熔点	198-202 ºC (dec.)
水溶性	不溶

危险品标志	Xn
危险类别码	R36/37/38;R68
安全说明书	S26;S36/37/39;S45

来源	SDS样本
没有数据	没有数据

产品合成路线

更多

名称	CAS号
Neratinib	698387-09-6	查看

更多

文章

同行评议文献

Bioassay-guided identification of α-amylase inhibitors in herbal extracts.Snezana Agatonovic-Kustrin et al.Journal of chromatography. A, 1620, 460970-460970 (2020-02-25) Evaluation of ursolic acid isolated from Ilex paraguariensis and derivatives on aromatase inhibition.Simone C B Gnoatto et al.European journal of medicinal chemistry, 43(9), 1865-1877 (2008-01-15) Qualitative characterization of Desmodium adscendens constituents by high-performance liquid chromatography-diode array ultraviolet-electrospray ionization multistage mass spectrometry.Claudio Baiocchi et al.European journal of mass spectrometry (Chichester, England), 19(1), 1-15 (2013-07-12) HPTLC-densitometry determination of triterpenic acids in Origanum vulgare, Rosmarinus officinalis and Syzygium aromaticum.Renata Nowak et al.Acta poloniae pharmaceutica, 70(3), 413-418 (2013-06-14) A novel screening model for the molecular drug for diabetes and obesity based on tyrosine phosphatase Shp2.Yanyan Bu et al.Bioorganic & medicinal chemistry letters, 21(2), 874-878 (2010-12-21) Transcriptional profiles of the response of methicillin-resistant Staphylococcus aureus to pentacyclic triterpenoids.Pooi Yin Chung et al.PloS one, 8(2), e56687-e56687 (2013-02-26) Antimicrobial action of oleanolic acid on Listeria monocytogenes, Enterococcus faecium, and Enterococcus faecalis.Sejeong Kim et al.PloS one, 10(3), e0118800-e0118800 (2015-03-11) [Survey of pharmacology of oleanolic acid].Li-ting Tian et al.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 27(12), 884-886 (2003-06-05) Oleanolic acid modulates multiple intracellular targets to inhibit colorectal cancer growth.Li Li et al.International journal of oncology, 47(6), 2247-2254 (2015-10-16) Mechanistic insights on petrosaspongiolide M inhibitory effects on immunoproteasome and autophagy.Maria Chiara Monti et al.Biochimica et biophysica acta, 1844(4), 713-721 (2014-02-18) Triterpenoids from the leaves of Diospyros kaki (persimmon) and their inhibitory effects on protein tyrosine phosphatase 1B.Phuong Thien Thuong et al.Journal of natural products, 71(10), 1775-1778 (2008-09-19) Immunomodulatory effects of two sapogenins 1 and 2 isolated from Luffa cylindrica in Balb/C mice.Anamika Khajuria et al.Bioorganic & medicinal chemistry letters, 17(6), 1608-1612 (2007-02-03) In Vitro Cytotoxicity of Oleanolic/Ursolic Acids-Loaded in PLGA Nanoparticles in Different Cell Lines.Amélia M Silva et al.Pharmaceutics, 11(8) (2019-07-28) Remarks on Sasidharan et al. "Evaluation of the hepatoprotective effects of lantadene A, a pentacyclic triterpenoid of Lantana plants against acetaminophen-induced liver damage". Molecules 2012, 17, 13937-13947.Manu Sharma Molecules (Basel, Switzerland), 18(3), 3442-3444 (2013-03-16) Isolation of methyl 27-caffeoyloxyoleanolate--a new oleanane Triterpenoid from the roots of Hibiscus vitifolius.Duraisamy Ramasamy et al.Natural product communications, 8(4), 433-434 (2013-06-07) [Research on quality standards of zhuang medicine Lonicerae dasystylae flos].Rui-Song Huang et al.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(5), 762-767 (2013-06-04) Pharmacology of oleanolic acid and ursolic acid.J Liu Journal of ethnopharmacology, 49(2), 57-68 (1995-12-01) Preventive and therapeutic oral administration of the pentacyclic triterpene α,β-amyrin ameliorates dextran sulfate sodium-induced colitis in mice: the relevance of cannabinoid system.Israel Matos et al.Molecular immunology, 54(3-4), 482-492 (2013-03-05) Changes in the triterpenoid content of cuticular waxes during fruit ripening of eight grape (Vitis vinifera) cultivars grown in the