Microsomes To Identify Selective Substrates of UGT2B10.Nicolo Milani et al.Drug metabolism and disposition: the biological fate of chemicals, 48(3), 176-186 (2019-12-17) Validated GC/MS method for the simultaneous determination of clozapine and norclozapine in human plasma. Application in psychiatric patients under clozapine treatment.I Vardakou et al.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 878(25), 2327-2332 (2010-08-03) Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 receptor agonist with unprecedented selectivity and procognitive potential.Anette G Sams et al.Journal of medicinal chemistry, 53(17), 6386-6397 (2010-08-06) Simultaneous Determination of Antipsychotic Drugs and Their Active Metabolites by LC-MS-MS and its Application to Therapeutic Drug Monitoring.Igor I Miroshnichenko et al.Journal of chromatographic science, 56(6), 510-517 (2018-04-11) Glucuronidation of the second-generation antipsychotic clozapine and its active metabolite N-desmethylclozapine. Potential importance of the UGT1A1 A(TA)₇TAA and UGT1A4 L48V polymorphisms.Kathryn K Erickson-Ridout et al.Pharmacogenetics and genomics, 22(8), 561-576 (2012-05-09) Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.Nandita Sinha et al.European journal of medicinal chemistry, 46(2), 618-630 (2010-12-28) Ultra-high-pressure liquid chromatography tandem mass spectrometry determination of antidepressant and anxiolytic drugs in neonatal meconium and maternal hair.Simona Pichini et al.Journal of pharmaceutical and biomedical analysis, 118, 9-16 (2015-10-30) Discriminative stimulus properties of N-desmethylclozapine, the major active metabolite of the atypical antipsychotic clozapine, in C57BL/6 mice.Jason M Wiebelhaus et al.Behavioural pharmacology, 23(3), 262-270 (2012-05-02) Age and sex impact clozapine plasma concentrations in inpatients and outpatients with schizophrenia.Zahinoor Ismail et al.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 20(1), 53-60 (2011-03-23) Plasma clozapine and norclozapine in patients prescribed different brands of clozapine (Clozaril, Denzapine, and Zaponex).Lewis Couchman et al.Therapeutic drug monitoring, 32(5), 624-627 (2010-08-20) N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl-D-aspartate receptor activity.Cyrille Sur et al.Proceedings of the National Academy of Sciences of the United States of America, 100(23), 13674-13679 (2003-11-05) Involvement of histamine receptors in the atypical antipsychotic profile of clozapine: a reassessment in vitro and in vivo.Marie Humbert-Claude et al.Psychopharmacology, 220(1), 225-241 (2011-09-14) Side chain flexibilities in the human ether-a-go-go related gene potassium channel (hERG) together with matched-pair binding studies suggest a new binding mode for channel blockers.Ulrich Zachariae et al.Journal of medicinal chemistry, 52(14), 4266-4276 (2009-06-19) Reliable clinical serum analysis with reusable electrochemical sensor: Toward point-of-care measurement of the antipsychotic medication clozapine.Mijeong Kang et al.Biosensors & bioelectronics, 95, 55-59 (2017-04-17) Antipsychotic effects of N-desmethylclozapine on sensorimotor gating function in rats--possible involvement of activation of M(1) muscarinic receptors.Shunsuke Maehara et al.European journal of pharmacology, 667(1-3), 242-249 (2011-06-11) On-line fully automated determination of clozapine and desmethylclozapine in human serum by solid-phase extraction on exchangeable cartridges and liquid chromatography using a methanol buffer mobile phase on unmodified silica.O V Olesen et al.Journal of chromatography, 622(1), 39-46 (1993-12-08) The Saliva Exposome for Monitoring of Individuals' Health Trajectories.Vincent Bessonneau et al.Environmental health perspectives, 125(7), 077014-077014 (2017-07-27) Plasma clozapine and norclozapine in relation to prescribed dose and other factors in patients aged 65 years and over: data from a therapeutic drug monitoring service, 1996-2010.Sally Bowskill et al.Human psychopharmacology, 27(3), 277-283 (2012-03-16) Kir2.1 Channel Regulation of Glycinergic Transmission Selectively Contributes to Dynamic Mechanical Allodynia in a Mouse Model of Spared Nerve Injury.Yiqian Shi et al.Neuroscience bulletin, 35(2), 301-314 (2018-09-12) Butyl Methacrylate-Co-Ethylene Glycol Dimethacrylate Monolith for Online in-Tube SPME-UHPLC-MS/MS to Determine Chlopromazine, Clozapine, Quetiapine, Olanzapine, and Their Metabolites in Plasma Samples.Luiz G M Beloti et al.Molecules (Basel, Switzerland), 24(2) (2019-01-19) The influence of N-desmethylclozapine and clozapine on recognition memory and BDNF expression in hippocampus.Aygün Ertuğrul et al.Brain research bulletin, 84(2), 144-150 (2010-12-08)

备注