熔点	82-86 ºC
水溶性	溶解, 216 g/100 mL
沸点	125 ºC (25 mmHg)
闪点	138 ºC

危险品标志	T
危险类别码	R22;R43;R45;R46;R48/20/21/22
安全说明书	S24;S53

来源	SDS样本
没有数据	没有数据

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The diazoxide derivative IDRA 21 enhances ischemic hippocampal neuron injury.K A Yamada et al.Annals of neurology, 43(5), 664-669 (1998-05-19) 7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide: a partial modulator of AMPA receptor desensitization devoid of neurotoxicity.F Impagnatiello et al.Proceedings of the National Academy of Sciences of the United States of America, 94(13), 7053-7058 (1997-06-24) The effects of IDRA 21, a positive modulator of the AMPA receptor, on delayed matching performance by young and aged rhesus monkeys.Jerry J Buccafusco et al.Neuropharmacology, 46(1), 10-22 (2003-12-05) 7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide (IDRA 21), a congener of aniracetam, potently abates pharmacologically induced cognitive impairments in patas monkeys.D M Thompson et al.Proceedings of the National Academy of Sciences of the United States of America, 92(17), 7667-7671 (1995-08-15) Changes in AMPA receptor-spliced variant expression and shift in AMPA receptor spontaneous desensitization pharmacology during cerebellar granule cell maturation in vitro.P Longone et al.Journal of molecular neuroscience : MN, 11(1), 23-41 (1998-11-25) The effects of huperzine A and IDRA 21 on visual recognition memory in young macaques.Ludise Malkova et al.Neuropharmacology, 60(7-8), 1262-1268 (2010-12-28) 5'-alkyl-benzothiadiazides: a new subgroup of AMPA receptor modulators with improved affinity.Dean Phillips et al.Bioorganic & medicinal chemistry, 10(5), 1229-1248 (2002-03-12) Effects of 5'-alkyl-benzothiadiazides on (R,S)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor biophysics and synaptic responses.Amy C Arai et al.Molecular pharmacology, 62(3), 566-577 (2002-08-16) 7-Chloro-3-methyl-3-4-dihydro-2H-1,2,4 benzothiadiazine S,S-dioxide (IDRA 21): a benzothiadiazine derivative that enhances cognition by attenuating DL-alpha-amino-2,3-dihydro-5-methyl-3-oxo-4-isoxazolepropanoic acid (AMPA) receptor desensitization.I Zivkovic et al.The Journal of pharmacology and experimental therapeutics, 272(1), 300-309 (1995-01-01) Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2.Christian Krintel et al.The Biochemical journal, 441(1), 173-178 (2011-09-08) Enantiomeric resolution with a new chiral stationary phase of 7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide, a cognition-enhancing benzothiadiazine derivative.D P Uzunov et al.Journal of pharmaceutical sciences, 84(8), 937-942 (1995-08-01) Mechanism and impact of allosteric AMPA receptor modulation by the ampakine CX546.N Nagarajan et al.Neuropharmacology, 41(6), 650-663 (2001-10-20) The diazoxide derivative 7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine-S,S-dioxide augments AMPA- and GABA-mediated synaptic responses in cultured hippocampal neurons.K A Yamada et al.Neurobiology of disease, 5(3), 196-205 (1998-12-16) Modulation of kainate--activated currents by diazoxide and cyclothiazide analogues (IDRA) in cerebellar granule neurons.G Puia et al.Progress in neuro-psychopharmacology & biological psychiatry, 24(6), 1007-1015 (2000-10-21) Therapeutic potential of positive AMPA modulators and their relationship to AMPA receptor subunits. A review of preclinical data.Mark D Black Psychopharmacology, 179(1), 154-163 (2005-01-27) Effect of the AMPA receptor modulator IDRA 21 on LTP in hippocampal slices.A Arai et al.Neuroreport, 7(13), 2211-2215 (1996-09-02) A novel class of allosteric modulators of AMPA/Kainate receptors.Giuseppe Cannazza et al.Bioorganic & medicinal chemistry letters, 19(4), 1254-1257 (2009-01-24) Chiral resolution of the enantiomers of 7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide using high-performance liquid chromatography on cellulose-based chiral stationary phases.G Cannazza et al.Journal of pharmaceutical and biomedical analysis, 23(1), 117-125 (2000-07-18) IDRA-21, a positive AMPA receptor modulator, inhibits synaptic and extrasynaptic NMDA receptor mediated events in cultured cerebellar granule cells.Gabriele Losi et al.Neuropharmacology, 46(8), 1105-1113 (2004-04-28)

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