Upper Rhine Valley.Flora Pensec et al.Journal of agricultural and food chemistry, 62(32), 7998-8007 (2014-07-25) Evaluation of ethnomedical claim III: anti-hyperglycemic activities of Gongronema latifolium root and stem.Adeleke Clement Adebajo et al.Journal of diabetes, 5(3), 336-343 (2012-12-12) Bardoxolone methyl in type 2 diabetes and stage 4 chronic kidney disease.Dick de Zeeuw et al.The New England journal of medicine, 369(26), 2492-2503 (2013-11-12) Anticancer activity of the roots of Ichnocarpus frutescens R. Br. and isolated triterpenes.Narendra Kumar Singh et al.Pakistan journal of pharmaceutical sciences, 27(1), 187-191 (2014-01-01) Cucurbitane glucosides from the root of Machilus yaoshansis.Maoluo Gan et al.Journal of natural products, 74(11), 2431-2437 (2011-11-03) [Chemical constituents of Gentiana rhodantha].Yun Chen et al.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(3), 362-365 (2013-05-15) The molecular insight into the antihyperuricemic and renoprotective effect of Shuang Qi gout capsule in mice.Nandani Darshika Kodithuwakku et al.Journal of ethnopharmacology, 163, 278-289 (2015-01-24) Inhibition of Oxidative Stress and Skin Aging-Related Enzymes by Prenylated Chalcones and Other Flavonoids from Helichrysum teretifolium.Olugbenga K Popoola et al.Molecules (Basel, Switzerland), 20(4), 7143-7155 (2015-04-24) Maslinic acid derivatives induce significant apoptosis in b16f10 murine melanoma cells.Andres Parra et al.European journal of medicinal chemistry, 46(12), 5991-6001 (2011-10-25) Efficient and scalable synthesis of bardoxolone methyl (cddo-methyl ester).Liangfeng Fu et al.Organic letters, 15(7), 1622-1625 (2013-03-28) Oleanolic acid acetate inhibits atopic dermatitis and allergic contact dermatitis in a murine model.Jin Kyeong Choi et al.Toxicology and applied pharmacology, 269(1), 72-80 (2013-03-19) Oleanolic acid synthetic oligoglycosides: a review on recent progress in biological activities.Kuo Xu et al.Die Pharmazie, 69(7), 483-495 (2014-07-31) Langmuir monolayer studies of the interaction of monoamphiphilic pentacyclic triterpenes with anionic mitochondrial and bacterial membrane phospholipids - searching for the most active terpene.Marcin Broniatowski et al.Biochimica et biophysica acta, 1838(10), 2460-2472 (2014-05-24) Purity-activity relationships of natural products: the case of anti-TB active ursolic acid.Birgit U Jaki et al.Journal of natural products, 71(10), 1742-1748 (2008-09-19) Assessment of rosehips based on the content of their biologically active compounds.Apurva Bhave et al.Journal of food and drug analysis, 25(3), 681-690 (2017-09-16) Novel 3alpha-methoxyserrat-14-en-21beta-ol (PJ-1) and 3beta-methoxyserrat-14-en-21beta-ol (PJ-2)-curcumin, kojic acid, quercetin, and baicalein conjugates as HIV agents.Reiko Tanaka et al.Bioorganic & medicinal chemistry, 17(14), 5238-5246 (2009-06-12) Functional Characterization of Cucurbitadienol Synthase and Triterpene Glycosyltransferase Involved in Biosynthesis of Mogrosides from Siraitia grosvenorii.Longhai Dai et al.Plant & cell physiology, 56(6), 1172-1182 (2015-03-12) Chemical Constituents of the Roots of Euphorbia micractina.Wendong Xu et al.Journal of natural products, 72(9), 1620-1626 (2009-08-26) Part I: Synthesis, cancer chemopreventive activity and molecular docking study of novel quinoxaline derivatives.Shadia A Galal et al.European journal of medicinal chemistry, 46(1), 327-340 (2010-12-15) Repeated oral administration of oleanolic acid produces cholestatic liver injury in mice.Yuan-Fu Lu et al.Molecules (Basel, Switzerland), 18(3), 3060-3071 (2013-03-09) Chemopreventive effect of a novel oleanane triterpenoid in a chemically induced rodent model of breast cancer.Anupam Bishayee et al.International journal of cancer, 133(5), 1054-1063 (2013-02-14) Saikosaponin D disrupts platelet-derived growth factor-β receptor/p38 pathway leading to mitochondrial apoptosis in human LO2 hepatocyte cells: a potential mechanism of hepatotoxicity.Li Chen et al.Chemico-biological interactions, 206(1), 76-82 (2013-09-03) Bardoxolone methyl in type 2 diabetes and advanced chronic kidney disease.Dionysios V Chartoumpekis et al.The New England journal of medicine, 370(18), 1767-1767 (2014-05-03) In vivo wound-healing activity of oleanolic acid derived from the acid hydrolysis of Anredera diffusa.Gustavo Moura-Letts et al.Journal of natural products, 69(6), 978-979 (2006-06-24) Potent microbial and tyrosinase inhibitors from stem bark of Bauhinia rufescens (Fabaceae).Aminu Muhammad et al.Natural product communications, 8(10), 1435-1437 (2013-12-21) Synthesis and Evaluation of a Series of Oleanolic Acid Saponins as α-Glucosidase and α-Amylase Inhibitors.Tiantian Guo et al.Archiv der Pharmazie, 348(9), 615-628 (2015-07-25) Oleanane-type triterpenoids from Aceriphyllum rossii and their cytotoxic activity.Le Thi Kim Van et al.Journal of natural products, 72(8), 1419-1423 (2009-07-22) Oleanolic acid and its derivatives: new inhibitor of protein tyrosine phosphatase 1B with cellular activities.Yi-Nan Zhang et al.Bioorganic & medicinal chemistry, 16(18), 8697-8705 (2008-08-19) Synthesis and evaluation of a novel series of heterocyclic oleanolic acid derivatives with anti-osteoclast formation activity.Jun-Feng Li et al.European journal of medicinal chemistry, 44(7), 2796-2806 (2009-01-28) Suppression of AMF/PGI-mediated tumorigenic activities by ursolic acid in cultured hepatoma cells and in a mouse model.Wen-Ling Shih et al.Molecular carcinogenesis, 52(10), 800-812 (2012-05-03) Synthesis and biological evaluation of oleanolic acid derivatives as inhibitors of protein tyrosine phosphatase 1B.Shan Qian et al.Journal of natural products, 73(11), 1743-1750 (2010-10-23) Herbal tea extracts inhibit Cytochrome P450 3A4 in vitro.Sophie Dufay et al.The Journal of pharmacy and pharmacology, 66(10), 1478-1490 (2014-05-16) Structure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: potential impact in diabetes.Cédric Genet et al.Journal of medicinal chemistry, 53(1), 178-190 (2009-11-17) Uralsaponins M-Y, antiviral triterpenoid saponins from the roots of Glycyrrhiza uralensis.Wei Song et al.Journal of natural products, 77(7), 1632-1643 (2014-06-25) Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies.Xiaoan Wen et al.Journal of medicinal chemistry, 51(12), 3540-3554 (2008-06-04) Bioactive triterpenoids from Salvia species.Gülaçti Topçu Journal of natural products, 69(3), 482-487 (2006-03-28) Design, synthesis, and antihepatocellular carcinoma activity of nitric oxide releasing derivatives of oleanolic acid.Li Chen et al.Journal of medicinal chemistry, 51(15), 4834-4838 (2008-07-05) Chemical constituents of Tilia taquetii leaves and their inhibition of MMP-1 expression and elastase activities.Su Yeong Kim et al.Natural product communications, 9(12), 1683-1685 (2015-01-30) Knockdown or inhibition of aldo-keto reductase 1B10 inhibits pancreatic carcinoma growth via modulating Kras-E-cadherin pathway.Wanying Zhang et al.Cancer letters, 355(2), 273-280 (2014-10-12) A novel oleanolic acid-loaded PLGA-TPGS nanoparticle for liver cancer treatment.Xu Bao et al.Drug development and industrial pharmacy, 41(7), 1193-1203 (2014-07-16) Pentacyclic triterpenes. Part 3: Synthesis and biological evaluation of oleanolic acid derivatives as novel inhibitors of glycogen phosphorylase.Jun Chen et al.Bioorganic & medicinal chemistry letters, 16(11), 2915-2919 (2006-03-21) Trichoketides A and B, two new protein tyrosine phosphatase 1B inhibitors from the marine-derived fungus Trichoderma sp.Hiroyuki Yamazaki et al.The Journal of antibiotics, 68(10), 628-632 (2015-04-23) Comparative analysis of CYP93E proteins for improved microbial synthesis of plant triterpenoids.Tessa Moses et al.Phytochemistry, 108, 47-56 (2014-12-03) Antitrypanosomal activity of triterpenoids and sterols from the leaves of Strychnos spinosa and related compounds.Sara Hoet et al.Journal of natural products, 70(8), 1360-1363 (2007-07-20) Oleanolic acid attenuates cisplatin-induced nephrotoxicity in mice and chemosensitizes human cervical cancer cells to cisplatin cytotoxicity.Iva Potočnjak et al.