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Description of route of synthesis:
Put 4-methylpyridine hydrochloride into tetrahydrofuran solvent, add organic base to free the secondary amine, slowly add benzyl chloroformate (Cbz Cl) at controlled temperature, and undergo acylation protection reaction of the amino group. Introduce Cbz benzyloxycarbonyl group on the pyridine nitrogen atom; After the reaction is completed, water is added to quench and the organic layer is separated. Water is washed to remove water-soluble salts, and the organic phase is concentrated and refined to obtain 1-CBZ-4-methylpiperidine.
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