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 132, 110676-110676 (2019-07-16) Modulation of cytokine secretion by pentacyclic triterpenes from olive pomace oil in human mononuclear cells.Ana Marquez-Martin et al.Cytokine, 36(5-6), 211-217 (2007-02-13) Hybrids of 3alpha-methoxyserrat-14-en-21beta-ol (PJ-1) and 3beta-methoxyserrat-14-en-21beta-ol (PJ-2) and various anti-oxidants as cancer chemopreventive agents.Hiroko Tsujii et al.European journal of medicinal chemistry, 45(6), 2191-2197 (2010-02-16) Bioactive constituents from the roots of Panax japonicus var. major and development of a LC-MS/MS method for distinguishing between natural and artifactual compounds.Hsiu-Hui Chan et al.Journal of natural products, 74(4), 796-802 (2011-03-23) Antitrypanosomal triterpenoid with an ε-lactone E-ring from Salvia urmiensis.Mahdi Moridi Farimani et al.Journal of natural products, 76(9), 1806-1809 (2013-09-07) Potential vasorelaxant effects of oleanolic acid and erythrodiol, two triterpenoids contained in 'orujo' olive oil, on rat aorta.Rosalía Rodríguez-Rodríguez et al.The British journal of nutrition, 92(4), 635-642 (2004-11-04) Protective effect of esculentoside A on lipopolysaccharide-induced acute lung injury in mice.Wei-ting Zhong et al.The Journal of surgical research, 185(1), 364-372 (2013-06-15) Protective effect of oleanolic acid against beta cell dysfunction and mitochondrial apoptosis: crucial role of ERK-NRF2 signaling pathway.X Wang et al.Journal of biological regulators and homeostatic agents, 27(1), 55-67 (2013-03-16) Report: structures and hepatocytotoxicity of co-occurring substances in oleanolic acid tablets.Shang-Gao Liao et al.Pakistan journal of pharmaceutical sciences, 27(3), 601-605 (2014-05-09) AMR-Me inhibits PI3K/Akt signaling in hormone-dependent MCF-7 breast cancer cells and inactivates NF-κB in hormone-independent MDA-MB-231 cells.Thangaiyan Rabi et al.Molecular carcinogenesis, 53(7), 578-588 (2013-03-12) Antituberculosis cycloartane triterpenoids from Radermachera boniana.Ngan B Truong et al.Journal of natural products, 74(5), 1318-1322 (2011-04-08) Oleanolic acid induces protective autophagy in cancer cells through the JNK and mTOR pathways.Jia Liu et al.Oncology reports, 32(2), 567-572 (2014-06-11) Inhibition of telomerase activity by oleanane triterpenoid CDDO-Me in pancreatic cancer cells is ROS-dependent.Dorrah Deeb et al.Molecules (Basel, Switzerland), 18(3), 3250-3265 (2013-03-15) Pharmacokinetics study of asperosaponin VI and its metabolites cauloside A, HN saponin F and hederagenin.Er-Wei Liu et al.Journal of natural medicines, 68(3), 488-497 (2014-03-13) Nanostructured lipid carrier based topical gel of Ganoderma Triterpenoids for frostbite treatment.Cheng-Ying Shen et al.Chinese journal of natural medicines, 13(6), 454-460 (2015-06-16) Innovative Natural Ingredients-Based Multiple Emulsions: The Effect on Human Skin Moisture, Sebum Content, Pore Size and Pigmentation.Ugne Cizauskaite et al.Molecules (Basel, Switzerland), 23(6) (2018-06-14) Oleanolic acid and related derivatives as medicinally important compounds.Nighat Sultana et al.Journal of enzyme inhibition and medicinal chemistry, 23(6), 739-756 (2008-07-12) Induction of highly curved structures in relation to membrane permeabilization and budding by the triterpenoid saponins, α- and δ-Hederin.Joseph Lorent et al.The Journal of biological chemistry, 288(20), 14000-14017 (2013-03-27) Study on formability of solid nanosuspensions during solidification: II novel roles of freezing stress and cryoprotectant property.Peng-Fei Yue et al.International journal of pharmaceutics, 475(1-2), 35-48 (2014-08-27) Bardoxolone methyl (BARD) ameliorates aristolochic acid (AA)-induced acute kidney injury through Nrf2 pathway.Juan Wu et al.Toxicology, 318, 22-31 (2014-02-18) Ursolic, oleanolic and betulinic acids: antibacterial spectra and selectivity indexes.Fontanay S, et al. Journal of Ethnopharmacology, 120(2), 272-276 (2008) Oleanolic acid.Jacob Pollier et al.Phytochemistry, 77, 10-15 (2012-03-02) Expanding the ChemGPS chemical space with natural products.Josefin Larsson et al.Journal of natural products, 68(7), 985-991 (2005-07-26) [Quality survey of different species of clematidis radix et rhizoma].Qian-Qian Li et al.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(8), 1203-1205 (2013-08-16) Identification of pentacyclic triterpenes derivatives as potent inhibitors against glycogen phosphorylase based on 3D-QSAR studies.Zhongjie Liang et al.European journal of medicinal chemistry, 46(6), 2011-2021 (2011-03-29) Studies on the reactivity of CDDO, a promising new chemopreventive and chemotherapeutic agent: implications for a molecular mechanism of action.Robin D Couch et al.Bioorganic & medicinal chemistry letters, 15(9), 2215-2219 (2005-04-20) Nutritional evaluation and health promoting activities of nuts and seeds cultivated in Greece.Nick Kalogeropoulos et al.International journal of food sciences and nutrition, 64(6), 757-767 (2013-05-07) Interactions of pentacyclic triterpene acids with cardiolipins and related phosphatidylglycerols in model systems.Marcin Broniatowski et al.Biochimica et biophysica acta, 1838(10), 2530-2538 (2014-06-08) Metabolite profiling of anhuienoside C by rat intestinal bacteria using the LC-MS metabolomic approach.Huinan Zhao et al.Xenobiotica; the fate of foreign compounds in biological systems, 45(3), 189-196 (2014-09-16) Lanostane-type triterpenoids from the sclerotia of Inonotus obliquus possessing anti-tumor promoting activity.Sayaka Taji et al.European journal of medicinal chemistry, 43(11), 2373-2379 (2008-04-05) Oleanane-type saponins from Anemone taipaiensis and their cytotoxic activities.Xiaoyang Wang et al.Fitoterapia, 89, 224-230 (2013-06-19) Oleanolic acid.Jacob Pollier et al.Phytochemistry, 77, 10-15 (2012-03-02) Expanding the ChemGPS chemical space with natural products.Josefin Larsson et al.Journal of natural products, 68(7), 985-991 (2005-07-26) [Quality survey of different species of clematidis radix et rhizoma].Qian-Qian Li et al.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(8), 1203-1205 (2013-08-16) Studies on the reactivity of CDDO, a promising new chemopreventive and chemotherapeutic agent: implications for a molecular mechanism of action.Robin D Couch et al.Bioorganic & medicinal chemistry letters, 15(9), 2215-2219 (2005-04-20) Nutritional evaluation and health promoting activities of nuts and seeds cultivated in Greece.Nick Kalogeropoulos et al.International journal of food sciences and nutrition, 64(6), 757-767 (2013-05-07) Interactions of pentacyclic triterpene acids with cardiolipins and related phosphatidylglycerols in model systems.Marcin Broniatowski et al.Biochimica et biophysica acta, 1838(10), 2530-2538 (2014-06-08) Hawthorn ethanolic extracts with triterpenoids and flavonoids exert hepatoprotective effects and suppress the hypercholesterolemia-induced oxidative stress in rats.Ali Rezaei-Golmisheh et al.Iranian journal of basic medical sciences, 18(7), 691-699 (2015-09-12) Protein tyrosine phosphatase 1B inhibitory activity of triterpenes isolated from Astilbe koreana.MinKyun Na et al.Bioorganic & medicinal chemistry letters, 16(12), 3273-3276 (2006-04-04) Identification of pentacyclic triterpenes derivatives as potent inhibitors against glycogen phosphorylase based on 3D-QSAR studies.Zhongjie Liang et al.European journal of medicinal chemistry, 46(6), 2011-2021 (2011-03-29) Cytotoxic activity of Pulsatilla chinensis saponins and their structure-activity relationship.Kun Xu et al.Journal of Asian natural products research, 15(6), 680-686 (2013-05-11) A non-michaelian behavior of the in vitro metabolism of the pentacyclic triterpene alfa and beta amyrins by employing rat liver microsomes.Fernanda de Lima Moreira et al.Journal of pharmaceutical and biomedical analysis, 84, 14-19 (2013-06-20) Oleanolic acid suppresses migration and invasion of malignant glioma cells by inactivating MAPK/ERK signaling pathway.Guo G, et al. PLoS ONE, 8(8), e72079-e72079 (2013) Determination of Raddeanin A in rat plasma by liquid chromatography-tandem mass spectrometry: application to a pharmacokinetic study.Xin Luan et al.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 923-924, 43-47 (2013-03-05) Design and synthesis of novel photoaffinity probes for study of the target proteins of oleanolic acid.Liying Zhang et al.Bioorganic & medicinal chemistry letters, 22(2), 1036-1039 (2011-12-30) Echinocystic acid, isolated from Gleditsia sinensis fruit, protects endothelial progenitor cells from damage caused by oxLDL via the Akt/eNOS pathway.Peng Lai et al.Life sciences, 114(2), 62-69 (2014-08-03) A new cycloartane nortriterpenoid from stem and leaf of Quercus variabilis.Ling-Yun Jia et al.Journal of Asian natural products research, 15(9), 1050-1054 (2013-07-23) New therapies for diabetic kidney disease.Jonathan Himmelfarb et al.The New England journal of medicine, 369(26), 2549-2550 (2013-11-12) The supplementation of Korean mistletoe water extracts reduces hot flushes, dyslipidemia, hepatic steatosis, and muscle loss in ovariectomized rats.Min Jung Kim et al.Experimental biology and medicine (Maywood, N.J.), 240(4), 477-487 (2014-09-27) Antidiabetic property of Symplocos cochinchinensis is mediated by inhibition of alpha glucosidase and enhanced insulin sensitivity.Kalathookunnel Antony Antu et al.PloS one, 9(9), e105829-e105829 (2014-09-04) Triterpenoids from the resin of Styrax tonkinensis and their antiproliferative and differentiation effects in human leukemia HL-60 cells.Feng Wang et al.Journal of natural products, 69(5), 807-810 (2006-05-27) Oleanolic acid acrylate elicits antidepressant-like effect mediated by 5-HT1A receptor.James O Fajemiroye et al.Scientific reports, 5, 11582-11582 (2015-07-23) Efficient synthesis and anti-fungal activity of oleanolic acid oxime esters.Hanqing Zhao et al.Molecules (Basel, Switzerland), 18(3), 3615-3629 (2013-03-23) Inhibitors of DNA polymerase beta: activity and mechanism.Zhijie Gao et al.Bioorganic & medicinal chemistry, 16(8), 4331-4340 (2008-03-18) Effect of corchorusin-D, a saikosaponin like compound, on B16F10 melanoma cells (in vitro and in vivo).Sumana Mallick et al.Journal of Asian natural products research, 15(11), 1197-1203 (2013-11-13) Biochemical basis of the antidiabetic activity of oleanolic acid and related pentacyclic triterpenes.Jose M Castellano et al.Diabetes, 62(6), 1791-1799 (2013-05-25) Stimulation of autophagic activity in human glioma cells by anti-proliferative ardipusilloside I isolated from Ardisia pusilla.Rong Wang et al.Life sciences, 110(1), 15-22 (2014-07-02) Palbinone and triterpenes from Moutan Cortex (Paeonia suffruticosa, Paeoniaceae) stimulate glucose uptake and glycogen synthesis via activation of AMPK in insulin-resistant human HepG2 Cells.Do Thi Ha et al.Bioorganic & medicinal chemistry letters, 19(19), 5556-5559 (2009-09-01) Determination of Raddeanin A in rat plasma by liquid chromatography-tandem mass spectrometry: application to a pharmacokinetic study.Xin Luan et al.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 923-924, 43-47 (2013-03-05) Triterpenoids from the resin of Styrax tonkinensis and their antiproliferative and differentiation effects in human leukemia HL-60 cells.Feng Wang et al.Journal of natural products, 69(5), 807-810 (2006-05-27) Oleanolic acid acrylate elicits antidepressant-like effect mediated by 5-HT1A receptor.James O Fajemiroye et al.Scientific reports, 5, 11582-11582 (2015-07-23) Antidiabetic property of Symplocos cochinchinensis is mediated by inhibition of alpha glucosidase and enhanced insulin sensitivity.Kalathookunnel Antony Antu et al.PloS one, 9(9), e105829-e105829 (2014-09-04) Effective melanoma inhibition by synthetic pentacyclic triterpenoid 2-(3-phenylprop-2-en-1-ylidene)-22β-hydroxy-3-oxoolean-12-en-28-oic acid: an in vitro and in vivo study.Navin Kumar Tailor et al.Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer, 32(1), 59-72 (2013-06-14) Biochemical basis of the antidiabetic activity of oleanolic acid and related pentacyclic triterpenes.Jose M Castellano et al.Diabetes, 62(6), 1791-1799 (2013-05-25) Determination of oleanolic acid in human plasma and study of its pharmacokinetics in Chinese healthy male volunteers by HPLC tandem mass spectrometry.Min Song et al.Journal of pharmaceutical and biomedical analysis, 40(1), 190-196 (2005-08-30) Isoflavonoids and other compounds from Psorothamnus arborescens with antiprotozoal activities.Manar M Salem et al.Journal of natural products, 69(1), 43-49 (2006-01-31) β-Amyrin biosynthesis: the critical role of steric volume at C-19 of 2,3-oxidosqualene for its correct folding to generate the pentacyclic scaffold.Tsutomu Hoshino et al.Organic letters, 16(13), 3548-3551 (2014-06-25) Inhibition of transglutaminase 2, a novel target for pulmonary fibrosis, by two small electrophilic molecules.Keith C Olsen et al.American journal of respiratory cell and molecular biology, 50(4), 737-747 (2013-11-02) Changes in Heligmosomoides polygyrus glycoprotein pattern by saponins impact the BALB/c mice immune response.Maria Doligalska et al.Experimental parasitology, 135(3), 524-531 (2013-09-17) Simultaneous determination of five triterpene acids in rat plasma by liquid chromatography-mass spectrometry and its application in pharmacokinetic study after oral administration of Folium Eriobotryae effective fraction.Zhen-Hua Li et al.Biomedical chromatography : BMC, 29(12), 1791-1797 (2015-06-03) Development of oleanane-type triterpenes as a new class of HCV entry inhibitors.Fei Yu et al.Journal of medicinal chemistry, 56(11), 4300-4319 (2013-05-15) Antidiabetogenic activity of oleanolic acid glycosides from medicinal foodstuffs.M Yoshikawa et al.BioFactors (Oxford, England), 13(1-4), 231-237 (2001-03-10) Suppression of inflammatory cascade is implicated in methyl amooranin-mediated inhibition of experimental mammary carcinogenesis.Animesh Mandal et al.Molecular carcinogenesis, 53(12), 999-1010 (2013-07-13) Changes of the wax contents in mixtures of olive oils as determined by gas chromatography with a flame ionization detector.Gassan Hodaifa et al.Journal of AOAC International, 95(6), 1720-1724 (2013-03-05) Bardoxolone methyl in type 2 diabetes and advanced chronic kidney disease.Glenn M Chertow et al.The New England journal of medicine, 370(18), 1768-1768 (2014-05-03) Inhibitors of DNA polymerase beta: activity and mechanism.Zhijie Gao et al.Bioorganic & medicinal chemistry, 16(8), 4331-4340 (2008-03-18) Haemolytic activity, cytotoxicity and membrane cell permeabilization of semi-synthetic and natural lupane- and oleanane-type saponins.Charles Gauthier et al.Bioorganic & medicinal chemistry, 17(5), 2002-2008 (2009-02-10) Oleanolic acid alters bile acid metabolism and produces cholestatic liver injury in mice.Jie Liu et al.Toxicology and applied pharmacology, 272(3), 816-824 (2013-08-21) Effects of saikosaponin A on cocaine self-administration in rats.Seong Shoon Yoon et al.Neuroscience letters, 555, 198-202 (2013-10-01) Antidiabetic effect of Streblus asper in streptozotocin-induced diabetic rats.Sanjay Kumar Karan et al.Pharmaceutical biology, 51(3), 369-375 (2013-02-15) Structure determination of inonotsuoxides A and B and in vivo anti-tumor promoting activity of inotodiol from the sclerotia of Inonotus obliquus.Tomoko Nakata et al.Bioorganic & medicinal chemistry, 15(1), 257-264 (2006-10-20) [Study on TLC identification of Dida commonly used in Tibetan medicine from different species].Yong Yang et al.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(5), 757-761 (2013-06-04) Bioactive Phytochemicals from Wild Arbutus unedo L. Berries from Different Locations in Portugal: Quantification of Lipophilic Components.Daniela F S Fonseca et al.International journal of molecular sciences, 16(6), 14194-14209 (2015-06-26) New triterpenoid saponins from the flowers of Pueraria thomsonii.Jing Lu et al.Journal of Asian natural products research, 15(10), 1065-1072 (2013-10-31) Modulating G-protein coupled receptor/G-protein signal transduction by small molecules suggested by virtual screening.Christina M Taylor et al.Journal of medicinal chemistry, 51(17), 5297-5303 (2008-08-19) Conjugates of 3α-methoxyserrat-14-en-21β-ol (PJ-1) and 3β-methoxyserrat-14-en-21β-ol (PJ-2) as cancer chemopreventive agents.Reiko Tanaka et al.European journal of medicinal chemistry, 46(8), 3368-3375 (2011-05-31) Oleanolic acid and ursolic acid: research perspectives.Jie Liu Journal of ethnopharmacology, 100(1-2), 92-94 (2005-07-05) Validated HPTLC method for qualitative and quantitative estimation of oleanolic acid in roots of Cissampelos pareira Linn. var. hirsuta, Menispermaceae.Patel VG, et al. Der Pharmacia Lettre, 7(5), 300-306 (2015) The crucial role of bile acids in the entry of porcine enteric calicivirus.Vinay Shivanna et al.Virology, 456-457, 268-278 (2014-06-04) A synthetic PPAR-γ agonist triterpenoid ameliorates experimental fibrosis: PPAR-γ-independent suppression of fibrotic responses.Jun Wei et al.Annals of the rheumatic diseases, 73(2), 446-454 (2013-03-22) Bardoxolone methyl analogs RTA 405 and dh404 are well tolerated and exhibit efficacy in rodent models of Type 2 diabetes and obesity.Melanie Chin et al.American journal of physiology. Renal physiology, 304(12), F1438-F1446 (2013-04-19) Racemosin C, a novel minor bisindole alkaloid with protein tyrosine phosphatase-1B inhibitory activity from the green alga Caulerpa racemosa.Hui Yang et al.Journal of Asian natural products research, 16(12), 1158-1165 (2014-10-09) Oleanolic acid alters bile acid metabolism and produces cholestatic liver injury in mice.Jie Liu et al.Toxicology and applied pharmacology, 272(3), 816-824 (2013-08-21) Synthesis of 3-deoxypentacyclic triterpene derivatives as inhibitors of glycogen phosphorylase.Pu Zhang et al.Journal of natural products, 72(8), 1414-1418 (2009-08-01) Effects of saikosaponin A on cocaine self-administration in rats.Seong Shoon Yoon et al.Neuroscience letters, 555, 198-202 (2013-10-01) Triterpenoid saponins from Symplocos lancifolia.Ivone Lucia Acebey-Castellon et al.Journal of natural products, 74(2), 163-168 (2011-02-04) 9,19-cyclolanostane derivatives from the roots of Actaea pachypoda.Zulfiqar Ali et al.Journal of natural products, 70(1), 107-110 (2007-01-27)

备注

RelatedAPI's